36 results about "Abdominal wall defect" patented technology

A physical model representing an anatomic model of the abdominal wall that provides for the option of: tactile feedback, the option for photo realism, the inclusion of various pathologies (including, but not limited to, abdominal wall defects such as hernia), and the customizability to mount the model to various training boxes or frames. This medical / anatomic simulation model is composed of various material layers including, but not limited to, non-elastomeric and elastomeric materials such as papers, fabrics, metallic sheets, metallic meshes, rubber-like foams, and other materials. This is a physical / mechanical model that simulates skin, tissue, and organs associated with abdominal wall morphology and pathology.

A physical model representing an anatomic model of the abdominal wall that provides for the option of: tactile feedback, the option for photo realism, the inclusion of various pathologies (including, but not limited to, abdominal wall defects such as hernia), and the customizability to mount the model to various training boxes or frames. This medical / anatomic simulation model is composed of various material layers including, but not limited to, non-elastomeric and elastomeric materials such as papers, fabrics, metallic sheets, metallic meshes, rubber-like foams, and other materials. This is a physical / mechanical model that simulates skin, tissue, and organs associated with abdominal wall morphology and pathology.

The invention discloses a method of using acellular bovine pericardia fixed with genipin as a surgical-repair material to fix an abdominal wall defect.

The invention relates to the technical field of biological medical engineering, and discloses a biological repairing material for an abdominal wall defect and a preparation method of the biological repairing material. The method comprises the following steps: (1) performing pre-treatment on the muscular tissue of rectus abdominis of a dead animal; (2) performing cell extraction treatment to prepare a skeletal muscle acellular matrix biological thin sheet; (3) dissolving the skeletal muscle acellular matrix biological thin sheet into pepsase for digestion; (4) performing electrostatic spinning on skeletal muscle acellular matrix microparticles obtained by digestion and polycaprolactone to obtain a polycaprolactone / skeletal muscle acellular matrix blended electrostatic spinning fiber film which is the biological repairing material disclosed by the invention. According to the method, a skeletal muscle acellular matrix from abdominal wall tissue and polycaprolactone are combined by an electrostatic spinning technology; the preparation materials can be degraded, and products from degradation are harmless to a human body; the prepared biological repairing material can well simulate constituents and the structure of an extracellular matrix and is good in biocompatibility and biomechanical property.

The invention discloses a preparation method of an anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and an obtained mesh material. The mesh uses a mesh woven by using polypropylene as a skeleton and the surface is coated with polydopamine; the mesh has the characteristic of reinforcing abdominal wall tension, preventing adhesion and tolerating infection, can be placed in a peritoneal cavity and is a brand new medical abdominal external hernia repair material. The specific preparation method of the mesh comprises the steps of putting the polypropylene mesh in trometamol solution, then adding dopamine hydrochloride and performing conditioned reaction to finally obtain the anti-adhesion polypropylene mesh coated with polydopamine.

The present invention discloses a preparation method of a material for abdominal wall defect intraperitoneal repair, and the obtained material thereof. The preparation method comprises: 1, preparing a quaternized bacterial cellulose solution; 2, carrying out polydopamine modification on a polypropylene mesh sheet; and 3, coating the quaternized bacterial cellulose solution on the obtained polypropylene mesh sheet. The present invention further provides the material used for the abdominal wall defect intraperitoneal repair and obtained through the process. The obtained material of the present invention has characteristics of good mechanical property, good biocompatibility, good adhesion resistance and good antibacterial property.

The invention belongs to the technical field of medical biological materials and discloses a compound biological patch for repairing abdominal wall defects. The compound biological patch is prepared from a biological patch layer and a bletilla striata fiber mesh layer which covers the surface of one side of the biological patch layer, wherein the bletilla striata fiber mesh layer is an electrospunnano-grade bletilla striata fiber mesh. According to the compound biological patch disclosed by the invention, the bletilla striata fiber mesh layer is combined with a traditional biological patch coating film, so that the anti-infection capability and the wound repairing capability of the compound biological patch are effectively improved; meanwhile, after the compound biological patch is implanted into an organism, the mechanical strength change is higher than needed mechanical strength all the time and tissue reconstruction can be accelerated; existing technical bottlenecks of the biological patch are conducive to solving and the treatment effect of repairing the abdominal wall defects is effectively improved.

The invention relates to a compound anti-adhesion herniorrhaphy tablet and a preparation method thereof, clinically belonging to the field of abdominal wall defect herniorrhaphy implant medical apparatuses and manufacturing methods thereof. The compound anti-adhesion herniorrhaphy tablet comprises a polypropylene patch and a puffed polytetrafluoroethylene anti-adhesion patch, wherein the puffed polytetrafluoroethylene anti-adhesion patch is compounded on the polypropylene patch. The manufacturing method of the compound anti-adhesion herniorrhaphy tablet is characterized by comprising the following steps of: (1) hot-pressing and fusing a polypropylene reticulated weaving matter and a puffed polytetrafluoroethylene anti-adhesion membrane into a whole through a fuse machine so as to prepare a compound comprising the polypropylene patch and the puffed polytetrafluoroethylene anti-adhesion patch; and (2) cutting the compound which is hot-pressed and fused into a whole and comprises the polypropylene patch and the puffed polytetrafluoroethylene anti-adhesion patch into the anti-adhesion herniorrhaphy tablet in a preset shape through ultrasonic waves by adopting a cutter in the preset shape. The preset shape of the compound anti-adhesion herniorrhaphy tablet is a circular shape, an elliptical shape, a rectangular shape or an irregular shape.

The invention relates to an anti-adhesion patch having an internal drainage function, belonging to the technical field of medical consumables. The anti-adhesion patch having the internal drainage function comprises a polypropylene mesh and a polylactide-caprolactone membrane layer, wherein the surface of the polypropylene mesh is dipcoated with a polylactide-caprolactone coating, and the polylactide-caprolactone membrane layer is laminated on the polypropylene mesh; drainage holes are formed in the polylactide-caprolactone membrane layer. The integrity of the polylactide-caprolactone membrane layer of the anti-adhesion patch can be maintained for 30 days or more in the human body, and the complete absorption time of the polylactide-caprolactone membrane layer is 90-120 days. Compared with hot-pressing or molding by casting, the anti-adhesion patch enables polypropylene and the anti-adhesion membrane to be completely nested with each other, and microscopic examination proves no obvious boundary surface exists, so that the phenomenon of stratification does not occur. The anti-adhesion patch is suitable for itra-abdominal herniorrhaphy of abdominal hernia and abdominal wall defect as well as itra-abdominal herniorrhaphy of laparoscopic inguinal hernia.

The invention relates to the technical field of biomedicine tissue engineering, and discloses a preparation method of a hydrogel composite biological patch for repairing abdominal-wall defects. According to the preparation method, powder of pig derma after extracellular matrix removal and gelatin are used as biomaterials, mold casting and an enzyme promoting cross-linking shaping technology are used, and the composite hydrogel biological patch is prepared. According to the preparation technology disclosed by the invention, biomaterials of the powder of the pig derma after extracellular matrixremoval and the gelatin are mixed to prepare the patch, so that the hydrogel patch shows excellent biocompatibility, the biological mechanics characteristics of the hydrogel patch are strengthened, and the defects of conventional patches prepared from homogenous materials are solved. Besides, the preparation process is simple, and desired materials are easy to obtain. The composite biological patch bracket prepared by the preparation method contains a pre-vascularization passage, exchange of oxygen and nutrient substances and discharge of metabolic waste are facilitated, and vascularization speed of tissue is accelerated; and in addition, a perforated passage structure contributes to growth in of cells and tissue in the bracket, the reconstruction of abdominal wall tissue can be accelerated, breaking through technical bottlenecks existing in the biological patches is facilitated, and the treatment effects of repairing the abdominal-wall defects can be effectively improved.

The invention discloses a multilayer composite abdominal wall repair patch support and a preparation method thereof, which are applied to the repair of complex abdominal wall defects. At first, that electrohydrodynamic jet prin method is used to directly write to prepare a porous structure scaffold as a biological base lay; Then, the three-dimensional structure scaffold layer with certain pore structure was fabricated on the biological substrate by electrohydrodynamic jet printing method. After that, the synthetic patch is placed on the three-dimensional structure scaffold layer as the intermediate layer. Finally, the three-dimensional structure scaffold layer which has the same structure as the second layer is fabricated on the three-layer structure which has been fabricated by the electrohydrodynamic jet printing method. Compared with the synthetic patch made of the traditional material, the multi-layer composite abdominal wall repair patch support has good plasticity and suitable porosity. At the same time, on the basis of ensuring that the patch support has original mechanical properties, the invention also has the function of promoting tissue adhesion and growth.

The invention relates to an abdominal wall repair patch having an elastic enhanced type reticular structure and a preparation method of the elastic enhanced type abdominal wall repair patch. The patchis characterized in that the patch is prepared by overlapping two patch layers which have identical shapes and sizes and are positioned in the perpendicular printing formation directions in parallel, and the problem that the mechanical performance of the abdominal wall repair patch made of biological materials in repairing of abdominal-wall defect is poor is solved. The abdominal wall repair patch having the elastic enhanced type reticular structure disclosed by the invention has the characteristics that the improved elastic enhanced type reticular structure changes the own shape more easilyalong with the change of force and resists tension caused by abdominal exercises, so that the patch has higher elastic performance and reduces the probability of recurrence of hernia. In addition, based on computed tomography (CT) or magnetic resonance imaging (MRI), the shapes and the sizes of defected areas of a abdominal wall can be obtained; through corresponding calculation, the shape and the size of the patch can be determined; and by utilizing a current-body dynamic injection technology, the patch is printed, the individual differences of patients need to be paid attention to, and improvement of a treatment effect of the repairing of the abdominal wall is facilitated.

The invention relates a compound anti-blocking herniorrhaphy patch and a preparation method thereof, clinically belonging to herniorrhaphy implant medical appliances for abdominal wall defects and preparation methods thereof. The compound anti-blocking herniorrhaphy patch comprises a polypropylene patch and a puffed polytetrafluoroethylene anti-blocking patch, wherein the polypropylene patch and the puffed polytetrafluoroethylene anti-blocking patch are sewn into a whole by using puffed polytetrafluoroethylene. The preparation method provided by the invention comprises the following steps: (1) cutting a polypropylene reticular braided fabric in an ultrasonic or hot melting mode, or directly cutting the polypropylene reticular braided fabric into a polypropylene patch in a predetermined shape by using laser light; (2) cutting a puffed polytetrafluoroethylene anti-blocking film in an ultrasonic mode, or directly cutting the puffed polytetrafluoroethylene anti-blocking film into a puffed polytetrafluoroethylene anti-blocking patch in a predetermined shape by using laser light; and (3) sewing the cut polypropylene patch and puffed polytetrafluoroethylene anti-blocking patch into a whole by using the puffed polytetrafluoroethylene, thereby obtaining the compound anti-blocking herniorrhaphy patch.

The invention relates to the technical field of biological medical engineering, and discloses a biological repairing material for an abdominal wall defect and a preparation method of the biological repairing material. The method comprises the following steps: (1) performing pre-treatment on the muscular tissue of rectus abdominis of a dead animal; (2) performing cell extraction treatment to prepare a skeletal muscle acellular matrix biological thin sheet; (3) dissolving the skeletal muscle acellular matrix biological thin sheet into pepsase for digestion; (4) performing electrostatic spinning on skeletal muscle acellular matrix microparticles obtained by digestion and polycaprolactone to obtain a polycaprolactone / skeletal muscle acellular matrix blended electrostatic spinning fiber film which is the biological repairing material disclosed by the invention. According to the method, a skeletal muscle acellular matrix from abdominal wall tissue and polycaprolactone are combined by an electrostatic spinning technology; the preparation materials can be degraded, and products from degradation are harmless to a human body; the prepared biological repairing material can well simulate constituents and the structure of an extracellular matrix and is good in biocompatibility and biomechanical property.

The invention discloses a three-dimensional visual preoperative planning method, system and terminal for abdominal wall defect reconstruction. The problems that in the prior art, the spatial positionrelation between a focus and surrounding adjacent blood vessels, tissue, organs and muscles cannot be displayed in a three-dimensional mode, great difficulty is caused for doctors to make and simulateoperation schemes, a large amount of time and labor are wasted during manual segmentation, and then the efficiency and accuracy of a cutting operation are greatly reduced are solved. According to themethod, the system and the terminal, the position, size, internal structure and relation between the focus and surrounding tissue in a three-dimensional reconstruction image of the abdominal wall focus constructed based on two-dimensional data can be accurately displayed; and on the premise of avoiding damaging important anatomical structures, the abdominal wall defect condition and the excisioncondition of invasive tissue and organs after abdominal wall focus expansion excision are simulated, the operation process of patch placement and abdominal wall reconstruction is planned, the operation time is shortened, the postoperative complication occurrence rate can be reduced, and a great and positive effect is achieved for improving the operation success rate.

The invention discloses an abdominal wall defect repair material and a preparation method thereof, and relates to the technical field of a medical device and the preparation thereof. The method comprises the steps of selecting bacterial strains capable of secreting bacterial cellulose, performing activation, preparing a seed mash, dropwise adding the seed mash with a strain concentration ranging from 60% to 95% evenly on a sterilized polypropylene mesh, adding an afermentation medium, and taking out fermentation products after 1-3 d of culture. The abdominal wall defect repair material of the bacterial cellulose composite polypropylene mesh is obtained after the fermentation products are purified. According to the abdominal wall defect repair material and the preparation method thereof, the process is simple, the operation is convenient, and the prepared abdominal wall defect repair material has good mechanical properties and can avoid reaction of chronic inflammation and adhesion with an abdominal wall after transplanted into a body.

The invention relates to a soft tissue repair patch and a preparation method thereof. The patch is prepared by taking mammalian skin tissues as a raw material by the following steps: carrying out pretreatment to remove subcutaneous auxiliary tissues, preparing a skin patch, carrying out primary decellularization, carrying out cross-linking modification, carrying out secondary decellularization, finally carrying out cleaning and cutting, carrying out drying and compounding, and carrying out terminal sterilization. The biological decellularized tissue patch prepared by the method not only has acomplete collagen three-dimensional structure, but also has the characteristics of good mechanical property, abdominal cavity adhesion prevention and the like. The patch product provided by the invention is suitable for repair of various soft tissue injuries and abdominal wall defects in surgical operations, and can also be used as a biological scaffold material in the field of biological engineering.

The invention discloses a net abdominal wall defect repairing material and a preparation method of the net abdominal wall defect repairing material, and relates to the fields of medical instruments and manufacturing techniques of the medical instruments. The net abdominal wall defect repairing material is prepared by dipping a polypropylene mesh which is subjected to sterilization treatment into a wax solution; taking out; after the wax is cured, dipping into n-hexane for 5-10min; selecting bacterial strains which can secrete bacterial cellulose to be activated and prepared into seed mash; subsequently uniformly dropping the seed mash of which the bacterial strain concentration is 60-95% on the surface of the polypropylene mesh subjected to wax treatment; and adding a fermentation medium, culturing for 1-3d and taking out a fermentation product. The fermentation product is subjected to wax elimination and purification treatment so as to obtain the net abdominal wall defect repairing material of the bacterial cellulose composite polypropylene mesh. The net abdominal wall defect repairing material is simple in process and convenient to operate; and the prepared net abdominal wall defect repairing material has excellent mechanical properties and after being implanted into a body, the net structure is beneficial for fiber textures to grow and penetrate through, thereby preventing chronic inflammatory response and adhesion inside abdominal walls.

Systems and methods for closing a tissue defect are disclosed. The systems may include a subcutaneous guide that is placed transcutaneously between two skin access sites and a self-locking strap thatmay be advanced into the body through a first access site via a first needle and then passed to a second needle. The strap may be withdrawn with the second needle through a second access site to the outside of the body. The strap may be withdrawn from the first needle, leaving the strap placed through both access sites and across the defect. As the subcutaneous guide is withdrawn from the body itpulls the captured strap such that both ends of the strap protrude from the first access site, allowing the strap to be tightened around the defect. Devices for closure of a tissue defect are also disclosed.

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

The invention discloses a bionic antimicrobial abdominal wall repair material. The bionic antimicrobial abdominal wall repair material includes a pig small intestine submucosa and a chitosan-elastin fiber mesh layer laminating on one side of the pig small intestine submucosa; and the chitosan-elastin fiber mesh layer is an electrostatic spinning nanoscale chitosan- elastin fiber mesh. According tothe bionic antimicrobial abdominal wall repair material, the laminating combination of the chitosan-elastin fiber mesh layer and the pig small intestine submucosa, so that the antimicrobial ability of the prepared abdominal wall repair material is improved effectively; meanwhile, the mechanical strength and degradation performance of the abdominal wall repair material meet the requirement of abdominal wall repair, angiogenesis can further be facilitated, tissue regeneration is facilitated, the existing technical bottleneck of the abdominal wall repair material is solved conveniently, and thetreatment effect of abdominal wall coloboma repair is effectively improved.

The invention relates to the technical field of biomedical tissue engineering, and discloses a method for preparing a hydrogel composite biological patch for repairing abdominal wall defects. In the preparation method, pig dermis de-extracellular matrix powder and gelatin are used as biomaterials, and a composite hydrogel biopatch is prepared by mold casting and enzymatic cross-linking forming techniques. The present invention mixes the biomaterial porcine dermis de-extracellular matrix powder with gelatin to prepare the patch, not only the hydrogel patch exhibits excellent biocompatibility, but also enhances the biomechanical properties of the hydrogel patch, solving the problem There are deficiencies with single material patches. At the same time, the preparation process is simple and the required materials are easy to obtain. The composite biological patch scaffold prepared by the present invention contains pre-vascularized channels, which is helpful for the exchange of oxygen and nutrients and the discharge of metabolic waste, and accelerates the vascularization of tissues; in addition, the through-channel structure helps cells and tissues in the scaffold The ingrowth can accelerate the reconstruction of abdominal wall tissue, help to solve the existing technical bottleneck of biological mesh, and effectively improve the therapeutic effect of abdominal wall defect repair.

The present invention provides a method of repairing a defect in an abdominal wall of a subject, including the steps of: making a small incision through a skin layer above the defect in the abdominal wall, introducing a surgical device including a deformable body through the incision to reach a preperitoneum underlying the abdominal wall around the defect, using the surgical device to identify a protruded region of the preperitoneum extending towards the abdominal wall around the defect, and flattening the protruded region of the preperitoneum and separating the protruded region of the preperitoneum from the abdominal wall with the deformable body in an expanded condition. The method results in low recurrence of abdominal wall defect, less pain, and a shorter hospital stay after surgery.

The invention discloses an emergency treatment device for war wound abdominal wall defects. The emergency treatment device comprises an anti-adhesion film, a suction tube, a filling layer and an air bag layer, wherein one side of the anti-adhesion film is provided with the filling layer; one side, which is far away from the anti-adhesion film, of the filling layer is provided with the air bag layer; the outer wall of one end of the suction tube is provided with a plurality of suction holes and extends into the filling layer; and the other end of the suction tube extends out of the filling layer. Due to utilization of the anti-adhesion film loaded with antibiotics, abdominal visceral organs can be isolated from contact with external air to avoid abdominal infection, and in addition, the abdominal visceral organs, especially the intestinal canals, can be protected from adhesion, even damage and the like. Since the suction tube is placed in the sponge part of the filling layer, suction can be carried out to lead out seepage or oozing liquid, and through negative pressure suction, a wound surface is prevented from being overlarge. After the latticed air bag layer on the outmost layer is inflated, the air bag layer can perform a function of pressurized binding and bleeding stopping, the traumatic condition of a wounded person can be prevented from getting worse during wartime and after the war, and a protecting and cushioning function is performed for the abdominal visceral organs or the intestinal canals.

The present invention provides a method of repairing a defect in an abdominal wall of a subject, including the steps of: making a small incision through a skin layer above the defect in the abdominal wall, introducing a surgical device including a deformable body through the incision to reach a preperitoneum underlying the abdominal wall around the defect, using the surgical device to identify a protruded region of the preperitoneum extending towards the abdominal wall around the defect, and flattening the protruded region of the preperitoneum and separating the protruded region of the preperitoneum from the abdominal wall with the deformable body in an expanded condition. The method results in low recurrence of abdominal wall defect, less pain, and a shorter hospital stay after surgery.

The invention discloses a net abdominal wall defect repairing material and a preparation method of the net abdominal wall defect repairing material, and relates to the fields of medical instruments and manufacturing techniques of the medical instruments. The net abdominal wall defect repairing material is prepared by dipping a polypropylene mesh which is subjected to sterilization treatment into a wax solution; taking out; after the wax is cured, dipping into n-hexane for 5-10min; selecting bacterial strains which can secrete bacterial cellulose to be activated and prepared into seed mash; subsequently uniformly dropping the seed mash of which the bacterial strain concentration is 60-95% on the surface of the polypropylene mesh subjected to wax treatment; and adding a fermentation medium, culturing for 1-3d and taking out a fermentation product. The fermentation product is subjected to wax elimination and purification treatment so as to obtain the net abdominal wall defect repairing material of the bacterial cellulose composite polypropylene mesh. The net abdominal wall defect repairing material is simple in process and convenient to operate; and the prepared net abdominal wall defect repairing material has excellent mechanical properties and after being implanted into a body, the net structure is beneficial for fiber textures to grow and penetrate through, thereby preventing chronic inflammatory response and adhesion inside abdominal walls.

The three-dimensional visualization preoperative planning method, system and terminal for abdominal wall defect reconstruction of the present invention solve the problem that the prior art cannot three-dimensionally display the spatial position relationship between the lesion and the surrounding adjacent blood vessels, tissues, organs, and muscles, and is helpful for doctors to formulate and simulate operations. The solution caused great difficulties, and manual segmentation wasted a lot of time and manpower, which greatly reduced the efficiency and accuracy of cutting operations. The present invention can not only accurately display the location, size, internal structure and relationship with surrounding tissues in the three-dimensional reconstruction image of abdominal wall lesions constructed based on two-dimensional data, but also simulate the expansion of abdominal wall lesions on the premise of avoiding damage to important anatomical structures Abdominal wall defect after resection and the resection of invading tissues and organs, planning the surgical process of patch placement and abdominal wall reconstruction can not only reduce the operation time, but also reduce the incidence of postoperative complications, which has a significant and positive effect on improving the success rate of surgery. effect.

The invention discloses a polyacrylonitrile fiber with biological activity, which is prepared by the following method: after hydrolyzing the polyacrylonitrile fiber in an alkaline solution, it is mixed with a collagen aqueous solution and a cross-linking solution, the pH value is adjusted, and chemical modification is carried out. 2~72h; the raw material of the alkaline solution includes NaHCO 3 , NaOH and water; the raw materials of the cross-linking solution include a cross-linking agent, a buffer substance and water; the collagen-modified polyacrylonitrile fiber contains collagen and polyacrylonitrile. The polyacrylonitrile fiber prepared by the method of the invention maintains the good natural structure of collagen, can better promote the adhesion and proliferation of fibroblasts, is conducive to the directional growth and functional expression of fibroblasts, and has good biocompatibility, The mechanical properties are beneficial to the repair of soft tissue, and are especially suitable for the mechanical strength requirements such as abdominal wall defects.