57 results about "Vascular reconstruction" patented technology

A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter. The guide catheter includes a wear resistant coating and is constructed so that its distal end includes plural sections of different outside diameters, with the distal most section being of the smallest outside diameter. A control console is provided to establish various modes of operation of the system based on manual inputs via switches or voice commands via voice recognition circuitry. A video panel displays the various modes of operation and instructions to the operator.

A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

Disclosed are methods for vascular reconstruction of diseased, non-aneurysmal arteries.

A microcatheter with an enhanced inner liner that has low of friction and improved toughness which facilitates delivery of expandable vascular reconstruction devices.

Devices, systems and methods are provided for performing intra-lumenal medical procedures in a desired area of the body. Stents, stent delivery devices and methods of performing medical procedures to redirect and or re-establish the intravascular flow of blood are provided for the treatment of hemorrhagic and ischemic disease states.

Certain embodiments of the present invention provide a method and apparatus for identifying and segmenting vascular structure in an image including: receiving at least one image including a vascular network; identifying at least one seed point corresponding to the vascular network; identifying automatically at least a portion of the vascular network to form an original vascular identification based at least in part on the at least one seed point; and allowing a dynamic user interaction with the vascular identification to form an iterative vascular identification. In an embodiment, the iterative vascular identification is formable in real-time. In an embodiment, the iterative vascular identification is displayable in real-time. In an embodiment, the iterative vascular identification is formable without re-identifying substantially unaltered portions of the vascular identification.

An apparatus for creating revascularization channels in tissue, such as the myocardium of the heart, mechanically cuts the channels using a hand piece with easily removable cutting tip assemblies having angled, sharpened edges to allow rapid tip replacement. The cutting tip assembly has an inner needle within an outer hollow needle with each needle attached to the hand piece for independent rotation and axial movement. The inner needle may be hollow, or formed with a pointed tip, and may rotate counter to the outer needle to enhance gripping and storage of the tissue excised by the outer needle. The hand piece may attach a cylindrical magazine of cutting tip assemblies or one cutting tip assembly. The cutting tip assembly may be heated to provide thermal damage to the heart muscle during the creation of the channel, providing some of the advantages of the laser method of TMR.

The present invention provides an implantable prosthesis comprising a viscera separating barrier that defines a shell having a pocket with an opening that receives an insert. It is contemplated that the insert comprises at least one of an absorbable mesh, a non-absorbable mesh, or an absorbable and non-absorbable mesh combination inserted into the pocket through the opening. In preferred embodiments the viscera separating barrier is acellular collagen, and the absorbable mesh is selected from at least one of a polyglactin, a polyglycolic acid, a polyglactin and a polylactic acid, and the non-absorbable mesh comprises a polypropylene mesh. It is contemplated that the viscera separating barrier acts to reduce or even eliminate attachment of viscera to the prosthesis to encourage rapid cell penetration and revascularization; the non-absorbable mesh will provide immediate, reliable in-growth; and the absorbable mesh will give stability to the prosthesis.

The present invention discloses a preparation method of a double-layer intravascular stent. The method is characterized by comprising the steps of preparing an electrostatic spinning solution, conducting the electrostatic spinning operation, preparing a tubular stent, processing ethanol, and conducting the freeze-drying operation. In this way, the double-layer intravascular stent is prepared. According to the technical scheme of the invention, the intravascular stent is able to withstand the impact of the blood stream and can be well fused with surrounding tissues. Meanwhile, the double-layer intravascular stent creates a good microenvironment for the migration, the adhesion, the growth and the function exertion of vascular tissue repair cells, and has the activities of promoting the vascular regeneration and the vascular reconstruction. The inner diameter of the prepared intravascular stent is about 2 mm, and the wall thickness thereof is about 650 mum. The double-layer intravascular stent is composed of two layers of fibers in density arrangement, wherein the inner layer of the stent is composed of tight, uniform and randomly-oriented fibers, and the outer layer of the stent is composed of loose, uniform and directionally-aligned fibers. Therefore, the functional partitions of the intravascular stent are formed.

The invention discloses a cerebral aneurysm intracavity blood vessel rebuilding device which comprises a bare metal stent and a tectorial membrane. The bare metal stent comprises a near supporting end, a far supporting end and a middle part, the near supporting end and the far supporting end are located at the two ends of the bare metal stent and used for supporting a aneurysm-carried cerebral artery blood vessel wall, the length of the middle part is slightly larger than the width of a cerebral aneurysm neck, and the middle part is arranged between the two supporting ends. The radial size of the middle part is smaller than that of the two supporting ends, and a blood supply cavity is formed between the middle part and the aneurysm-carried cerebral artery blood vessel wall. The tectorial membrane covers the near supporting end and part of the middle part so as to isolate the cerebral aneurysm from receiving the forward blood flowing, large in vector, of an aneurysm-carried cerebral artery and allow the far supporting end without the tectorial membrane to provide backward blood flow, small in vector, from the far end of the aneurysm-carried cerebral artery. The cerebral aneurysm intracavity blood vessel rebuilding device solves the problems that according to very large and huge cerebral aneurysm stent-assisted coil embolization, the aneurysmal obliteration rate is low and the recurrence rate is high, side branch and perforating branch blood supply is ensured, the cerebral aneurysm rupture is effectively prevented, and the space occupying effect of the cerebral aneurysm is reduced.

The invention provides a method for detecting guidewire-free FFR, guidewire-free IMR and guidewire-free CFR. The method comprises the following steps: acquiring a 2D coronary DSA image of a blood vessel to be measured; extracting a 2D target blood vessel from the 2D coronary DSA image; reconstructing a 3D blood vessel model according to the 2D target blood vessel; calculating the guidewire-free CFR according to the 3D blood vessel model; acquiring the central arterial pressure of the blood vessel to be measured by using a non-invasive measurement method; determining the inlet pressure of the blood vessel to be measured according to the central arterial pressure; according to the 3D blood vessel model and the inlet pressure of the blood vessel to be measured, constructing a 3D coronary CFD model of the blood vessel to be measured; and calculating the guidewire-free FFR and the guidewire-free IMR according to the 3D coronary CFD model. The non-invasive detection of the CFR, FFR and IMR by adopting a DSA image auxiliary technology is realized.

The invention provides a three-dimensional reconstruction method and device for coronary blood vessels, electronic equipment and a storage medium, and the method comprises the steps: extracting an IVUS blood vessel inner contour based on an IVUS sequence; determining blood vessel geometric parameters based on CAG images at different angles at the same moment in a coronary artery angiography CAG sequence, the frame number corresponding to the IVUS at the key point position and the IVUS retracement rate, and performing three-dimensional blood vessel reconstruction based on the blood vessel geometric parameters; and positioning and orienting the IVUS sequence on the center line of the reconstructed three-dimensional blood vessel based on the inner contour of the IVUS blood vessel to obtain a fused three-dimensional coronary blood vessel model.

The embodiment of the invention discloses an aneurysm analysis method and a device, and the method comprises the steps: carrying out the registration of first image data and second image data, and obtaining a registration image, the obtaining time of the first image data is earlier than the obtaining time of the second image data; performing three-dimensional surface reconstruction on the registration image and the first image data to obtain a blood vessel reconstruction image; and performing aneurysm analysis on the vascular reconstruction image to obtain an aneurysm analysis result. By adopting the method provided by the embodiment of the invention, the influence of human factors can be eliminated or reduced, the growth change of the aneurysm can be visually understood, rapid diagnosis is realized, and popularization and application are facilitated, so that an observer can analyze the aneurysm more visually and clearly.

The invention discloses an intracranial dense mesh stent with an anticoagulant coating. The intracranial dense mesh stent comprises a dense mesh stent body and a hydrophilic polymer material covering the dense mesh stent body, wherein the dense mesh stent body is coated with the anticoagulant coating. According to the intracranial dense net stent, not only can a channel be reconstructed for blood vessels, but also antithrombotic treatment can be carried out on the blood vessel wall at the position of stent implantation, and embolism treatment can be carried out on aneurysm at the same time.

The invention relates to a blood vessel reconstruction method and device based on a dynamic perfusion image, equipment and a medium. The method comprises the following steps: screening a first blood vessel voxel belonging to an input artery and a second blood vessel voxel belonging to an output vein from each blood vessel voxel of a dynamic perfusion image; respectively generating an artery input curve and a vein output curve based on the contrast agent concentration change curves of the first blood vessel voxels and the second blood vessel voxels; determining a starting time when the contrast agent begins to reach the input artery based on the artery input curve, and determining a deadline based on an intersection point of the artery input curve and the vein output curve, so as to determine an artery time interval; determining the average contrast agent concentration of each vascular voxel in the artery time interval to generate a concentration distribution three-dimensional diagram; segmenting the concentration distribution three-dimensional image to obtain a candidate blood vessel voxel segmentation image, and reconstructing a three-dimensional artery blood vessel image after removing blood vessel voxels of which the peak reaching time is outside the artery time interval from the candidate blood vessel voxel segmentation image. According to the scheme, limitation can be avoided.

The invention relates to a transplant cold protection bag which is formed by three layers of plastic composite films. A transplanted organ placement bag, a refrigerating bag and a heat insulation bag which are formed by middle films, are mutually closed and are provided with inner films are arranged in a wear-resistant plastic bag of an outer film; the transplant cold protection bag can be used for storing organ preservation solution, transplanted organs, a cool storage material and a heat insulation material which have temperatures of 0 to 4 DEG C; one end of the transplanted organ placement bag, together with the wear-resistant plastic bag, is provided with a transplanted organ taking and storing port formed by two magnets and a sealing material together; and the other end of the transplanted organ placement bag, together with the wear-resistant plastic bag, is provided with a liquid replacement tube with a blockage cap. The transplant cold protection bag disclosed by the invention ensures a low temperature of 0 to 4 DEG C, which is required by transplants in an operation and enables the transplants to have no warm ischemia time; the body temperature of a receptor is prevented from being reduced due to conduction of brine ice gauze and complications are reduced; and the transplants are convenient to move and a touch technology is not adopted. The transplant cold protection bag greatly improves the survival rate of postoperative organs and has important clinical significance and application prospect for storage of the transplants in the organ transplantation and vascular reconstruction process.

An agent for the prophylaxis and treatment of vascular constriction is provided, which contains a compound having a Rho kinase inhibitory activity. In particular, a compound having a Rho kinase inhibitory activity, for example, (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)cyclohexane, suppresses regenerative intima proliferation after disorder of blood vessel and has various other actions. Therefore, it is useful as an agent for the prophylaxis and treatment of vascular constriction, specifically, an agent for the prophylaxis and treatment of vascular constriction induced by disorder of vascular wall, such as vascular restenosis that occurs after an operation of percutaneus transluminal coronary angioplasty, vascular restenosis that occurs after an operation of percutaneus transluminal angioplasty, vascular constriction that occurs after vascular reconstruction, such as DCA, operation of intravascular indwelling of stent and the like, and vascular constriction that occurs after organ transplantation.

The invention discloses a blood flow guiding dense net stent. The dense net stent is formed by a plurality of independent net pipe stents. A plurality of multiple independent net pipe stents can penetrate through one another to form an independent net pipe stent, and the independent net pipe stent is formed by weaving metal wires, anti-thrombus polymer fibers and polymer fibers for promoting endothelialization of vascular cells; when used for interventional therapy of aneurysm, the blood flow guiding dense net stent has good anti-thrombus and endothelialization promotion performance of a cardiovascular stent, and the diameter of the stent meshes is gradually increased along with gradual closure of the aneurysm and vascular reconstruction, so that artery occlusion of perforator and collateral branches in a coverage area of the interventional stent can be effectively prevented; the safety and effectiveness of vascular reconstruction are greatly improved; meanwhile, due to the fact that the metal wires with different diameters and the polymer fibers are used, the dense net stent is rigid and soft, good radial supporting force can be kept, and safety and effectiveness of the stent are further guaranteed; and the stent is simple in preparation process and low in cost, and can be used for automatic production.

The invention discovers novel application of glucagon-like peptde-1 receptor agonist to preparation of a pulmonary hypertension treating medicine for the first time. It is proved through various experiments that the medicine can effectively reduce the cell glycolysis level, restrain the abnormal proliferation of pulmonary vascular cells and remarkably relieve pulmonary vascular reconstruction, thereby reducing pulmonary vascular resistance and pulmonary artery pressure and treating pulmonary hypertension.

The invention belongs to the field of rescue robots, and particularly relates to a cardio-pulmonary resuscitation robot. Swing arm mechanisms are symmetrically arranged on the two sides of a robot vehicle body, and the swing arm mechanisms on the two sides synchronously rotate through a swing arm driving mechanism installed in the robot vehicle body; a cardiopulmonary resuscitation instrument is installed at the front end of the mechanical arm, rotation of the swing arm mechanism can adjust the inclination angle of the vehicle body to be matched with movement of the mechanical arm to hold and fix a trapped person, then the cardiopulmonary resuscitation instrument presses the heart of the trapped person, and blood flow of the heart and brain of a sudden cardiac arrest patient is increased. The bridge bearing effect is achieved for subsequent defibrillation, intravenous medication, vascular reconstruction and the like, and the survival probability of trapped people is increased. The cardio-pulmonary resuscitation robot can implement cardio-pulmonary resuscitation treatment on trapped persons in the ruin environment, is high in environment adaptability, can freely cross obstacles, cross gullies and climb steps in the non-structural environment, and has the advantages of being flexible in movement, wide in adaptability, compact in structure and the like.

Certain embodiments of the present invention provide a method and apparatus for identifying vascular structure in an image including: receiving at least one image including a vascular network; identifying at least one seed point corresponding to the vascular network; identifying automatically at least a portion of the vascular network to form an original vascular identification based at least in part on the at least one seed point; and allowing a dynamic user interaction with the vascular identification to form an iterative vascular identification. In an embodiment, the iterative vascular identification is formable in real-time. In an embodiment, the iterative vascular identification is displayable in real-time. In an embodiment, the iterative vascular identification is formable without re-identifying substantially unaltered portions of the vascular identification.

The invention discloses a detecting method based on coaxial time-domain distinguishing photoacoustic imaging. The method includes the steps of system initial positioning, single-point testing, time-domain distinguishing photoacoustic positioning and analyzing, photoacoustic single-point blood vessel measuring and photoacoustic three-dimensional blood vessel reestablishing. The detecting method hasthe advantages that through a coaxial laser emitting and ultrasonic receiving light path, an optical focus and an acoustic focus coincide, same-vortex laser stereoscopic angle exciting and receivingstereoscopic angle receiving are achieved, and measurement errors can be reduced; with blood flow photoacoustic echoes in blood vessels as the space analysis standard, through time-domain distinguishing photoacoustic echo signal analysis, photoacoustic echo signals corresponding to the blood flow, blood vessel inner tissue and blood vessel wall layered substances passing through a main-axis routeat the same time can be analyzed, and photoacoustic detection can be conducted on the outer appearance of the blood vessels and the inner tissue form distribution at the same time.

The present invention shows that VEGF-B is required for myocardial revascularization after myocardial infarction and discloses methods of promoting or stimulating vascular development, such as angiogenesis and / or arteriogenesis, especially in ischemic mammals.

The invention relates to the field of medical diagnosis, and in particular, relates to a system for predicting risks of adverse events (including a composite endpoint of death, re-infarction, heart failure and target vascular reconstruction) after myocardial infarction. The system includes an access controller, a detection part, a sample information receiving functional module, an assignment module, a risk calculation module and a reporting system main interface; the risk calculation module receives assignment values of the assignment module and calculates to obtain the risk of the adverse events after myocardial infarction according to the total score of the assignment values. The system is easy to operate, the results of the evaluation are intuitionistic to display, and the system provided by the invention can accurately and quickly do reasonable risk detection on the patient crowd with myocardial infarction, guides an individualized precise treatment strategy and has important clinical application value.

The invention relates to the technical field of medical teaching aids, in particular to a rapid generation method of a blood vessel teaching aid based on automatic advancing of a bounding box, which comprises the following steps of: manually operating to give an initial point and an initial direction vector on original three-dimensional data, and establishing the bounding box by using the initial point and the initial direction vector; performing offset rotation calculation through the initial point and the initial direction vector to obtain the range of the bounding box; based on the range, six surfaces of the bounding box are cut out through a slicing algorithm; solving a blood vessel outlet based on the six surfaces and the blood vessel inlet, and making direction vectors by using the blood vessel inlet and the blood vessel outlet to obtain a known direction vector; re-establishing a bounding box by using a blood vessel outlet and a known direction vector until a point data group is obtained; fitting the point data set through a spline to obtain a blood vessel center line; the blood vessel teaching aid is obtained by performing blood vessel reconstruction and generation based on the blood vessel center line, and the problem that an existing center line extraction method for a blood vessel tree depends on user interaction is solved.

The invention discloses a cerebral aneurysm intracavity blood vessel rebuilding device which comprises a bare metal stent and a tectorial membrane. The bare metal stent comprises a near supporting end, a far supporting end and a middle part, the near supporting end and the far supporting end are located at the two ends of the bare metal stent and used for supporting a aneurysm-carried cerebral artery blood vessel wall, the length of the middle part is slightly larger than the width of a cerebral aneurysm neck, and the middle part is arranged between the two supporting ends. The radial size of the middle part is smaller than that of the two supporting ends, and a blood supply cavity is formed between the middle part and the aneurysm-carried cerebral artery blood vessel wall. The tectorial membrane covers the near supporting end and part of the middle part so as to isolate the cerebral aneurysm from receiving the forward blood flowing, large in vector, of an aneurysm-carried cerebral artery and allow the far supporting end without the tectorial membrane to provide backward blood flow, small in vector, from the far end of the aneurysm-carried cerebral artery. The cerebral aneurysm intracavity blood vessel rebuilding device solves the problems that according to very large and huge cerebral aneurysm stent-assisted coil embolization, the aneurysmal obliteration rate is low and the recurrence rate is high, side branch and perforating branch blood supply is ensured, the cerebral aneurysm rupture is effectively prevented, and the space occupying effect of the cerebral aneurysm is reduced.

The invention relates to a cerebral apoplexy typing method and device based on vascular image completion, and the method comprises the steps: carrying out the image processing of a first target image of an object brain, and obtaining cerebral infarction focus information; performing image processing on the second target image of the brain of the object to obtain a blood vessel reconstruction result; performing blood vessel fracture state detection on the blood vessel reconstruction result to obtain a to-be-complemented interruption point; performing blood vessel completion at the interruption point to be completed to obtain a completed blood vessel reconstruction result; obtaining brain vasculopathy information according to the complemented vascular reconstruction result; and according to the cerebral infarction lesion information and the brain vasculopathy information, obtaining a cerebral apoplexy typing result of the object. According to the embodiment of the invention, the blood vessel occlusion condition can be effectively counted, and the blood vessel occlusion position is automatically complemented to be in a normal through state under the condition that the blood vessel fracture form exists in the obtained blood vessel reconstruction result, so that the accuracy and efficiency of cerebral apoplexy typing result recognition are improved.

The invention discovers novel application of glucagon-like peptde-1 receptor agonist to preparation of a pulmonary hypertension treating medicine for the first time. It is proved through various experiments that the medicine can effectively reduce the cell glycolysis level, restrain the abnormal proliferation of pulmonary vascular cells and remarkably relieve pulmonary vascular reconstruction, thereby reducing pulmonary vascular resistance and pulmonary artery pressure and treating pulmonary hypertension.

The three-dimensional reconstruction method of angiography guided by dynamic model belongs to the intersection field of digital image processing and medical imaging, and its purpose is to meet the special requirements of auxiliary detection of cardiovascular diseases and surgical navigation in clinical medicine in my country. The invention includes the steps of contrast image preprocessing, blood vessel segmentation, blood vessel skeleton and radius extraction, model-guided blood vessel primitive identification, blood vessel matching and blood vessel three-dimensional reconstruction steps. The present invention also provides a method for establishing a dynamic cardiovascular model, which includes the steps of extracting cardiovascular slice data, the steps of static and dynamic modeling of the heart, and the steps of static and dynamic modeling of the cardiovascular system. The invention can obtain good three-dimensional reconstruction results of angiography, effectively assists the detection and operation navigation of cardiovascular diseases, and meets the clinical requirements.