27 results about "Hemostatic drug" patented technology

The utility model relates to the technical field of medical instruments, in particular to a simple and convenient brachial artery hemostat which comprises a supporting pressing plate, open grooves are formed in the two side ends of the supporting pressing plate, a threaded sleeve is fixedly installed at the upper end of the supporting pressing plate, a threaded block is in threaded connection with the interior of the threaded sleeve and located on a screw rod, and the screw rod is fixedly connected with the threaded sleeve. A cushion block is installed at the bottom end of the screw rod, and the cushion block is rotationally connected with the screw rod through a bearing. According to the hemostat, the screw rod is manually rotated, the height of the cushion block at the bottom end of the screw rod is adjusted, the cushion block presses the hemostasis position, when the bottom end of the cushion block is squeezed, medicine in the hemostasis medicine area can be squeezed out, the medicine enters the hemostasis cushion and makes contact with the hemostasis position of a patient, and the hemostasis effect is better in cooperation with the medicine; and the upper end shell and the lower end shell are directly and quickly disassembled and assembled through the disassembling and assembling assembly, so that after the upper end shell and the lower end shell are disassembled, the internal sleeve gaskets can be conveniently replaced, and a next patient can use the shell conveniently.

This invention discloses a radioactive particle strip implantation system and method, relating to the field of medical device technology. It includes: an implantation gun and a particle strip module; the implantation gun includes: a gun body; a drive assembly disposed within the gun body, including a driver and a thrust control unit; a push rod, drively connected to the power output end of the driver; a particle strip placement slot disposed at the front end of the gun body for placing the particle strip module, and coaxially arranged with the push assembly; the gun body has a docking part at the front end of the particle strip module compartment for connecting an implantation needle; the push rod can pass through the particle strip module to push the particle strip into the implantation needle; the particle strip module includes: a module body; multiple radioactive particles and multiple hemostatic drug units are pre-sealed in an alternating arrangement within the module body; the radioactive particles and hemostatic drug units are coaxially arranged and can be pushed into the implantation needle by the push rod. This invention uses a pre-assembled plate stacking structure to make the spacing of the radioactive particles adjustable, simplifying on-site operation.

The invention provides a combined debridement device for dermatological nursing, and relates to the technical field of skin care, the combined debridement device comprises a bottom plate, the top surface of the bottom plate is fixedly provided with two vertical plates, the two vertical plates are symmetrically arranged, the top surfaces of the two vertical plates are fixedly provided with the same top plate, one side of the top surface of the top plate is fixedly provided with a debridement table, and the other side of the top surface of the top plate is provided with a debridement groove; two limiting bandages are arranged above the debridement table, water through hoses are fixedly installed in the two limiting bandages, medicine storage sponges are symmetrically arranged in the two water through hoses, a plurality of water outlet holes are formed in the bottom faces of the two water through hoses, a water pump is started, debridement liquid in a water storage tank is pumped into a flow dividing hose through a first water pumping pipe, and the flow dividing hose is connected with a water pump through a second water pumping pipe. The wound cleaning liquid flows through the water supply hose and then is shunted into the water supply hose in the two limiting bandages, the sponge in the water supply hose adsorbs nursing drugs such as antibacterial drugs and hemostatic drugs in advance, the drugs are dissolved when the wound cleaning liquid flows through the water supply hose to form medicated bath liquid, then the medicated bath liquid is evenly sprayed to the surface of a wound through a plurality of water outlet holes in the bottom face of the water supply hose, and flushing and drug administration integrated nursing is achieved.

The invention relates to the technical field of rapid hemostasis application, in particular to a rapid compression hemostasis device which comprises a compression hemostasis block, two positioning clamping belts and an elastic buckling belt, and the rapid compression hemostasis device not only conducts physical compression hemostasis on a wound through the compression hemostasis block, but also combines the function of medicine hemostasis. The compression ring in the compression hemostasis block can accurately compress the periphery of a wound, the bleeding amount is reduced, the medicine block enables hemostasis medicine to directly act on the wound through the medicine penetrating layer, and the hemostasis effect is enhanced. In a battlefield or an emergency medical scene, bleeding can not be completely controlled by purely relying on compression hemostasis, but the hemostasis efficiency can be remarkably improved and the blood loss risk can be reduced by adding the medicine. In addition, due to the design of the cotton ring and the medicine permeating layer of the medicine block, air permeability of the wound can be kept, it can be guaranteed that medicine continuously acts on the wound, and wound oxygen deficit or infection caused by too tight compression is avoided.

The utility model provides a kind of hemostatic gauze ball with hemostatic medicament, it is related to gauze technical field, including sphere and medicament ball, the sphere includes absorbent cotton and gauze mesh belt, the absorbent cotton is spherical, the gauze mesh belt is wrapped in the outside of absorbent cotton, the inside center of absorbent cotton is equipped with inner cavity, the medicament ball is equipped inside inner cavity;The side of the sphere is equipped with hole, and hole is connected to the inside of inner cavity, the inside of hole is equipped with extrusion membrane;The utility model embeds medicament ball in sphere, without extra preparation medicine, when using, only need to lay under sphere to wound, extrude extrusion membrane, press the membrane of broken medicament ball, hemostatic medicament can flow out downwards, carry out quality to wound, it is convenient and fast to operate, it is convenient to use anytime, and when laying, by liquid guide wire core increase the speed of hemostatic medicament in inner cavity flowing downwards gauze mesh belt, with quick-dissolving effect, improve the efficiency of drug action.

The invention relates to the technical field of medical apparatus and instruments, and discloses an adjustable decayed tooth extractor which comprises a mounting seat, a first hinge shaft is rotatably arranged on the mounting seat, two tooth extraction forceps are arranged on the first hinge shaft, a drug delivery mechanism is arranged on one tooth extraction forceps, and a liquid extraction mechanism is arranged on the other tooth extraction forceps; the dosing mechanism comprises a medicine storage groove, a piston, a first spring and a plurality of discharge ports, the medicine storage groove is formed in one of the dental forceps, the piston is slidably arranged in the medicine storage groove, the first spring is arranged in the dental forceps, one end of the first spring is connected with the dental forceps, the other end of the first spring is connected with the piston, and the discharge ports are formed in the dental forceps; and the plurality of discharge ports are communicated with the medicine storage tank. According to the adjustable tooth decay tooth extraction device, the position of the jaw can be fixed during tooth extraction, so that a doctor does not need to maintain the position with hands for a long time, one of the forceps parts is used for coating a wound with a hemostatic drug, and the other forceps part is used for sucking bloodstain.

This invention discloses the application of microRNAs or combinations thereof derived from palm charcoal in the preparation of hemostatic drugs. The microRNAs derived from palm charcoal are selected from any one of ath-miR159a, cpa-miR159b, and ath-miR166a-3p. This study identified miRNAs in palm charcoal and clarified the changes in miRNAs after palm is processed into charcoal drugs. ath-miR159a and cpa-miR159b in palm charcoal can bind to the 3'-UTR of ADRA2C. ath-miR166a-3p in palm charcoal can target and inhibit the expression and secretion of t-PA in HUVEC cells.

The invention discloses a rapid hemostasis and pressurization fixing device for trauma in the emergency department, and belongs to the technical field of medical instruments, the hemostasis and pressurization fixing device comprises a buckle plate, a pressing plate arranged at the bottom of the buckle plate, a driving structure arranged on the buckle plate and a fixing structure arranged on the buckle plate, the hemostasis and pressurization fixing device further comprises a medicine feeding structure which is arranged on the pressing plate, connected with the driving structure and used for infiltrating hemostasis liquid medicine into a wound surface in advance before the pressing plate makes contact with the wound surface for pressurization. According to the rapid hemostasis and pressurization fixing device for the wound in the emergency department, through the linkage design of the driving structure and the dosing structure, dosing can be conducted before the pressing plate makes contact with the wound surface, liquid medicine directly acts on the wound surface along with pressurization of the pressing plate, and the hemostasis efficiency and the liquid medicine utilization effect are improved. Meanwhile, the universal structure of the device can enable the pressing plate to be adjusted in multiple directions and angles according to the shape of the wound surface, so that the pressing plate is comprehensively attached to the wound surface, and the pressurization hemostasis effect is further enhanced.

The invention relates to a polyamino acid electrostatic spinning mineralization bracket with a hierarchical pore structure and a preparation method thereof. A three-dimensional PBLG electrostatic spinning fiber scaffold is prepared through a gas foaming method, and the structural stability of the three-dimensional scaffold is remarkably improved through welding and subsequent in-situ mineralization in a CH2Cl2 steam atmosphere. The prepared bionic fiber scaffold can play a temporary supporting role after being implanted into a defect area, good osteogenesis induction and angiogenesis activity are provided for subsequent bone defect repair, a pore structure formed through foaming can also support ingrowth of new tissues, and the scaffold has good application prospects in the field of bone defect repair and is suitable for popularization and application in the field of bone defect repair. The method can also be expanded to the medical fields of hemostasis, drug delivery and the like.

This invention belongs to the field of biomedicine and relates to a procoagulant polypeptide TPTX and its applications. The procoagulant polypeptide TPTX of this invention can exert its procoagulant and hemostatic effects by specifically inhibiting plasmin activity. Experiments have shown that TPTX exhibits significant dose-dependent procoagulant and hemostatic effects in ferric chloride-induced mouse carotid artery thrombosis models, mouse liver hemorrhage models, mouse tail hemorrhage models, and mouse saphenous vein hemorrhage models, with effects superior to the positive control drug 6-aminocaproic acid. Simultaneously, TPTX can reduce the area of ​​atorvastatin-induced cerebral hemorrhage in zebrafish and improve their motor dysfunction. Mechanistic studies show that TPTX has an inhibitory constant Ki of 17.76 nM on plasmin and has no significant effect on the activity of seven other key serine proteases in the coagulation system, demonstrating a clear target and high selectivity. The procoagulant polypeptide of this invention can be used to prepare hemostatic drugs, possessing the advantages of high efficiency, clear target, and high selectivity, with broad prospects for clinical application.

The utility model discloses a gynaecology and obstetrics hemostasis leather bag capable of preventing liquid from flowing back, which comprises a hemostasis bag body, a second connecting pipe arranged on the right side of the hemostasis bag body, an inflation inner plug arranged on the right side of the second connecting pipe, and a first connecting pipe arranged inside the hemostasis bag body. A limiting outer tube is mounted at the right end of the hemostasis bag body, and the right end of the limiting outer tube is in threaded connection with a threaded connection joint; and the third connecting pipe is arranged at the right end of the second connecting pipe, an adjusting valve is installed at the right end of the third connecting pipe, and an inflation head is installed in the adjusting valve. The gynaecology and obstetrics hemostasis leather bag capable of preventing the liquid from flowing back solves the problems that when an existing hemostasis bag is used, although internal water can be prevented from flowing back, hemostasis medicine is inconvenient to stir and crush better, meanwhile, the medicine is inconvenient to filter and input better, use is inconvenient, and a medicine filter screen is inconvenient to clean.

The application relates to the technical field of biomedical engineering, and discloses a VTE system execution method and system combined with a standardized scale, wherein the method comprises the following steps: performing standardized processing on original data to obtain standardized data; constructing a risk intensity flow; performing integral operation to obtain a cumulative integral value of a risk factor; calculating a dynamic risk trajectory; fusing a baseline score value of the standardized scale with the dynamic risk trajectory to obtain a total risk trajectory; calculating an instantaneous risk probability, and judging whether a VTE risk early warning is triggered according to an adaptive threshold value; the four-dimensional risk intensity flow of a body position, anesthesia, hemostatic drugs and circulation parameters is constructed, continuous quantitative monitoring of VTE risk factors is realized, early identification and timely early warning of VTE risks are realized through a dual mechanism of continuous triggering and acute triggering, and the accuracy, real-time performance and individualization level of risk assessment are significantly improved.

The invention discloses a hemostasis and fixing device for a puncture position after arterial blood sampling, which can effectively realize the hemostasis effect of the puncture position after arterial blood sampling under the medical conditions of field disaster relief and emergency rescue. The hemostasis and fixing device for the puncture position after artery blood sampling comprises a main machine and a bandage. The host comprises a shell, an air bag type hemostasis mechanism, a monitoring unit, a control unit and a medicine release unit, and the air bag type hemostasis mechanism, the monitoring unit, the control unit and the medicine release unit are all arranged on the shell; the air bag type hemostasis mechanism is used for pressing a puncture part, the monitoring unit is used for obtaining bleeding state information of the puncture part and transmitting the bleeding state information to the control unit, and the control unit adjusts the pressing force of the air bag type hemostasis mechanism based on the control unit and / or activates the medicine release unit to slowly release hemostasis medicine to the puncture part. One end of the bandage is connected with the host, and the other end of the bandage is detachably connected with the host.

The invention discloses an ovum retrieval postoperative vagina compression hemostasis device with a degradable film layer composite air bag, which comprises an air bag and a controller, the air bag is connected with the controller through a catheter, and an inner cavity of the catheter comprises an inflation channel and an exhaust channel; one end of the airbag is connected with the catheter, and the other end of the airbag is compounded with a degradable film layer; the degradable film layer comprises a PHBV bottom layer, a temperature-sensitive hydrogel layer and a silk fibroin layer, the temperature-sensitive hydrogel layer is arranged between the PHBV bottom layer and the silk fibroin layer, and hemostatic drugs are embedded in the temperature-sensitive hydrogel layer; a supporting rod is arranged at the center axis position in the air bag; the controller is provided with an inflation connector, and a safety relief valve is arranged in the controller. According to the vagina compression hemostasis device for the degradable film layer composite air bag after ovum extraction, directional deep flexible compression on a vagina puncture point can be achieved, compression hemostasis and medicine hemostasis can be achieved at the same time, the pain and secondary injury of a patient are reduced, the postoperative recovery efficiency is improved, and the possibility of infection is reduced.

The invention relates to the technical field of auxiliary hemostasis devices, and discloses an emergency auxiliary hemostasis device for a blood coagulation dysfunction patient, which comprises a fixing plate I, a drug delivery mechanism arranged on the inner side of the fixing plate I, a compression mechanism arranged at the bottom of the fixing plate I, and a fixing mechanism arranged on the inner side of the fixing plate I, the fixing mechanism is arranged at the bottom of the first fixing plate, and the dosing mechanism comprises a hemostasis assembly. According to the hemostasis device, the hemostasis assembly is arranged, specifically, when a rotating sleeve rotates, a rotating ring is driven to rotate, a first sliding rod at the bottom of the rotating sleeve slides in a sliding groove, a sliding plate is pushed to be separated towards the two sides along a sliding rail, a second fixing plate extrudes a telescopic rod and a first spring, medicine in a fixing sleeve is released, and after releasing is completed, the rotating sleeve is loosened; under the elastic reset action of the telescopic rod and the first spring, the second fixing plate and the sliding plate are close to each other, the bottom of the fixing sleeve is closed, the utilization efficiency of hemostatic medicine is improved, and a hemostatic environment is rapidly formed.

This invention relates to a 3D-printed cuttlebone elastic hemostatic scaffold and its construction method. Existing hemostatic materials suffer from problems such as effectiveness only for mild to moderate bleeding, significant side effects, poor biocompatibility, and the need for compression and wound closure. This method involves dissolving a prepolymer of polyglycerol sebacate and polycaprolactone in tetrahydrofuran to prepare a polymer solution. Sodium chloride particles and cuttlebone powder are added and heated and stirred to obtain the 3D printing ink. This ink is then placed in a 3D printer to print sheet-like and block-like mesh scaffolds. The mesh scaffolds are then placed in a vacuum drying oven for vacuum thermal cross-linking. After cross-linking, they are immersed in distilled water for washing and desalting, and then freeze-dried to obtain the hemostatic scaffold. The hemostatic scaffold of this invention is particularly suitable for systemic lacunar wounds with deep bleeding sites that are difficult to control with compression. By combining a biodegradable elastic biopolymer with the traditional hemostatic drug cuttlebone powder, it possesses advantages such as porosity, elastic memory, rapid hemostasis, compressibility, and biodegradability.

The application relates to the technical field of surgical instruments, and discloses a medical tunnel device, which comprises a hollow needle, a flexible pipe body, a bending part and a side branch part, a helical metal wire is arranged in the peripheral wall of the main supporting part, the hollow needle is movably sleeved on the outer side of the main supporting part, the bending part is connected with the front end of the main supporting part and located in the inner cavity of the main supporting part, the inside of the bending part is formed with a medicament cavity for containing hemostatic medicament, the side branch part is communicated with the main supporting part and extends obliquely relative to the main supporting part, a rigid supporting layer is arranged in the peripheral wall of the side branch part, one end of an inflation pipe is connected with a gas source, and the other end of the inflation pipe is connected with an inflation opening on a side branch end cover, the structure is simple, easy to produce and manufacture, and the medical tunnel device is favorable for reducing the damage to human soft tissues during the establishment of the medical tunnel.

The application discloses screening of hemostatic active components in Euphorbiaceae plants and application thereof, and based on ultrafiltration mass spectrometry technology and taking urokinase-type plasminogen activator as a key target enzyme, a hemostatic active component, breynol, of cyclopentanone isocoumarins in Euphorbiaceae plants is screened for the first time. The breynol shows strong specific binding to urokinase plasminogen activator, and the activity inhibition (IC 50 ) of the breynol to the urokinase plasminogen activator is 0.187±0.000 mM, which is superior to that of the positive control tranexamic acid (IC 50 =2.425±0.001 mM). The breynol is reported for the first time in the research of hemostatic activity of Euphorbiaceae plants, and can be used for preparation of daily or clinical hemostatic drugs.

The present invention relates to technology for delivering a peptide drug and, specifically, to a pharmaceutical composition comprising albumin and a peptide comprising a fatty acid chain. Using the composition according to the present invention prevents a rapid increase in initial blood concentration compared to existing peptide drugs and minimizes blood concentration deviation, and thus can significantly reduce side effects compared to existing peptide derivatives. In addition, the dosing interval is extended, thus enhancing patient convenience.

The invention discloses a porous composite hemostatic sponge loaded with hemostatic drug-loading microspheres and a preparation method of the porous composite hemostatic sponge, and belongs to the technical field of biological medicines. According to the porous composite hemostatic sponge, the liquid absorption, hemostasis and antibacterial effects of a product can be remarkably improved. After a cation solution, hemostatic drug-loaded microspheres and a sponge matrix precursor solution are mixed, the hemostatic drug-loaded microspheres are dispersed and tightly combined with a sponge matrix through the synergistic effect of electrostatic interaction and coordination among microsphere surface groups, matrix components and cations, and the structural stability of the hemostatic drug-loaded microspheres can be maintained in the sponge liquid absorption process; and the continuity of the liquid absorption performance is ensured. Finally, synergistic interaction of hemostasis, bacteriostasis, anti-inflammation and tissue repair is achieved, and the porous composite hemostatic sponge with rapid hemostasis, efficient bacteriostasis and auxiliary tissue healing promoting functions is obtained.

The invention relates to the technical field of biomedical materials, in particular to a controllable degradable collagen-based composite scaffold and a preparation method thereof. The invention relates to an adjustable and degradable collagen-based composite scaffold, which is prepared from the following raw materials in parts by weight: 10 parts of type I collagen, 2 to 4 parts of glycosaminoglycan consisting of chondroitin sulfate and hyaluronic acid, 1 to 2 parts of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1 to 15 parts of glycerol, and is a flexible film with the thickness of 0.5 to 1.5 mm, the flexible thin film is of a double-layer flexible thin film structure with a surface compact layer and an inner porous layer, pores are formed in the surface compact layer and the inner porous layer, therapeutic drugs are loaded in the pores, and the therapeutic drugs comprise at least one of hemostatics, hormones, contraceptives, antibiotic drugs or traditional Chinese medicine extracts.

The utility model discloses a kind of self-adhesive wound protective stickers, including supporting base layer, release paper and adhesive layer, the center of supporting base layer bottom is provided with cavity, the edge position of inside of cavity is provided with antibacterial layer, antibacterial layer below is provided with hemostatic absorbent cotton layer, the inside of hemostatic absorbent cotton layer is uniformly provided with analgesic powder and hemostatic powder, and the inside of antibacterial layer above hemostatic absorbent cotton layer is provided with drug sustained-release layer, the inside of drug sustained-release layer is uniformly provided with biodegradable material bag, the inside of each biodegradable material bag is filled with healing drug.The breathable film layer of the utility model is arranged on the top of antibacterial layer, below the secondary waterproof film layer, this design not only ensures waterproof effect, but also can tear the secondary waterproof film layer when necessary, allow the gas exchange of skin at wound, avoid the skin stuffy, uncomfortable and other problems caused by poor breathability, improve the use experience of patient.

The invention relates to the technical field of medical apparatus and instruments, and discloses a gynecological clinical accurate cervical polyp extirpating and medicine spraying device which comprises a handle, a catheter and a forceps head which are connected in sequence, and further comprises an extirpating assembly which comprises a control part and an extirpating part, the extirpating part is arranged at the front end of the forceps head, and the control part is arranged in the handle; the control part is used for controlling the removing part to extend out of the forceps head and form an annular sleeve which sleeves the cervical polyp; the visual assembly comprises a cleaning part and a visual module, the visual module is installed at the front end of the forceps head, and the cleaning part is arranged on the forceps head and used for cleaning the visual module; the hemostasis assembly comprises a medicine spraying part and an electric coagulation module, the medicine spraying part and the electric coagulation module are both arranged on the forceps head, the electric coagulation module is used for conducting electric coagulation hemostasis on the removed part, and the medicine spraying part is used for spraying hemostasis liquid medicine to the removed wound surface. The invention provides an integrated instrument which integrates precise extirpation, intraoperative visualization, instant hemostasis and drug delivery, and the minimally invasive property, safety and overall efficiency of a cervical polyp treatment operation are improved.

The application discloses a kind of vascular surgery arteriovenous operation hemostasis device, including adjustable restraint belt, the adjustable restraint belt adopts polyurethane material, multiple groups of buffer air bags are distributed in annular array on the inner wall of the adjustable restraint belt, adhere to blood vessel running, opening is set in the upper portion of the adjustable restraint belt, adjusting plate is equipped above the opening, further include pressure monitoring unit, the pressure monitoring unit includes the hemostatic drug bag of fixedly connected in the lower portion of adjusting plate, multiple groups of partition air bags are equipped in the hemostatic drug bag, micro pressure sensor is equipped below the partition air bag, the micro pressure sensor is integrated on the bendable substrate below the partition air bag by using with signal transmission line circuit.The application belongs to the technical field of medical devices, effectively solve the problem that vascular surgery arteriovenous operation hemostasis device lacks real-time monitoring, cannot dynamically monitor hemostasis pressure, because of blood scouring loss, lead to the problem of poor hemostasis effect.

The present application relates to the medical hemostasis technical field, specifically to a perineum lateral incision wound hemostasis device, comprising: a cloth body, including a soft film, a hemostatic medicine block is placed on the surface of the soft film; a squeezing mechanism, including a first silica gel outer frame, the first silica gel outer frame is fixedly connected to the surface of the soft film, and a movable plate is fixedly connected to the surface of the first silica gel outer frame. The present application is adsorbed on the skin of the patient by two groups of second films, the movement of the second film on the skin of the patient is driven by the movement between the rack and the gear on the first silica gel outer frame, the guidance and fixation of the ratchet mechanism make the skin of the patient cut continuously close to the inside, at the same time, the position of the gear will not change in the opposite direction, ensure that the wound of the lateral cut skin is squeezed together, prevent the lateral cut part from bleeding again, promote the lateral cut part to have the corresponding basis between the suture, so that the nurse can be more rapid in the process of suture of the lateral cut part, reduce the pain of the patient.

The invention relates to the technical field of nursing of the digestive system department, in particular to a simple bedside hemostasis device for upper gastrointestinal hemorrhage. The stomach tube body comprises an insertion end and a conveying end, the conveying end comprises a central tube used for sucking exchange liquid and injection tubes used for injecting hemostatic drugs, and the injection tubes are symmetrically arranged with the central tube as the center; the insertion end is detachably connected with the conveying end, and a detection mechanism used for detecting the contact condition of the insertion end and gastric juice is arranged in the insertion end; clinical hemostasis nursing operation of nurses is facilitated, the bleeding rate is reduced, and the prognosis effect of upper gastrointestinal hemorrhage patients is improved.

The application provides a milk protein source urokinase-type plasminogen activator inhibitory peptide and application thereof. Through a combination of virtual screening by molecular docking and in-vitro experiment verification, two u-PA inhibitory activity polypeptides PEVMGVSK and HIQKEDVPSE derived from bovine milk casein are obtained. The two polypeptides can be stably combined with the u-PA active site through multiple intermolecular forces, have a significant inhibitory effect on u-PA-mediated plasminogen activation, can effectively improve the storage period stability of ultra-high temperature instant sterilized milk, delay protein hydrolysis and aging gel formation, and can inhibit the plasmin clot lysis and MDA-MB-231 human breast cancer cell migration in a concentration-dependent manner. The polypeptides obtained by the application have application potential and practical value in the fields of dairy product quality improvement, hemostatic drugs and anti-cancer drug research, etc. as natural source active ingredients.