Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Biological coupling material and its preparing method

A biological and raw material technology, applied in medical science, surgery, etc., can solve the problems of difficult to ensure the quality of dead corner coverage, the lack of fluidity of the diaphragm, and the difficulty of ensuring the combination, etc., to achieve the effects of abundant raw materials, prevention of surgical leakage, and low product cost.

Active Publication Date: 2008-01-09
孙雨龙 +1
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In short, the current physical diaphragm method still has the following problems in clinical application: the diaphragm is not fluid, and it is not easy to coat; it is only a physical process, and it is difficult to ensure its combination with the tissue; it is difficult to ensure the coverage quality of the dead corner when the solid film covers the wound.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biological coupling material and its preparing method
  • Biological coupling material and its preparing method
  • Biological coupling material and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 0.1 gram of gelatin was dissolved in 0.85 milliliters of physiological saline (pH6.0) containing 0.1M 4-Morpholineethanesulfonic acid (MES) at 60 ° C, and 0.05 milliliters of 10% EDC and 10% NHS dissolved in the same solution were uniformly mixed at 37 ° C, A bioconjugate material of the invention is formed. The product was tested for fluidity change (ie, viscosity change) at different reaction times.

[0053]Please use tweezers to easily check the fluidity of the material as shown in pictures A-F in Figure 1. After the raw materials were mixed for 90 seconds, the formed coupling material could still be pulled out as filaments with tweezers, and as time increased, thicker filaments and more and more materials could be pulled out, about After three minutes (180 seconds), the viscosity of the product increased significantly, and its fluidity weakened. After about ten minutes, the material formed a gel and basically lost its fluidity.

[0054] The fluid material adheres ...

Embodiment 2

[0056] Dissolve 0.2 g of gelatin in 0.75 ml of physiological saline (PH6.0) containing 0.1M 4-Morpholineethanesulfonicacid (MES) at 60°C, mix evenly with 0.05 ml of 10% EDC and 10% NHS in the same solution, and react for an appropriate time The fluid bioconjugate material of the present invention can be formed within.

[0057] As the reaction continues, the fluid material turns into a gel, and the changes are shown in Example 1. The fluid material adheres to tissue surfaces, eventually forming a transparent gel film as the reaction continues.

Embodiment 3

[0059] Dissolve 0.1g of gelatin in 0.80ml of physiological saline (pH6.0) containing 0.1M MES at 60°C, mix evenly with 0.10ml of 10% EDC and 10% NHS dissolved in the same solution to form a fluid material, and react for an appropriate time The fluid bioconjugate material of the present invention can be formed within.

[0060] As the reaction continues, the fluid material turns into a gel, and the changes are shown in Example 1. The fluid material adheres to tissue surfaces, eventually forming a transparent gel film as the reaction continues.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention is concerned with the organism coupling material, which is collagen, or the production of hydrolyze material and carbodiimide after imperfective coupling reaction. The coupling material is with fluidity and conglutination, which can be use for antiseep and anti-conglutination processing in surgery. The coupling material of the invention is imperfective coupling when it is using, which continues reaction to finish coupling during the process, it can adhere to the organic surface by coupling reaction in order to prevent organic conglutination and body fluid effusion of the wound surface.

Description

technical field [0001] The invention relates to a biological coupling material, in particular to a coupling material formed by utilizing biological macromolecules under the action of carbodiimide and a preparation method thereof. The coupling material can be used for anti-leakage and anti-adhesion treatment in operations . Background technique [0002] Surgical adhesions are a common problem after abdominal, cardiovascular, spinal, and tendon surgery. Surgical adhesions can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation and the potential risk of further complications. [0003] The causes of adhesion are complex and can be summarized as follows: (1) surgical trauma; (2) local ischemia; (3) foreign body retention; (4) bleeding and exposed wound surface; (5) bacterial infection. [0004] At present, there are two main ways to prevent adhesions: adjusting surgical te...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/04
Inventor 孙雨龙梁文华王勇孙雨霞
Owner 孙雨龙
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com