32 results about "Dermal sensitization" patented technology

The invention relates to an active energy ray curable composition, cured product, composition storage container, image forming apparatus, and image forming method, and provides an active energy ray curable composition which causes no sensitization to the skin, and can be cured with less energy. The active energy ray curable composition includes a polymerizable monomer (A) and a polymerization initiator (B). The polymerization initiator (B) includes a skin-sensitizing polymerization initiator (B1) in an amount less than 1.0% by mass but not less than 0.1% by mass of the active energy ray curable composition, and 99.0% by mass or more of the active energy ray curable composition consists of non-skin-sensitizing constituents.

The invention relates to a preparation method of silver ion hydrogel dressing. The method comprises the following steps: firstly, a hydrophilic high-molecular polymer aqueous solution is prepared, and is subjected to vacuum defoamation for standby; secondly, the hydrophilic high-molecular polymer aqueous solution obtained in the first step is prepared into a hydrogel material semi-finished product through a coating method or an injection molding method; thirdly, the hydrogel material semi-finished product is prepared into hydrogel material through the radiation of high energy ray; fourthly, the hydrogel material is dipped into silver salt aqueous solution, so that the hydrogel material absorbs silver ion loaded in the silver salt aqueous solution, and then the silver ion hydrogel dressing is obtained. The prepare silver ion hydrogel dressing prepared through the method has good biocompatibility, is non-irritative and non-sensitized to skin, provides wet healing environment for wound healing, promotes wound healing, moreover can slowly release silver ion, effectively restrains and prevents the growth of common bacteria on the wound, and can be applied to nursing of various acute and chronic wounds.

The invention belongs to the technical field of cosmetics, and specifically relates to an antiseptic composition for cosmetics and a preparation method thereof, which comprises the following components in parts by weight: 1-10 parts of pistachio extract, 1 ~10 parts, 1~8 parts of isoferulic acid, 3~20 parts of polyols and 40~60 parts of deionized water. The antiseptic composition provided by the present invention is composed of pistachio extract, Phyllostachys spp. extract and isoferulic acid. The antibacterial spectrum of a single component, the above-mentioned active ingredients are all natural ingredients, low skin allergy, and wide pH tolerance (3-9), can be used in various skin care products, cosmetics or cosmeceuticals.

The invention discloses a method for detecting the sensitization of cosmetic ingredients through an ultra-weak biophoton imaging system, which comprises the following steps: S1, pretreatment of materials; S2, tissue block culture; S3, experimental group setting; S4, experimental preparation and Imaging system preheating; S5, positioning and photographing; S6, experimental imaging; S7, sequence image processing and data analysis. The invention uses ultra-weak biophoton imaging technology and immunohistochemical staining method to rapidly detect the changes in the biophoton radiation intensity of the skin tissue donated by the dead body after the culture is treated with DNCB, a common cosmetic sensitizer. The invention can quickly and accurately explore the sensitization of cosmetic ingredients, detect whether the cosmetic contains chemical ingredients that cause skin allergic damage, and has the characteristics of simple and fast operation.

The invention discloses a swelling-type hollow silk fibroin micro-needle drug delivery system and a preparation method thereof. According to the technical scheme of the preparation method, a swelling modified silk fibroin solution is casted in a PDMS mold to be vacuumized, dried and molded as a hollow needle-type housing. After that, a silk fibroin micro-needle array provided with cavities in the hollow needle-type housing is filled with powder-like or solution-like drugs, vacuumizing and drying are carried out to form a drug part. Finally, a layer of modified silk fibroin solution is cast, dried and molded as a cladded coating. The cladded coating is removed to obtain the swelling-type hollow silk fibroin micro-needle drug delivery system. The drugs are wrapped inside the cavities of the silk fibroin micro-needle arrays, so that the system is high in drug loading ratio and low in skin allergenicity and stimulation. The system facilitates the sustained release and the controlled release of micro-needle drugs. Meanwhile, according to the preparation method, since the swelling modified silk fibroin solution is cast, dried and molded in a mild processing condition, the system is low in processing cost and suitable for large-scale production. Drugs are directly wrapped in the cavities of the swelling hollow micro-needles, so that controlled-release drugs are swelled in the micro-needle base material. In this way, the biological activities of the controlled-release drugs are maintained, while the structure of the hollow silk fibroin micro-needle drug delivery system is greatly simplified. The system is better in practicality.

The invention discloses a medical ultrasonic coupling agent and a preparation method thereof and belongs to the field of traditional Chinese medicines. The medical ultrasonic coupling agent disclosed by the invention is prepared from the following raw materials of effective components: yellow soybeans, hibiscus tiliaceus, persicaria hydropiper, lysimachia christinae, fruits of few flower wildrice, smallfruit fig aerial roots, sambucus chinensis, dwarf elm fruits, ligustrum leaves, buddleia, sundew, hibiscus syriacus, iris-leaf oberonia herb, mint, cimicifugae foetidae and giant soft-shelled turtle fat. The medical ultrasonic coupling agent disclosed by the invention is prepared from natural Chinese herbal medicines in compatibility, has the unique curative effect of lubricating skins and promoting circulation and removing stasis, has the characteristics of efficient disinfection and sterilization, no cytotoxicity, no cutaneous sensitization and no irritation and can be used for avoiding cross infection of clinically ultrasonic inspection. The medical ultrasonic coupling agent disclosed by the invention for ultrasonic inspection is more remarkable in acoustic transmission effect and clearer in ultrasonic imaging.