In-situ hemostatic containing desmopressin

A desmopressin and drug technology, which is applied in the directions of medical preparations containing active ingredients, drug combinations, pharmaceutical sciences, etc., can solve the problems such as the lack of aminopressin, and achieve the effect of obvious hemostatic effect.

Inactive Publication Date: 2013-03-06
海南建邦制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no related dosage form of desmopressin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Chitosan 50g

[0020] water 1000ml

[0021] Desmopressin 500 micrograms

[0022] Mix the cross-linked chitosan with 800 milliliters of water, heat to dissolve, add 200 milliliters of water containing 500 micrograms of desmopressin after cooling, fully stir, and place in a suitable mold. Pre-freeze at -40 for 5 hours and freeze-dry for 24 hours to obtain desmopressin chitosan sponge hemostatic agent.

Embodiment 2

[0024] Dextrin 50g

[0025] water 200ml

[0026] Desmopressin 500 micrograms

[0027] The dextrin is firstly cross-linked into microspheres, and the particle size is controlled at 50-100 mesh. Fully mix 50 grams of dextrin with 200 milliliters of an aqueous solution containing 500 micrograms of desmopressin, stir for two hours, drain the water, and dry in a vacuum oven at 30 degrees for 36 hours until the water content is below 5%. Sterilize. That is, the dextrin powder of desmopressin is obtained.

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PUM

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Abstract

The invention discloses an in-situ hemostatic containing desmopressin. A preparation prepared from the hemostatic directly acts on a bleeding part without oral administration or injection, can be used for treating bleeding caused by surgery, trauma, accidents and war wounds, and can also be used for organ bleeding and facial bleeding caused by hemophilia and medicaments. The hemostatic does not enter a circulating system, so that the side effects of serious urinary retention and the like caused by the desmopressin are avoided; and a rational preparation form can be completely absorbed by a human body, and a hemostatic effect is remarkable.

Description

technical field [0001] The present invention is an in-situ hemostatic drug containing desmopressin, and the preparation made of the drug can be used for treating bleeding caused by surgery, trauma, accidents, organs, facial features and war wounds, and can also be used for hemophilia , drugs, etc. cause bleeding. The preparation directly acts on the bleeding site without entering the circulatory system, has no side effects such as urinary retention caused by desmopressin, can be completely absorbed by the human body by adopting a reasonable preparation form, and has obvious hemostatic effect. Background technique [0002] First aid treatment of sudden accidents in daily life, trauma hemostasis in the operation process of patients in the hospital, especially the rescue of wounded soldiers in war, it is very important to effectively and quickly stop bleeding locally in patients, because uncontrolled bleeding is Leading cause of sudden accidents, hemorrhage during medical oper...

Claims

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Application Information

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IPC IPC(8): A61K38/11A61L15/44A61L15/46A61P7/04A61K38/095
Inventor 杨顶建姜月霞
Owner 海南建邦制药科技有限公司
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