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Zwitter-ion hydrogel external circulation pipeline material and preparation method thereof

A technology of amphoteric ion and external circulation tube, applied in the direction of blood circulation treatment, chemical instruments and methods, synthetic resin layered products, etc., can solve bleeding and other problems, and achieve the effect of solving blood compatibility

Pending Publication Date: 2022-07-29
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In production practice, heparin coating is often used to prevent platelet aggregation, but excessive use of heparin can cause problems such as bleeding, thrombocytopenia (HIT) or risk of allergies

Method used

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  • Zwitter-ion hydrogel external circulation pipeline material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of a zwitterionic hydrogel extracorporeal circulation pipeline material of the present invention is specifically implemented according to the following steps:

[0030] Step 1, using polyester as a raw material, and processing it into a tubular fabric with a diameter of 4 mm at one time to obtain a tissue reinforcement layer;

[0031] Step 2: Diffuse a 4 mm tubular mold into an aqueous dispersion composed of zwitterions, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate, and polymerize for 5 h under anaerobic conditions at 50 °C to prepare get an anticoagulant layer;

[0032] In step 3, the tissue reinforcement layer obtained in step 1 is placed on the surface of the tubular mold obtained in step 1, and then immersed in a water dispersion composed of zwitterionic monomer, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate. The zwitter...

Embodiment 2

[0034] The preparation method of a zwitterionic hydrogel extracorporeal circulation pipeline material of the present invention is specifically implemented according to the following steps:

[0035] Step 1, using silk, and processing it into a tubular fabric with a diameter of 6 mm at one time to obtain a tissue reinforcement layer;

[0036] Step 2: Diffuse a 6 mm tubular mold into an aqueous dispersion composed of zwitterions, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate, and polymerize for 6 h under anaerobic conditions at 70 °C to prepare get an anticoagulant layer;

[0037] In step 3, the tissue reinforcement layer obtained in step 1 is placed on the surface of the tubular mold obtained in step 1, and then immersed in a water dispersion composed of zwitterionic monomer, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate. The zwitterionic hydrogel extracor...

Embodiment 3

[0039] The preparation method of a zwitterionic hydrogel extracorporeal circulation pipeline material of the present invention is specifically implemented according to the following steps:

[0040] Step 1, using spandex as a raw material, and processing it into a tubular fabric with a diameter of 8 mm at one time to obtain a tissue reinforcement layer;

[0041] Step 2: Diffuse an 8mm tubular mold into an aqueous dispersion composed of zwitterions, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate, and polymerize at 70 °C for 6 h under anaerobic conditions to prepare get an anticoagulant layer;

[0042] In step 3, the tissue reinforcement layer obtained in step 1 is covered on the surface of the tubular mold obtained in step 1, and then immersed in a water dispersion composed of zwitterionic monomer, cross-linking agent, ultrafine protein powder and free radical polymerization initiator ammonium persulfate. The zwitteri...

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Abstract

The invention discloses a zwitterionic water gel external circulation pipeline material which comprises an anticoagulation layer located on the inner layer, an elastic bonding layer located on the outer layer and a tissue enhancement layer located in the elastic bonding layer. Both the anticoagulation layer and the elastic bonding layer are hydrogel blends formed by zwitterions and superfine protein powder, and the fabric reinforcing layer is a tubular fabric which is formed by processing polyester or silk or spandex or polytetrafluoroethylene fiber as a raw material at a time. The zwitterionic hydrogel external circulation pipeline material is an artificial blood vessel with good blood compatibility, mechanical properties, good permeability resistance, high adhesion resistance and the like, and meets the requirements on the artificial blood vessel in ECMO.

Description

Technical field [0001] The invention belongs to the technical field of biomedical material preparation, specifically relates to a zwitterionic hydrogel extracorporeal circulation pipeline material, and also relates to a preparation method of a zwitterionic hydrogel extracorporeal circulation pipeline material. Background technique [0002] Extracorporeal membrane oxygenation equipment (ECMO for short) is known as a "life-saving tool" for critically ill patients. ECMO, commonly known as "artificial lung", is the most advanced life support technology in the world. One of its important functions is to provide extracorporeal breathing and circulation for patients with acute or severe heart and lung failure, thereby gaining valuable time for rescue. ECMO uses a centrifugal pump to guide the patient's venous blood outside the body. After the blood is oxygenated through the membrane lung outside the body, it is then returned to the patient's body, thereby maintaining the oxygen su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36C08J3/075C08L89/00C08L33/14C08F289/00C08F220/36B32B1/08B32B9/00B32B9/04B32B9/02B32B27/02B32B27/36B32B27/40B32B27/32
CPCB32B1/08B32B5/18B32B5/02B32B5/245A61M1/3673C08J3/075C08F289/00B32B2262/0253B32B2262/0284B32B2262/0292B32B2262/08B32B2266/02B32B2266/122B32B2307/50B32B2535/00C08J2389/00C08J2433/14C08F220/365
Inventor 李仁杰焦森李星瑶王荃吕霞赵睿
Owner SHAANXI UNIV OF SCI & TECH
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