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Chitosan biofilm polypropylene mesh and preparation method thereof

A technology of polypropylene mesh and chitosan film, applied in the direction of coating, etc., to achieve the effects of strong practicability, reduced erosion, and easy process

Active Publication Date: 2012-01-04
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no chitosan polypropylene mesh and corresponding production method suitable for the preparation of implanted medical materials for the treatment of female pelvic floor organ prolapse at present.

Method used

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  • Chitosan biofilm polypropylene mesh and preparation method thereof
  • Chitosan biofilm polypropylene mesh and preparation method thereof
  • Chitosan biofilm polypropylene mesh and preparation method thereof

Examples

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Effect test

preparation example Construction

[0025] The invention provides a kind of preparation method of chitosan film-coated polypropylene net sheet, it comprises the following steps:

[0026] Step 1: Weigh a certain amount of chitosan and dissolve it in 1~3% acetic acid solution; then add glutaraldehyde and n-heptane to the solution; and cross-link reaction at 45~50°C for 0.5~1.5 hours , after standing for a period of time, the casting film solution of chitosan with a mass content of chitosan of 1 to 5% was obtained; through experimental determination, the performance parameters of the prepared chitosan-coated polypropylene mesh include, the softness of the product The pore size and uniformity of chitosan in the product are all related to the concentration of the casting solution used. Generally, the higher the concentration, the weaker the softness of the prepared chitosan-coated polypropylene mesh and the smaller the pores. , and the poorer the uniformity of the pores, the chitosan-coated polypropylene mesh suitabl...

Embodiment

[0032] Step 1: Cleaning of polypropylene mesh: Soak ordinary polypropylene mesh in absolute ethanol to remove impurities on the surface of the mesh; after 24 hours, take out the mesh, rinse with deionized water several times, and place Dry in an oven at 60°C to obtain a clean polypropylene mesh.

[0033] Step 2: Preparation of casting solution: respectively weigh 1g, 1.25g and 1.5g of chitosan and dissolve them in 2% acetic acid solution by volume fraction, then add 5% of total solid weight glutaraldehyde and 50% of total solid weight % n-heptane, under the conditions of magnetic stirring speed of 230r / min and temperature of 45°C, cross-linking reaction for 1h; after that, static defoaming for one night, so that the mass fractions of chitosan were respectively 2.0%, 2.5% and 3.0% casting solution.

[0034] Step 3: Preparation of chitosan-coated polypropylene mesh: Pour the prepared casting solution into a petri dish, soak the clean polypropylene mesh in the casting solution f...

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Abstract

The invention relates to a chitosan biofilm polypropylene mesh and a preparation method thereof. According to the invention, a polypropylene mesh is processed by using waterless ethanol and deionized water; the polypropylene mesh is modified by using 1.0 to 5.0% of a chitosan film forming solution through a process of biofilm forming, such that a chitosan biofilm polypropylene mesh is obtained. The method of the invention is simple and operable. No toxic or harmful reagent is included. No adverse effect is brought to subsequent applications of the medical mesh. According to the invention, the polypropylene mesh has a high porosity, peripheral tissue can well contact and grow on the polypropylene mesh, such that the anti-stretching property of a repaired part is enhanced; also, chitosan has a good biocompatibility, such that complications such as polypropylene mesh erosion, exposure and tissue adhesion at an implantation position are effectively reduced. The chitosan biofilm polypropylene mesh is especially suitable for clinical women pelvic reconstructive surgery. With the chitosan biofilm polypropylene mesh, histocompatibility of the polypropylene materials in pelvic reconstructive operations is improved, and pelvic reconstruction postoperative complications are reduced.

Description

technical field [0001] The invention relates to the field of tissue engineering and medical supplies, in particular to a chitosan film-coated polypropylene mesh and a preparation method and application thereof. Background technique [0002] Female pelvic floor prolapse (pelvic floor prolapse, POP) and stress urinary incontinence (stress urinary incontinence, referred to as: SUI) caused by pelvic floor injury and functional degradation seriously affect the quality of life of women. The specific causes of female pelvic floor organ prolapse include birth trauma, neuromuscular injury, environmental factors and genetic factors. [0003] The traditional surgical treatment options are surgical repair of the anterior and posterior vaginal walls and hysterectomy. However, the above two treatment options can only repair prolapsed female pelvic floor organs, but cannot improve the strength of the tissue itself, and cannot achieve the purpose of reconstructing the anatomical structure ...

Claims

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Application Information

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IPC IPC(8): A61L27/34
Inventor 吴氢凯程慧张荣孙俊芬滕银成
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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