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Multienzyme cleaning agent for medical appliances

A medical device and cleaning agent technology, applied in the medical field, can solve the problems of poor cleaning effect and low biological enzyme activity of enzyme cleaning agents, and achieve the effects of reducing enzyme damage, preventing the reduction of enzyme activity, and low destructive power

Active Publication Date: 2018-12-07
JIANGXI KEXING BIOLOGICAL ENG CO LTD
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  • Summary
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention: Aiming at the problem that protease in the current multi-enzyme cleaning agent can decompose other biological enzymes in the solution, resulting in low biological enzyme activity and poor cleaning effect in the enzyme cleaning agent, a multi-enzyme cleaning method for medical equipment is provided agent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of active alkaline protease additive is:

[0025] (1) In parts by mass, take 3~6 parts of calcium chloride, 0.5~0.8 parts of 4-formylphenylboronic acid, 1~3 parts of propylene glycol monomethyl ether, 5~10 parts of glycerol, 3~8 parts 1 part of alkaline protease, stirred and mixed at 25~30°C for 30~50min to obtain a stirred mixture, took Pluronic-F88 and added distilled water in a mass ratio of 1~3:20~30 and mixed to obtain a mixed solution a, took β-cyclodextrin by Mass ratio 1~3: 90~100 Add distilled water and mix to get mixed liquid b;

[0026] (2) Take the stirred mixture and add the mixed solution b according to the mass ratio of 2~5:80~100, stir and mix at 20~25°C for 30~50min, then add dropwise the mixed solution a with 70~80% of the mass of the stirred mixture, and control the dropwise addition Time 30~50min, keep warm at 25~30℃ for 1~3h, centrifuge, take the precipitate and freeze-dry to obtain the active alkaline protease additive.

[...

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Abstract

The invention discloses a multienzyme cleaning agent for medical appliances, and belongs to the technical field of medical treatment. According to the multienzyme cleaning agent, 4-formylbenzeneboronic acid is added to effectively inhibit the protease activity during storage, and protease activity is prevented from being reduced; beta cyclodextrin and nonionic surfactant Pluronic-F88 in an aqueoussolution are subjected to host-guest recognition, a hydrogen bond is formed from adjacent beta-cyclodextrins through cavity peripheral cyclodextrin, and functions of other cleaning activators cannotbe influenced; polymethylhydrosiloxane, hexamethyldisiloxane and like are used as raw materials, tert-amino in intermediate and sodium chloroacetate perform a quaternization reaction, the appliance surface is protected from secondary pollution; and baicalin and bacterium prodigiosum polysaccharides are added to reduce rejection and pyrogen reaction caused by over-high load of microorganisms, and the use safety of medical appliances can be improved. The multienzyme cleaning agent can solve the problems of low bioenzyme activity and poor cleaning effect in an enzyme cleaning agent since proteasein current multi-enzyme cleaning agent can decompose other bioenzyme in a solution.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a multi-enzyme cleaning agent for medical instruments. Background technique [0002] In recent years, in order to reduce the occurrence of nosocomial infections, more and more attention has been paid to the cleaning of contaminated medical devices. Many precious and precise medical instruments have small hollow cavities. After entering the human body, they are contaminated with mucus secretions, blood, etc., which cannot be removed by ordinary biological cleaning agents. In addition, mucus secretions, blood and other substances are easily adsorbed on the inner wall of the cavity such as the endoscope, so that the disinfectant cannot fully reach it, resulting in disinfection failure. After surgical instruments are used, organic pollutants such as blood stains and oily tissue fluids often remain on the surface. Moreover, the repeated use of surgical instruments will ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/94C11D3/60C11D3/386C11D3/37C11D3/20C11D3/36C11D3/48
CPCC11D1/722C11D1/88C11D1/94C11D3/22C11D3/222C11D3/364C11D3/3707C11D3/38636C11D3/38681C11D3/48
Inventor 胡次兵路芸庞成荣
Owner JIANGXI KEXING BIOLOGICAL ENG CO LTD
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