5 results about "Hemostatic drug" patented technology

This invention discloses a radioactive particle strip implantation system and method, relating to the field of medical device technology. It includes: an implantation gun and a particle strip module; the implantation gun includes: a gun body; a drive assembly disposed within the gun body, including a driver and a thrust control unit; a push rod, drively connected to the power output end of the driver; a particle strip placement slot disposed at the front end of the gun body for placing the particle strip module, and coaxially arranged with the push assembly; the gun body has a docking part at the front end of the particle strip module compartment for connecting an implantation needle; the push rod can pass through the particle strip module to push the particle strip into the implantation needle; the particle strip module includes: a module body; multiple radioactive particles and multiple hemostatic drug units are pre-sealed in an alternating arrangement within the module body; the radioactive particles and hemostatic drug units are coaxially arranged and can be pushed into the implantation needle by the push rod. This invention uses a pre-assembled plate stacking structure to make the spacing of the radioactive particles adjustable, simplifying on-site operation.

The utility model provides a kind of hemostatic gauze ball with hemostatic medicament, it is related to gauze technical field, including sphere and medicament ball, the sphere includes absorbent cotton and gauze mesh belt, the absorbent cotton is spherical, the gauze mesh belt is wrapped in the outside of absorbent cotton, the inside center of absorbent cotton is equipped with inner cavity, the medicament ball is equipped inside inner cavity;The side of the sphere is equipped with hole, and hole is connected to the inside of inner cavity, the inside of hole is equipped with extrusion membrane;The utility model embeds medicament ball in sphere, without extra preparation medicine, when using, only need to lay under sphere to wound, extrude extrusion membrane, press the membrane of broken medicament ball, hemostatic medicament can flow out downwards, carry out quality to wound, it is convenient and fast to operate, it is convenient to use anytime, and when laying, by liquid guide wire core increase the speed of hemostatic medicament in inner cavity flowing downwards gauze mesh belt, with quick-dissolving effect, improve the efficiency of drug action.

This invention belongs to the field of biomedicine and relates to a procoagulant polypeptide TPTX and its applications. The procoagulant polypeptide TPTX of this invention can exert its procoagulant and hemostatic effects by specifically inhibiting plasmin activity. Experiments have shown that TPTX exhibits significant dose-dependent procoagulant and hemostatic effects in ferric chloride-induced mouse carotid artery thrombosis models, mouse liver hemorrhage models, mouse tail hemorrhage models, and mouse saphenous vein hemorrhage models, with effects superior to the positive control drug 6-aminocaproic acid. Simultaneously, TPTX can reduce the area of ​​atorvastatin-induced cerebral hemorrhage in zebrafish and improve their motor dysfunction. Mechanistic studies show that TPTX has an inhibitory constant Ki of 17.76 nM on plasmin and has no significant effect on the activity of seven other key serine proteases in the coagulation system, demonstrating a clear target and high selectivity. The procoagulant polypeptide of this invention can be used to prepare hemostatic drugs, possessing the advantages of high efficiency, clear target, and high selectivity, with broad prospects for clinical application.

The utility model discloses a kind of self-adhesive wound protective stickers, including supporting base layer, release paper and adhesive layer, the center of supporting base layer bottom is provided with cavity, the edge position of inside of cavity is provided with antibacterial layer, antibacterial layer below is provided with hemostatic absorbent cotton layer, the inside of hemostatic absorbent cotton layer is uniformly provided with analgesic powder and hemostatic powder, and the inside of antibacterial layer above hemostatic absorbent cotton layer is provided with drug sustained-release layer, the inside of drug sustained-release layer is uniformly provided with biodegradable material bag, the inside of each biodegradable material bag is filled with healing drug.The breathable film layer of the utility model is arranged on the top of antibacterial layer, below the secondary waterproof film layer, this design not only ensures waterproof effect, but also can tear the secondary waterproof film layer when necessary, allow the gas exchange of skin at wound, avoid the skin stuffy, uncomfortable and other problems caused by poor breathability, improve the use experience of patient.

The application provides a milk protein source urokinase-type plasminogen activator inhibitory peptide and application thereof. Through a combination of virtual screening by molecular docking and in-vitro experiment verification, two u-PA inhibitory activity polypeptides PEVMGVSK and HIQKEDVPSE derived from bovine milk casein are obtained. The two polypeptides can be stably combined with the u-PA active site through multiple intermolecular forces, have a significant inhibitory effect on u-PA-mediated plasminogen activation, can effectively improve the storage period stability of ultra-high temperature instant sterilized milk, delay protein hydrolysis and aging gel formation, and can inhibit the plasmin clot lysis and MDA-MB-231 human breast cancer cell migration in a concentration-dependent manner. The polypeptides obtained by the application have application potential and practical value in the fields of dairy product quality improvement, hemostatic drugs and anti-cancer drug research, etc. as natural source active ingredients.