11 results about "Adhesion barrier" patented technology

An implantable prosthesis for preventing, reinforcing and / or repairing anatomical defects, including parastomal hernia that may occur after forming a stoma or an ostomy opening, such as parastomal hernia formed in conjunction with ileostomy or colostomy. The prosthesis may include a body made of a biocompatible material having a preformed three-dimensional channel configured to receive a portion of a lateral intestinal tract created in conjunction with parastomal hernia repair or ostomy. An anti-adhesion barrier may be located on the inner side of the channel to isolate the portion of the lateral intestinal tract from the tissue permeable surface of the body to reduce or eliminate potential adhesion between the body and the lateral intestinal tract. A portion of the channel may include a flared section extending inwardly from the outer periphery to reduce pressure of the portion of the lateral intestinal tract at the open end of the channel.

The invention relates to a double-layer microneedle patch and a preparation method and application thereof.The double-layer microneedle patch comprises a drug delivery unit and an adhesion unit, the drug delivery unit is a GCM-MN microneedle array, the adhesion unit is a CSH hydrogel patch, and when the double-layer microneedle patch is used, firstly, the GCM-MN microneedle array acts on a wound through pressure, and then the CSH hydrogel patch covers the GCM-MN microneedle array. The CSH hydrogel patch is beneficial to creating a wet healing environment, has excellent adhesion stability and skin adaptability and provides an adhesion barrier for a wound, and the GCM-MN microneedle array has good cell compatibility, cell affinity, blood compatibility and biodegradability. Along with the degradation of the microneedle array at the wound, the packaged GCM nanoparticles are continuously released and go deep into the wound. Therefore, the double-layer microneedle patch disclosed by the invention has huge clinical application potential in the field of infectious wound treatment.

An adhesion barrier is comprised of, consists of, or consists essentially of a sheet having a top surface and a bottom surface. The sheet includes either (i) interconnected links or (ii) interconnected, vertically aligned, partitions. The links form pores or the partitions form pores, with the pores extending from the top surface through the bottom surface. The sheet is comprised of, consists of, or consists essentially of a flexible or elastic polymer.

The invention discloses a manufacturing method of a metal gate transistor, which comprises the following steps of: completing a metal gate process flow to form a metal gate which contains Cl; and forming an interlayer film. And forming a contact hole, wherein the step of forming the contact hole comprises the sub-steps of performing graphical etching to form a contact hole opening. And performing pre-cleaning by using F-containing plasmas, wherein F replaces Cl in the metal gate under the action of the plasmas and enables the Cl to be diffused to the bottom surface of the opening of the contact hole. And NH3 plasma processing is carried out to consume Cl in the metal gate. And an adhesion barrier layer is deposited, wherein the adhesion barrier layer comprises a first Ti layer and a second TiN layer which are stacked in sequence. The content of Cl in the metal gate is reduced to ensure that in the metal silicification reaction, the first Ti layer at the top of the metal gate does not form a cavity under the action of Cl. And filling metal in the contact hole opening to form a contact hole. The stability of the metal gate can be improved.

The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps:a°) a first solution, comprising an oxidized collagen is prepared,b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7%, by weight, with respect to the total weight of the solution,c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid,d) a diluted solution is prepared by adding water to solution of c),e) a first layer of solution obtained in c) is casted on an inert support,f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify,g) the gelified first and second layers are dried to obtain a film.The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

An implantable prosthesis for preventing, reinforcing and / or mending an anatomical defect, including a parastomal hernia which may occur following the formation of a stoma or ostomy opening, such as formed in conjunction with an ileostomy or colostomy. The prosthesis may include a body of biocompatible material having a preformed three-dimensional channel configured to receive a portion of a lateralized bowel formed in conjunction with a parastomal hernia repair or ostomy creation. An adhesion resistant barrier may be located on an inner side of the channel to isolate the portion of the lateralized bowel from a tissue infiltratable surface of the body to reduce or eliminate potential adhesions between the body and the lateralized bowel. A portion of the channel may include a flared segment extending inwardly from the outer periphery to reduce pressure on the portion of the lateralized bowel at the open end of the channel.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a film comprising same, and uses thereof. More specifically, the present invention relates to a film containing a dispersion comprising acellular dermal matrix microparticles obtained through supercritical fluid extraction and high-pressure dispersion operations, and a manufacturing method therefor. The acellular dermal film according to the present invention exhibits excellent biostability and biocompatibility, and demonstrates significantly superior preservation of extracellular matrix components such as collagen. In addition, the present invention has excellent mechanical properties and thus can be easily applied to graft surgery and suturing, and has a porous structure that facilitates the movement of body fluids, and thus may support tissue regeneration. Accordingly, the acellular dermal film can be usefully employed in the field of regenerative medicine as as wound dressings, adhesion barriers, and as implantable biomaterials such as drug delivery implants and artificial skin.

The application discloses a high-entropy AlCrNbSiTi composite hard coating with high toughness and a preparation method thereof. The composite hard coating has a gradient layer structure and is composed of an adhesion barrier layer and a tough layer which are sequentially deposited on a substrate by an arc ion plating method. The adhesion barrier layer is a pure Cr layer, and the tough layer is an AlCrNbSiTi layer. The AlCrNbSiTi layer has a composite structure in which nanocrystals and amorphous phases coexist. The AlCrNbSiTi composite hard coating with high hardness, high toughness, excellent high-temperature stability and high film-substrate adhesion can be flexibly designed and prepared according to requirements, so as to meet the required performance of cutting tools, precision molds and wear-resistant parts. The prepared coating has good adhesion and high deposition rate, the performance and production efficiency of the coating are improved, the production cost is reduced, and it is also possible to prepare a relatively thick functional coating.

A zwitterionic-based material used to inhibit and / or prevent post-surgical adhesions is described. In particular, a method of synthesizing zwitterionic polymers for use in the zwitterionic material is disclosed. Zwitterionic components have both positive and negative charges yet remain electrically neutral. Cross-linking zwitterionic polymers with polysaccharides may result in a material that exhibits ultralow fouling properties. The zwitterionic-based material can be synthesized and self-assemble in the form of a liquid or gel, enabling uniform deposition during surgery. A zwitterionic-based material described herein may be applied during a surgical procedure. The degradation rate of the adhesion barrier is highly tunable to accommodate various healing times and is naturally excreted by the body, eliminating the need for post-operative surgery to remove the material.

The invention relates to the technical field of anti-adhesion barrier materials, in particular to a high-barrier coating liquid, a preparation method thereof and a composite material. The high-barrier coating liquid is prepared from the following raw material components in parts by mass: polyvinyl alcohol accounting for 14-29% of the total mass; polyethylene glycol accounts for 0.5-1.5% of the total mass; the acidic functionalized ionic liquid accounts for 0.05-0.15% of the total mass; fumed silica accounts for 30-40% of the total mass; the surfactant accounts for 0.01 to 0.03 percent of the total mass; the cross-linking agent accounts for 0.01-0.03% of the total mass; the defoaming agent accounts for 0.001 to 0.003 percent of the total mass; and the balance of water. The high-barrier coating liquid provided by the invention contains a double-polymer network composed of polyvinyl alcohol-cross-linking agent and polyethylene glycol, the barrier property is improved on the premise of not influencing the transparency of a film, and the high-barrier coating composite material has the properties of high barrier, high transparency and steaming and boiling resistance.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a membrane comprising the same, and uses thereof. More specifically, the present invention relates to a membrane comprising a dispersion containing acellular dermal matrix microparticles obtained by supercritical fluid extraction and high pressure dispersion operations, and a method for preparing the same. The acellular dermal membrane according to the present invention exhibits excellent biological stability and biocompatibility, and shows significantly better preservation of extracellular matrix components such as collagen. In addition, the material has excellent mechanical properties, so that the material is easily applied to transplantation operation and suture, and has a porous structure, so that body fluid flow is facilitated, and tissue regeneration can be supported. Thus, the acellular dermal membrane can be applied as wound dressing, adhesion barrier and implantable biomaterials such as drug delivery grafts and artificial skin in the field of regenerative medicine.