Anti-microbial healing-promoting hydrogel dressing and preparation method therefor

Abstract

The invention discloses an anti-microbial healing-promoting hydrogel dressing and a preparation method therefor. The main ingredients of the dressing are water-soluble high-molecular polymers, functional polymers with pseudoplastic, anti-microbial agents and water. The above ingredients are dissolved into a whole after a series of technologies. The solution is poured into a mold, and the hydrogel dressing is obtained after curing and irradiation disinfection. The results of wound healing experiments and in vitro anti-microbial experiments show that the hydrogel dressing can promote wound healing effectively, and has good bacteriostatic activity to multiple bacteria (the sterilizing rate is above 70%). The anti-microbial healing-promoting hydrogel dressing is better than existing hydrogel dressings obviously, and has advantages of substantial anti-microbial curative effects, transparency, high water content, simple preparation method, pure product, nontoxicity, innocuousness, no stimulation, good biocompatibility and the like. The hydrogel dressing is suitable for large-area promotion and application.

Description

technical field [0001] The invention belongs to the field of medical wound dressings and preparation thereof, in particular to an antibacterial and healing-promoting hydrogel dressing suitable for the protection and treatment of burns, mechanical wounds, surgical incisions and chronic wounds and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it is a natural barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms; however, the large area exposed to the outside world makes the skin vulnerable to external injuries such as burns and mechanical injuries. Because Staphylococcus aureus, Escherichia coli and other pathogens multiply on the wound, it is easy to cause wound infection; the infected wound is not easy to heal, and it is easy to cause loss of body fluid and various complications. [0003] Gauze-type dressings, known as traditional dressings, are generally mad...

AI Technical Summary

Problems solved by technology

The advantages of this type of dressing are: certain absorbency, easy to make, cheap, and reusable; the disadvantages are: the inability to keep the wound moist leads to delayed wound healing, the dressing fibers are likely to cause foreign body reactions and affect healing, and the newborn is easily damaged when changing dressings. Tissues and pathogens are easy to pass through the soaked dressing, and the workload of changing the dressing is heavy, and the bacterial resistance caused by the local application of antibiotics in the gauze dressing makes it difficult to heal the infected wound

[0006] "Polyvinyl Alcohol Hydrogel Dressing Containing Drugs and Chitosan and Its Preparation Method" (CN1320931C) published on June 13, 2007 discloses a polyvinyl alcohol hydrogel dressing containing drugs and chitosan , the medical hydrogel dressing can be used to treat various skin wounds and burns, but has the disadvantages of poor absorption of seepage fluid and the presence of harmful substances such as plasticizers; Nano-silver and carboxymethyl chitosan medical dressing and its preparation method" (CN102114265A) discloses a medical dressing containing nano-silver and carboxymethyl chitosan, which has good antibacterial effect, but has the ability to keep the wound moist, Lead to delayed wound healing; not easy to lift from the wound and other disadvantages; published on October 25, 2006 "Liquid wound dressing with promoting wound healing and antibacterial function" (CN100471528C) discloses a wound dressing with promoting wound healing and antibacterial function Liquid (gel-like) wound dressing, the medical dressing has the effect of anti-inflammatory, pain-relieving, and promoting wound healing, but has the disadvantage of poor ability to absorb exudate

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