Nano-silver anti-microbial regenerated silk fibroin material and preparation method thereof

An antibacterial technology for regenerated silk fibroin and nano-silver, which is applied in the direction of single-component silk fibroin rayon, rayon manufacturing, wet spinning, etc. Achieve the effect of preventing agglomeration, durable antibacterial, and easy to run off

Active Publication Date: 2017-07-07
江苏诺阳家居科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The plan of arranging the prepared nano-silver on the material is not a good method, because the nano-silver will agglomerate, the uniform dispersion is not good, and the fixation of the nano-silver is also a problem

Method used

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  • Nano-silver anti-microbial regenerated silk fibroin material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Dissolve the conventional regenerated silk fibroin film in 88% formic acid aqueous solution with a mass fraction of 10% silk fibroin;

[0033] (2) Then add silver nitrate to the formic acid solution, the mass fraction of silver nitrate is 0.001%, and dissolve with magnetic stirring for 30 minutes in the dark, at a temperature of 15°C;

[0034] (3) Pour the solution obtained in step (2) into a polyethylene dish, and dry it naturally to form a film;

[0035] (4) Soak the film obtained in step (3) in an ethanol solution with a mass fraction of 75% for 30 minutes, then fully wash it with deionized water, and dry it naturally to obtain a nano-silver antibacterial regenerated silk fibroin film; carry out X- The ray diffraction test found that a large amount of nano-silver exists in the product, and the X-ray diffraction test pattern showed the characteristic diffraction peaks of nano-silver at 38°, 44°, 64° and 77°. The transmission electron microscope test also observed ...

Embodiment 2

[0037] (1) Dissolve the conventional regenerated silk fibroin film in 98% formic acid aqueous solution with a mass fraction of 15% silk fibroin;

[0038] (2) Then add silver sulfate to the formic acid solution, the mass fraction of silver sulfate is 0.005%, and dissolve with magnetic stirring for 1 hour in the dark, at a temperature of 25°C;

[0039] (3) wet spinning the solution obtained in step (2), using ethanol as a coagulation bath, and winding to obtain regenerated silk fibroin filament fibers;

[0040] (4) Stretch the filament fiber obtained in step (3) in a wet state, the stretching ratio is 2 times, and obtain nano-silver antibacterial regenerated silk fibroin filament fiber with excellent mechanical properties after vacuum drying; perform X-ray diffraction During the test, it was found that a large amount of nano-silver exists inside the fiber. The X-ray diffraction test pattern shows the characteristic diffraction peaks of nano-silver at 38°, 44°, 64° and 77°. The t...

Embodiment 3

[0042](1) Dissolve the conventional regenerated silk fibroin film in 90% formic acid aqueous solution with a mass fraction of 12% silk fibroin;

[0043] (2) Then add silver fluoride to the formic acid solution, the mass fraction of silver fluoride is 0.002%, and dissolve with magnetic stirring for 2 hours in the dark, at a temperature of 35°C;

[0044] (3) Electrospinning the solution obtained in step (2) with a spinning voltage of 12kV, a spinning distance of 12cm, and a flow rate of 0.5ml / h to obtain electrospun fibroin nanofibers with a fiber diameter of 100-500nm between;

[0045] (4) Soak the nanofibers obtained in step (3) in a methanol solution with a mass fraction of 75% for 30 minutes, then fully wash with deionized water, and dry naturally to obtain a nano-silver antibacterial silk fibroin nanofiber membrane; X-ray diffraction test found that a large amount of nano-silver exists inside the product, and the X-ray diffraction test pattern showed characteristic diffrac...

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Abstract

The invention discloses a nano-silver anti-microbial regenerated silk fibroin material and a preparation method thereof. The method comprises the following steps: 1) dissolving degumming silk or regenerated silk fibroin in a solvent taking formic acid as a main component, thereby acquiring a fibroin formic acid solution, and then adding a silver salt, stirring and dissolving; 2) adopting different regenerating technologies for processing the fibroin formic acid solution into the regenerated silk fibroin material in different forms; and 3) performing organic solvent after-treatment on the regenerated silk fibroin material, fully washing with deionized water and drying, thereby acquiring the nano-silver anti-microbial regenerated silk fibroin material. The nanometer silver in the regenerated silk fibroin material provided by the invention has the advantages of small grain size, excellent dispersity, high stability and excellent and long-lasting anti-microbial property. The preparation method is simple, the operation is easy, the cost is low and the material can be easily industrialized.

Description

technical field [0001] The invention relates to a nano-silver antibacterial regenerated silk fibroin material and a preparation method thereof, belonging to the technical field of polymer materials. Background technique [0002] my country is the main producer of silk, and its silk output accounts for more than 70% of the world's output. Silk protein is a natural polymer biomaterial derived from nature. It has excellent mechanical properties, controllable biodegradability, and easy processing, especially its biocompatibility with collagen, making it an ideal raw material for regenerative medical scaffolds. . In recent years, the research and application of silk has extended from the traditional textile field to high-tech fields, such as optoelectronics and biomedical materials, especially as biomedical materials have made important progress. [0003] At present, silk has been successfully processed into regenerated silk fibroin materials with different properties through d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08K3/08C08J5/18D01F4/02D01F1/10C08J9/26D04H1/728D01D5/00D01D5/06
Inventor 黄继伟张锋
Owner 江苏诺阳家居科技有限公司
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