51 results about "Hemostatic drug" patented technology

The invention relates to the technical field of biomedical engineering, and discloses a VTE system execution method and system combined with a standardized scale, and the method comprises the steps: carrying out the standardization processing of original data, and obtaining the standardized data; constructing a risk intensity flow; carrying out integral operation to obtain an accumulated integral value of the risk factor; calculating a dynamic risk trajectory; fusing the baseline score value of the standardized scale with the dynamic risk trajectory to obtain a total risk trajectory; calculating an instantaneous risk probability, and judging whether VTE risk early warning is triggered or not according to a self-adaptive threshold value; according to the method, continuous quantitative monitoring of VTE risk factors is achieved by constructing the body position, anesthesia, hemostatic and circulation parameter four-dimensional risk intensity flow, early recognition and timely early warning of VTE risks are achieved through double mechanisms of continuous triggering and acute triggering, and the accuracy, the real-time performance and the individualized level of risk assessment are remarkably improved.

The utility model relates to the technical field of medical instruments, in particular to a simple and convenient brachial artery hemostat which comprises a supporting pressing plate, open grooves are formed in the two side ends of the supporting pressing plate, a threaded sleeve is fixedly installed at the upper end of the supporting pressing plate, a threaded block is in threaded connection with the interior of the threaded sleeve and located on a screw rod, and the screw rod is fixedly connected with the threaded sleeve. A cushion block is installed at the bottom end of the screw rod, and the cushion block is rotationally connected with the screw rod through a bearing. According to the hemostat, the screw rod is manually rotated, the height of the cushion block at the bottom end of the screw rod is adjusted, the cushion block presses the hemostasis position, when the bottom end of the cushion block is squeezed, medicine in the hemostasis medicine area can be squeezed out, the medicine enters the hemostasis cushion and makes contact with the hemostasis position of a patient, and the hemostasis effect is better in cooperation with the medicine; and the upper end shell and the lower end shell are directly and quickly disassembled and assembled through the disassembling and assembling assembly, so that after the upper end shell and the lower end shell are disassembled, the internal sleeve gaskets can be conveniently replaced, and a next patient can use the shell conveniently.

This invention discloses a radioactive particle strip implantation system and method, relating to the field of medical device technology. It includes: an implantation gun and a particle strip module; the implantation gun includes: a gun body; a drive assembly disposed within the gun body, including a driver and a thrust control unit; a push rod, drively connected to the power output end of the driver; a particle strip placement slot disposed at the front end of the gun body for placing the particle strip module, and coaxially arranged with the push assembly; the gun body has a docking part at the front end of the particle strip module compartment for connecting an implantation needle; the push rod can pass through the particle strip module to push the particle strip into the implantation needle; the particle strip module includes: a module body; multiple radioactive particles and multiple hemostatic drug units are pre-sealed in an alternating arrangement within the module body; the radioactive particles and hemostatic drug units are coaxially arranged and can be pushed into the implantation needle by the push rod. This invention uses a pre-assembled plate stacking structure to make the spacing of the radioactive particles adjustable, simplifying on-site operation.

This invention belongs to the field of pharmaceutical combination technology, specifically relating to an antibacterial and hemostatic pharmaceutical composition for skin healing and its preparation method. The pharmaceutical composition is a dual-gel, consisting of an oleogel and a hydrogel in a mass ratio of 3-5:5-7. The oleogel uses medium-chain triglycerides and *Ipomoea aquatica* wax as a matrix and is loaded with astragaloside A, while the hydrogel uses chitosan and sodium alginate as a matrix and is loaded with the antimicrobial peptide GL13K. The preparation method includes preparing a CS-SA-GL13K hydrogel and a medium-chain triglyceride *Ipomoea aquatica* wax-astragaloside A oleogel, then mixing the two in a specific ratio, homogenizing and emulsifying, and rapidly cooling to obtain the dual-gel. Testing showed that the pharmaceutical composition exhibits a bactericidal rate of over 95% against Staphylococcus aureus and Escherichia coli, good hemostatic effect, promotes skin wound healing, and demonstrates good stability.

The invention provides a combined debridement device for dermatological nursing, and relates to the technical field of skin care, the combined debridement device comprises a bottom plate, the top surface of the bottom plate is fixedly provided with two vertical plates, the two vertical plates are symmetrically arranged, the top surfaces of the two vertical plates are fixedly provided with the same top plate, one side of the top surface of the top plate is fixedly provided with a debridement table, and the other side of the top surface of the top plate is provided with a debridement groove; two limiting bandages are arranged above the debridement table, water through hoses are fixedly installed in the two limiting bandages, medicine storage sponges are symmetrically arranged in the two water through hoses, a plurality of water outlet holes are formed in the bottom faces of the two water through hoses, a water pump is started, debridement liquid in a water storage tank is pumped into a flow dividing hose through a first water pumping pipe, and the flow dividing hose is connected with a water pump through a second water pumping pipe. The wound cleaning liquid flows through the water supply hose and then is shunted into the water supply hose in the two limiting bandages, the sponge in the water supply hose adsorbs nursing drugs such as antibacterial drugs and hemostatic drugs in advance, the drugs are dissolved when the wound cleaning liquid flows through the water supply hose to form medicated bath liquid, then the medicated bath liquid is evenly sprayed to the surface of a wound through a plurality of water outlet holes in the bottom face of the water supply hose, and flushing and drug administration integrated nursing is achieved.

The invention discloses an intestinal tract hemostatic composition as well as a preparation method and application thereof, and relates to the field of hemostatic drugs. Wherein the catechin, the hyperoside, the isoquercitrin, the quercetin-3-O-glucuronide, the gallocatechin, the myricetin-3-O-galactoside, the proanthocyanidin B1, the proanthocyanidin B3, the syringe-3-O-glucoside and the astragalus smicus glycoside are flavonoid compounds; nuciferine, higenamine, N-methyl-higenamine and N-trans-feruloyl tyramine are taken as alkaloid compounds, and the compound is selected from the group consisting of higenamine, nuciferine, higenamine The composition has the advantages of simple preparation process, good hemostatic effect and the like, and provides a new raw material choice for the development of intestinal bleeding treatment medicines.

The invention relates to the technical field of rapid hemostasis application, in particular to a rapid compression hemostasis device which comprises a compression hemostasis block, two positioning clamping belts and an elastic buckling belt, and the rapid compression hemostasis device not only conducts physical compression hemostasis on a wound through the compression hemostasis block, but also combines the function of medicine hemostasis. The compression ring in the compression hemostasis block can accurately compress the periphery of a wound, the bleeding amount is reduced, the medicine block enables hemostasis medicine to directly act on the wound through the medicine penetrating layer, and the hemostasis effect is enhanced. In a battlefield or an emergency medical scene, bleeding can not be completely controlled by purely relying on compression hemostasis, but the hemostasis efficiency can be remarkably improved and the blood loss risk can be reduced by adding the medicine. In addition, due to the design of the cotton ring and the medicine permeating layer of the medicine block, air permeability of the wound can be kept, it can be guaranteed that medicine continuously acts on the wound, and wound oxygen deficit or infection caused by too tight compression is avoided.

The utility model provides a kind of hemostatic gauze ball with hemostatic medicament, it is related to gauze technical field, including sphere and medicament ball, the sphere includes absorbent cotton and gauze mesh belt, the absorbent cotton is spherical, the gauze mesh belt is wrapped in the outside of absorbent cotton, the inside center of absorbent cotton is equipped with inner cavity, the medicament ball is equipped inside inner cavity;The side of the sphere is equipped with hole, and hole is connected to the inside of inner cavity, the inside of hole is equipped with extrusion membrane;The utility model embeds medicament ball in sphere, without extra preparation medicine, when using, only need to lay under sphere to wound, extrude extrusion membrane, press the membrane of broken medicament ball, hemostatic medicament can flow out downwards, carry out quality to wound, it is convenient and fast to operate, it is convenient to use anytime, and when laying, by liquid guide wire core increase the speed of hemostatic medicament in inner cavity flowing downwards gauze mesh belt, with quick-dissolving effect, improve the efficiency of drug action.

The invention discloses a hemostasis device for acute gastrointestinal hemorrhage, and relates to the field of medical instruments, the hemostasis device comprises a hemostasis capsule, a medicine release mechanism is arranged in the hemostasis capsule, hemostasis liquid medicine can be directly released to the gastrointestinal hemorrhage position through the medicine release mechanism, and an outer spray hole is formed in the position, located at the medicine release mechanism, of the surface of the hemostasis capsule. The medicine release mechanism comprises a medicine cylinder which is fixed in the hemostasis capsule and used for storing hemostasis liquid medicine, a gap is formed between the medicine cylinder and the outer wall of the hemostasis capsule to form a medicine release space, the bottom of the medicine cylinder is communicated with the medicine release space through a medicine release opening, a movable shielding plate is arranged in the medicine release space, and an inner spraying hole is formed in the surface of the shielding plate. According to the hemostatic capsule, in the absence of operation conditions or in an emergency, the gastrointestinal hemorrhage position of a patient with acute gastrointestinal hemorrhage can be preliminarily subjected to hemostasis through the hemostatic capsule without gastrointestinal endoscopic surgery, and time and conditions are created for preparation of subsequent operations.

The invention relates to the technical field of medical apparatus and instruments, and discloses an adjustable decayed tooth extractor which comprises a mounting seat, a first hinge shaft is rotatably arranged on the mounting seat, two tooth extraction forceps are arranged on the first hinge shaft, a drug delivery mechanism is arranged on one tooth extraction forceps, and a liquid extraction mechanism is arranged on the other tooth extraction forceps; the dosing mechanism comprises a medicine storage groove, a piston, a first spring and a plurality of discharge ports, the medicine storage groove is formed in one of the dental forceps, the piston is slidably arranged in the medicine storage groove, the first spring is arranged in the dental forceps, one end of the first spring is connected with the dental forceps, the other end of the first spring is connected with the piston, and the discharge ports are formed in the dental forceps; and the plurality of discharge ports are communicated with the medicine storage tank. According to the adjustable tooth decay tooth extraction device, the position of the jaw can be fixed during tooth extraction, so that a doctor does not need to maintain the position with hands for a long time, one of the forceps parts is used for coating a wound with a hemostatic drug, and the other forceps part is used for sucking bloodstain.

The uterine cavity hemostat comprises a pair of forceps rods, the two forceps rods are connected in a hinged mode through a rotating shaft, hemostasis heads are arranged at the front ends of the two forceps rods, anti-skid layers are arranged on the opposite side faces of the two hemostasis heads, clamping protrusions arranged on the anti-skid layers of the two hemostasis heads are arranged in a staggered mode, and the rear ends of the forceps rods are sleeved with forceps handles in a sliding mode. Wherein one of the forceps handles is provided with a dosing tube, one end of the dosing tube is connected with an elastic hemostasis medicine bag, and the other end of the dosing tube is communicated with a dosing hole formed in the side face of the hemostasis head. When the forceps are used, the extension length of the forceps rod is adjusted according to the depth of a hemostasis position, and the clamping protrusions which are arranged in a staggered mode are arranged on the anti-skid layer arranged on the hemostasis head, so that the clamping hemostasis effect on the hemostasis position can be guaranteed; the hemostatic stored in the hemostatic bag is output from the administration hole under the action of pressure, the hemostatic effect can be improved at the bleeding position after clamping hemostasis under the action of the hemostatic, and the hemostatic efficiency is accelerated.

A thumbtack needle dressing for hemostasis after an operation includes a dressing body and a hollow thumbtack needle. The dressing body includes a patch layer, a drug groove and a hemostatic drug layer connected in sequence. The hollow thumbtack needle includes a needle body and a needle tip, the needle body is communicated with the drug groove, the hollow thumbtack needle penetrates through the hemostatic drug layer to make the needle body and the needle tip expose from the hemostatic drug layer, and a needle cap is further provided on the needle tip. The drug groove is provided with a drug, and the hemostatic drug layer is a self-adhesive layer provided with a hemostatic drug. The patch layer is provided with a fixing strap to adjust and fit. The thumbtack needle dressing can achieve precise drug delivery and localized high-concentration medication.

This invention discloses the application of microRNAs or combinations thereof derived from palm charcoal in the preparation of hemostatic drugs. The microRNAs derived from palm charcoal are selected from any one of ath-miR159a, cpa-miR159b, and ath-miR166a-3p. This study identified miRNAs in palm charcoal and clarified the changes in miRNAs after palm is processed into charcoal drugs. ath-miR159a and cpa-miR159b in palm charcoal can bind to the 3'-UTR of ADRA2C. ath-miR166a-3p in palm charcoal can target and inhibit the expression and secretion of t-PA in HUVEC cells.

The application discloses a hemostatic device for acute gastrointestinal hemorrhage, and relates to the field of medical devices, which comprises a hemostatic capsule, a drug releasing mechanism is arranged in the hemostatic capsule, the drug releasing mechanism can directly release hemostatic liquid to the gastrointestinal hemorrhage position, an outer spray hole is arranged on the surface of the hemostatic capsule at the position of the drug releasing mechanism, the drug releasing mechanism comprises a cartridge fixed to the inside of the hemostatic capsule and used for storing the hemostatic liquid, a gap is formed between the cartridge and the outer wall of the hemostatic capsule, a drug releasing space is formed, the bottom of the cartridge is communicated with the drug releasing space through a drug releasing port, a movable shutter is arranged in the drug releasing space, and an inner spray hole is formed in the surface of the shutter. The application can be used for the patients with acute gastrointestinal hemorrhage under the condition of lacking operation or in an emergency, does not need a gastroscopy operation, can preliminarily perform hemostasis on the gastrointestinal hemorrhage position of the patient through the hemostatic capsule, and creates time and conditions for the preparation of subsequent operation.

The invention discloses a rapid hemostasis and pressurization fixing device for trauma in the emergency department, and belongs to the technical field of medical instruments, the hemostasis and pressurization fixing device comprises a buckle plate, a pressing plate arranged at the bottom of the buckle plate, a driving structure arranged on the buckle plate and a fixing structure arranged on the buckle plate, the hemostasis and pressurization fixing device further comprises a medicine feeding structure which is arranged on the pressing plate, connected with the driving structure and used for infiltrating hemostasis liquid medicine into a wound surface in advance before the pressing plate makes contact with the wound surface for pressurization. According to the rapid hemostasis and pressurization fixing device for the wound in the emergency department, through the linkage design of the driving structure and the dosing structure, dosing can be conducted before the pressing plate makes contact with the wound surface, liquid medicine directly acts on the wound surface along with pressurization of the pressing plate, and the hemostasis efficiency and the liquid medicine utilization effect are improved. Meanwhile, the universal structure of the device can enable the pressing plate to be adjusted in multiple directions and angles according to the shape of the wound surface, so that the pressing plate is comprehensively attached to the wound surface, and the pressurization hemostasis effect is further enhanced.

The application provides an analgesic hemostatic agent and a preparation method thereof, and belongs to the technical field of medicines. A decellularized material is coupled with a snake venom thrombin and ibuprofen, embedded in a pH-responsive polymer to prepare pH-responsive microspheres, and added into a temperature-sensitive hydrogel together with a traditional Chinese medicine fermentation product to prepare an analgesic hemostatic agent water agent. Porous calcium carbonate microspheres with fixed solid acid are mixed with hydroxyapatite to prepare a spray analgesic hemostatic agent powder, which is used in combination with the analgesic hemostatic agent water agent to prepare the analgesic hemostatic agent. The analgesic hemostatic agent prepared by the application adopts a combination of the powder and the water agent, can better maintain the drug activity, has good hemostatic, analgesic, anti-inflammatory and antibacterial effects, and has a slow and controlled release and a long-acting effect, so that the drug application amount is reduced, the patient compliance is improved, and the analgesic hemostatic agent has a wide application prospect.

The invention relates to a polyamino acid electrostatic spinning mineralization bracket with a hierarchical pore structure and a preparation method thereof. A three-dimensional PBLG electrostatic spinning fiber scaffold is prepared through a gas foaming method, and the structural stability of the three-dimensional scaffold is remarkably improved through welding and subsequent in-situ mineralization in a CH2Cl2 steam atmosphere. The prepared bionic fiber scaffold can play a temporary supporting role after being implanted into a defect area, good osteogenesis induction and angiogenesis activity are provided for subsequent bone defect repair, a pore structure formed through foaming can also support ingrowth of new tissues, and the scaffold has good application prospects in the field of bone defect repair and is suitable for popularization and application in the field of bone defect repair. The method can also be expanded to the medical fields of hemostasis, drug delivery and the like.

The utility model discloses an intrahepatic bile duct calculus removal postoperative hemostat, and relates to the field of medical supplies. The utility model provides the hemostat which is simple in structure and is used after the intrahepatic bile duct calculus removal operation. The hemostat used after intrahepatic bile duct calculus removal comprises a medicine guide tube, an annular air bag, a push rod, an inflation structure and a hemostasis medicine block. An air bag groove is formed in the inner wall of the front end of the medicine guide tube, and an air guide hole extending to the air bag groove from the rear end of the medicine guide tube is formed in the medicine guide tube; the annular air bag is positioned in the air bag groove, is connected with the medicine guide tube and is communicated with the air guide hole; the inflating structure is positioned at the rear end of the medicine guide tube, is connected with the medicine guide tube and is communicated with the air guide hole; the push rod is inserted into the catheter; the tourniquet block can be placed in the medicine guide tube, and the annular air bag is inflated and swelled so that the tourniquet block placed in the medicine guide tube can be limited to move forwards. The utility model has the advantages of simple structure, portability, convenience in operation, low cost and disposable use, and ensures cleanness and sterility, and the main parts can be made of plastics.

This invention belongs to the field of biomedicine and relates to a procoagulant polypeptide TPTX and its applications. The procoagulant polypeptide TPTX of this invention can exert its procoagulant and hemostatic effects by specifically inhibiting plasmin activity. Experiments have shown that TPTX exhibits significant dose-dependent procoagulant and hemostatic effects in ferric chloride-induced mouse carotid artery thrombosis models, mouse liver hemorrhage models, mouse tail hemorrhage models, and mouse saphenous vein hemorrhage models, with effects superior to the positive control drug 6-aminocaproic acid. Simultaneously, TPTX can reduce the area of ​​atorvastatin-induced cerebral hemorrhage in zebrafish and improve their motor dysfunction. Mechanistic studies show that TPTX has an inhibitory constant Ki of 17.76 nM on plasmin and has no significant effect on the activity of seven other key serine proteases in the coagulation system, demonstrating a clear target and high selectivity. The procoagulant polypeptide of this invention can be used to prepare hemostatic drugs, possessing the advantages of high efficiency, clear target, and high selectivity, with broad prospects for clinical application.

The utility model discloses a gynaecology and obstetrics hemostasis leather bag capable of preventing liquid from flowing back, which comprises a hemostasis bag body, a second connecting pipe arranged on the right side of the hemostasis bag body, an inflation inner plug arranged on the right side of the second connecting pipe, and a first connecting pipe arranged inside the hemostasis bag body. A limiting outer tube is mounted at the right end of the hemostasis bag body, and the right end of the limiting outer tube is in threaded connection with a threaded connection joint; and the third connecting pipe is arranged at the right end of the second connecting pipe, an adjusting valve is installed at the right end of the third connecting pipe, and an inflation head is installed in the adjusting valve. The gynaecology and obstetrics hemostasis leather bag capable of preventing the liquid from flowing back solves the problems that when an existing hemostasis bag is used, although internal water can be prevented from flowing back, hemostasis medicine is inconvenient to stir and crush better, meanwhile, the medicine is inconvenient to filter and input better, use is inconvenient, and a medicine filter screen is inconvenient to clean.

The application relates to the technical field of biomedical engineering, and discloses a VTE system execution method and system combined with a standardized scale, wherein the method comprises the following steps: performing standardized processing on original data to obtain standardized data; constructing a risk intensity flow; performing integral operation to obtain a cumulative integral value of a risk factor; calculating a dynamic risk trajectory; fusing a baseline score value of the standardized scale with the dynamic risk trajectory to obtain a total risk trajectory; calculating an instantaneous risk probability, and judging whether a VTE risk early warning is triggered according to an adaptive threshold value; the four-dimensional risk intensity flow of a body position, anesthesia, hemostatic drugs and circulation parameters is constructed, continuous quantitative monitoring of VTE risk factors is realized, early identification and timely early warning of VTE risks are realized through a dual mechanism of continuous triggering and acute triggering, and the accuracy, real-time performance and individualization level of risk assessment are significantly improved.

The invention discloses a hemostasis and fixing device for a puncture position after arterial blood sampling, which can effectively realize the hemostasis effect of the puncture position after arterial blood sampling under the medical conditions of field disaster relief and emergency rescue. The hemostasis and fixing device for the puncture position after artery blood sampling comprises a main machine and a bandage. The host comprises a shell, an air bag type hemostasis mechanism, a monitoring unit, a control unit and a medicine release unit, and the air bag type hemostasis mechanism, the monitoring unit, the control unit and the medicine release unit are all arranged on the shell; the air bag type hemostasis mechanism is used for pressing a puncture part, the monitoring unit is used for obtaining bleeding state information of the puncture part and transmitting the bleeding state information to the control unit, and the control unit adjusts the pressing force of the air bag type hemostasis mechanism based on the control unit and / or activates the medicine release unit to slowly release hemostasis medicine to the puncture part. One end of the bandage is connected with the host, and the other end of the bandage is detachably connected with the host.

The present invention provides a pharmaceutical composition containing azilsartan medoxomil potassium and a calcium channel blocker, as well as a method for preparing and using the same. The development of a combination formulation using azilsartan medoxomil potassium and a calcium channel blocker is advantageous in terms of improving antihypertensive effects, improving safety and tolerability, and reducing side effects. Azilsartan medoxomil potassium can alleviate amlodipine-induced peripheral edema by dilating peripheral venous blood vessels, while amlodipine can alleviate adverse reactions such as angioedema and dry cough caused by azilsartan medoxomil potassium. Compared with single drugs, the advantages of combination drugs include: (1) reducing medication dosage and improving patient compliance; (2) improving compliance for elderly people and those with dysphagia; and (3) preventing frequent fluctuations in blood drug concentrations, maintaining stable blood drug concentrations, stabilizing blood pressure in hypertensive patients over the long term, and reducing the side effects of each drug. (4) Avoid patients discontinuing medication on their own, and prevent disease recurrence and progression of malignant complications.

The invention discloses an ovum retrieval postoperative vagina compression hemostasis device with a degradable film layer composite air bag, which comprises an air bag and a controller, the air bag is connected with the controller through a catheter, and an inner cavity of the catheter comprises an inflation channel and an exhaust channel; one end of the airbag is connected with the catheter, and the other end of the airbag is compounded with a degradable film layer; the degradable film layer comprises a PHBV bottom layer, a temperature-sensitive hydrogel layer and a silk fibroin layer, the temperature-sensitive hydrogel layer is arranged between the PHBV bottom layer and the silk fibroin layer, and hemostatic drugs are embedded in the temperature-sensitive hydrogel layer; a supporting rod is arranged at the center axis position in the air bag; the controller is provided with an inflation connector, and a safety relief valve is arranged in the controller. According to the vagina compression hemostasis device for the degradable film layer composite air bag after ovum extraction, directional deep flexible compression on a vagina puncture point can be achieved, compression hemostasis and medicine hemostasis can be achieved at the same time, the pain and secondary injury of a patient are reduced, the postoperative recovery efficiency is improved, and the possibility of infection is reduced.

To provide a method and a tool for controlling hemostatic agents and achieving proper tissue contact with the agent at an appropriate pressure and flow rate.SOLUTION: A medical device comprises: a delivery device having a first fluid passageway; and a container movably attached to the delivery device. The container and the delivery device have a second fluid passageway extending therethrough, the container including an interior chamber at intermediate proximal and distal portions of the second fluid passageway. The internal chamber is fluidly isolated from the proximal portion of the second fluid passageway at a first position of the container and fluidly connected to the proximal portion and distal portion of the second fluid passageway at a second position of the container. The first fluid passageway bypasses the container, and passage of fluid through the first fluid passageway is separately controllable from passage of fluid through the second fluid passageway.SELECTED DRAWING: Figure 2

The invention discloses a wound dressing with a hemostatic function, which is characterized in that a gel fiber fabric with hydrophilicity and a porous structure is used as a base material, and hemostatic drugs are distributed in surface micropores or internal pore spaces of the gel fiber base material through surface smearing or soaking loading; the gel fiber fabric is prepared from one or more of acylated chitosan fiber, carboxymethyl chitosan fiber, carboxymethyl cellulose (CMC) fiber, carboxyethyl cellulose fiber, alginate fiber and hydrophilic formalized polyvinyl alcohol fiber; the hemostatic drug is tranexamic acid or a derivative thereof, thrombin, chitosan or fibrinogen in an internal pore space. By utilizing the hygroscopicity of the gel fiber dressing and the softness of the wet gel, the hemostatic medicine is effectively sent to each part of the wound surface, so that the aim of effectively stopping bleeding on the complex wound surface is fulfilled.

A method for preparing a thermosensitive submucosal injection for endoscopic submucosal dissection (ESD), relating to the technical field of regenerative medicine. The specific method involves constructing a novel thermosensitive submucosal injection solution capable of sustained-release hemostatic drugs and growth factors using high-pH chitosan, polyvinylpyrrolidone, calcium ions, and disodium β-glycerophosphate. This injection has very low viscosity, does not require special injection devices, is able to be injected using conventional endoscopic injection needles currently used in clinical practice, and exhibits high injection rate. Additionally, after being injected into the submucosal layer, this injection rapidly forms a high-strength hydrogel under body temperature, more stably supporting the raised state of the mucosal layer to facilitate ESD operations. It also reduces intraoperative and postoperative bleeding, promotes postoperative wound healing, and holds significant clinical practical application value.

The invention relates to the technical field of auxiliary hemostasis devices, and discloses an emergency auxiliary hemostasis device for a blood coagulation dysfunction patient, which comprises a fixing plate I, a drug delivery mechanism arranged on the inner side of the fixing plate I, a compression mechanism arranged at the bottom of the fixing plate I, and a fixing mechanism arranged on the inner side of the fixing plate I, the fixing mechanism is arranged at the bottom of the first fixing plate, and the dosing mechanism comprises a hemostasis assembly. According to the hemostasis device, the hemostasis assembly is arranged, specifically, when a rotating sleeve rotates, a rotating ring is driven to rotate, a first sliding rod at the bottom of the rotating sleeve slides in a sliding groove, a sliding plate is pushed to be separated towards the two sides along a sliding rail, a second fixing plate extrudes a telescopic rod and a first spring, medicine in a fixing sleeve is released, and after releasing is completed, the rotating sleeve is loosened; under the elastic reset action of the telescopic rod and the first spring, the second fixing plate and the sliding plate are close to each other, the bottom of the fixing sleeve is closed, the utilization efficiency of hemostatic medicine is improved, and a hemostatic environment is rapidly formed.

The invention relates to the technical field of medical instruments, in particular to a tool for temporarily blocking blood supply of the lower section of the uterus in cesarean section, which comprises a hemostasis mechanism, an inflation mechanism is fixedly connected to the right side of the upper end of the hemostasis mechanism, an adjusting mechanism is fixedly connected to the right end of the hemostasis mechanism, and the hemostasis mechanism comprises a hemostasis ball. Medicine outlet holes are uniformly formed in the periphery of the hemostasis ball, a medicine adding pipe is fixedly connected into an opening in the right end of the hemostasis ball, and first elastic rods are uniformly distributed in the hemostasis ball. Through cooperation of the hemostasis mechanism and the inflation mechanism, the bleeding point position of the lower section of the uterus of a patient is pressed, and the hemostasis effect can be achieved; and through cooperation of the hemostasis mechanism, the medicine adding needle and the blood drawing needle, hemostasis medicine can be added to the bleeding point position of the lower section of the uterus of the patient, residual blood and redundant medicine in the uterus can be sucked out, and rehabilitation of the patient is facilitated.

This invention relates to a 3D-printed cuttlebone elastic hemostatic scaffold and its construction method. Existing hemostatic materials suffer from problems such as effectiveness only for mild to moderate bleeding, significant side effects, poor biocompatibility, and the need for compression and wound closure. This method involves dissolving a prepolymer of polyglycerol sebacate and polycaprolactone in tetrahydrofuran to prepare a polymer solution. Sodium chloride particles and cuttlebone powder are added and heated and stirred to obtain the 3D printing ink. This ink is then placed in a 3D printer to print sheet-like and block-like mesh scaffolds. The mesh scaffolds are then placed in a vacuum drying oven for vacuum thermal cross-linking. After cross-linking, they are immersed in distilled water for washing and desalting, and then freeze-dried to obtain the hemostatic scaffold. The hemostatic scaffold of this invention is particularly suitable for systemic lacunar wounds with deep bleeding sites that are difficult to control with compression. By combining a biodegradable elastic biopolymer with the traditional hemostatic drug cuttlebone powder, it possesses advantages such as porosity, elastic memory, rapid hemostasis, compressibility, and biodegradability.