Composite polypropylene patch for mitigating foreign matter reaction and preventing adhesion, and preparation method thereof

Abstract

The invention provides a composite polypropylene patch for mitigating foreign matter reaction and preventing adhesion. The composite polypropylene patch is characterized by comprising a polypropylenewarp-knitted macroporous mesh, chondroitin sulfate / gelatin porous crosslinked sponge and an anti-adhesion film, wherein the polypropylene warp-knitted macroporous mesh is used as an intermediate support layer, the chondroitin sulfate / gelatin porous crosslinked sponge is penetratingly wrapped around the polypropylene warp-knitted macroporous mesh, and the anti-adhesion film is attached to one sideof the chondroitin sulfate / gelatin porous crosslinked sponge. A preparation method comprises the steps of performing plasma hydrophilic activation on the polypropylene mesh, immersing the polypropylene mesh in a mixed solution of chondroitin sulfate and gelatin, covering the mesh with a nanofiber membrane, performing integral freeze-drying, soaking the mesh in an EDC / NHS solution to conduct sufficient cross-linking, soaking the mesh in deionized water to remove impurities, and performing freeze-drying. The prepared composite polypropylene patch has anti-inflammation and anti-adhesion functions, and is light, soft, and convenient for surgical operation, thereby having a good application prospect.

Description

technical field [0001] The invention belongs to the field of biomedical textile materials, in particular to a composite polypropylene patch for reducing foreign body reaction and preventing adhesion and a preparation method thereof. Background technique [0002] A hernia is any organ or tissue that leaves its original location and enters another location through normal and abnormal weak points or defects or pores in the human body. At present, the main method of clinical treatment of hernia is to implant a patch that can strengthen or replace the weak and damaged fascial tissue. Laparoscopic intraperitoneal mesh repair (IPOM), as a commonly used hernia surgery, has the advantages of less trauma, less postoperative pain, shorter hospital stay, faster recovery, less seroma formation, and less recurrence. [0003] At present, the most widely used clinically is the warp-knitted polypropylene mesh. It has many advantages: (1) it is soft, compliant and easy to handle, resistant ...

AI Technical Summary

Problems solved by technology

The problems with this method are that the acellular matrix is ​​expensive, which increases the cost of the patch, and the composite process is costly, and it is easy to fall apart, and it is inconvenient to cut and operate.

However, this method will destroy the structure and shape of the non-woven mesh soft tissue repair diaphragm, and ultimately affect the overall physical and chemical properties of the composite patch.

Images