57 results about "Adhesion barrier" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.

A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.

A collagen device is prepared by mixing collagen with purified water for a period of time sufficient to form a mixture. The pH of the mixture is adjusted to a pH level sufficient to substantially solubilize the collagen. A first predetermined amount of the mixture is placed into a container. The mixture is subject to a lyophilizing process and formed into a collagen device. The collagen device is also cross-linked. The collagen device has a plurality of pores wherein a majority of the pores have a diameter of less than 10 μm. To use the collagen device as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the collagen device is placed in contact with bodily tissue and that contact is maintained until the collagen device is substantially resorbed within the bodily tissue.

The present invention relates generally to using at least one green sheet that is originally very thin with the help of at least one thicker green sheet. At least one organic adhesion barrier is used to build the multi-layer ceramic laminates. Basically, the present invention relates to a structure and method for forming laminated structures and more particularly to a structure and method for fabricating multi-density, multi-layer ceramic products using at least one very thin green sheet and/or at least one green sheet with very dense electrically conductive patterns secured to at least one thicker green sheet using at least one organic adhesion barrier.

An improved composite prosthesis for laparoscopic repair of inguinal or femoral hernias, and also for the laparoscopic repair of large incisional ventral hernias incorporates two different layers, namely an upper layer made of polypropylene mesh to promote tissue ingrowth, and a lower layer formed with an adhesion barrier material to prevent adhesions to the intestines. Both layers are secured together with a highly visible dark seam at the perimeter of the prosthesis to assist the surgeon in visualizing the peripheral edge. The lower layer is slightly larger than the polypropylene mesh so there is an adhesion barrier edge around the prosthesis to conceal the edges of the polypropylene mesh. The upper layer includes a guiding cone to facilitate placement of the prosthesis at the exact center of the hernial defect. The base of this cone is attached to the central part of the prosthesis, and the apex of the cone will be attached later to a guiding thread that is inserted to from the outside of the abdomen using a long straight needle through the skin and hernial sac. Furthermore the laparoscopic hernia prosthesis lower layer is provided with a bounding rim to guide the tip of the spiral tacker to the very edges of the prosthesis in order to stretch the prosthesis in place, and also to conceal the staples or tacks.

A blended electrophilic material with a first component having a functionality of at least three and a second component having a functionality of two is mixed with a nucleophilic material. The blended electrophilic material cross-links with the nucleophilic material to form a non-liquid, three dimensional structure which can applied, e.g., as an adhesion barrier.

The present invention relates to an adhesive hydrogel composition containing catechol group-coupled chitosan and Pluronic comprising a thiol group coupled to the end thereof, and more specifically, to an adhesive composition which is safe in vivo and in vitro, is temperature sensitive, and has an excellent hemostatic effect and thus can be used as a bioadhesive, and a medical adhesive, an adhesion barrier and a surface adsorption inhibitor comprising the same.

The present disclosure is generally directed to multi-layer barrier layer stacks for interconnect structures that may be used to reduce mechanical stress levels between the interconnect structure and a dielectric material layer in which the interconnect structure is formed. One illustrative method disclosed herein includes forming a recess in a dielectric layer of a substrate and forming an adhesion barrier layer including an alloy of tantalum and at least one transition metal other than tantalum to line the recess, wherein forming the adhesion barrier layer includes creating a first stress level across a first interface between the adhesion barrier layer and the dielectric layer. The method also includes forming a stress-reducing barrier layer including tantalum over the adhesion barrier layer, wherein the stress-reducing barrier layer reduces the first stress level to a second stress level less than the first stress level, and filling the recess with a fill layer.

The present invention relates generally to using at least one green sheet that is originally very thin with the help of at least one thicker green sheet. An adhesion barrier to build multi-layer ceramic laminates and process thereof is also disclosed. Basically, the present invention relates to a structure and method for forming laminated structures and more particularly to a structure and method for fabricating multi-density, multi-layer ceramic products using at least one very thin green sheet and/or at least one green sheet with very dense electrically conductive patterns on top of at least one thicker green sheet.

A formulation for generating an adhesion barrier that includes a plurality of particles or a dry powder that is made of a polymer combination of at least one biodegradable polymer and at least one water soluble polymer is disclosed. Methods of making and delivering the formulation are further disclosed. The formulation of particles is deposited on a surface of internal body tissue and the deposited formulation absorbs moisture from the tissue and forms a film over the surface. The film acts as an adhesion barrier by reducing or preventing adhesion of the surface to other body tissue.

The present invention relates to a postsurgical adhesion barrier of carboxymethylchitosan, carboxymethylchitosan/carboxymethylcellulose cross-linked with multivalent ions and a method for preparation of the barrier. The method of preparation comprises: preparing a carboxymethxylchitosan polymer aqueous solution and carboxymethylcellulose polymer aqueous solution in purified water respectively, applying the carboxymethxylchitosan solution, or a mixed solution of carboxymethxylchitosan and carboxymethylcellulose with certain weight ratio on a smooth plate, drying the plate with the applied polymer aqueous solution to obtain a film thereon, socking the dried film on the plate in a aqueous solution of cross-linking agent selected from Ca⁺⁺ ion, Fe⁺⁺⁺ ion, a mixture of Ca⁺⁺ and Fe⁺⁺⁺, or a mixture of Ca⁺⁺ and Al⁺⁺⁺ to complete cross-linking reaction, and drying and detaching the cross-linked film. The obtained postsurgical adhesion barrier is biocompatible and bioresorbable.

In accordance with one aspect of the invention, a method is provided in which post-surgical adhesions at a surgical site in a patient are prevented or inhibited. The method comprises topically applying a liquid composition comprising a hydrophobic species, which has a melting point above normal body temperature, to tissue at the surgical site in an amount effective to prevent or inhibit the formation of adhesions during healing. Application of the liquid composition results in the formation of a solid adhesion barrier layer on the tissue. Moreover, the properties of the hydrophobic species are such that the adhesion barrier sublimes in vivo after the surgical site is closed. In another aspect, A medical device that comprises first and second lumens, wherein the medical device is configured to deliver a first fluid medium through the first lumen at a temperature above normal body temperature and to concurrently or sequentially deliver a second fluid medium through the second lumen at a temperature below normal body temperature.

The instant invention relates to a composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′.

Additionally, the invention also relates to the development of a bioresorbable patch comprising:

• • (a) an adhesion barrier component comprising a composition according to the invention in the form of a film; and
  • (b) an adhesive component comprising:
    • (i) at least one synthetic adhesive polymer; and/or
    • (ii) at least one polysaccharide.

The present invention provides a method of wound healing, comprising administering the composition or patch.

The invention provides a cellulose derivative having a repeating unit of the formula below, a composition including the cellulose derivative and a phospholipid, a method for production thereof, and an adhesion barrier including the cellulose derivative or the composition.

In the formula, R¹, R², and R³ are —H, —CH₂—COOH, —CH₂—COOX, or —CH₂CO-phosphatidylethanolamine, and X is an alkali metal or an alkali earth metal. The degree of substitution of —CH₂—COOH and —CH₂—COOX is 0.3 to 2.0 in total, and the degree of substitution of —CH₂CO-phosphatidylethanolamine is 0.001 to 0.05.

Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post- surgical adhesions.