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A kind of blood compatible polymer layer and preparation method thereof

A blood-compatibility, polymer layer technology, applied in coating, surgery, medical science, etc., can solve the problem that the hydrophobic property does not achieve the anti-fouling effect, and achieve excellent anti-erythrocyte adhesion performance and anti-platelet adhesion performance excellent effect

Active Publication Date: 2022-07-12
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although it has been reported that AACA monomers have been successfully used to construct blood-compatible polymer layers (Colloids and Surfaces B: Biointerfaces, 2018, 161, 73-82, DOI: 10.1016 / j.colsurfb.2017.10.035), but The strong hydrophobic properties of the monomer itself did not achieve a very ideal antifouling effect

Method used

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  • A kind of blood compatible polymer layer and preparation method thereof
  • A kind of blood compatible polymer layer and preparation method thereof
  • A kind of blood compatible polymer layer and preparation method thereof

Examples

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Effect test

Embodiment 1

[0047] A method for preparing a blood-compatible polymer layer. Under the condition of ultraviolet light irradiation, a copolymerization reaction of 6-acrylamidohexanoic acid and N-vinylpyrrolidone is initiated on the surface of a silanized silicon wafer to prepare a grafted polymer layer. Hemocompatible polymer layers on silanized samples, such as Figure 9 shown, the specific steps are as follows:

[0048] (1) Place the silicon wafer in mixed solution I (a mixed solution of concentrated sulfuric acid and hydrogen peroxide, concentrated sulfuric acid is a sulfuric acid solution with a mass fraction of 90%, and hydrogen peroxide is a volume fraction of 30% hydrogen peroxide), and heated at 80 ° C 30min, after taking out, clean the surface with deionized water, and dry it by blowing high-purity nitrogen (purity 99.999%) to obtain a silicon wafer with hydroxylation on the surface, named Si-OH, and denoted as A; wherein concentrated sulfuric acid and hydrogen peroxide The volume...

Embodiment 2

[0067] A preparation method of a blood-compatible polymer layer, the specific steps are as follows:

[0068] (1) Place the substrate (ceramic) in mixed solution I (a mixed solution of concentrated sulfuric acid and hydrogen peroxide, concentrated sulfuric acid is a sulfuric acid solution with a mass fraction of 98%, and hydrogen peroxide is a volume fraction of 30% hydrogen peroxide), and at 78 ° C Under heating 30min, after taking out, clean the surface with deionized water, after adopting the mode of blowing high-purity nitrogen (purity 99.999%) to dry, obtain the substrate of surface hydroxylation; The volume ratio of vitriol oil and hydrogen peroxide in mixed solution I is 3: 1;

[0069] (2) silanizing the surface hydroxylated substrate obtained in step (1) to obtain a silanized substrate;

[0070] The specific silanization process is as follows: the surface hydroxylated substrate obtained in step (1) is placed in mixed solution II (silane coupling agent with double bonds...

Embodiment 3

[0075] A preparation method of a blood-compatible polymer layer, the specific steps are as follows:

[0076] (1) Place the substrate (glass) in mixed solution I (a mixed solution of concentrated sulfuric acid and hydrogen peroxide, concentrated sulfuric acid is a sulfuric acid solution with a mass fraction of 98%, and hydrogen peroxide is a volume fraction of 30% hydrogen peroxide), and at 79 ° C Under heating 32min, after taking out, clean the surface with deionized water, after adopting the mode of blowing high-purity nitrogen (purity 99.999%) to dry, obtain the substrate of surface hydroxylation; The volume ratio of vitriol oil and hydrogen peroxide in mixed solution I is 3: 1;

[0077] (2) silanizing the surface hydroxylated substrate obtained in step (1) to obtain a silanized substrate;

[0078] The specific silanization process is as follows: the surface hydroxylated substrate obtained in step (1) is placed in mixed solution II (silane coupling agent with double bonds, ...

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Abstract

The invention relates to a blood-compatible polymer layer and a preparation method thereof. Under the condition of ultraviolet light irradiation, a copolymerization reaction of 6-acrylamidocaproic acid and N-vinylpyrrolidone is initiated on the surface of a silanized substrate to obtain the preparation method. The blood-compatible polymer layer; the water contact angle of the prepared blood-compatible polymer layer is 40 to 45°; after the blood-compatible polymer layer is grafted on the surface of the silanized substrate, the BSA and Fib proteins are adsorbed The amount was reduced by 75-80% and 60-68% respectively. Using laser confocal microscope test, no obvious adhesion phenomenon was observed on the red blood cell adhesion test picture and the platelet adhesion test picture. The invention utilizes ultraviolet light to initiate the copolymerization of AACA and NVP monomers, and introduces a blood-compatible polymer layer with hydrophilic-hydrophobic balance ability on the surface of the substrate, the operation is simple, the reaction process is controllable, clean and pollution-free, and large-scale production is possible; The blood-compatible polymer layer has excellent anti-protein adsorption properties, anti-erythrocyte adhesion properties and anti-platelet adhesion properties.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and relates to a blood-compatible polymer layer and a preparation method thereof. Background technique [0002] In recent years, with the rapid development of economy and science and technology, people's demand for biomedical materials is increasing, especially artificial blood vessels, tissue scaffolds, bionic joints, etc. However, due to the non-polar and hydrophobic surface characteristics of biological materials such as general polymer materials, metal materials, and ceramics, protein adsorption, coagulation, and hemolysis often occur after contact with blood, resulting in acute toxicity, inflammation, teratogenicity, and teratogenicity. Reactions such as foreign body rejection seriously limit the application in the field of biomedicine. Therefore, the development of blood-compatible medical biomaterials has application value and social significance. [0003] Polymer ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F220/58C08F226/10A61L31/10A61L31/14
CPCC08F292/00A61L31/10A61L31/14C08F220/58C08F226/10
Inventor 杜艳秋姜旸李义代正伟
Owner JIAXING UNIV
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