Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hydrogel artificial blood vessel and preparation method thereof

An artificial blood vessel and hydrogel technology, applied in the field of artificial blood vessels, can solve the problems of low strength, instable natural mulberry silk mesh structure, poor shape retention, etc., and achieve simple operation process, good application prospect and good repeatability. Effect

Active Publication Date: 2021-11-02
TIANJIN UNIV +1
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The caliber of natural mulberry silk artificial blood vessels can be as low as 1 mm, and it is not easy to generate thrombus. The natural protein structure has excellent histocompatibility and biosafety, but the network structure of the prepared natural mulberry silk is not stable enough, which can easily lead to vascular suction. Shrunken, poor shape retention, and low strength, which limit the clinical application of natural mulberry silk artificial blood vessels

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrogel artificial blood vessel and preparation method thereof
  • Hydrogel artificial blood vessel and preparation method thereof
  • Hydrogel artificial blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Such as figure 2 As shown, Embodiment 1 of the present invention discloses a hydrogel artificial blood vessel and a preparation method thereof, and the technical scheme adopted is as follows:

[0047] A method for preparing a hydrogel artificial blood vessel, the specific steps are as follows:

[0048] S1, under the protection of argon, inject the aqueous dispersion of zwitterionic monomer, cross-linking agent and free radical polymerization initiator ammonium persulfate into the mold, set the temperature at 60°C, and polymerize for 6 h under anaerobic conditions to obtain amphoteric The inner layer of the ionic hydrogel;

[0049] S2, under the condition of argon protection, using a mold sleeve, inject the aqueous dispersion of PNAGA and free radical polymerization initiator ammonium persulfate outside the inner layer obtained in step S1, set the temperature at 60°C, and polymerize under anaerobic conditions After 6 hours, a hydrogel artificial blood vessel with doub...

Embodiment 2

[0058] Embodiment 2 of the present invention discloses a hydrogel artificial blood vessel, and the technical scheme adopted is as follows:

[0059] An artificial blood vessel is a double-layer hydrogel hollow circular tube structure, wherein the inner layer is a zwitterionic hydrogel, and the mass percentage concentration of the zwitterionic methacryloylethyl carboxybetaine (CBMA) is 5%, The mass percent concentration of crosslinking agent N,N-methylenebisacrylamide (MBA) is 1%, the inner diameter is 3 mm, and the thickness of the inner layer is 100 μm; the outer layer is poly-N-acryloyl glycinamide (PNAGA) water In the gel, the mass percent concentration of PNAGA in the outer layer is 20%, and the thickness is 200 μm; the wall thickness of the artificial blood vessel is 300 μm.

Embodiment 3

[0061] Embodiment 3 of the present invention discloses a hydrogel artificial blood vessel, and the technical scheme adopted is as follows:

[0062] An artificial blood vessel is a double-layer hydrogel hollow circular tube structure, wherein the inner layer is a zwitterionic hydrogel, and the mass percent concentration of the zwitterionic methacryloylethylsulfobetaine (SBMA) is 50%, The mass percent concentration of the crosslinking agent N,N-bis(acryloyl)cystamine (MSBA) is 3%, the inner diameter is 3 mm, and the inner layer thickness is 300 μm; the outer layer is poly-N-acryloyl glycinamide (PNAGA) water In the gel, the mass percent concentration of PNAGA in the outer layer is 20%, and the thickness is 300 μm; the wall thickness of the artificial blood vessel is 600 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Average pore sizeaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a hydrogel artificial blood vessel and a preparation method thereof, the artificial blood vessel is of a double-layer structure, the inner layer is zwitterionic hydrogel, and the outer layer is poly (N-acryloylglycinamide) (PNAGA) hydrogel; zwitterions of the zwitterionic hydrogel are selected from one or more of methacryloyloxyethyl sulphobetaine, 2-methacryloyloxyethyl phosphorylcholine, methacryloyloxyethyl carboxylic acid betaine and methacryloyloxyethyl trifluoropropyl carboxylic acid betaine. According to the technical scheme, the problems of blood compatibility, compliance, biocompatibility, mechanical performance and the like of the artificial blood vessel in the using process can be effectively solved, and the artificial blood vessel is expected to be widely applied to the field of vascular surgery.

Description

technical field [0001] The invention relates to the technical field of artificial blood vessels, and more specifically relates to a hydrogel artificial blood vessel and a preparation method thereof. Background technique [0002] According to the latest statistics of the World Health Organization, cardiovascular disease is one of the diseases with the highest morbidity and mortality in the world. The death toll due to cardiovascular disease accounts for about 30% of the death rate, which seriously threatens human health. The development trend of cardiovascular diseases in my country is more severe. According to the "China Cardiovascular Disease Report 2019", there are about 290 million patients with cardiovascular diseases in my country, and they are showing a rapid growth trend. Vascular grafting and vascular reconstruction are the main or auxiliary treatments for cardiovascular diseases. In addition, patients with end-stage renal disease require arteriovenous fistula for d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/40A61L27/16A61L27/00A61L27/50A61L27/52A61F2/06
CPCA61L27/16A61L27/00A61L27/507A61L27/50A61L27/52A61F2/06A61L2300/42A61L2300/41A61L2300/416A61F2240/002C08L35/00
Inventor 李双阳黄平升王伟伟李青华董岸杰
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com