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Blood purification adsorbent with embedding material and preparation method of blood purification adsorbent

An embedding material and blood purification technology, applied in chemical instruments and methods, blood circulation treatment, inorganic chemistry, etc., can solve the problems of low adsorption efficiency, poor biocompatibility, etc., and achieve retention of adsorption performance, avoid leakage, excellent resistance The effect of protein adsorption

Active Publication Date: 2017-09-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a blood purification adsorbent with embedding material and a preparation method for the disadvantages of poor biocompatibility and low adsorption efficiency of the blood purification adsorbent in the existing blood purification technology. Compatible zwitterionic materials are used as activated carbon or resin embedding materials to prepare blood purification adsorbents, which are used in blood purification technology

Method used

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  • Blood purification adsorbent with embedding material and preparation method of blood purification adsorbent
  • Blood purification adsorbent with embedding material and preparation method of blood purification adsorbent
  • Blood purification adsorbent with embedding material and preparation method of blood purification adsorbent

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Preparation of activated carbon with 2-methacryloyloxyethyl phosphorylcholine embedding material

[0052] Weigh 256 mg of 2-methacryloyloxyethyl phosphorylcholine, 2.52 μL of triethylene glycol dimethacrylate, 6 μL of 2-hydroxy-2-methyl-1-phenyl-1-propanone and dissolve in 1 mL Phosphate buffer solution, the mass percentages of the above components are as follows:

[0053]

[0054]

[0055] Add 61 mg of activated carbon (the mass of activated carbon is 24% of the zwitterionic monomer) to the above solution, and stir to form a uniform mixed solution.

[0056] Activated carbon with 2-methacryloyloxyethylphosphorylcholine embedding material was prepared by template method. The preparation process was to add the mixed solution containing activated carbon into the pouring template made of glass slide and Teflon spacer , and reacted in an ultraviolet cross-linking apparatus for 5 minutes to cross-link and embed 2-methacryloyloxyethyl phosphorylcholine on the surface of...

Embodiment 2

[0058] Preparation of resin with carboxybetaine methacrylate-1 (CBMA-1) embedding material

[0059] Weigh 692 mg of carboxybetaine methacrylate-1 (CBMA-1), 4.29 μL of polyethylene glycol diglycidyl ether, 1 mg of ammonium persulfate, 2 μL of tetramethylethylenediamine dissolved in 1 mL of 1M chloride In the sodium solution, the mass percentages of the above-mentioned components are as follows:

[0060]

[0061] Add 346 mg of H103 resin (the mass of the resin is 50% of the mass of the zwitterionic monomer) to the above solution, and stir to form a uniform mixed solution.

[0062] The resin with carboxybetaine methacrylate-1 (CBMA-1) embedding material is prepared by microfluidic method. The preparation process is to use the mixed solution containing resin as the dispersed phase, and corn oil (containing a volume ratio of 1 % tetramethylethylenediamine) as the continuous phase; the injection flow rate of the dispersed phase is 10 μL / min, and the injection flow rate of the co...

Embodiment 3

[0064] Preparation of activated carbon with carboxybetaine methacrylamide embedding material

[0065] Weigh 194 mg of carboxybetaine methacrylamide, 41 mg of N,N'-dimethylacrylamide cystine, and 5 mg of azobisisoheptanonitrile and dissolve them in 1.7 mL of distilled water. The mass percentages of the above components are as follows:

[0066]

[0067] Add 45 mg of activated carbon (the mass of activated carbon is 23% of the zwitterionic monomer) to the above solution, and stir to form a uniform mixed solution.

[0068] Adopt the method for inverse emulsion polymerization to prepare the gac with carboxybetaine methacrylamide embedding material, the preparation process is that the mixed solution containing gac is added to the acetonitrile containing 4.2g of Tween 80 and 4.8g of Span 80 In alkanes (120mL); the solution was mixed with high-speed stirring to form a microemulsion, nitrogen deoxidation was carried out at 4°C, and stirring was carried out under nitrogen protection ...

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Abstract

The invention relates to a blood purification adsorbent with an embedding material and a preparation method of the blood purification adsorbent. The embedding material comprises zwitterionic monomer, a cross-linking agent, an initiator and a solvent, and the zwitterionic monomer comprises one or two types of zwitterionic molecules of carboxyl betaine, sulfobetaine and phosphorylcholine. The method includes: mixing the zwitterionic monomer, the cross-linking agent, the initiator and the solvent; adding activated carbon or resin to form mixed solution, wherein the mass of added activated carbon or resin is 6%-50% of that of the zwitterionic monomer; subjecting the mixed solution with activated carbon or resin to ultraviolet radiation or heating or normal-temperature standing to enable curing of the monomer on the surface of the adsorbent through cross-linking polymerization to form the adsorbent with the zwitterionic embedding material. The embedding material is excellent in protein adsorption resistance and biocompatibility and is extremely high in toxin diffusion efficiency in application to blood adsorption. The blood purification adsorbent is easy to store, and the preparation method is simple and feasible.

Description

technical field [0001] The application belongs to the field of biomedical materials, and specifically relates to a class of adsorption materials prepared by embedding adsorbents in zwitterionic hydrogels with high biocompatibility. The present application also relates to the preparation method and application of the adsorption material, especially for the application of blood purification adsorption. Background technique [0002] Blood purification technology is an effective treatment technology for many difficult diseases, such as acute drug or poison poisoning, end-stage renal disease, and acute and chronic liver failure. This is because when this type of disease occurs, harmful substances in the blood accumulate excessively, and the patient cannot detoxify, remove or neutralize through his own protection system (liver detoxification system, human body's own immune system, excretion system, etc.), resulting in blood poisoned. Therefore, the treatment of such diseases req...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C08F220/36C08F222/20C08F2/44C08K3/04C08F283/06C08F220/60C08F222/38C08F220/38A61M1/16A61M1/36
CPCA61M1/16A61M1/3687B01J20/20B01J20/26B01J20/264B01J20/267B01J20/268B01J20/28004C08F2/44C08F220/36C08F220/38C08F220/387C08F220/60C08F220/603C08F283/06C08K3/04C08F220/365C08F222/385C08F222/102
Inventor 张雷蔡娜娜杨静李庆斯赵维强
Owner TIANJIN UNIV
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