4 results about "Propranolol Hydrochloride" patented technology

The application relates to the technical field of pharmaceutical preparations, and particularly discloses a propranolol hydrochloride tablet with low N-nitrosopropylol impurity content and a preparation method thereof. The propranolol hydrochloride tablet with low N-nitrosopropylol impurity content comprises the following components in parts by weight: 0.2-0.3 parts of propranolol hydrochloride, 2.0-2.3 parts of mannitol, 0.2-0.3 parts of glycerin behenate and 0.05-0.1 parts of magnesium stearate. In the application, mannitol, glycerin behenate and magnesium stearate are used as excipients, the mannitol, the glycerin behenate and the magnesium stearate all have high fluidity, and the glycerin behenate has lubricating and excipient effects, so that the compression of the tablets is facilitated.

The invention discloses a drug-loaded hydrogel ball as well as a preparation method and application thereof. The drug-loaded hydrogel ball comprises a hydrogel matrix and loaded propranolol hydrochloride, wherein the hydrogel matrix comprises a cross-linked network formed by cross-linking sodium carboxymethyl cellulose and iron ions, a cross-linked network formed by cross-linking water chestnut starch and iron ions, and zinc oxide nanoparticles. The drug-loaded hydrogel ball has the advantages of being excellent in targeted slow release performance, high in antibacterial activity, good in biocompatibility, high in drug loading capacity, good in stability, green, degradable and the like, can be used for long-acting drug treatment of cardiovascular diseases such as hypertension and angina pectoris, and is simple in preparation process, low in production cost and suitable for large-scale industrial production and application.

The invention discloses a propranolol synthesis method, the purity of a propranolol product obtained by the synthesis method is not less than 99.5%, the content of an impurity B in the product is not more than 0.1%, and after the obtained propranolol and hydrochloric acid are subjected to a salifying reaction, a propranolol hydrochloride finished product with the content of the impurity B not more than 0.05% can be directly obtained without re-purification. Compared with a traditional solvent recrystallization method, the method has the advantages that the intermediate product propranolol is high in purity, high in yield, controllable in quality, suitable for industrial production and the like.

The application relates to the technical field of chemical medicine preparation, and particularly discloses a propranolol hydrochloride drop, a preparation method and application thereof, and the propranolol hydrochloride drop is characterized in that, based on 10ml, the following components are included: an active component carrier 500-520mg, a suspending agent 30-40mg, a sweetening agent 20-25mg, a pH regulator 0.06-0.10mg, essence 3-6mg, and water to 10ml. The propranolol hydrochloride drop provided by the application is accurate in dose, suitable in taste, good in stability and high in safety.