Chinese medicine emplastrum dosage form and externally-applied emplastrum preparations prepared from the dosage form

Abstract

The invention relates to a Chinese medical emplastrum substrate and an external use emplastrum prepared by the substrate, which comprises the materials in weight proportion as follows: paraffin 5% to 40%, monoglyceride 5% to 20%, glycerol 1% to 10%, swelling gelatin 2% to 20%, sodium polyacrylate/glycerol solution 5% to 15%, or neutralization 70% sodium polyacrylate liquid 5% to 20%, or polyacrylic resin 5% to 15%, sodium lauryl sulfate 0.5% to 2%, stearic acid 0 to 50%, ethanolamine 0 to 20%. The substrate is suitable for the external use emplastrum which is made of the drug efficacy material powder, the water soluble extract of a drug efficacy material or a volatility component of extraction combined with a backing composite material. The added raw powder amount can reach to 25 wt%; the added extract amount can reach to 40 wt%. The Chinese medical emplastrum substrate has the advantages of good compatibility, large drug loading, good skin stickness, easy uncovering, easy sticking, no skin allergy, good steady, original shape maintaining and no melting in 50 DEG C, good discharging, good skin permeability, easy cleaning and no skin stickness.

Description

technical field [0001] The invention relates to a dosage form of traditional Chinese medicine plaster for external use. It is an external ointment formulation made by mixing several commonly used bases for external ointment and combining them with backing materials. Background technique [0002] The plaster formulations of traditional Chinese medicine for external use contained in "Chinese Pharmacopoeia" in 2005 include patch, rubber plaster, black plaster, and cataplasm plaster. The preparations prepared in these 4 dosage forms can be directly bonded to the skin (without additional adhesive pressure-sensitive adhesive tape or rubber cloth for fixing) to achieve therapeutic effect. These four dosage forms have their own characteristics and relative deficiencies: ①Patch: It is especially suitable for the preparation of single-ingredient preparations extracted from western medicine or traditional Chinese medicine, which is beautiful; but due to the small drug loading and diff...

AI Technical Summary

Problems solved by technology

These four dosage forms have their own characteristics and relative deficiencies: ①Patch: It is especially suitable for the preparation of single-ingredient preparations extracted from western medicine or traditional Chinese medicine, which is beautiful; but due to the small drug loading and difficult production technology, it cannot be used for Preparation of traditional Chinese medicine compound preparations with large drug content

②Rubber ointment: It has a long production history, and the production cost is low, but the drug loading is small, and quite a few patients have skin allergies after sticking

③Black plaster: Black plaster is a traditional preparation with a history of more than 1,000 years. The production cost is low. The disadvantage: its base is refined from yellow dandelion and vegetable oil, which is sensitizing to the skin and contains lead elements harmful to the human body. In addition, the medicinal ingredients are refined with vegetable oil under high temperature conditions, which seriously damages the active ingredients. If the medicinal powder is added to the plaster matrix, the release will be slow and the absorption will not be complete.

However, due to its large water content, the catarrh ointment is prone to melting when used. If it is not well preserved, it is easy to become moldy or lose water. Than, the preparation conditions are strict