1924results about How to "No pain" patented technology

A device for delivering a substance into the skin of a patient includes a body and a skin penetrating device having at least one skin penetrating member, such as a microneedle. The body includes an internal cavity and a device for indicating the delivery of a sufficient amount of the substance to the patient and for producing a dispensing pressure to dispense and deliver the substance from the cavity. The indicating device is visible from the exterior of the delivery device. In some embodiments, the indicating device is an elastic expandable diaphragm which, when the cavity is filled with a substance, creates the dispensing pressure.

A blood glucose measuring system includes a lancet assembly and a meter for use with the lancet assembly. The lancet assembly has a lancet member with a lance, a lancet body having a drive wing extending outwardly from a side, and a sinuous portion, and an elongated carrier having a lancet member recess to contain the lancet member. The elongated carrier has an open end, a closed end, a side elongated opening for receiving the drive wing therethrough, and an anchoring member operatively connected to the end of the sinuous portion. The meter includes a measuring circuit, a lancet trigger, and a lancet driver where the lancet driver includes a driver piston engageable with the lancet trigger and a charging member that operatively engages with the driver piston to move the driver piston into an armed position and to stop the driver piston when released from the armed position.

A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5–250 microns and generally about 50–100 microns.

A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.

A personal portable painless lancing device and a blood glucose meter using the same, which can lance at the minimum without any pain and use it to measure the blood glucose. The minimum painless lancing device using an Er:YAG laser includes an Er:YAG laser beam-generating section in which the laser beam is generated to punch skin and radiated in a single direction; an adapter installed at the front end of the Er:YAG laser beam-generating section so that the laser beam can be locally concentrated on a skin punch portion; a skin adhesion cap installed at the front end of the adapter so that it can be easily detached, and can reduce the contamination of the Er:YAG laser beam-generating section, which is produced at the time of the lancing, and the danger due to the reuse of it among the patients of lancing; and a case to accommodate the Er:YAG laser beam-generating section and the adapter therein.

A sensing apparatus and methods for measuring or detecting an analyte present in a biological system are provided. The methods entail use of the sensing apparatus that contains a reporter system specific for the analyte of interest, where the reporter system is either affixed to a planar backing or attached to particles that are delivered to the superficial layers of the skin. The reporter system includes a reporting reagent that absorbs or emits a detectable radiation and is placed in communication with the analyte, or in communication with tissue or body fluids suspected of containing the analyte. The sensing apparatus is illuminated, and a radiation signal from the reporting reagent is measured or detected and then associated with the presence or quantity of analyte.

This invention provides monitoring garments for non-invasively monitoring physiological parameters in un-restrained and / or restrained animals, such as monkeys, rabbits, dogs, horses, and the like. The invention also includes methods and systems for collecting and processing monitoring data.

A lightweight, portable, electrically-powered dermabrasive device adapted to gently and painlessly remove keratinized epidermal portions of the hands and feet. The dermabrasive device includes a protective shield which shields user against contact from flakes of flying or ejected epidermis or other detritus.

A syringe adapter with a ball-typed valve has a base, a dosing tube mounted around the base and a resilient valve mounted in the base and the dosing tube. The base has a guiding groove and an inner liquid channel communicating with each other, as well as an exhaust channel. Liquid medicine injected into the syringe adapter flows through the guiding groove and causes the inner liquid channel to be injected into a patient's body. The liquid medicine remaining in the split is cleaned when cleaning fluid is injected to clean the syringe adapter. Air in the syringe adapter flows out through the exhaust channel and is not injected into the patient's body, so the patient is free from pain. Furthermore, elements and assembling processes of the syringe adapter are simplified and manufacturing cost of the syringe adapter is lowered.

The invention relates to an active controllable type capsule endoscope robot system comprising a capsule endoscope robot, a receiving memory, a motion control box and an image display system. A driving mechanism of the capsule endoscope robot generates the radial expansion and contraction of an oil bag and the extension and contraction of a capsule by a direct-current motor, a double-shaft multiplexing speed reducer and a geometer motion distribution mechanism and realizes progression and retrogression by matching according to a certain time sequence; after the capsule endoscope robot enters the gastrointestinal tract of a human body by oral administration, the capsule endoscope robot shoots the image information of each position of the gastrointestinal tract at real time by the self geometer creeping and transmits the image information outside the body in a wireless mode. In a part outside the body, the receiving memory is used for receiving and storing image data transmitted by the capsule endoscope robot in a wireless way; the motion control box controls the progression, the retrogression or the stop of the capsule endoscope robot in a wireless transmission mode so as to repeatedly observe a questionable position in the gastrointestinal tract; and the image display system reads and processes the image data recorded in the receiving memory at real time by a computer so as tobe observed and diagnosed by a doctor.

A bandage remains securely attached to the skin of a wearer during extended exposure to arid, humid or wet conditions. The bandage is readily removed from the attached condition upon application of pressure to its exterior surface. Adhesive portions of the contain pockets or microcapsules filled with an adhesive-inactivating ingredient. The pockets are formed in the backing layer. Microcapsules, if present, are incorporated in the adhesive. The adhesive inactivating ingredient comprises oil from vegetable source, mineral source or fatty acids. The wearer ruptures the pockets or microcapsules by applying pressure to the bandage above the adhesive portions. The adhesive-inactivating ingredient is thereby released at the skin-adhesive interface, permitting an easy, pain-free removal of the bandage.

A syringe adapter with a ball-typed valve has a base, a dosing tube mounted around the base and a resilient valve mounted in the base and the dosing tube. The base has a guiding groove and an inner liquid channel communicating with each other, as well as an exhaust channel. Liquid medicine injected into the syringe adapter flows through the guiding groove and causes the inner liquid channel to be injected into a patient's body. The liquid medicine remaining in the split is cleaned when cleaning fluid is injected to clean the syringe adapter. Air in the syringe adapter flows out through the exhaust channel and is not injected into the patient's body, so the patient is free from pain. Furthermore, elements and assembling processes of the syringe adapter are simplified and manufacturing cost of the syringe adapter is lowered.

The invention discloses a visual cognitive behavioral learning automatic training system of big and small mice. The visual cognitive behavioral learning automatic training system of the big and small mice comprises a training box, a main control unit, a video monitor, a microcontroller, a reward unit, a punishment unit, and a visual clue display unit. The microcontroller is connected with the main control unit through a universal serial bus (USB) interface in a communication mode. The training box is a structure that an opening is formed in the upper portion of the training box. The video monitor is arranged on the upper portion of the training box. The reward unit is composed of a food plate which is arranged on the lower portion of the training box, an infrared induction switch which is arranged on one side of the training box, and a water supply pipe which is arranged above the food plate and controlled by an electric control valve. The punishment unit is composed of a sweep frequency ultrasonic speaker which is arranged on the upper portion of the training box. The visual clue display unit comprises a capacitance-type touch screen and a display screen. The capacitance-type touch screen is arranged inside a frame. The lower frame of the frame is hinged with the side wall of the training box. The upper frame of the frame is connected with the side wall of the training box through a tension spring. The display screen is arranged at a rear position of the capacitance-type touch screen. The visual cognitive behavioral learning automatic training system of the big and small mice has the advantages that a visual cognitive behavioral learning automatic training to experimental animals is achieved.

A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.

An imaging system comprising an imaging device assembled on a carrier tube, and a first outwardly expandable element and a second outwardly expandable element mounted on the carrier tube, wherein the second expandable element is expandable both radially and axially, the imaging system comprising a mode of operation, wherein during expansion of the second expandable element, obstruction of the radial expansion of the second expandable element causes the axial expansion of the second expandable element to propel the carrier tube and the imaging device axially.

A method of manufacturing a dressing (1) which incorporates a honey composition (7) and a base material (2) is disclosed. The method includes the steps of preparing the honey composition (7) and of the base material (2), characterised by a change in the physical characteristics of the base material (2). The dressing (1) may include additional agents (3) either in the honey composition (7) or the base material (7) or both. The dressing can include further layers further layers for adhesion; be covered with a waxed material and packaged. The dressing can be applied to a wide range of wounds including exudated and / or infected wounds.

A removable, adjustable intraoral apparatus having an upper plate and a lower plate, which, upon insertion into a user's mouth, cause advancement of the lower jaw relative to the upper jaw. One of either the lower plate or the upper plate can include length-adjustable blocks on the occlusal (biting) side thereof for causing further advancement of the lower jaw. Each length-adjustable block includes an advancement screw which is embedded in and extends from one of a pair of stationary raised block portions, and each of the plates without the embedded advancement screws also has a pair of raised block portions extending therefrom. The pairs of upper and lower blocks include contact surfaces which cooperate with each other to exert opposing forces upon the upper and lower dental arches and cause mandibular advancement. The length-adjustable portions allow for further mandibular advancement.

A delivery device for delivering a substance intradermally into the skin of a patient including a housing for contacting the surface of the skin and a disposable cartridge to be received in the housing. The cartridge includes an internal reservoir containing a substance to be delivered to the patient, a plurality of micro skin penetrating members and a fluid channel extending between the micro skin penetrating members and the reservoir. The housing includes a bottom wall with a central opening and a cover member. The cartridge is positioned in the housing with the micro skin penetrating members extending through the central opening of the bottom wall and positioned on the surface of the skin of a patient. The cover is closed onto the cartridge to dispense the substance from the cartridge through the micro skin penetrating members and into or through the skin of the patient.

A personalized stereo health index measuring method and device features that the variation of multiple physiologic data in different psychological and spirits states of a person is monitored to indicate its health state and health potential.

A circumcision anastomat is structurally characterized in that a glans penis head is an oval cavity, the left side of the oval cavity is open, the top of the right end of the glans penis head is fixedly connected with the left end of a glans penis head pull rod, an angle of 45-90 degrees is formed between the head body center axis of the glans penis head and the plane of a glans penis head edge, clamping grooves are formed in the glans penis head edge, an elastic ring which is matched with the clamping grooves to be used is arranged in the clamping grooves, a circumcision body which can slide along the glans penis head pull rod is arranged on the glans penis head pull rod coaxially, a blade is arranged on the inner side of the circumcision body, a fixed handle is arranged on the circumcision body coaxially, a movable handle is connected with the left side of the fixed handle, the left end of the circumcision body is contacted with the movable handle through a damping piece, a reset spring and an insurance piece are connected between the movable handle and the fixed handle, a tractive rotary knob is arranged on the right side of the movable handle, and the right end of the glans penis head pull rod is connected with the tractive rotary knob through a threaded structure. By means of the circumcision anastomat, circumcision anastomose operations are simple, efficient, safe and fast, surgical wounds are smooth and attractive and are in conformity with normal anatomical structures and appearances, and requirements for postoperative care are low.

The invention relates to a micro plasma pen for removing freckles on skin, and comprises a plasma skin cleaning head, a handle shell, a micro transducer arranged in the shell, a power output controller and a power module. The pen is characterized in that: a high and variable frequency plasma power occurrence circuit made of an integrated circuit chip or a semiconductor microprocessor MCU is installed in the shell; and in a loop, a circuit connection is formed by a medium and high frequency output magnetic core transformer or a ceramic piezoelectric type medium and high frequency transformer. Since the mini plasma pen for removing the freckles on the skin has a small size, a long service life and extremely low cost, the pen has the advantages of no pain when put into use, a self-sterilizing function, capability of being used as a tool for personal beautifying like nail clippers and small blades, a large social demand of nearly for anyone, and capability of replacing a carbon dioxide laser epidermal freckle removing machine in a hospital on a plurality of occasions.

The invention discloses a preparation method of a CAR-T cell for treating AIDS-related lymphoma. A CD8+ T cell is used to produce the CAR-T cell, and the CD8-T cell derives from a cord blood T cell. The method includes the following steps: preparing cord blood mononuclear cells from cord blood, removing tumors and other cells by using a human T cell purification kit to obtain T cells, and carryingout separation by using magnetic beads to obtain the CD8+ T cell; activating the CD8+ T cell by using an appropriate medium and appropriate stimulation conditions; transferring CAR to the CD8+ T cellby using lentivirus to prepare the CAR-T cell; and amplifying the CAR-T cell in vitro by using cytokines and activating stimulators to achieve the desired effective dose. The invention also relates to the CAR-T cell prepared by the method, and an application thereof. The CAR-T cell prepared in the invention has a good cell activity and a high proliferation speed, and reduces the attack risk of GVHD; and only the CD8+T cell of the umbilical blood T cells of AIDS patients is used to prepare the CAR-T cell for, so the risk of input CAR-T infected with in-vivo HIV is reduced.

The invention provides a traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and a preparation method thereof, and the traditional Chinese medicine comprises the following raw medicinal materials: cumin, galangal, rhizome cyperi, three-nerved spicebush roots, cuttlebone, green tangerine peels, medicated leaven, malts, immature bitter orange, rheum officinale, mirabilite, cortex magnoliae officinalis, radix aucklandiae, amomum, agastache rugosa, finger citron, hawthorns, radish seeds, calcined concha arcae, evodia, pinellia ternate, semen arecae, atractylodes macrocephala koidz, rhizoma nardostachyos and fritillary bulb. The traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic has the beneficial effects of being safe to use, painless, noninvasive, non-toxic, free from anaphylactic reaction, short in examination time, high in development rate, convenient to use and low in cost, providing a new technology and a new method for corrective early-stage diagnosis of diseases, and powerful basis for clinical diagnosis, and being a desirable novel auxiliary. Furthermore, the preparation process is simple and practical.

The object of the present invention is to provide footwear that exactly matches the feet of many people, the movement of a big toe inward and away from a second toe is not restricted, movement of the five toes is not limited, the base sections of the toes are stimulated, putting on the footwear is easy, the toes are made uncomfortable, and the footwear will not slip off even during fast walking. The footwear comprises a sole and instep covers formed of a soft material, wherein five openings and holes are provided on toe tip parts of the instep covers, the instep covers serve as guides, the five toes are led to the corresponding openings and holes, the five toes can easily protrude from the openings and holes, and broad sections between the openings and holes serve as straps.

Fat-dissolving oil of Chinese herbal medicine for weight loss and preparation method thereof. It belongs to a slimming beauty product and a preparation method thereof. It is based on honeysuckle, lotus leaf, hawthorn, cassia seed, saponin leaves, hemp seed, radish seed, tangerine peel, fleece-flower root, licorice, aurantium, guarana, evening primrose, safflower, ginger, pepper, wild pepper, corn Mustard, Tianqi, mulberry leaf, mulberry, wolfberry, Codonopsis, rhubarb, angelica, lovage, salvia, yam, turmeric, Daxueteng, mugwort, antler, ginseng, Kochia, cabbage, castor bean, raspberry, Atractylodes, Coptidis, Alisma, white peony, radish skin, mirabilite, astragalus, capers, morning glory, euphorbia, and ephedra are crushed, mixed with olive oil, heated and decocted, and the residue is filtered off. When using it, apply it evenly on the parts that need to lose weight and melt fat, and massage repeatedly until the skin is hot. The formula of the invention is scientific and reasonable, convenient to use, non-irritating and painless to the skin, has no side effect on the human body and can exert long-term effect, and enhance skin elasticity and gloss.

The invention discloses a blood flowing detection device and method. The detection device comprises an inflation pressure binding belt, a detection host, as well as a temperature sensor and a humidity sensor which are connected with the detection host; and the detection host comprises a control button, a switching voltage-stabilized power supply circuit, a singlechip microcomputer central control-processing unit, a preamplifier, an A / D (analog-to-digital) conversion circuit, a display and a buzzer. The detection method comprises the following steps: releasing restriction after a blood flow atthe proximal end of a heart is restrained for a certain period of time; measuring changes of skin temperature and humidity on a position at a distal end of the heart, and comparing the changes with the standard parameters of people with a normal blood flowing condition; determining whether a testee has vascular endothelial dysfunction or not; and evaluating the severity of early symptoms of cardiovascular sclerosis and hemodynamics of the testee. The detection device has the advantages of simple structure, low cost and convenience for operation, causes no trauma or pain, and can be used for routine physical examination and community general examination.

The invention discloses an automated training device for behavior learning of non-human primates, wherein a personal computer (PC) is provided with two displays, wherein one of the displays and a camera are respectively positioned in front of an animal seat; a water supply control system comprises a water receiver, a driving control circuit and an electromagnetic valve, wherein the water receiver is connected with the electromagnetic valve through a guide tube, the electromagnetic valve is electrically connected with the driving control circuit, and the driving control circuit is electrically connected with a microcontroller; a swinging rod and a water faucet are fixed on the animal seat, a pressure sensor is fixed on a handle of the swinging rod, the pressure sensor and a potentiometer of the swinging rod are electrically connected with the microcontroller respectively, and the water faucet is connected with the electromagnetic valve of the water supply control system through the guide tube; and the PC is electrically connected with the camera and the microcontroller respectively. The invention can realize a painless automated animal behavior training method, and the camera can be used for displaying and monitoring the animal behavior in real time, thereby greatly improving the training speed and saving human resources.

An apparatus for circumcising a penis comprising a fixture device and a balanus ferrule, wherein said fixture device has an opening, an upper blade conjoined part and a lower blade conjoined part are provided on the either end of said opening, and round angles are provided at the edges of said upper blade conjoined part and the lower blade conjoined part.

A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.