6 results about "Propranolol Hydrochloride" patented technology

The invention relates to the technical field of analytical chemistry, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method of propranolol hydrochloride genotoxic impurity 1-naphthylamine and application of the HPLC detection method. The HPLC detection method for the propranolol hydrochloride genotoxic impurity 1-naphthylamine provided by the invention comprises the following steps: preparing a reference substance solution, preparing a test solution, and carrying out liquid chromatography detection, liquid chromatography detection: injecting the reference substance solution and the test solution into a liquid chromatograph, and carrying out separation detection by adopting a mobile phase gradient elution method; a used chromatographic column is a chromatographic column with octadecylsilane chemically bonded silica as a filler. The HPLC detection method of the propranolol hydrochloride genotoxic impurity 1-naphthylamine provided by the invention can rapidly and accurately detect the genotoxic impurity 1-naphthylamine in a propranolol hydrochloride bulk drug or a propranolol hydrochloride injection, and has the advantages of good detection accuracy, high sensitivity, good reliability and high detection sensitivity. And the quality control of propranolol hydrochloride bulk drugs or injections can be realized.

The present invention relates to a propranolol hydrochloride sustained release tablet, the sustained release tablet is prepared by filling a 3D printing shell with a 3D printing propranolol hydrochloride tablet core, and the tablet core contains 5-20% by weight of propranolol hydrochloride, 35-50% by weight of a lipid material, 20-35% by weight of a filler and 15-25% by weight of a plasticizer. The propranolol hydrochloride sustained-release tablet with the core-shell structure is prepared by filling the 3D printing shell with the 3D printing propranolol hydrochloride tablet core for the first time, medicine release is precisely regulated and controlled, precise administration is realized, plasma concentration release is stable, and bioavailability, medication safety and effectiveness and medication compliance are remarkably improved.

The application relates to the technical field of pharmaceutical preparations, and particularly discloses a propranolol hydrochloride tablet with low N-nitrosopropylol impurity content and a preparation method thereof. The propranolol hydrochloride tablet with low N-nitrosopropylol impurity content comprises the following components in parts by weight: 0.2-0.3 parts of propranolol hydrochloride, 2.0-2.3 parts of mannitol, 0.2-0.3 parts of glycerin behenate and 0.05-0.1 parts of magnesium stearate. In the application, mannitol, glycerin behenate and magnesium stearate are used as excipients, the mannitol, the glycerin behenate and the magnesium stearate all have high fluidity, and the glycerin behenate has lubricating and excipient effects, so that the compression of the tablets is facilitated.

The invention discloses a drug-loaded hydrogel ball as well as a preparation method and application thereof. The drug-loaded hydrogel ball comprises a hydrogel matrix and loaded propranolol hydrochloride, wherein the hydrogel matrix comprises a cross-linked network formed by cross-linking sodium carboxymethyl cellulose and iron ions, a cross-linked network formed by cross-linking water chestnut starch and iron ions, and zinc oxide nanoparticles. The drug-loaded hydrogel ball has the advantages of being excellent in targeted slow release performance, high in antibacterial activity, good in biocompatibility, high in drug loading capacity, good in stability, green, degradable and the like, can be used for long-acting drug treatment of cardiovascular diseases such as hypertension and angina pectoris, and is simple in preparation process, low in production cost and suitable for large-scale industrial production and application.

The invention discloses a propranolol synthesis method, the purity of a propranolol product obtained by the synthesis method is not less than 99.5%, the content of an impurity B in the product is not more than 0.1%, and after the obtained propranolol and hydrochloric acid are subjected to a salifying reaction, a propranolol hydrochloride finished product with the content of the impurity B not more than 0.05% can be directly obtained without re-purification. Compared with a traditional solvent recrystallization method, the method has the advantages that the intermediate product propranolol is high in purity, high in yield, controllable in quality, suitable for industrial production and the like.

The application relates to the technical field of chemical medicine preparation, and particularly discloses a propranolol hydrochloride drop, a preparation method and application thereof, and the propranolol hydrochloride drop is characterized in that, based on 10ml, the following components are included: an active component carrier 500-520mg, a suspending agent 30-40mg, a sweetening agent 20-25mg, a pH regulator 0.06-0.10mg, essence 3-6mg, and water to 10ml. The propranolol hydrochloride drop provided by the application is accurate in dose, suitable in taste, good in stability and high in safety.