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Moisture absorption self-adhesion barrier film capable of preventing postoperative adhesions and preparation method thereof

An isolation film and self-adhesive technology, which is applied in the field of moisture-absorbing self-adhesive anti-adhesion isolation film and its preparation field, can solve the problems of easy loss, low effective utilization rate, uneven coating, etc., so as to prevent postoperative adhesion. Adhesion formation, no pyrogen and irritant sensitization, simple and convenient clinical use

Active Publication Date: 2009-02-11
ZHEJIANG SHUGUANG TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that: gelatin sponge can make fibroblasts spread along it or hinder the survival of fat, and the scar adhesion is more extensive. Autologous fat will liquefy and necrosis and induce scar formation. Used in the form of gel, it is easy to cause uneven coating, easy to lose, and the effective utilization rate is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Hygroscopic self-adhesive anti-adhesion barrier film contains (by weight):

[0020] Carboxylated Chitosan 90%

[0021] Glycerin 2%

[0022] Citric acid 2%

[0023] The balance is water, and the sum of the above components is 100%.

[0024] Preparation method, the steps are as follows:

[0025] 1) Weigh carboxymethyl chitosan, glycerin and citric acid according to the amount of the contained ingredients, first add carboxymethyl chitosan to water to make a 4% carboxymethyl chitosan solution, then add glycerin and citric acid, stir evenly to obtain a mixed solution;

[0026] 2) Pour the above mixture into a glass mold for self-leveling, then put it in an oven and dry it at 40°C for 8 hours to form a film, take out the mold, and cool to room temperature; peel off the film, it is a hygroscopic self-adhesive anti-adhesion after surgery isolation film.

[0027] The prepared hygroscopic self-adhesive anti-postoperative adhesion isolation film has a water content of 6%, a ...

Embodiment 2

[0030] Hygroscopic self-adhesive anti-adhesion barrier film contains (by weight):

[0031] Carboxylated Chitosan 95%

[0032] Glycerin 1%

[0033] Citric Acid 0%

[0034] The balance is water, and the sum of the above components is 100%.

[0035] 1) Weigh carboxypropionyl chitosan and glycerin according to the amount of the contained components, first add carboxypropionyl chitosan to water to make a 6% aqueous solution, then add glycerin, stir evenly, and prepare a mixed solution;

[0036] 2) Pour the above mixed solution into a glass mold for self-leveling, then put it in an oven and dry it at 50°C for 6 hours to form a film, take out the mold, and cool to room temperature; peel off the film, it is a hygroscopic self-adhesive anti-postoperative adhesion isolation film.

[0037] The prepared hygroscopic self-adhesive anti-postoperative adhesion isolation film has a water content of 4%, a pH value of 6.8, ash content of the film ≤ 2%, insoluble matter in the film of 0.05%, ...

Embodiment 3

[0040] Hygroscopic self-adhesive anti-adhesion barrier film contains (by weight):

[0041] Carboxylated Chitosan 65%

[0042] Glycerin 10%

[0043] Citric Acid 5%

[0044] The balance is water, and the sum of the above components is 100%.

[0045] 1) Weigh carboxypropionyl chitosan, glycerol and citric acid according to the amount of the ingredients contained, first add carboxypropionyl chitosan to water, stir until carboxylated chitosan dissolves, and make 2% carboxylated chitosan chitosan aqueous solution, then add glycerin and citric acid, and stir evenly to obtain a mixed solution;

[0046] 2) Pour the above mixture into a glass mold for self-leveling, then put it in an oven and dry it at 55°C for 5 hours to form a film, take out the mold, and cool to room temperature; peel off the film, it is a hygroscopic self-adhesive anti-postoperative adhesion isolation film.

[0047] The prepared hygroscopic self-adhesive anti-postoperative adhesion isolation film has a water co...

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Abstract

The invention discloses an isolating film of hygroscopicity and self-adhesion which is used for preventing postoperative synechia. The isolating film is characterized by comprising 65 percent to 99 percent of carboxylation chitosan, 1 percent to 10 percent of glycerin, 0 percent to 5 percent of citric acid, and the rest being water. The preparing steps are as follows: weighing the ingredients by weight percentage; adding the carboxylation chitosan into water and stirring for thorough dissolution; adding the other ingredients into the solution and stirring; pouring the mixed solution into a glass mold for self-leveling, drying the solution for forming film and then cooling to room temperature; and at last, stripping the film from the mold. The isolating film is bacteria-free; when being implanted in human bodies, the film immediately absorbs tissue fluid once in contact with surface of wound, thus having viscidity. The isolating film which is simple and convenient in clinic can be automatically adhered on surface of wound which needs isolating. Therefore, the isolating film has the efficacy of promoting wound healing and preventing tissues from adhesion.

Description

technical field [0001] The invention relates to a hygroscopic self-adhesive anti-postoperative adhesion isolation film and a preparation method thereof. Background technique [0002] Postoperative adhesions are a worldwide problem that plagues surgeons. According to statistics, 60-95% of abdominal surgery patients will have different degrees of adhesions. Severe postoperative adhesions can make a successful operation fail. Therefore, research on the prevention and treatment of postoperative adhesions has always been one of the hot spots that people pay attention to. The prevention and treatment of postoperative adhesions can be roughly divided into two categories: pharmaceutical preparations and temporary mechanical isolation. Drug-based preparations are generally based on the formation mechanism of adhesions and use drugs to intervene to inhibit the formation of adhesions, such as anti-inflammatory preparations, antihistamine preparations, and fibrinolytic preparations com...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K31/047A61K31/194A61P41/00
Inventor 胡巧玲
Owner ZHEJIANG SHUGUANG TECH
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