7 results about "Dermal sensitization" patented technology

This information processing device comprises a processor, wherein the processor uses a plurality of determination models pertaining to different events among a plurality of events including an important event in an expression pathway of skin sensitization of a chemical substance and including an expression itself of skin sensitization, outputs a determination result of presence / absence of skin sensitization of the chemical substance from each of the determination models, and performs final determination of presence / absence of skin sensitization of the chemical substance on the basis of a plurality of determination results output from each of the determination models.

This invention discloses a method for preparing tree tomato leaf extract, its products, and applications, belonging to the field of natural product extraction and application. The method involves taking tree tomato leaf powder, using a 60% ethanol aqueous solution as the extraction solvent, extracting at a material-to-liquid ratio of 1:30 g / mL and a temperature of 60°C for 45 min, repeating the extraction twice, combining the two filtrates, concentrating, and drying to obtain the tree tomato leaf extract. This extract is highly enriched with polyphenols, flavonoids, and other active ingredients, exhibiting multiple effects such as antioxidant, anti-inflammatory, tyrosinase inhibition, and promotion of hyaluronic acid synthesis. It has also been confirmed that it has no significant cytotoxicity, phototoxicity, or skin sensitization. Cosmetic compositions containing this extract can effectively improve skin hydration, barrier function, redness, and dullness, and are suitable for preparing multifunctional pharmaceuticals or cosmetics with anti-inflammatory, whitening, moisturizing, and anti-aging properties, providing strong support for the high-value utilization and development of tree tomato leaf resources.

This invention discloses a method for preparing anthocyanin extract from tree tomato, along with its products and applications, belonging to the field of natural plant extraction and application. The method uses tree tomato peel as raw material, employing an acidic ethanol aqueous solution containing 0.5% (w / v) trifluoroacetic acid as the extraction solvent, at a material-to-liquid ratio of 1:30 (g / mL), at a temperature of 50℃, and for 60 minutes to obtain a high-content anthocyanin extract. This tree tomato anthocyanin extract possesses excellent anti-inflammatory, antioxidant, anti-glycation, elastase-inhibiting, and whitening activities, and exhibits low cytotoxicity, no phototoxicity, and no skin sensitization. The efficient and stable anthocyanin extraction process provided by this invention has high extraction efficiency and good enrichment effect of active ingredients, meeting the requirements for subsequent industrial production. The obtained extract has whitening, anti-aging, and anti-inflammatory effects, providing a high-quality raw material and formulation solution for developing multifunctional and highly safe natural plant-based skincare products.

The invention relates to traditional Chinese medicine, in particular to a traditional Chinese medicine composition with red fading and repairing effects and application of the traditional Chinese medicine composition in preparation of cosmetics or drugs, and the traditional Chinese medicine composition for promoting expression of sodium / hydrogen antitransporter 1 comprises the following traditional Chinese medicinal materials or extracts thereof: gentiana macrophylla, fructus cnidii and liquorice. The traditional Chinese medicine composition can up-regulate NHE1 protein expression and recover the normal microcirculation state of skin, and is free of skin sensitization and irritation, excellent in safety and good in compatibility.

This invention discloses a bovine colostrum exosome, its preparation method, composition, and applications. The preparation method includes pretreatment, microfiltration clarification, ultrafiltration concentration and impurity removal, density gradient ultracentrifugation purification, washing, and resuspension to obtain high-purity exosome BCE-01. This exosome exhibits no cytotoxicity or skin sensitization at safe concentrations and possesses multiple functions, including promoting skin cell migration and repair, inhibiting the release of inflammatory factors, upregulating the expression of genes involved in collagen and other matrix synthesis, and inhibiting elastase activity. This invention also provides cosmetic and pharmaceutical compositions containing BCE-01. Human trials have demonstrated that this composition can significantly improve skin barrier function, enhance elasticity, reduce wrinkles, and soothe redness. This invention particularly provides innovative raw materials and complete solutions for developing multi-functional, highly safe skincare products.

The present invention belongs to the technical field of cosmetic-grade 1,3-butanediol products, and particularly relates to a method for reducing impurities contained in the acetaldehyde feed stream during the production of a cosmetic-grade 1,3-butanediol product. With regard to the storage of the acetaldehyde feed stream as a raw material, the storage period is greater than 0 and less than or equal to 90 days; the storage temperature is greater than 0 and less than or equal to 50℃; the storage is carried out under air-excluded conditions; and the content of polyacetaldehyde in the acetaldehyde feed stream as a raw material is greater than 0 and less than or equal to 2 wt%. According to the present invention, an odorless cosmetic-grade 1,3-butanediol product with low skin sensitization can be obtained.

An object of the present invention is to provide a skin sensitization measuring reagent, a method for measuring skin sensitization, and a compound that allow the sensitization of a test substance to be measured using a single reagent. According to the present invention, there is provided a skin sensitization measuring reagent including, as a main measuring agent, an organic compound having at least one thiol group derived from an amino acid and at least one amino group derived from a side chain of an amino acid. The organic compound has an absorption spectrum in an ultraviolet, visible, or near-infrared region and has a molar absorption coefficient of 100 L / mol·cm or more and 500,000 L / mol·cm or less at a maximal absorption wavelength.