The invention discloses a
drug-loaded mesoporous polydopamine
coating polypropylene patch, and belongs to the field of medical material preparation, a preparation method comprises the following steps: dissolving 450-600mg of a mesoporous template agent in a specific amount of a water /
ethanol mixed
solvent, then adding 0.6-1.2 mL of a pore-enlarging agent, and treating to obtain a template solution; adding 700-800mg of a DA
monomer into the template solution, adding a PP patch, after the DA
monomer is uniformly dispersed, adding 1.5-2.0 mL of an alkaline
reagent, keeping out of light at
room temperature until the DA
monomer is subjected to oxidative auto-
polymerization, and generating an MPDA
coating on the surface of the PP patch to obtain an MPDA-PP patch; immersing the MPDA-PP patch into anti-
fibrosis PBS (
Phosphate Buffer Solution), and shaking in a dark place until
medicine loading is completed, so as to obtain the
medicine-loaded mesoporous polydopamine
coating polypropylene patch. The patch can realize
visual detection while actively inhibiting peritoneal
fibrosis, so that the
recurrence risk is reduced, the postoperative management accuracy is improved, and an innovative solution is provided for incisional
hernia treatment. The invention also discloses an application of the patch in herniorrhaphy.