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Preparation method of anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and obtained mesh material

A polypropylene mesh, polydopamine technology, applied in the coating and other directions, can solve the problems of perforation of the digestive tract, many preparation requirements, complicated processes, etc., and achieves good hydrophilicity and biocompatibility, and the production process is simple and reduced. The effect of intestinal adhesions

Inactive Publication Date: 2015-07-29
王辉 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the repair of abdominal wall defects can only place polypropylene mesh outside the peritoneum, and cannot directly contact the abdominal organs. complication
At this stage, the way to solve this scientific problem is to combine polypropylene materials with substances that can be decomposed and metabolized in the body, such as polylactic acid and animal gelatin, to achieve anti-adhesion effects. However, the preparation of these materials requires more, complicated processes, and expensive It is expensive and has a certain timeliness, so it is of great significance to develop a simple, effective and anti-adhesion repair mesh with certain tensile strength

Method used

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  • Preparation method of anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and obtained mesh material
  • Preparation method of anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and obtained mesh material
  • Preparation method of anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and obtained mesh material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Put 3 pieces of 3cm×3cm polypropylene mesh into the tris (Tris) buffer solution with a concentration of 9mmol / L. The surface of the polypropylene material is smooth as observed by the electron microscope. The polypropylene mesh is woven from polypropylene. The medical lightweight patch has a pore size of 2mm, and the surface of the polypropylene material is smooth, and no dopamine and other substances are attached; then 0.9g of dopamine hydrochloride is added, and the final concentration of the prepared dopamine hydrochloride is 1.8g / L. The stirring reaction was carried out under the atmosphere, the rotation speed was 400 rpm, and the reaction was taken out after 24 hours. The resulting polypropylene mesh was rinsed with a large amount of deionized water until the solution was clear, and dried in a vacuum oven at 30°C to obtain a black polydopamine-coated anti-adhesion polypropylene mesh material for abdominal wall defect repair.

[0032] as attached Figure 7 Shown: 1...

Embodiment 2

[0036] Put 2 pieces of 2cm×3cm polypropylene mesh into 50ml buffer solution of Tris (Tris) with a concentration of 10mmol / L. The polypropylene mesh is a medical lightweight patch made of polypropylene weaving , the pore diameter is 2.5mm, then add 1g of dopamine hydrochloride, the final concentration of the prepared dopamine hydrochloride is 2g / L, carry out stirring reaction at 30°C, the rotation speed is 600rpm, take out after 48h of reaction. The resulting polypropylene mesh was rinsed with a large amount of deionized water until the solution was clear, and dried in a vacuum oven at 30° C. to obtain a dark black polydopamine-coated anti-blocking polypropylene mesh material.

[0037] The thickness of the polydopamine film was measured to be about 1.5 μm by electron microscope observation of the deep black polypropylene / polydopamine repair material.

Embodiment 3

[0039] Put 4 pieces of 2cm×2cm polypropylene mesh into 50ml buffer solution of Tris (Tris) with a concentration of 11mmol / L. The polypropylene mesh is a medical lightweight patch woven from polypropylene , the pore diameter is 3mm, then add 1.2g of dopamine hydrochloride, the final concentration of the prepared dopamine hydrochloride is 2.4g / L, carry out stirring reaction at 25°C, the rotation speed is 600rpm, take out after 36h of reaction. The resulting polypropylene mesh was rinsed with a large amount of deionized water until the solution was clear, and dried in a vacuum oven at 30° C. to obtain a light black polydopamine-coated anti-blocking polypropylene mesh material.

[0040] The thickness of polydopamine film is about 800nm ​​observed by electron microscope on light black polypropylene / polydopamine repair material.

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Abstract

The invention discloses a preparation method of an anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and an obtained mesh material. The mesh uses a mesh woven by using polypropylene as a skeleton and the surface is coated with polydopamine; the mesh has the characteristic of reinforcing abdominal wall tension, preventing adhesion and tolerating infection, can be placed in a peritoneal cavity and is a brand new medical abdominal external hernia repair material. The specific preparation method of the mesh comprises the steps of putting the polypropylene mesh in trometamol solution, then adding dopamine hydrochloride and performing conditioned reaction to finally obtain the anti-adhesion polypropylene mesh coated with polydopamine.

Description

technical field [0001] The invention relates to the technical field of medical devices and their preparation, in particular to a method for preparing a polydopamine-coated anti-adhesion polypropylene mesh used for repairing abdominal wall defects, and the polydopamine mesh used for repairing abdominal wall defects obtained by the preparation method. Dopamine-coated non-adhesive polypropylene mesh material. Background technique [0002] Polypropylene is a traditional repair material for abdominal wall defects. Since Usher used polypropylene mesh for inguinal hernia repair in 1963, the tension-free repair of abdominal defects has become a common operation in surgery, and tens of thousands of surgical meshes are used for the repair of abdominal wall defects every day. [0003] At present, the repair of abdominal wall defects can only place polypropylene mesh outside the peritoneum, and cannot directly contact the abdominal organs. complication. At this stage, the way to solv...

Claims

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Application Information

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IPC IPC(8): A61L27/34
CPCA61L31/10
Inventor 王辉吴丁财陈双胡民辉黄榕康杨科力赵日升曾杨赵洁梁业如
Owner 王辉
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