12 results about "Dermal sensitization" patented technology

The present invention relates to a bio-based and biodegradable superabsorbent polymer (SAP) comprising sodium alginate, modified cellulose, at least one activation agent, and at least one crosslinking agent. The SAP exhibits a high bio-based content of up to 93% and fulfills industrial composting standards such as EN 13432. The crosslinking reactions are performed under mild conditions, including ambient temperatures and neutral to alkaline pH, eliminating the need for high thermal energy. The resulting SAP granules demonstrate excellent liquid absorption performance, rapid swelling, high retention, and no observed toxicity or skin sensitization. The invention provides a sustainable alternative to petroleum-based SAPs for use in hygiene products, agriculture, and other disposable applications.

This information processing device comprises a processor, wherein the processor uses a plurality of determination models pertaining to different events among a plurality of events including an important event in an expression pathway of skin sensitization of a chemical substance and including an expression itself of skin sensitization, outputs a determination result of presence / absence of skin sensitization of the chemical substance from each of the determination models, and performs final determination of presence / absence of skin sensitization of the chemical substance on the basis of a plurality of determination results output from each of the determination models.

A method of predictively assessing skin sensitization of a personal care product formulation includes: calculating an upper confidence limit at a desired confidence level from multiple physical tests for skin sensitization of each of the ingredients in the personal care product formulation to define calculated skin sensitization values for the respective ingredients; applying at least one safety factor to at least one of the calculated skin sensitization values for the ingredients to define adjusted skin sensitization values for the respective ingredients; summing the adjusted skin sensitization values of the ingredients to define a total sensitization of the personal care product formulation; and comparing the total sensitization to a target product sensitization for the personal care product formulation. Such personal care product formulations do not require further testing and are capable of application to skin by users. Predictive systems and methods of preparing a personal care products are also disclosed.

This invention discloses a method for preparing tree tomato leaf extract, its products, and applications, belonging to the field of natural product extraction and application. The method involves taking tree tomato leaf powder, using a 60% ethanol aqueous solution as the extraction solvent, extracting at a material-to-liquid ratio of 1:30 g / mL and a temperature of 60°C for 45 min, repeating the extraction twice, combining the two filtrates, concentrating, and drying to obtain the tree tomato leaf extract. This extract is highly enriched with polyphenols, flavonoids, and other active ingredients, exhibiting multiple effects such as antioxidant, anti-inflammatory, tyrosinase inhibition, and promotion of hyaluronic acid synthesis. It has also been confirmed that it has no significant cytotoxicity, phototoxicity, or skin sensitization. Cosmetic compositions containing this extract can effectively improve skin hydration, barrier function, redness, and dullness, and are suitable for preparing multifunctional pharmaceuticals or cosmetics with anti-inflammatory, whitening, moisturizing, and anti-aging properties, providing strong support for the high-value utilization and development of tree tomato leaf resources.

The application discloses a kind of semi-fluorocarbon for removing emulsified silicone oil filling and its preparation method and application, comprising, olefin and perfluoroalkyl iodine are dissolved in acetonitrile, initiator is added and reacted under light source, to obtain fluorine-containing iodoalkane;Fluorine-containing iodoalkane is dissolved in isopropyl alcohol, and after adding reducing agent and heating reaction, it is washed to obtain semi-fluorocarbon with the structure of CF3 (CF2) 3 (CH2) 4CH3, named semi-fluorinated nonafluorononane;Wherein, the molar ratio of the olefin and perfluoroalkyl iodine is 1:1-1.4, and the initiator is cuprous chloride.The application controls the proportion of raw materials, carries out reaction under the condition of suitable initiator, simultaneously preferably zinc powder is used as reducing agent, effectively improves product purity and product yield, and operation process is simple, safe, and CF3 (CF2) 3 (CH2) 4CH3 prepared has not only good stability, but also good biocompatibility, no cytotoxicity, no skin sensitization, no acute eye irritation, can dissolve or wrap emulsified silicone oil droplets, and play a great role in the removal of emulsified silicone oil.

This invention discloses a method for preparing anthocyanin extract from tree tomato, along with its products and applications, belonging to the field of natural plant extraction and application. The method uses tree tomato peel as raw material, employing an acidic ethanol aqueous solution containing 0.5% (w / v) trifluoroacetic acid as the extraction solvent, at a material-to-liquid ratio of 1:30 (g / mL), at a temperature of 50℃, and for 60 minutes to obtain a high-content anthocyanin extract. This tree tomato anthocyanin extract possesses excellent anti-inflammatory, antioxidant, anti-glycation, elastase-inhibiting, and whitening activities, and exhibits low cytotoxicity, no phototoxicity, and no skin sensitization. The efficient and stable anthocyanin extraction process provided by this invention has high extraction efficiency and good enrichment effect of active ingredients, meeting the requirements for subsequent industrial production. The obtained extract has whitening, anti-aging, and anti-inflammatory effects, providing a high-quality raw material and formulation solution for developing multifunctional and highly safe natural plant-based skincare products.

The invention belongs to the technical field of essential oil preparation, and particularly relates to a method for preparing low-sensitivity agilawood essential oil and application of the low-sensitivity agilawood essential oil. According to the method, original agilawood essential oil obtained through a supercritical carbon dioxide extraction method is subjected to desensitization treatment, and the desensitization treatment is that water is added for dissolution and removal after low-temperature heating. The agilawood essential oil prepared by the method disclosed by the invention can reduce skin sensitization and irritation, and main active ingredients of the agilawood essential oil are reserved at the same time.

The invention relates to traditional Chinese medicine, in particular to a traditional Chinese medicine composition with red fading and repairing effects and application of the traditional Chinese medicine composition in preparation of cosmetics or drugs, and the traditional Chinese medicine composition for promoting expression of sodium / hydrogen antitransporter 1 comprises the following traditional Chinese medicinal materials or extracts thereof: gentiana macrophylla, fructus cnidii and liquorice. The traditional Chinese medicine composition can up-regulate NHE1 protein expression and recover the normal microcirculation state of skin, and is free of skin sensitization and irritation, excellent in safety and good in compatibility.

This invention discloses a bovine colostrum exosome, its preparation method, composition, and applications. The preparation method includes pretreatment, microfiltration clarification, ultrafiltration concentration and impurity removal, density gradient ultracentrifugation purification, washing, and resuspension to obtain high-purity exosome BCE-01. This exosome exhibits no cytotoxicity or skin sensitization at safe concentrations and possesses multiple functions, including promoting skin cell migration and repair, inhibiting the release of inflammatory factors, upregulating the expression of genes involved in collagen and other matrix synthesis, and inhibiting elastase activity. This invention also provides cosmetic and pharmaceutical compositions containing BCE-01. Human trials have demonstrated that this composition can significantly improve skin barrier function, enhance elasticity, reduce wrinkles, and soothe redness. This invention particularly provides innovative raw materials and complete solutions for developing multi-functional, highly safe skincare products.

The present invention belongs to the technical field of cosmetic-grade 1,3-butanediol products, and particularly relates to a method for reducing impurities contained in the acetaldehyde feed stream during the production of a cosmetic-grade 1,3-butanediol product. With regard to the storage of the acetaldehyde feed stream as a raw material, the storage period is greater than 0 and less than or equal to 90 days; the storage temperature is greater than 0 and less than or equal to 50℃; the storage is carried out under air-excluded conditions; and the content of polyacetaldehyde in the acetaldehyde feed stream as a raw material is greater than 0 and less than or equal to 2 wt%. According to the present invention, an odorless cosmetic-grade 1,3-butanediol product with low skin sensitization can be obtained.

The present invention relates to a bio-based and biodegradable superabsorbent polymer (SAP) comprising sodium alginate, modified cellulose, at least one activator and at least one cross-linking agent. The SAP exhibits a high bio-based content of up to 93% and meets industrial composting standards such as EN 13432. The need for high thermal energy is eliminated by conducting the crosslinking reaction under mild conditions, including ambient temperature and neutral to alkaline pH. The produced SAP particles exhibit excellent liquid absorption properties, rapid swelling, high retention rate, and no observed toxicity or skin sensitization. The present invention provides a regimen for sustainable replacement of petroleum-based SAP for hygiene products, agricultural and other disposable applications.

An object of the present invention is to provide a skin sensitization measuring reagent, a method for measuring skin sensitization, and a compound that allow the sensitization of a test substance to be measured using a single reagent. According to the present invention, there is provided a skin sensitization measuring reagent including, as a main measuring agent, an organic compound having at least one thiol group derived from an amino acid and at least one amino group derived from a side chain of an amino acid. The organic compound has an absorption spectrum in an ultraviolet, visible, or near-infrared region and has a molar absorption coefficient of 100 L / mol·cm or more and 500,000 L / mol·cm or less at a maximal absorption wavelength.