Application of delta opiate receptor antagonist ICI174, 864 for preparing haemorrhagic shock resisting medicine

Abstract

The invention relates to the application of a delta opiate receptor antagonist ICI174, 864 for preparing a haemorrhagic shock resisting medicine. The delta opiate receptor antagonist ICI174, 864 has effective treatment, does not need to be supplemented with body fluid when in use, does not depend on volume resuscitation and does not influence the pain threshold of a shock person, and therefore, the delta opiate receptor antagonist ICI174, 864 is more suitable for the early treatment of war injury haemorrhagic shock, especially for the treatment on the way of evacuation and gains time for the evacuation of war injury haemorrhagic shock patients without fluid resuscitation.

Description

technical field [0001] The present invention relates to a new application of δ opioid receptor antagonist ICI174,864, in particular, relates to the anti-hemorrhagic shock effect of δ opioid receptor antagonist ICI174,864. Background technique [0002] Traumatic hemorrhagic shock, whether in wartime or in peacetime (such as trauma caused by traffic accidents and various disasters), has a high incidence and mortality. In general war trauma, the incidence of shock is 10% to 15%. In future high-tech local wars, the incidence of traumatic hemorrhagic shock can be as high as 25% to 30%. It has been reported that 32.6% to 59.5% of the wounded in war died of traumatic hemorrhagic shock, and about 40% of these casualties died within 5 to 30 minutes after injury. Early treatment appears to be very important. For severe traumatic hemorrhagic shock wounded, in addition to general fluid resuscitation, functional support and other measures, it is of great significance to develop good an...

AI Technical Summary

Problems solved by technology

[0003] In recent years, with the deepening of research on the pathophysiology of shock, many anti-shock drugs have appeared, such as calcium ion antagonists, oxygen free radical scavengers such as allopurinol, superoxide dismutase (SOD), cytokine antagonists As well as some new vasoactive drugs, these anti-shock drugs have a certain degree of anti-shock effect, but they all need to be supplemented with fluids during use, rely on volume resuscitation, and some of them will also affect the pain threshold of shock patients. There are certain difficulties in the infusion of fluids at the scene of shock and during evacuation, which limits their application in the early first aid of war trauma shock

At present, there is no relevant report on the application of the δ opioid receptor antagonist ICI174,864 in the preparation of anti-shock drugs

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