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Method and apparatus for the transdermal administration of a substance

a technology of transdermal administration and substance, applied in the field of method and apparatus for transdermal administration of substances, can solve the problems of skin damage, low drug delivery rate, and difficulty in controlling the amount and rate of iontophoresis,

Inactive Publication Date: 2006-03-02
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] The present invention is directed to a method and apparatus for the transdermal delivery of a substance, such as a drug, vaccine or other pharmaceutical agent, to a patient. In particular, the invention is directed to a method and apparatus for delivering a pharmaceutical agent to the stratum corneum of the skin to a sufficient depth where the pharmaceutical agent can be absorbed and utilized by the body. In embodiments where the pharmaceutical agent is a vaccine, the vaccine is introduced into the intradermal tissue below the stratum corneum where the vaccine can generate an immune response.
[0011] Accordingly, a primary object of the invention is to provide a method and apparatus for efficiently administering a pharmaceutical agent transdermally through the skin substantially without pain to the patient.

Problems solved by technology

Iontophoresis can be difficult to control the amount and rate of drug delivery.
Under some circumstances, iontophoresis can cause skin damage depending on the extent of ionization, the energy applied to ionize the drug and duration of the treatment.
Although numerous efforts to enhance drug delivery using sonic energy have been proposed, the results generally show a low rate of drug delivery.
The prior methods and apparatus for the transdermal administration of drugs has exhibited limited success.

Method used

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  • Method and apparatus for the transdermal administration of a substance

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Embodiment Construction

[0036] The present invention is directed to an intraepidermal delivery device for administering a substance to a patient. More particularly, the invention is directed to a delivery device and to a method for administering a substance into or below the stratum corneum of the skin of a patient. As used herein, the term penetrate refers to entering a layer of the skin without necessarily passing completely through. Piercing refers to passing completely through a layer of the skin. As used herein, transdermal refers to the delivery of a substance, such as a pharmaceutical, biological agent or vaccine, through one or more layers of skin. Intradermal refers to one or more layers within the skin and not limited to the dermis layer of the skin.

[0037] The device and method of the present invention are particularly suitable for use in administering various substances, including pharmaceutical agents, to a patient, and particularly to a human patient. As used herein, a pharmaceutical agent in...

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PUM

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Abstract

A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] The present application is a continuation of U.S. patent application Ser. No. 10 / 441,035 filed on May 20, 2003 which is a continuation of U.S. patent application Ser. No. 09 / 401,452 filed on Sep. 22, 1999, now U.S. Pat. No. 6,623,457 issued on Sep. 23, 2003.FIELD OF THE INVENTION [0002] The present invention relates to a method and apparatus for delivering a substance and particularly a pharmaceutical agent transdermally to a patient. More particularly, the invention is directed to a method and apparatus for delivering a pharmaceutical agent such as a vaccine to a patient through the stratum corneum. BACKGROUND OF THE INVENTION [0003] The skin is made up of several layers with the upper composite layer being the epithelial layer. The outermost layer of the skin is the stratum corneum which has well known barrier properties to prevent molecules and various substances from entering the body and analytes from exiting the body. The stratum ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B17/20A61M37/00
CPCA61B17/205A61M2037/003A61M2037/0023A61M37/0015
Inventor ROSENBERG, ZEIL B.
Owner BECTON DICKINSON & CO
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