56 results about "Vascular reconstruction" patented technology

A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

An apparatus for creating revascularization channels in tissue, such as the myocardium of the heart, mechanically cuts the channels using a hand piece with easily removable cutting tip assemblies having angled, sharpened edges to allow rapid tip replacement. The cutting tip assembly has an inner needle within an outer hollow needle with each needle attached to the hand piece for independent rotation and axial movement. The inner needle may be hollow, or formed with a pointed tip, and may rotate counter to the outer needle to enhance gripping and storage of the tissue excised by the outer needle. The hand piece may attach a cylindrical magazine of cutting tip assemblies or one cutting tip assembly. The cutting tip assembly may be heated to provide thermal damage to the heart muscle during the creation of the channel, providing some of the advantages of the laser method of TMR.

The present invention discloses a preparation method of a double-layer intravascular stent. The method is characterized by comprising the steps of preparing an electrostatic spinning solution, conducting the electrostatic spinning operation, preparing a tubular stent, processing ethanol, and conducting the freeze-drying operation. In this way, the double-layer intravascular stent is prepared. According to the technical scheme of the invention, the intravascular stent is able to withstand the impact of the blood stream and can be well fused with surrounding tissues. Meanwhile, the double-layer intravascular stent creates a good microenvironment for the migration, the adhesion, the growth and the function exertion of vascular tissue repair cells, and has the activities of promoting the vascular regeneration and the vascular reconstruction. The inner diameter of the prepared intravascular stent is about 2 mm, and the wall thickness thereof is about 650 mum. The double-layer intravascular stent is composed of two layers of fibers in density arrangement, wherein the inner layer of the stent is composed of tight, uniform and randomly-oriented fibers, and the outer layer of the stent is composed of loose, uniform and directionally-aligned fibers. Therefore, the functional partitions of the intravascular stent are formed.

The embodiment of the invention discloses an aneurysm analysis method and a device, and the method comprises the steps: carrying out the registration of first image data and second image data, and obtaining a registration image, the obtaining time of the first image data is earlier than the obtaining time of the second image data; performing three-dimensional surface reconstruction on the registration image and the first image data to obtain a blood vessel reconstruction image; and performing aneurysm analysis on the vascular reconstruction image to obtain an aneurysm analysis result. By adopting the method provided by the embodiment of the invention, the influence of human factors can be eliminated or reduced, the growth change of the aneurysm can be visually understood, rapid diagnosis is realized, and popularization and application are facilitated, so that an observer can analyze the aneurysm more visually and clearly.

The invention relates to a blood vessel reconstruction method and device based on a dynamic perfusion image, equipment and a medium. The method comprises the following steps: screening a first blood vessel voxel belonging to an input artery and a second blood vessel voxel belonging to an output vein from each blood vessel voxel of a dynamic perfusion image; respectively generating an artery input curve and a vein output curve based on the contrast agent concentration change curves of the first blood vessel voxels and the second blood vessel voxels; determining a starting time when the contrast agent begins to reach the input artery based on the artery input curve, and determining a deadline based on an intersection point of the artery input curve and the vein output curve, so as to determine an artery time interval; determining the average contrast agent concentration of each vascular voxel in the artery time interval to generate a concentration distribution three-dimensional diagram; segmenting the concentration distribution three-dimensional image to obtain a candidate blood vessel voxel segmentation image, and reconstructing a three-dimensional artery blood vessel image after removing blood vessel voxels of which the peak reaching time is outside the artery time interval from the candidate blood vessel voxel segmentation image. According to the scheme, limitation can be avoided.

The invention relates to a transplant cold protection bag which is formed by three layers of plastic composite films. A transplanted organ placement bag, a refrigerating bag and a heat insulation bag which are formed by middle films, are mutually closed and are provided with inner films are arranged in a wear-resistant plastic bag of an outer film; the transplant cold protection bag can be used for storing organ preservation solution, transplanted organs, a cool storage material and a heat insulation material which have temperatures of 0 to 4 DEG C; one end of the transplanted organ placement bag, together with the wear-resistant plastic bag, is provided with a transplanted organ taking and storing port formed by two magnets and a sealing material together; and the other end of the transplanted organ placement bag, together with the wear-resistant plastic bag, is provided with a liquid replacement tube with a blockage cap. The transplant cold protection bag disclosed by the invention ensures a low temperature of 0 to 4 DEG C, which is required by transplants in an operation and enables the transplants to have no warm ischemia time; the body temperature of a receptor is prevented from being reduced due to conduction of brine ice gauze and complications are reduced; and the transplants are convenient to move and a touch technology is not adopted. The transplant cold protection bag greatly improves the survival rate of postoperative organs and has important clinical significance and application prospect for storage of the transplants in the organ transplantation and vascular reconstruction process.

The invention discovers novel application of glucagon-like peptde-1 receptor agonist to preparation of a pulmonary hypertension treating medicine for the first time. It is proved through various experiments that the medicine can effectively reduce the cell glycolysis level, restrain the abnormal proliferation of pulmonary vascular cells and remarkably relieve pulmonary vascular reconstruction, thereby reducing pulmonary vascular resistance and pulmonary artery pressure and treating pulmonary hypertension.

The present invention shows that VEGF-B is required for myocardial revascularization after myocardial infarction and discloses methods of promoting or stimulating vascular development, such as angiogenesis and / or arteriogenesis, especially in ischemic mammals.

The invention discloses a cerebral aneurysm intracavity blood vessel rebuilding device which comprises a bare metal stent and a tectorial membrane. The bare metal stent comprises a near supporting end, a far supporting end and a middle part, the near supporting end and the far supporting end are located at the two ends of the bare metal stent and used for supporting a aneurysm-carried cerebral artery blood vessel wall, the length of the middle part is slightly larger than the width of a cerebral aneurysm neck, and the middle part is arranged between the two supporting ends. The radial size of the middle part is smaller than that of the two supporting ends, and a blood supply cavity is formed between the middle part and the aneurysm-carried cerebral artery blood vessel wall. The tectorial membrane covers the near supporting end and part of the middle part so as to isolate the cerebral aneurysm from receiving the forward blood flowing, large in vector, of an aneurysm-carried cerebral artery and allow the far supporting end without the tectorial membrane to provide backward blood flow, small in vector, from the far end of the aneurysm-carried cerebral artery. The cerebral aneurysm intracavity blood vessel rebuilding device solves the problems that according to very large and huge cerebral aneurysm stent-assisted coil embolization, the aneurysmal obliteration rate is low and the recurrence rate is high, side branch and perforating branch blood supply is ensured, the cerebral aneurysm rupture is effectively prevented, and the space occupying effect of the cerebral aneurysm is reduced.

The invention discovers novel application of glucagon-like peptde-1 receptor agonist to preparation of a pulmonary hypertension treating medicine for the first time. It is proved through various experiments that the medicine can effectively reduce the cell glycolysis level, restrain the abnormal proliferation of pulmonary vascular cells and remarkably relieve pulmonary vascular reconstruction, thereby reducing pulmonary vascular resistance and pulmonary artery pressure and treating pulmonary hypertension.

The three-dimensional reconstruction method of angiography guided by dynamic model belongs to the intersection field of digital image processing and medical imaging, and its purpose is to meet the special requirements of auxiliary detection of cardiovascular diseases and surgical navigation in clinical medicine in my country. The invention includes the steps of contrast image preprocessing, blood vessel segmentation, blood vessel skeleton and radius extraction, model-guided blood vessel primitive identification, blood vessel matching and blood vessel three-dimensional reconstruction steps. The present invention also provides a method for establishing a dynamic cardiovascular model, which includes the steps of extracting cardiovascular slice data, the steps of static and dynamic modeling of the heart, and the steps of static and dynamic modeling of the cardiovascular system. The invention can obtain good three-dimensional reconstruction results of angiography, effectively assists the detection and operation navigation of cardiovascular diseases, and meets the clinical requirements.