6 results about "Abdominal wall defect" patented technology

Systems, devices, and methods for laparoscopic closure of abdominal wall defects by placement of one or more self-locking tourniquets. The tourniquets can include a toothed portion that can be cinched within a lock head of the tourniquet. The tourniquets can be initially placed intraperitoneally, which can be suitable for use with robotic surgical instruments. A fully tensioned tourniquet can be translated (or axially rotated) to move the lock head out of the abdominal cavity, to a second location within or in front of the abdominal wall and outside of the abdominal cavity, thereby avoiding complications such as bowel perforation, organ laceration, blood vessel rupture, and increased adhesion formation due to the presence of a large profile lock head in the abdominal cavity. Once the lock head is in the second location, the lock head can be embedded in the surrounding tissue to resist potential rotational migration of the tourniquet over time.

The invention discloses injectable conductive anti-adhesion hydrogel and a preparation method and application thereof, hydrogel raw materials comprise a phytic acid doped hydrazide group-containing gelatin-based conductive polymer, an aldehyde group-containing amphiphilic block copolymer and a catalyst, and the three raw materials are mixed under body temperature and physiological conditions and then subjected to in-situ crosslinking to form the hydrogel. The hydrogel has the characteristics of rapid gelling, self-healing, injectability, electric conduction, oxidation resistance and the like. In-vivo experiments show that the hydrogel can significantly inhibit postoperative abdominal adhesion, reduce inflammatory response and remove active oxygen; meanwhile, the hydrogel can promote collagen deposition, angiogenesis and muscle regeneration, is suitable for abdominal wall defect repair and postoperative adhesion prevention, and solves the problem that an existing material is difficult to give consideration to adhesion prevention and repair promotion.

This invention relates to an asymmetric porous bilayer composite hydrogel, its preparation method, and its applications, belonging to the field of medical materials technology. Specifically, the asymmetric porous bilayer composite hydrogel provided by this invention comprises a polyvinyl alcohol (PVA) hydrogel layer and an activated carbon / PVA composite hydrogel layer. The asymmetric porous bilayer composite hydrogel has a bi-asymmetric structure; the dense porous surface formed by the PVA hydrogel prevents tissue adhesion, while the loose porous surface formed by the activated carbon / PVA composite hydrogel promotes the repair of abdominal wall defects. More importantly, by introducing activated carbon into the PVA hydrogel system, reactive oxygen species (ROS) can be effectively adsorbed, simultaneously improving the cell adhesion and anti-swelling properties of the asymmetric porous bilayer composite hydrogel, further promoting tissue repair.

The invention relates to the technical field of surgical medical biological materials, and particularly discloses a double-sided asymmetric multifunctional composite patch and a preparation method thereof, which adopt self-induced phase separation, solvent replacement and in-situ photo-crosslinking technologies to safely and efficiently improve the performance of the patch. Therefore, the anti-pollution and anti-sticking adhesive tape has multiple functions of deformation resistance, degradation resistance, infection resistance, pollution resistance, adhesion resistance, healing promotion and the like. The obtained double-sided asymmetric multifunctional composite patch is of a two-layer structure, the rough and porous surface of the substrate layer is improved, the substrate layer is similar to an extracellular matrix skeleton, and tissue repair and wound healing are promoted; the bPVA layer is formed by grafting PVA molecules with zwitterions, the surface aperture is small, a hydration layer is formed, and adhesion of intestinal canals and other viscera is effectively prevented. Experiments show that the patch is excellent in deformation resistance and degradation resistance in an in-vivo wet environment, good in integrity after operation for 14 days, and free of complications. The patch is suitable for clinical scenes accompanied by infection, particularly meets the complete-cycle functional requirements of infectious abdominal wall defect repair, and has remarkable clinical application value.

This application discloses a method for preparing an antibacterial acellular extracellular matrix patch, its product, and its application, belonging to the field of medical materials technology. The preparation method includes: providing an acellular extracellular matrix patch matrix, and immersing the matrix in a sodium hypochlorite solution for chlorination treatment to obtain an antibacterial acellular extracellular matrix patch. This method enables N-haloamine functionalization at the molecular level of the acellular extracellular matrix patch matrix, not only endowing the prepared patch with excellent antibacterial properties and reducing the likelihood of bacterial resistance, but also allowing it to intelligently switch to an antibacterial effect after partial chlorination consumption, achieving long-lasting antibacterial action. Simultaneously, N-haloamine functionalization effectively maintains the good cell compatibility of the acellular extracellular matrix, making the prepared patch material promising for efficient repair of abdominal wall defects, with excellent application prospects.

This invention discloses a fully absorbable PDO-P4HB binary composite gradient degradable hernia repair patch, comprising: a PDO support layer, a P4HB toughening layer, and multiple composite connection nodes and edge reinforcement rings composed of PDO-P4HB blend materials. This invention uses a fully absorbable and non-immunogenic PDO+P4HB composite material, which can be completely degraded into non-toxic products and excreted from the body through hydrolysis and enzymatic degradation postoperatively, reducing the risk of complications such as infection and adhesions. It is suitable for complex repair scenarios such as infected abdominal wall defects. Utilizing the inherent difference in degradation rates between the two materials, and through specific weaving structures and parameter design, a gradient degradation structure is constructed to achieve a dynamic adaptation process of "early high-strength support (PDO-dominated) – mid-term flexible transition (synergistic between the two) – late complete degradation (P4HB finishing)," meeting both the rigidity requirements of intraoperative operations and the mechanical and biological needs of each stage of tissue repair, balancing support stability and tissue ingrowth.