30results about How to "Prevent postoperative adhesions" patented technology

Production of amphiphilic chitose derivative and its usage are disclosed. The process is carried out by taking chitose as raw material, alkalizing, reacting with 4-methyl bromoethyl acid in 2-propanol medium to obtain 6-0-carboxy-propyl-chitose, purifying, and reacting with long-chain fatty acyl chloride to obtain N-acyl-6-0-carboxy-propyl-chitose. In chemical formula, R=-(CH) n, n=8, 10, 12, 14, 16 and 18. It has excellent biological compatibility and degradation, good tissue adhesion and mechanical strength. It can improve wound heal and have styptic and adhesion-preventing functions.

The invention discloses a medicinal sustained-release and hemostatic composition and a preparation method thereof, which belong to the technical field of novel hemostatic materials. The medicinal sustained-release and hemostatic composition comprises the composition of a medicament-loaded chitosan microsphere, chitosan and hyaluronic acid, wherein the medicament-loaded chitosan microsphere comprises medicinal grade chitosan and medicinal grade tranexamic acid. The novel hemostatic composition is prepared by using chitosan and the hyaluronic acid as a main hemostatic matrix, combining chitosan medicament sustained-release microsphere composite medicament, namely tranexamic acid, utilizing the special property of the chitosan with a hemostatic function and a medicament sustained-release function, and adopting the composition of the hyaluronic acid with good hemostatic function and high biocompatibility and the chitosan as the main matrix. The novel hemostatic composition has the advantages of stopping bleeding rapidly and releasing medicament/factors continuously and stably in a certain time, along with great economic and social benefits.

The invention provides a hemostatic material based on chitosan, collagen and sodium carboxymethyl cellulose which includes chitosan, collagen and sodium carboxymethyl cellulose for forming hemostatic sponge of chitosan, collagen and sodium carboxymethyl cellulose.

A soluble hemostatic gauze for anti-inflammation and pain relieving and the preparing method, relating to field of medical sanitary goods. The hemostatic gauze comprises the following substance according to the percentage by weight: dibasic sodium phosphate 0.1-0.3%, sodium alginate 1-1.8%, carbomu 0.5-25, antibacterial drugs 1-10%, polyethylene glycol 1-2%, tuwen 1-4%, dimethicone 0.1-1%, sodium carboxymethylcellulose 0.2-0.8%, americaine 0.05% and the left is ethanol solution. The product possesses functions of special pain relieving, preventing adhesion after surgery besides functions of hemostatic, broad spectrum antibiotic and promoting wound healing, which is of great importance for relieving patient pain and improving their survival quality.

The invention relates to a biodegradable and absorbable hemostasis composition. The hemostasis composition is prepared from hyaluronic acid and modified starch or hyaluronic acid, chitosan and modified starch. The hemostasis composition is capable of stopping bleeding rapidly and has the effect superior to that of the prior art.

The invention discloses operation flushing fluid and particularly relates to an anti-adhesion flushing fluid for preventing operation adhesion. The anti-adhesion flushing fluid mainly comprises 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid, sodium chloride and water for injection. In the anti-adhesion flushing fluid for an operation, concentration of 1,4,5,6-tetralin-2-methyl-4-pyrimidine carboxylic acid is 0.1 to 40 g/L and concentration of sodium chloride is 1 to 50 g/L. The operation flushing fluid disclosed by the invention also can be added with a pH buffer. The inventor of the invention makes a series of animal experiments and researches to show that the human operation flushing fluid disclosed by the invention has an excellent operation cleaning effect and also has an excellent effect of preventing postoperative adhesion.

Disclosed is a soluble hemostatic gauze for diminishing inflammation, killing bacteria and calming pain, and its making method, which comprises the following raw materials (by weight portion), 0.1-0.3% of disodium hydrogen phosphate, 1-1.8% of sodium alginate, 0.5-2% of Carbomer, 1-10% of cationic surface active agent, 1-2% of polyethylene glycol, 1-4% of Tween-80, 0.1-1% of dimethyl silicon oil, 0.2-0.8% of sodium carboxymethylcellulose, 0.05% of benzocain and balancing ethanol solution.

The invention belongs to a medical biological material technology field, concretes a chitosan fiber film, wherein the fiber film is prepared from a chitosan spinning solution, which is a mixed solution containing chitosan, hexafluroisopropyl alcohol and acetate. The invention further provides a method for preparing the chitosan fiber film, and applications of the fiber film for preparing endocranium or endorhachis defect repairing material, cerebrospinal fluid leakage plugging material or a tissue adhesion prevention medicament.

The instant invention relates to a composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′.

Additionally, the invention also relates to the development of a bioresorbable patch comprising:

• • (a) an adhesion barrier component comprising a composition according to the invention in the form of a film; and
  • (b) an adhesive component comprising:
    • (i) at least one synthetic adhesive polymer; and/or
    • (ii) at least one polysaccharide.

The present invention provides a method of wound healing, comprising administering the composition or patch.

The invention provides a single-sided adhesive hydrogel adhesive, which comprises a hydrogel body and a surfactant sprayed on the single side surface of the hydrogel body, and the hydrogel body comprises the following components in parts by weight: 10-15 parts of anionic monomer, 10-15 parts of cationic monomer, 0.5-1 part of photoinitiator and 0.25-1 part of cross-linking agent, 0.5-3 parts by weight of a coupling agent and 100 parts by weight of water; the weight part of the surface active agent is 0.01 to 0.05. According to the invention, the anionic monomer and the cationic monomer are mixed, the photoinitiator, the cross-linking agent and the coupling agent are added to form a polyelectrolyte hydrogel adhesive film, and the hydrogel body is subjected to single-side surface physical treatment by using the biocompatible surfactant, so that the long-term stable adhesion effect with the achilles tendon tissue interface can be realized; repair of damaged tissues is promoted, and postoperative adhesion existing in the achilles tendon repair process is effectively avoided.

The invention discloses an isolating film of hygroscopicity and self-adhesion which is used for preventing postoperative synechia. The isolating film is characterized by comprising 65 percent to 99 percent of carboxylation chitosan, 1 percent to 10 percent of glycerin, 0 percent to 5 percent of citric acid, and the rest being water. The preparing steps are as follows: weighing the ingredients by weight percentage; adding the carboxylation chitosan into water and stirring for thorough dissolution; adding the other ingredients into the solution and stirring; pouring the mixed solution into a glass mold for self-leveling, drying the solution for forming film and then cooling to room temperature; and at last, stripping the film from the mold. The isolating film is bacteria-free; when being implanted in human bodies, the film immediately absorbs tissue fluid once in contact with surface of wound, thus having viscidity. The isolating film which is simple and convenient in clinic can be automatically adhered on surface of wound which needs isolating. Therefore, the isolating film has the efficacy of promoting wound healing and preventing tissues from adhesion.

The invention belongs to the technical field of medicine and sanitation, and particularly relates to preparation and application of biological adhesion enhanced temperature-sensitive chitosan-based postoperative adhesion prevention hydrogel. The preparation method comprises the following steps: 1, grafting hydroxybutyl groups on chitosan to prepare hydroxybutyl chitosan with temperature-sensitive performance; 2, grafting thioglycollic acid on the chitosan to prepare the thiolated chitosan with enhanced biological adhesion performance. and 3, physically mixing the hydroxybutyl chitosan solution and the sulfhydrylated chitosan solution according to a certain proportion to obtain the biological adhesion enhanced temperature-sensitive chitosan-based postoperative adhesion prevention hydrogel. The product has the following advantages: the product has reversible temperature-sensitive phase change ability, is a liquid with good fluidity at low temperature, is convenient to inject and use, can rapidly flow to fit and cover irregular wounds after being injected to the wounds, rapidly forms a hydrogel barrier at physiological temperature to isolate adjacent tissue or organ surfaces, and prevents postoperative adhesion.

The invention is concerned with the organism coupling material, which is collagen, or the production of hydrolyze material and carbodiimide after imperfective coupling reaction. The coupling material is with fluidity and conglutination, which can be use for antiseep and anti-conglutination processing in surgery. The coupling material of the invention is imperfective coupling when it is using, which continues reaction to finish coupling during the process, it can adhere to the organic surface by coupling reaction in order to prevent organic conglutination and body fluid effusion of the wound surface.

The invention discloses a hydroxyapatite-polylactic acid biological double-sided magical film, which is a double-sided film with one side being hydroxyapatite and the other side being polylactic acidwith a thickness of 0.01[mu]m-2mm; the film is prepared by combining hydroxyapatite with various nano-structures synthesized by a hydrothermal method with polylactic acid at normal temperature and pressure, and using an infiltration and evaporation film self-forming method. The invention also discloses application of the biological double-sided magical film in a tooth bone tissue repair or regeneration process. The biological double-sided magical film provided by the invention is an ideal, safe and excellent biological composite material which has different properties for cells on two surfaces, can promote bone repair while on one surface and prevent postoperative adhesion on the other surface, has simple preparation method and low cost, can be produced on a large scale and has a wide application prospect.

An antiadhesive material is provided and contains a poly-γ-glutamic acid having a weight-average molecular weight of 600,000 to 13,000,000, or a kinematic viscosity at 37° C. of 2 cSt to 15 cSt when dissolved in distilled water at a concentration of 0.05% by mass and/or a salt thereof, as an effective ingredient. The antiadhesive material may have any form such as powder or gel form, and therefore, for example, is easy to handle even in relatively localized surgery such as endoscopic surgery and can more reliably prevent adhesion.