132 results about "Hemostatic drug" patented technology

The invention provides hemostatic bacteriostatic biological dressing and a preparation method thereof. Nano silver and hemostatic medicament are uniformly distributed in a spongy or film-like biological dressing matrix made of a biological material, wherein the weight of the nano silver is 0.01 to 3 percent of the weight of the biological material, and the weight of the hemostatic medicament is 0.1 to 10 percent of the weight of the biological material. The method for preparing the spongy biological dressing comprises the following steps of: soaking the freeze-dried sponge into silver nitrate solution to prepare nano silver-carrying biological sponge at a high temperature under a high pressure, and soaking the nano silver-carrying biological sponge into solution containing the hemostatic medicament to obtain the spongy biological dressing by freeze drying. The method for preparing the film-like biological dressing comprises the following steps of: preparing biological material solution containing silver nitrate into nano silver-carrying solution at a high temperature under a high pressure, adding the hemostatic medicament into the cooled nano silver-carrying solution, casting the mixture to form a film, and drying the film at room temperature to obtain the film-like biological dressing. The hemostatic bacteriostatic biological dressing has the characteristics of safety, no toxicity, good biocompatibility and degradability and obvious bacteriostatic and hemostatic effects; and the preparation method is simple and has strong operability and low cost.

A self-assembling peptide constituted by D-amino acid is named as d-RAD16 and has an amino acid sequence represented by SEQ ID NO.1 in a sequence list. Test shows that hydrogel formed by the self-assembling peptide can be used for preparing a moisture keeping and water locking agent, and has the function of stopping bleeding rapidly for wound, so that the hydrogel can be used for preparing a hemostatic drug suiting clinical application by adding a pharmaceutically acceptable carrier or excipient. Nanofiber scaffold formed by the self-assembling peptide supports the growth of various cells and can be used as the substrate material for 3D cell culture. The substrate material for 3D cell culture can simulate the in-vivo environment to support the 3D growth of cells in the substrate, thereby providing a cell 3D culture drug screening mode capable of simulating the in-vivo environment and improving the success rate for the development of new drugs.

Disclosed is a hemostatic injection of carbazochrome sodium sulfonate and method for preparation, wherein the injection comprises carbazochrome sodium sulfonate 0.005-0.5 wt%, the optimum content being 0.008-0.2%, auxiliary solvent 0.001-0.5 wt%, the optimum content being 0.002-0.1%, osmoregulation agent 0.8-15 wt%, and water for injection 84.0-99.1%. The preparing process consists of boiling, filtering, removing charcoal, adjusting pH to 4.5-6.5, passing soup through a charcoal layer, loading into transfusion bottles, venting nitrogen, rolling the caps, and sterilizing.

The invention provides a drag sustained release stent. The drag sustained release stent is characterized by comprising a stent body and a polymer membrane, and the stent body and the polymer membraneare connected together; the polymer membrane is a biodegradable polymer membrane or a non-biodegradable polymer membrane, the polymer membrane and/or the stent body is provided with at least one layerof drug coating, and the drug coating includes one or several kinds of antibacterial drugs, anti-inflammatory drugs, anti-cancer drugs and hemostatic drugs. The drug sustained release stent is applied to the treatment of sinusitis, and can not only play a supporting and continuously dosing role in a lesion location after FESS surgery, but also play a role in hemostasis after the surgery.

The invention relates to an extracting method of Malus halliana Koehne flower polysaccharides. The extracting method includes the steps of firstly, crushing Malus halliana Koehne flowers, sequentially using petroleum ether and 70+/-5% ethanol to extract the crushed Malus halliana Koehne flowers under normal temperature, filtering, drying residues, extracting with distilled water, performing vacuum concentration on filtrate, performing alcohol precipitation, drying precipitate, dissolving with distilled water, using an Sevag method to remove protein, performing vacuum concentration on obtained supernate, performing alcohol precipitation again, drying precipitate, dissolving with distilled water, performing dialysis, and performing freeze drying to obtain crude polysaccharides; secondly, dissolving the crude polysaccharides with distilled water, feeding to a DEAE-52 chromatographic column, performing gradient elution with 0.0 mol/L NaCl, 0.1 mol/L NaCl and 0.2 mol/L NaCl, collecting and combining solutions with the same component, performing vacuum concentration, performing dialysis, and performing freeze drying; dissolving with distilled water again, feeding to a Sephadex G-100 chromatographic column, eluting with distilled water, combining solutions with the same component, performing vacuum concentration, and performing freeze drying to obtain the Malus halliana Koehne flower polysaccharides. Coagulation tests show that the Malus halliana Koehne flower polysaccharides have certain in-vitro coagulation-promoting activity and can be used as potential hemostatic medicine.

The invention provides a hemostatic drug composition and application thereof. The hemostatic drug composition is prepared from the following components in parts by weight: 30 to 40 parts of nanometer silicon dioxide, 30 to 40 parts of montmorillonite, and 10 to 20 parts of honeysuckle flower. The hemostatic drug composition has the advantages that the nanometer silicon dioxide and the montmorillonite have the blood condensing function, the honeysuckle flower powder has the sterilizing and inflammation diminishing functions, various types of wound blooding can be quickly stopped, the effects of diminishing inflammation and relieving pain are realized, and the effect of promoting the wound healing is obvious.

The compound hemostatic originated from venom features the main active components comprising batoxobin and blood coagulation factor X activator in the purity higher than 97 5 and weight ratio of 1-1000. The compound hemostatic has ensured curative effect, lowered proteinase consumption and thus reduced negative immune response probability.

The invention relates to pain-easing hemostasis medicine and a preparation method and application thereof and belongs to the technical field of Chinese herb deep processing. With traditional national herbs (Asiatic toddalia roots) being raw materials, the pain-easing hemostasis medicine is obtained through deep processing, and the preparation method and application of the medicine are provided. Extraction is performed on the Asiatic toddalia roots through water and an ethyl alcohol solution, then yellowish-brown particles are obtained through purification and separation, the content of coumarin chemical substances serving as main components is larger than or equal to 25%, the content of alkaloid substances is smaller than 5%, and the balance is mainly starch substances, saccharide substances, tanned substances, terpene substances and sterol substances. The medicine has good pain-easing and hemostatic effects and can be applied to medicine and preparations meeting modern preparation technologies, pharmacodynamics studies show that the pain-easing effect is comparable to that of aspirins, and the hemostatic effect is close to that of Yunnan white drug powder; the technology is simple and convenient to implement, operation is convenient, industrial production can be achieved, and market prospects are good.

The invention discloses a traditional Chinese medicine extract for haemostasis and a preparation method thereof, and particularly a fraxinus platypoda oliver bark extract and a preparation method thereof. The extract of the invention is obtained by extracting and purifying fraxinus platypoda oliver barks by water or petroleum ether. The extract overcomes the disadvantages of great toxic and side effect for current western medicines and large dosage and low purity for traditional Chinese medicine compounds, has significant haemostasis effect, and also has the characteristics of few administration amount, high purity, and less toxic and side effect. The extract is an ideal medicament for haemostasis, and is widely applicable to various internal and external haemorrhage, surgical haemostasis, and the like.

The invention discloses an effect of giant salamander mucus for hemostasis and application of a giant salamander mucus extract in hemostatic drugs and hemostatic medical devices. The giant salamander mucus extract is used for bleeding caused by external injuries, bleeding caused by burns, bleeding caused by scalds and bleeding caused by surgery; pharmacological experiments indicate that the obtained giant salamander mucus extract has the very good hemostasis effect.

The invention discloses anti-inflammatory hemostatic dendrobium officinale fruit toothpaste, belongs to the field of Chinese herbal medicine auxiliary treatment oral daily necessities. Every 100g of the finished toothpaste body contains 0.2%-4% of an anti-inflammatory hemostatic drug ingredient and a blank matrix toothpaste body; the medicinal ingredient three kinds of traditional Chinese medicine extract powder extracted from three kinds of raw medicines of dendrobium officinale fruit, folium isatidis and radix scutellariae, the mass ratio of the three kinds of traditional Chinese medicine extract powder is 2:1:1. The anti-inflammatory hemostatic dendrobium officinale fruit toothpaste aims at oral problems, especially is anti-inflammatory hemostatic, and is free of toxic and side effects, and the Chinese herbal medicine ingredients can play very good prevention function on gingival bleeding and periodontal disease. Compared with Western medicines, the added Chinese herbal medicine ingredients has the advantages of being natural and safe, the hemostatic effect of the anti-inflammatory hemostatic dendrobium officinale fruit toothpaste is more significant than that of hemostatic toothpaste in the market, and the added folium isatidis and radix scutellariae have anti-inflammatory properties, so that the anti-inflammatory hemostatic dendrobium officinale fruit toothpaste is suitable for the needs of the public.

The invention relates to the field of medical devices, in particular to a multifunctional device for continuously supplying nasal cavity wounds, which consists of a catheter part, an inflatable part and a drug supply part, and the drug supply part includes: a drug injection valve (9), an injection valve Drug tube (6) and drug storage balloon (4). The drug storage balloon (4) is located outside the inflatable balloon (3) in the middle of the nasal catheter (2), and the two are in a nested relationship, the inner surface is the inflatable balloon (3), and the outer surface is the drug storage balloon (4) . The drug storage balloon is made of microporous silica gel film. The invention is mainly used in the repair of nasal passage wounds after nasal cavity surgery, in addition to pressurized hemostasis, fluid drainage, nasal passage cleaning and nasal ventilation, as well as preventing patient nasal cavity healing deviation, nasal septum deviation and postoperative cerebrospinal fluid rhinorrhea, etc. In addition to functions such as complications, the more important thing is that through the drug supply part, hemostatic drugs, painkillers and anti-inflammatory and anti-infective drugs can be continuously used locally on the wound to speed up wound healing and reduce patient pain.

The invention provides a method for manufacturing specific hemostatic powder, which is a necessary medicament for rescuing body injury, i.e. hemorrhage caused by current war preparation, counter strike, accidents (knife injuries and traffic accidents) in life and natural disasters (earthquakes). The specific hemostatic powder has stronger blood pressure resistance (over 200mmHg) and effective hemostasis on medium-small arterial hemorrhage, besides basic requirement of effective hemostasis and medicament absorption in human tissues. According to the characters of the traditional Chinese medicines, the prepared hemostatic powder which is not studied domestically and overseas has the functions of antiphlogosis and tissue regeneration, and common wound is naturally healed in 4 to 5 days without any scar. Because of the advantages of tissue absorption and strong hemostatic efficacy, the hemostatic powder can effectively stop bleeding in only 2 minutes on parenchymatous organic rupture (liver and spleen rupture). The hemostatic powder has obvious hemostatic effect in a specific state (patients of hypertension, liver disease, cancer and thrombocytopenia, patients in blood transfusion, and patients lacking prothrombin and the like).

The invention discloses a drug-loaded composite hernia patch and a preparation method thereof. The composite hernia patch comprises a polylactic acid/polypropylene skin-core structure fiber substrateand a drug-loaded slow-release layer which are combined together through hot pressing. The invention further provides a preparation method of the composite hernia patch. The method comprises the following steps: 1) preparing developer-doped polypropylene; 2) preparing polylactic acid/polypropylene skin-core structure fibers, and performing weaving to obtain the substrate; 3) preparing drug-loadedmicrospheres of an antibacterial drug, a hemostatic drug and an anesthetic drug; 4) preparing the drug-loaded slow-release layer through electrostatic spinning; and 5) performing hot pressing to obtain the finished product. The drug-loaded composite hernia patch avoids the problem of adhesion caused by direct contact between a polypropylene material and tissues, meanwhile, different drugs can be added to the drug-loaded slow-release layer according to needs, surgical healing is promoted, the polylactic acid material can be slowly degraded and absorbed in vivo, and discomfort of the patch is reduced after healing.

The invention discloses a portable open chest trauma treating and curing device which comprises a compressing plate. An installing pad is arranged on the side surface of the compressing plate, stypticcotton is arranged on the side surface of the installing pad, sterile gauze is arranged on the side surface of the styptic cotton, and fixing devices are arranged on the two side surfaces of the compressing plate. The portable open chest trauma treating and curing device can stop bleeding of a patient in time, has good hemostatic property and prevents trauma condition exacerbation due to excessive bleeding of the patient, the styptic cotton can stop bleeding of the patient, the sterile gauze prevents wound infection, and a first bandage and a second bandage can bonded and fixed through a hookfastener face and a loop fastener face, are adjusted in length and can be adjusted according to the body shape of the patient. The portable open chest trauma treating and curing device is suitable for patients different in body shape, the universality of the device is improved, first-aid drugs, hemostatic drugs and the like can be put in a drug box, a hemostatic effect is further improved, the drug box is slidingly connected in an installing groove, and the portable open chest trauma treating and curing device can be dismounted according to the use demands and is more convenient and flexibleto use.

The invention discloses a preparation method and preparation of absorbable micropore vacuum polysaccharide particles. The preparation method comprises the steps that plant starch is added to an extrusion mechanism for extrusion and gelatinization, after soybean oil, span 80 and polysorbate 80 are added for emulsification, perforating, crosslinking and desolvation are carried out, pigments and pyrogen are removed, drying, screening, packaging and sterilization are carried out, and the micropore vacuum polysaccharide particles are obtained. Packaging is carried out under the aseptic conditions, and cobalt 60 is used for sterilization. Micropore vacuum polysaccharide particles of 20 micrometers and 50 micrometers are used for preparing external-use hemostasis medicine, and the micropore vacuum polysaccharide particles of 51 micrometers to 100 micrometers are used for preparing intraoperative hemostasis medicine. The absorbable micropore vacuum polysaccharide particles are free of toxins, stimulation, immunogenicity, apyrogeneity and mutagenesis effects, and can be degraded and absorbed by human tissue and body fluid. Metabolite is CO2 and H2O. The absorbable micropore vacuum polysaccharide particles are directly used for bleeding wound surfaces, have the advantages of being good in biocompatibility and water absorption performance, short in hemostasis time and the like, are completely absorbed within 72 hours, and are free of adhesion.

The invention relates to white-flower Chinese loropetalum extract which comprises quinate derivative ingredients and glucoside ingredients. The quinate derivative ingredients include one or multiple of chlorogenate methyl ester, chlorogenate ethyl ester and 5-O-p-coumaroyl quinate methyl ester, and the glucoside ingredients include one or multiple of rhodioside, (Z)-3-hexenyl-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside, benzyl-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside, myricitrin and quercetin-3-O-(6'-O-galloyl)-beta-glucoside. The invention further relates to a preparation method of and a drug combination of the white-flower Chinese loropetalum extract and application of the extract in preparing hemostatic drug or products. Pharmacodynamic and acute toxicity experiments of the extract show that the extract has the advantages of clear active ingredients, strong pharmacodynamic effect, little toxic and side effect, high product purity, low administration dosage and controllable quality.

The invention discloses a camellia hemostatic medicine, and relates to the technical field of external Chinese patent medicines. The camellia hemostatic medicine is prepared from the following raw materials in parts by weight: 45-65 parts of fresh camellia, 4-7 parts of tea oil, 10-18 parts of chitosan, 5-10 parts of cacumen biotae, 2-5 parts of incense ashes, 1.5-3.5 parts of vitamin K, 1-4 parts of calcium alginate, 2-5 parts of liquorice and 0.4-1.5 parts of tea saponin. The camellia hemostatic medicine is prepared by the following preparation processes: 1 preparing raw materials; 2 pretreating the raw materials, namely (1) pretreating fresh camellia, (2) pretreating liquorice, (3) pretreating incense ashes, and (4) pretreating cacumen biotae; and 3 preparing, namely A, primarily mixing, B, secondarily mixing, and C, homogenizing. The camellia hemostatic medicine has the efficacies of cooling blood, stopping bleeding, diminishing inflammation, easing pain, and promoting normal solidification of blood, has the characteristics of good biological degradability and biocompatibility, and is suitable for stopping bleeding for kinds of wounds.

The invention provides a cattail pollen sauting method, sauted cattail pollen and application thereof. The sauting method comprises the following steps of: preheating a medicament sauting machine, adding cattail pollen and auxiliary materials in a weight ratio of 4:2-5:2 into the medicament sauting machine, sauting for 8-12 minutes at the temperature between 200 DEG C and 220 DEG C and the revolving speed of 14-24r.min<-1>, taking out the sauted cattail pollen and auxiliary materials, screening the auxiliary materials, and cooling to obtain the sauted cattail pollen. The sauted cattail pollenis applied in preparation of hemostatic and medicaments for treating hematemesis, hemoptysis, hemorrhinia, bloody dysentery, hemafecia, metrorrhagia and metrostaxis, bleeding from injuries and/or vaginal wet and itching. The method is low in energy consumption and high in yield in unit time, and meets the requirement of modern Chinese medicinal clinical application; the sauted cattail pollen is not stuck to a pot, and the produced sauted cattail pollen product has uniform appearance and color and controllable quality; and the method is simple and reasonable.

The invention provides a traditional Chinese medicine composition, application of the traditional Chinese medicine composition to regulation of intestinal microorganisms and application of the traditional Chinese medicine composition to medicine preparation. The traditional Chinese medicine composition is prepared from a medicine for reinforcing qi and nourishing blood, a medicine for cooling blood and stopping bleeding and a medicine for resolving phlegm and resolving stasis. The medicines are used for treating diseases related to intestinal flora disturbance.

The invention provides a directionally driven targeted hemostasis micromotor, which is characterized in that microporous starch is used as a carrier for delivering a hemostasis drug, nano Fe3O4 is self-assembled on the surface of the microporous starch to serve as a power system, and the hemostasis drug (thrombin) is loaded on the surface of the microporous starch/nano Fe3O4 by using bovine serum albumin. The thrombin on the micromotor can stably exist on the carrier, and under the stimulation of a magnetic field, the effect of centralized and directional delivery is achieved, so that the blood coagulation function of the thrombin is fully played; and meanwhile, under the stimulation of an external magnetic field, the micromotor can generate power to move towards a target position, and when the position of the magnetic field is changed, the movement direction of the micro motor can be changed, so that the micromotor is suitable for various types of wound surfaces and wounds.

The invention discloses a rapid hemostasis device for hepatobiliary surgery, and relates to the technical field of medical instruments. The rapid hemostasis device comprises a handle, a medicine hemostasis part and an electrocoagulation hemostasis part, wherein the medicine hemostasis part and the electrocoagulation hemostasis part are fixedly connected with the left end of the handle; the upper part of the medicine hemostasis part is provided with a medicine supply bin; the lower part of the medicine hemostasis part is provided with a restraining bin used for restraining sterile sponge; the medicine supply bin and the restraining bin are separated by a diaphragm made of an elastic material; a plurality of liquid medicine channels are uniformly distributed on the diaphragm; each liquid medicine channel comprises an opening and a valve-shaped structure located at the top part of the opening; and an elastic piece is connected with and arranged between the center of the upper surface of the diaphragm and the center of the surface of the inner wall of the top end of the medicine supply bin, and comprises springs and a balancing weight. The rapid hemostasis device provided by the invention realizes seamless combination of electrocoagulation hemostasis and medicine hemostasis, can automatically supplement a hemostatic medicine into the sterile sponge in the hemostasis process, greatly improves the efficiency of hemostasis, avoids the loss of excessive blood of a patient, reduces the waste of the hemostatic medicine, and relieves the labor intensity of a doctor.