The invention discloses a marine biomedical material for repairing skin wounds and a preparation method and application thereof. From many marine biological actives, the preferred marine fish skin collagen, carboxymethyl chitosan, alginate with good biocompatibility, easy processing and degradation, and the platelet-derived growth factor PDGF-BB are scientifically combined and optimized for preparation made. The material has the advantages of high porosity, high swelling ratio, good mechanical properties, controlled release of PDGF-BB, and no cytotoxicity. It can significantly promote cell adhesion, proliferation, migration and angiogenesis, effectively reduce inflammation and reduce scarring. . The biomedical material has a wide range of applications, is easy to use, can prevent bacterial infection without frequent replacement, and is effective in promoting burns, scalds, cuts, traffic injuries, surgical injuries, war injuries, firearm injuries combined with seawater immersion injuries, diabetic ulcers, inflammation The regeneration and repair effect of chronic ulcers, pressure ulcers and chronic refractory wounds is remarkable.