153results about How to "Inhibition of activity" patented technology

The present invention describes a novel approach whereby small molecules may be used to modulate activity of microRNA and GAM oligonucleotides. This mode of therapy allows inter alia up regulation of a disease-related target gene of novel GAM oligonucleotides of the present invention, by countering the activity of a GAM oligonucleotides which naturally inhibits expression of that target gene. Nucleic acid molecules are provided respectively encoding 122,764 GAM oligonucleotides and their respective precursors, and 18602 GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament/factors continuously and stably in a certain time, along with great economic and social benefits.

The invention discloses a drug-delivery absorbable hemostatic sponge, which belongs to the technical field of novel hemostatic materials and comprises drug-loaded chitosan microsphere and collagen protein, wherein the drug-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The weight ratios of the medicinal grade chitosan to the medicinal grade tranexamic acid are (0.01-100):1 respectively. The invention also discloses a method for preparing the drug-delivery absorbable hemostatic sponge. By selecting collagen with good hemostatic function and biocompatibility as the main hemostatic substrate, compounding the drug-delivery chitosan microsphere and the medicinal grade tranexamic acid, and making use of the special properties of the chitosan including hemostatic function and drug-delivery function, a novel hemostatic sponge with rapid hemostasis and lasting and steady drug delivery in a period of time can be prepared, and has considerable economic and social benefits.

The invention relates to an application of a black raspberry extract in preparing an anti-diabetic medicine, and an application of the black raspberry extract in preventing type-II diabetes mainly characterized by glucose metabolic disorders, beta islet cell damage and insulin resistance. A novel anti-diabetic medicine preparation provided by the invention takes the black raspberry extract as an active ingredient, and the total effective dose is 1-100mg/kg/d. According to the novel anti-diabetic medicine preparation provided by the invention, the black raspberry extract can be compounded with the diabetes treatment medicines on the current market including sulfonylureas, biguanides or thiazolidinediones to prepare a compound preparation. The black raspberry extract can promote islet cell multiplication and inhibit the PTP1B activity; and meanwhile, in-vivo study finds that the black raspberry extract can be used for improving the increase of the mice blood glucose level caused by alloxan and has an obvious effect in reducing blood glucose. Through verification, the blood glucose reducing effect of the black raspberry fruit or leaf extract is superior to that of the selected positive medicine diaformin.

An anionic antistaling material is prepared from natural ore powder, coupling agent, high-molecular resin, disperser, and filler through high-speed proportionally mixing, extruding granulating, and injection (or blowing) moulding. Its advantage is hgih effect on killing bacteria, disinfecting, deodoring, demoistening and holding freshness.

The invention discloses a toothpaste for stopping bleeding, brightening and refreshing breath and a preparation method thereof. The toothpaste for stopping bleeding, brightening and refreshing breath contains the following materials: olive oil, palm oil, grape seed oil, silica, a universal self emulsified composite emulsifier, a general emulsifier, polyethylene glycol 6000, sodium dodecyl sulfate, sorbitol, a coconut extract, a bletilla striata extract, an Eclipta alba extract, a peppermint extract, a pyracantha fortuneana extract, glycerin, saturated salt water, sodium cyclamate, propylene glycol, distilled water and ethylparaben. Compared with the prior art, the toothpaste contains additional natural plant extracts, has mild property, high safety, powerful effects of removing bad breath, making the mouth breath fragrant and refreshing oral cavity, good foamability and good hemostatic effect; in addition, the toothpaste also has anti-inflammatory effect to prevent inner heat and control inflammation, and can repair mucous membrane tissue wound and enhance the oral mucosal resistance.

The invention relates to a polypeptide and chemotherapy drug combined drug-loaded micelle and a preparation method and an application thereof. Polypeptide with a tumor targeting therapeutical effect and a chemotherapy drug are combined to prepare the tumor-targeting polypeptide-PEGylated phospholipid complex-chemotherapy drug drug-loaded micelle; the polypeptide with the tumor targeting therapeutical effect is specifically combined with a chemotactic factor receptor CXCR4, the CXCR4 polypeptide antagonist is used for increasing a targeting penetration ability of the drug to tumor tissues, the PEGylated phospholipid micelle is used for increasing the drug biological stability and the drug loading amount, and compared with a single chemotherapy drug doxorubicin, the combined drug-loaded micelle shows a stronger characteristic of inhibiting tumor cell vitality. The polypeptide and chemotherapy drug combined drug-loaded micelle provides a feasible method and technique for improving the tumor therapeutic effect.

A nutritive composite vitamine-trace element-white sugar necessary for normal energy metabolism for preventing and treating obesity, fatty liver, alcoholic liver, diabetes and hyperlipemia is prepared from VB1, VB2, VC, Se, Zn and white sugar. It can be used as food or food additive.

The invention discloses a bacteria reducing method for freshwater crawfish meat. The method comprises the following steps: (1) selecting a freshwater crawfish raw material; (2) cleaning; (3) carryingout ultra high pressure treatment; (4) soaking: removing a head and a tail of the whole crawfish in the step (3), removing a shell, pulling the crawfish meat out of the shell integrally, putting the crawfish meat in a fresh-keeping liquid, and carrying out ultrasonic treatment, wherein the fresh-keeping liquid is a mixed solution prepared with an acidic electrolyzed water solvent and containing chitosan, epsilon-polylysine, lactic acid, a Chinese yam peel extract and a corn peel extract; (5) carrying out vacuum prepackaging; (6) carrying out electron beam irradiation treatment: carrying out electron beam irradiation treatment of the crawfish meat after being vacuum-prepackaged in the step (5); and (7) storing. The method can inhibit the growth of exogenous microorganisms of raw crawfish meat of the freshwater crawfish, well keeps the color and texture characteristics of the crawfish meat, delays oxidation of proteins and degradation of astaxanthin, has no significant influence on the meat quality, color and odor of the crawfish meat, and solves the problem of difficult fresh keeping of raw crawfish meat.

The invention discloses a multienzyme cleaning agent for medical appliances, and belongs to the technical field of medical treatment. According to the multienzyme cleaning agent, 4-formylbenzeneboronic acid is added to effectively inhibit the protease activity during storage, and protease activity is prevented from being reduced; beta cyclodextrin and nonionic surfactant Pluronic-F88 in an aqueoussolution are subjected to host-guest recognition, a hydrogen bond is formed from adjacent beta-cyclodextrins through cavity peripheral cyclodextrin, and functions of other cleaning activators cannotbe influenced; polymethylhydrosiloxane, hexamethyldisiloxane and like are used as raw materials, tert-amino in intermediate and sodium chloroacetate perform a quaternization reaction, the appliance surface is protected from secondary pollution; and baicalin and bacterium prodigiosum polysaccharides are added to reduce rejection and pyrogen reaction caused by over-high load of microorganisms, and the use safety of medical appliances can be improved. The multienzyme cleaning agent can solve the problems of low bioenzyme activity and poor cleaning effect in an enzyme cleaning agent since proteasein current multi-enzyme cleaning agent can decompose other bioenzyme in a solution.

The invention provides a refrigerator. The refrigerator comprises a cabinet body, door bodies, heating modules and sterilization modules, wherein storage spaces are limited in the cabinet body; storage containers are respectively arranged in the storage spaces; variable-temperature spaces are respectively limited in the storage containers; each door body is arranged on the front surface of the cabinet body to close the corresponding storage space; each heating module is arranged on the corresponding storage container and is configured to provide heat for the corresponding variable-temperature space in a controlled manner; each sterilization module is arranged on one side of the corresponding heating module, and space around each sterilization module communicates with the corresponding variable-temperature space; and each sterilization module comprises tourmaline, so that negative ions are released through the corresponding tourmaline under the situation that the corresponding heating module is started to perform sterilization and preservation on the corresponding variable-temperature space. According to the refrigerator disclosed by the invention, the negative ions are released through the tourmaline under the situation that the corresponding heating module is started, the growth of bacteria is inhibited, the activity of enzymes during the metabolism of fruits and vegetables is inhibited, and the yield quantity of ethylene with the function of accelerating maturation is reduced, so that sterilization and preservation for food materials in the corresponding variable-temperature space are realized, and the storage effect of the food materials is improved.

The invention discloses a traditional Chinese medicine composition having the function of reducing blood fat and a method for preparing the same. The traditional Chinese medicine composition is prepared from green tea, ginkgo leaf, hawthorn, chrysanthemum and medlar according to certain weight ratio. The composition can be prepared into any common dosage form for internal use. The composition has the efficacy of reducing blood fat, so that the composition can be used to treat hyperlipemia.

The invention discloses an aquatic product fresh-keeping agent which is formed by mixing the following components in percentage by weight: 20-30% of sodium tripolyphosphate, 20-30% of sodium pyrophosphate, 10-20% of sodium hexametaphosphate, 5-10% of dipotassium phosphate, 5-10% of trisodium phosphate and 10-20% of edible salt. A method for keeping aquatic products fresh by using the fresh-keeping agent comprises the following steps: 1) weighing clean aquatic products with an automatic weighing machine, and conveying the aquatic products to a stirring mixer by a screw conveyer; 2) placing the aquatic product fresh-keeping agent in a storage bin, adding the fresh-keeping agent into the stirring mixer by a constant weight feeder; 3) fully mixing the aquatic products and the fresh-keeping agent in the stirring mixer, then conveying the aquatic products and the fresh-keeping agent into an automatic packaging unit for packaging, and freezing and preserving. The method applies a chemical preservation and freezing preservation coupled technique, not only can effectively keep freshness, prevent corrosion and retain moisture, but also can restrain growth and propagation of bacteria in the aquatic products.

The invention discloses a compound antiseptic for meat and a preparation method thereof. The compound antiseptic comprises star anise oil, edible refined oil and sucrose fatty acid esters with aHBL value from 1 to 6. Wherein, Solution A comprises star anise oil and edible refined oil and the volume ratio is (5.9 to 6.1) : (3.9 to 4.1). Solution B comprises sucrose fatty acid esters and edible refined oil and the volume ratio is 1:20. The volume ratio of Solution A to Solution B is 1:1. Since star anise oil belongs to pure natural product, it is characterized by obviously low toxicity and aromaticity. Compared with other chemical synthetic antiseptics, the antiseptic compounded by star anise oil is safer. Meanwhile, activity of the microorganisms and enzymes in meat can be inhibited and fat oxidation can be reduced, thereby, brilliant meat color and normal smell can be guaranteed.

The invention relates to the field of medicines, and concretely relates to a polypeptide having focal adhesion kinase inhibition activity and capable of treating acute lymphocytic leukemia. The sequence of the polypeptide is FRLCSHLRSEECVHW which is a brand new sequence, and the polypeptide can inhibit the focal adhesion kinase activity in vitro, can improve the survival rate of tumor-bearing mice in in-vivo tests, and has potential new drug exploitation values.

The invention discloses compounds disclosed as Formula II. In the Formula II, R is disclosed in the specification, wherein R1 is H, OH or halogen; R2 is disclosed in the specification, n1=0-10, n2=0-10, and n3=0-10; Ar is aryl, arylidene, R99-substituted aryl or R99-substituted arylidene; at least one of R3, R4, R5 and R6 is selenium or sulfur atom, and the rest is carbon or nitrogen atom; and R3, R4, R5 and R6 are connected through a single bond or double bond. As for old patients with osteoporosis, the compounds can keep the osteocyte bone formation and bone destroy at an ideal dynamic balance.

The invention provides a freckle-removing composition, which includes antioxidants, tyrosinase inhibitors, melanin inhibitors, and free radical scavengers, and the tyrosinase inhibitors are composed of deoxyarbutin, snow lotus quercetin or paeonol One or more components of phenols. The synergistic action of the composition can block the normal transport of melanin in the melanocytes and inhibit the activity of tyrosinase through scavenging free radicals, so as to achieve the purpose of removing freckles. In addition, the freckle-removing composition can be used as a freckle-removing additive, which can effectively remove freckles and make the skin fairer and more elastic.

The invention relates to an mRNA-coding nanobody and application thereof, belongs to the field of biomedicine, and particularly relates to the field of nanobody drugs. In order to solve the problems, a new thought and method system is provided for regulating intracellular proteins by using the RNA-coding nanobody. According to the mRNA-coding nanobody provided by the invention, the coded message carried by mRNA is recognized and translated in cells to express a single-stranded nanobody capable of binding to a target protein. The function of disease-related proteins in cells can be effectively and specifically intervened by adopting the method so as to achieve the purpose of treating diseases. Different from the common strategy for expressing nanobodies in cells by using a DNA or virus as a carrier, the method eliminates the risk of altering of the genome sequence of host cells, has the characteristics of safety and easiness in removal, and is very suitable for clinical drug design and production needs.

The invention discloses a polypeptide derived from mammary gland adipose tissue and anti-tumor application thereof. The amino acid sequence of the polypeptide PDBAG1 derived from the mammary gland adipose tissue is shown in SEQ ID No. 2. When the concentration of polypeptide molecules is low, the activity of breast cancer cells can be inhibited, apoptosis of the breast cancer cells can be promoted, and the anti-cancer effect is achieved mainly by damaging the glycolysis storage capacity and up-regulating active oxygen in tumor cells. When the dosage of the polypeptide PDBAG1 derived from the mammary gland adipose tissue is low, the remarkable cancer inhibition effect can be achieved, and the polypeptide is a small-molecule polypeptide, is easy to synthesize, efficient and low in toxicity and has a good anti-tumor effect.

Sun-blocking and skin-whitening essence is prepared from raw materials in parts by weight as follows: 6-7 parts of wheat germ oil, 2-3 parts of disodium PEG-5 laurylcitrate sulfosuccinate, 2-3 parts of potassium cetyl phosphate, 5-6 parts of nano-titania, 90-100 parts of purified water, 1-1.5 parts of EDTA (ethylene diamine tetracetic acid), 7-9 parts of caprylyl glycol, 5-6 parts of isododecane,0.1-0.2 parts of stearyl glycyrrhetinate, 2-3 parts of polyvinylpyrrolidone, 3-4 parts of a tuber aestivum extract, 5-6 parts of a lactobacillus reuteri fermented fructus amomi rotundus extract, 4-5 parts of pine pollen and 3-4 parts of a matricaria recutita extract. The potassium cetyl phosphate and the disodium PEG-5 laurylcitrate sulfosuccinate as very mild surfactants and caprylyl glycol as amild preservative combined to have a synergistic effect in cosmetics together with isododecane, the chelating agent EDTA and other formula components, the irritation is very small, and the stability is high.

One aspect of the invention provides an ice-temperature fresh-keeping method for lotus seeds and lotus seeds kept fresh. The fresh-keeping method includes the following steps: 1) performing sterilization: immersing the lotus seeds in electrolyzed oxidizing water for sterilization; 2) performing color protection and fresh keeping: immersing the lotus seeds treated in the step 1) in a color-protecting fresh-keeping solution, and performing drying; 3) performing ice burying: putting the lotus seeds treated in the step 2) in a modified atmosphere packaging bag filled with electrolyzed oxidizing water ice; 4) performing gas flush packaging: introducing modified atmosphere fresh-keeping gas into the modified atmosphere packaging bag in the step 3); and 5) performing ice-temperature storage: performing ice-temperature storage on the packaged lotus seeds. The method provided by the invention is used for keeping freshness of the fresh lotus seeds, under the condition of -1 DEG C to -3 DEG C, the product can be kept fresh for at least 5 to 6 months or even 6 months or more, lotus seed skin has no obvious browning or no softening phenomena in the fresh keeping stage, and the lotus seeds haveno softening phenomena, do not generate odor, and meet relevant health standards of fruit and vegetable products.