11results about How to "Non-allergenic" patented technology

The present application relates to the field of biotechnology, and more particularly to a competitive alpha-glucosidase inhibitory hippocampus peptide and a preparation method thereof. The application comprises a polypeptide with an amino acid sequence as shown in SEQ ID NO. 1, and the application uses hippocampus as a raw material, adopts double-enzyme synergistic hydrolysis, and combines an optimized process to prepare an alpha-glucosidase inhibitory peptide and its application. The application significantly improves the polypeptide yield and enhances the inhibitory activity on alpha-glucosidase, and provides a new technical path for the high-value utilization of marine biological resources and the development of natural hypoglycemic functional components.

The application belongs to the technical field of molecular biology, and relates to a polypeptide with a light protection function and application of the polypeptide. An amino acid sequence of the polypeptide comprises a sequence shown in SEQ ID No. 1 or SEQ ID No. 2. The polypeptide disclosed by the application is derived from heat-soluble protein, has a significant light protection effect, can effectively prevent and repair skin damage caused by light, has strong stability, has no sensitization, has no phototoxicity, and has a good application prospect.

The present application relates to the field of biotechnology, and more particularly to a cassava peptide for inhibiting alpha-glucosidase activity and a preparation method thereof. The present application recovers cassava starch wastewater protein by acid precipitation method, and obtains high-activity alpha-glucosidase inhibitory peptides by heat and ultrasonic pretreatment of cassava protein to assist enzymatic hydrolysis. The peptide sequence is analyzed, the alpha-glucosidase inhibition type is determined, four cassava peptides with alpha-glucosidase activity are obtained, and their high alpha-glucosidase inhibitory activity in vivo and in vitro is verified. A new alpha-glucosidase inhibitory peptide is given, the blank in the prior art is overcome, and a new idea for high-value utilization of cassava processing wastewater is provided.

The invention relates to the technical field of veterinary drugs, and particularly provides a polynucleotide molecule composition for preventing cat infectious peritonitis, a chimeric polynucleotide molecule and an mRNA vaccine. In order to overcome the ADE effect caused by S protein full-length antigen in the prior art, FIPV N protein without ADE risk is adopted and is combined with screened S protein specific T cell and B cell epitopes. Core schemes include two classes: one is a separate polynucleotide composition comprising epitope peptides encoding N and S proteins; and 2, a single chimeric polynucleotide encoding N protein and S protein epitope peptides. The polynucleotides are optimized by codons and encapsulated in lipid nanoparticles (LNP) to prepare vaccines. Experiments prove that the vaccine can synergistically stimulate powerful immune response, the survival rate of immune cats is remarkably increased to 80%-100% from standard 40% on the premise that ADE is not caused, and FIP is effectively prevented.

The invention relates to the technical field of biology, in particular to a swelling hippocampus hypoglycemic peptide as well as a preparation method and application thereof. Comprising a polypeptide with an amino acid sequence as shown in SEQ ID NO.1. The invention provides a hippocampus japonicus hypoglycemic peptide as well as a preparation method and application thereof, and particularly relates to a method for preparing an alpha-glucosidase inhibitory peptide by taking hippocampus japonicus as a raw material and adopting double-enzyme synergistic hydrolysis in combination with an optimization process and application of the alpha-glucosidase inhibitory peptide. According to the invention, the polypeptide yield is obviously improved, the inhibitory activity on alpha-glucosidase is enhanced, and a new technical path is provided for high-value utilization of marine biological resources and development of natural hypoglycemic functional components.

The application discloses a silk fiber-based anti-bedsores decompression pad and a preparation method thereof, which comprises a fabric layer in a concave shape, an aerogel layer and a fiber layer are arranged in the fabric layer from bottom to top, the total height of the aerogel layer and the fiber layer after being stacked is equal to the depth of the fabric layer, the fiber layer is prepared from drug-loaded hydrophobically modified sodium alginate fiber, and the aerogel layer is prepared from degummed silk-sodium alginate composite aerogel with a three-dimensional porous structure. The decompression pad has antibacterial and healing promotion effects, the silk fiber enhances the physical and mechanical properties of the aerogel layer, can greatly reduce external pressure, has excellent air permeation effect due to the through-hole structure in the interior, can fully and quickly absorb wound exudates, the sodium alginate-based material also provides a suitable microenvironment for cell growth, accelerates wound healing, and is suitable for the prevention and treatment of bedsores of patients who need to be in bed for a long time.

The utility model discloses an object taking device for endoscopic surgery, and belongs to the technical field of medical instruments. The device comprises an outer sheath rod, the inner side of the outer sheath rod is movably connected with an inner sheath rod, a memory steel wire is installed at the end, located on the inner side of the outer sheath rod, of the inner sheath rod, a collection bag is arranged on the memory steel wire, and a liquid suction assembly is arranged on the outer sheath rod; the liquid suction assembly comprises an installation sleeve installed on the outer side of the outer sheath rod. A liquid suction assembly is arranged at the front end of an outer sheath rod, when the outer sheath rod goes deep into a body, a mounting sleeve of the outer sheath rod is also located in the body, a liquid suction device of the outer sheath rod is connected with a connecting base at one end of a liquid drainage pipe, suction force is generated by a liquid suction hole of the outer sheath rod through starting of the liquid suction device, and waste liquid in the body is sucked into a liquid suction cavity; and then the liquid enters the liquid absorption device through the liquid discharge pipe, so that a doctor or a nurse does not need to pause an operation to carry out manual liquid absorption operation, the operation process is simplified, the operation efficiency is greatly improved, and the operation time is shortened.

The invention provides a preparation method of a pure-spinning polylactic acid fiber functional bedding, and belongs to the technical field of textile, the polylactic acid fiber functional bedding comprises a fabric and / or a filler, and the fabric and the filler are both made of polylactic acid fibers. The prepared polylactic acid bedding is completely prepared from 100% polylactic acid fibers, is free of sensitization, skin-friendly, antibacterial, free of peculiar smell, warm-keeping and breathable, avoids potential pathogenic hazards caused by the fact that microfibers are inhaled into a human body during sleeping, is flame-retardant, less in smoke, non-toxic and extinguished after being away from fire, and has a good application prospect. And moreover, the green and environment-friendly property that 100% of all-polylactic acid fibers can be recycled and reused is realized.

The invention belongs to the technical field of postoperative cooling patches in clinical medicine, and particularly relates to a postoperative stepped continuous cooling patch which sequentially comprises a base layer, a quick-release cooling layer, a slow-release temperature stabilizing layer, a long-acting temperature slowing layer and an adhesive layer from outside to inside. The quick-release cooling layer comprises a double-layer wall material microcapsule, the core material of the double-layer wall material microcapsule is tetrafluoroethane, and the wall material of the double-layer wall material microcapsule is a polylactic acid-sodium alginate composite wall; the slow-release temperature stabilizing layer comprises menthol glyceryl ether and paraffin microspheres with the melting point of 18-20 DEG C; the long-acting temperature slowing layer is high-water-retention gel containing hyaluronic acid; the continuous cooling duration of the cooling patch is larger than or equal to 8 hours, and the cooling curve meets the conditions that the temperature is 15-20 DEG C within 0-2 hours, the temperature is 18-22 DEG C within 2-6 hours, and the temperature is 22-25 DEG C within 6-8 hours. According to the invention, the local temperature is controlled in a safe and effective interval of 15-25 DEG C, and the swelling control effect and the skin safety are both considered; meanwhile, through the design of the high-elasticity and high-fitness base material, the two hands of the patient are liberated, and cutting can be conducted to meet the movement requirements of different parts after an operation.

This invention relates to the field of biotechnology, and more particularly to a hypoglycemic peptide from swollen seahorse, its preparation method, and its applications. It comprises a polypeptide with the amino acid sequence shown in SEQ ID NO.1. This invention provides a hypoglycemic peptide from swollen seahorse, its preparation method, and its applications. Using swollen seahorse as raw material, a method for preparing an α-glucosidase inhibitory peptide is employed through dual-enzyme synergistic hydrolysis combined with optimized processes, along with its applications. This invention significantly improves peptide yield and enhances inhibitory activity against α-glucosidase, providing a new technical pathway for the high-value utilization of marine biological resources and the development of natural hypoglycemic functional components.

The invention belongs to the technical field of polypeptide preparation and biological medicine, and particularly relates to a pilose antler polypeptide, a virtual enzymolysis preparation method thereof and application of the pilose antler polypeptide in the anti-aging aspect. The eight pilose antler polypeptides provided by the invention are polypeptides which are screened from pilose antler proteins and have DRP1 inhibitory activity, and have relatively high anti-aging activity and clear action mechanism; through prediction, it is found that the compound is free of toxicity and sensitization, high in DRP1 target combining capacity, good in druggability and application safety and capable of being used for developing anti-aging products, and a new lead compound is provided for research and development of new drugs, health care products or cosmetics. Furthermore, the pilose antler polypeptide is obtained based on a virtual enzymolysis preparation method, a set of complete and efficient pilose antler anti-aging peptide computer screening process is established, virtual enzymolysis, activity prediction, safety evaluation and targeted molecular docking are organically combined, the blindness of a traditional separation technology is overcome, and the separation efficiency is improved. The screening efficiency and the success rate are obviously improved.