Polypropylene mesh/electro-spinning nano-fiber membrane as well as preparation method and application thereof

Abstract

The invention relates to a polypropylene mesh / electro-spinning nano-fiber membrane as well as a preparation method and an application thereof. The polypropylene mesh / electro-spinning nano-fiber membrane is prepared through the following steps: (1) preparing a chitosan-polyethylene glycol hydrogel; (2) preparing basic fibroblast growth factor (bFGF) embedded polylactic acid-poly lactic-co-glycolic acid (PLGA) microspheres; (3) preparing an electro-spinning solution; (4) preparing the polypropylene mesh / electro-spinning nano-fiber membrane by use of an electro-spinning method. According to the polypropylene mesh / electro-spinning nano-fiber membrane, the polypropylene mesh and the nano-fiber membrane are compounded creatively, and therefore, the biocompatibility of the polypropylene mesh is improved by use of the nano-fiber membrane and the tensile strength of the nano-fiber membrane is improved by use of the polypropylene mesh, and the polypropylene mesh and the nano-fiber membrane supplement each other; in addition, the microspheres are introduced to realize controlled drug release; as a result, lots of defects of the clinical existing polypropylene meshes can be overcome.

Description

Technical field

[0001] The invention belongs to the field of medical equipment, and relates to a polypropylene mesh / electrospun nanofiber membrane and a preparation method and application thereof. Background technique

[0002] Experiences and lessons in the treatment of war injuries from the Second World War to the local wars in Afghanistan and Iraq show that the incidence of abdominal war injuries has never dropped significantly, and it has always been the third fatal war injury. Abdominal injuries caused by explosion injuries can cause varying degrees of abdominal wall damage, exposure of abdominal organs, and prolapse of intestines. Abdominal hypertension combined after resuscitation from hemorrhagic shock and traumatic shock can cause the abdominal incision to dehisce, leading to passive opening of the abdominal cavity. In order to treat shock combined with abdominal cavity syndrome (ACS), active abdominal cavity opening is often required. Whether the abdominal cavity is op...

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