4-aminopyrrolopyrimidine derivative and preparation method and application thereof

Abstract

The invention relates to a 4-aminopyrrolopyrimidine derivative and a preparation method and application thereof, and belongs to the field of medicines. The invention provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The compound can significantly inhibit the activity of RIPK1 kinase, has high selectivity and good safety, and is a potential therapeutic drug for RIPK1 kinase related diseases. TNF alpha induced SIRS model and mouse melanoma lung metastasis model experiments prove that the compound disclosed by the invention can play a role in inhibiting RIPK1 kinase in vivo and has remarkable anti-inflammatory and anti-tumor metastasis activity. The invention provides a new strategy and means for comprehensively treating tumor metastasis.

Description

technical field

[0001] The invention relates to 4-aminopyrrolopyrimidine derivatives, a preparation method and application thereof, and belongs to the field of medicine. Background technique

[0002] In recent years, with the continuous improvement of medical conditions, although surgery and adjuvant therapy can quickly and effectively solve the problem of primary tumors, tumor metastasis is still a major medical problem. The reason lies in the complex mechanism of tumor metastasis and the emergence of drug resistance in malignant tumor metastasis. More than 90% of malignant tumor mortality is caused by tumor metastasis rather than primary tumor. Therefore, how to directly or indirectly inhibit tumor metastasis has become one of the key points and difficulties in the treatment of malignant tumors.

[0003] Studies have shown (see: Nature, 536, 215-218) that amyloid precursor protein (APP, amyloid precursor protein) on the surface of tumor cells can interact with death rece...

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