193 results about "Skin irritant" patented technology

The invention relates to application of a platelet reaction protein 4 in preparation of an alopecia medicine, and belongs to the field of medical biology. The invention aims to solve the technical problems of limited curative effect, obvious side effect and narrow application range of the existing alopecia treatment medicine. The invention provides an application of a platelet reaction protein 4 (THBS4) in preparation of an alopecia medicinal preparation, which can promote hair follicles to be converted from a resting period to a growing period by regulating and controlling a mechanical microenvironment around the hair follicles, enhancing the interaction between fibroblasts and hair follicle stem cells and activating regeneration signal channels in hair papilla and hair bud areas. The traditional Chinese medicine composition breaks through the limitation that existing treatment only aims at specific alopecia types, and can be widely applied to various alopecia diseases such as androgenetic alopecia, pressure alopecia and alopecia after chemotherapy. And compared with the traditional medicine, the traditional Chinese medicine composition has the advantages of quick response, no skin irritation reaction and improved hair follicle regeneration efficiency, and provides a brand new solution for safe and efficient treatment of alopecia.

The invention belongs to the technical field of active polypeptides and preparation, and particularly relates to an antioxidant and anti-inflammatory cyclopeptide capable of inhibiting matrix metalloproteinase as well as a preparation method and application of the antioxidant and anti-inflammatory cyclopeptide. The cyclic peptide is formed by end-to-end covalent coupling of linear peptide with the amino acid sequence of DEETGEF, has the activity of resisting oxidation, resisting inflammation and inhibiting matrix metalloproteinase, is free of cytotoxicity and skin irritation, and is suitable for being used as cosmetics for resisting skin aging, wrinkles and the like.

The invention relates to a phytoextraction external liniment for promoting black hair growth and a preparation method thereof. According to the liniment, a polygonum multiflorum extract, a cacumen biotae supercritical extract and molecular embedded black sesamin in a specific proportion are taken as cores and are matched with an azone-menthol transdermal enhancer and a propylene glycol-olive oil carrier, and black hair growth is synergistically promoted through triple mechanisms of activating tyrosinase, inhibiting melanocyte apoptosis and promoting cell migration. The preparation method adopts a gradient temperature extraction combined molecular embedding technology, the polygonum multiflorum is subjected to stepped purification at 40-60 DEG C-80 DEG C to retain thermosensitive active ingredients, the black sesamin is embedded by beta-cyclodextrin to improve the stability, and finally, the nano microemulsion is formed through two-stage homogeneous emulsification. The liniment can efficiently permeate into the deep layer of hair follicles, the efficiency of turning white hair into black is remarkably improved, and skin irritation is avoided.

The invention provides a formula of sleep-aiding essential oil containing cedar himalaya, relates to the technical field of sleep-aiding essential oil, and aims to solve the problems of single effect, poor stability and insufficient skin tolerance of existing sleep-aiding essential oil. The formula comprises the following components in parts by weight: 0.5-5 parts of Himalaya cedar essential oil, 80-95 parts of base oil, 1-10 parts of synergistic sleep-aiding essential oil, at least one of lavender essential oil, chamomile essential oil and sandalwood essential oil, and 0.1-1 part of optional antioxidant. During preparation, the components are ensured to be uniform through a process of stirring at a constant temperature of 25-35 DEG C and mixing at a rotating speed of 200-300rpm, the pH value of the product is 5.5-7.0, the retention rate of the active components is greater than or equal to 90% after the product is stored in a dark place at 25 DEG C for 6 months, and the use mode is that the product is smeared on wrists / necks / soles 1-2 hours before sleep, and 0.5-2mL of the product is smeared on each time. Tests show that the sleep time of insomnia people can be shortened to 15-22 min after the essential oil is continuously used for 28 days, the PSQI score is reduced by 40%-54%, the skin irritation is zero, the essential oil is suitable for preparing external sleep-aiding essential oil cream, ball bottles and other products, and a safe and efficient solution is provided for sleep disorder people.

The invention belongs to the technical field of textile fabrics, and discloses an intelligent temperature-adjusting phase change microcapsule and a preparation method of a fabric thereof. The phase change microcapsule is prepared from the following components in percentage by mass: 60 to 80 percent of organic phase change material, 6 to 15 percent of N-isopropylacrylamide, 4 to 10 percent of acrylic acid, 1 to 5 percent of polyether surfactant, 2 to 5 percent of urethane acrylate and 2 to 5 percent of initiator. Warp yarn, first weft yarn and second weft yarn containing the microcapsules are woven into the intelligent temperature-adjusting phase-change fiber fabric, the response speed of the phase-change microcapsules is increased through the thermosensitivity of the organic phase-change materials, temperature can be buffered and adjusted in a wide temperature range, the organic phase-change materials cooperate with the temperature-sensitive polymer capsule wall, heat release, warm keeping, ventilation and moisture removal are achieved, and the intelligent temperature-adjusting phase-change fiber fabric is obtained. Inlet of hot air is reduced through heat absorption and cooling, climate and air temperature adjustment is self-adapted, and somatosensory comfort is maintained. In addition, no components irritating to the skin are added in the formula, so that adverse reactions such as sensitization and the like on consumers are avoided.

The invention discloses a preparation method of a black drill truffle oil composition and application of the black drill truffle oil composition in cosmetics. The composition comprises the following components in percentage by mass: 6-10% of perigord truffle oil, 18-25% of decolorized sea buckthorn fruit oil, 15-20% of sunflower seed oil and the balance of meadowfoam seed oil. The perigord truffle oil is obtained by adopting CO2 supercritical extraction to extract perigord truffle sporocarp. The composition has multiple excellent effects of resisting oxidation, resisting aging, preserving moisture, repairing skin barrier and the like. In-vitro DPPH free radical scavenging experiments and human body efficacy tests prove that the product has extremely remarkable effects in the aspects of increasing the skin moisture content, reducing transdermal moisture loss and the like, is free of skin irritation and untoward effects, is suitable for cosmetics, is particularly suitable for high-end skin care product formulas such as eye essence, facial essence and skin care oil, and has a very good application prospect. The anti-aging, repairing and moisturizing properties of the product can be obviously improved.

The acne-removing skin-care conditioning oil is prepared from the following components in parts by weight: 90 to 95 parts of sweet almond oil, 0.5 to 1.5 parts of ginger root oil, 0.5 to 1.5 parts of peppermint oil, 1.5 to 2.5 parts of lemon peel oil, 1 to 1.5 parts of eucalyptus globulus leaf oil and 2 to 3 parts of lemongrass leaf oil. The invention also discloses a preparation method of the acne-removing skin-care conditioning oil. The acne-removing skin-care conditioning oil disclosed by the invention is small in skin irritation, wide in universality and few in allergic phenomenon, and can also achieve the effects of repairing and skin care while removing acnes.

The invention relates to the technical field of cosmetics, and discloses a high-efficiency mild depilation cosmetic and a preparation method thereof, and the raw materials of the depilation cosmetic comprise, by weight, 8-10% of bromelain; 10%-12% of a turmeric root extract; 9%-11% of a calendula extract; 6%-9% of an aloe extract; 4%-7% of a soybean extract; 7%-10% of calcium thioglycolate; 2%-5% of L-cysteine; 1%-3% of sodium bicarbonate; 3%-6% of green tea polyphenol; 2%-4% of a chamomile extract; 1%-3% of dipotassium glycyrrhizinate; 0.9%-2.3% of a peptide component; 0.5%-1% of rosmarinic acid; 1%-3% of vitamin E; 2%-4% of gluconic acid; 4%-5% of beewax; 5%-10% of an emulsifier; according to the invention, dipotassium glycyrrhizinate and the chamomile extract form a dual anti-allergy barrier, the physical protection effect of aloe polysaccharide is combined to reduce skin irritation, and the turmeric root extract and the peptide component prolong the hair follicle resting period and reduce the hair regeneration rate, so that the safer and more effective hair removal cosmetic is prepared.

The invention belongs to the technical field of cardio-cerebral oil preparation, and provides cardio-cerebral oil and a preparation method thereof. The invention aims to solve the technical problems that kapur is easy to volatilize and short in efficacy, and skin irritation is easily caused by high-concentration addition. The preparation method comprises the following steps: firstly, wrapping menthol in a molecular cavity of beta-cyclodextrin through a molecular inclusion technology to prepare a molecular capsule capable of effectively delaying volatilization and reducing irritation; secondly, preparing a bionic repair emulsion from various bionic lipids such as ceramide, cholesterol and fatty acid through an emulsification process, and taking the bionic repair emulsion as a core delivery carrier; meanwhile, components such as vanillyl derivatives are compounded to prepare a temperature-sensitive compound; the preparation method comprises the following steps: uniformly dispersing independent kapur, the molecular capsule and the temperature-sensitive compound into the bionic repair emulsion, and curing to obtain a finished product. Through molecular inclusion and the bionic repair emulsion, long-acting release of the effect of the kapur is realized, and the skin irritation of the product is reduced.

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

The invention provides a posaconazole ethosome and a preparation method thereof, posaconazole is encapsulated in ethosome, and the posaconazole ethosome is composed of the following components by weight: 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, 0.1-5% of posaconazole, and the balance of ethanol. 1-8% of phospholipid; 0%-0.5% of cholesterol; 20%-45% of ethanol; 0-0.1% of an antioxidant; 0%-0.5% of a nonionic surfactant; and 40.9 to 78.9 percent of water. The invention has the characteristics of high encapsulation efficiency, uniform particle size distribution and no irritation to skin. And the ethosome can load both water-soluble drugs and fat-soluble drugs, and has the advantages of simple composition, high encapsulation efficiency, uniform particle size distribution, no skin irritation, simple preparation and the like.

The present invention relates to a cosmetic composition comprising galactomyces, having skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving properties, and more specifically, comprises a galatomyces fermentation filtrate, a rice lees distillate, sh-oligopeptide-1, a plant extract, a skin conditioning agent, a pH regulator, a surfactant, an emollient, a sequestering agent, a film-forming agent, and a thickener. The cosmetic composition comprising said ingredients is less likely to cause skin irritation by having a large amount of natural ingredients, is eco-friendly by upcycling rice lees, exhibits skin-soothing, moisture-retaining, skin tone-enhancing, and skin barrier-improving effects by containing an abundant amount of galactomyces, vitamins, minerals, and organic acid ingredients, and improves skin health by preventing skin aging and skin damage and promoting skin cell regeneration.

The application discloses a sunscreen composition based on the ultraviolet absorption characteristics of yellow water of liquor, and a preparation method and application thereof. The sunscreen composition comprises 10-60 parts by weight of a yellow water extract of a strong-flavor liquor, 20-70 parts by weight of a yellow water extract of a Maotai-flavor liquor, and 0-40 parts by weight of a yellow water extract of a light-flavor liquor. It is found that the yellow water of different flavor liquors has characteristic ultraviolet absorption spectrum, wherein the yellow water of the strong-flavor liquor has strong absorption in the UVB band (290-320 nm), the yellow water of the Maotai-flavor liquor has strong absorption in the UVA band (340-380 nm), and the yellow water of the light-flavor liquor has relatively uniform absorption in a wide band. According to the spectral complementarity, the natural sunscreen composition is obtained. The sunscreen composition has an in-vitro SPF value of 15-35, a PA value of ++~++++, good light stability and low skin irritation.

The invention relates to a traditional Chinese medicine external preparation for treating scalp inflammation. The traditional Chinese medicine external preparation is prepared from honeysuckle, radix sophorae flavescentis, fructus kochiae, cortex dictamni, dandelion, radix salviae miltiorrhizae, menthol, borneol and a transdermal enhancer. The preparation plays anti-inflammatory, bacteriostatic and barrier repairing roles through a multi-target synergistic mechanism, and is suitable for scalp inflammatory diseases such as seborrheic dermatitis and contact dermatitis. The preparation maximally retains active ingredients by adopting a specific extraction process, and the transdermal efficiency is improved by combining a triple permeation enhancing technology. The active ingredients reach the treatment concentration in the deep hair follicle. The pH value (5.5-6.0) of the preparation is matched with the weak acid environment of scalp, malassezia is selectively inhibited without damaging effective microbial communities, and the recurrence risk is reduced from the source. A spray, a lotion and a gel are proved to be capable of remarkably relieving erythema pruritus, inhibiting pathogenic bacteria colonization and accelerating cuticle repair, and have no skin irritation.

The invention provides a medical instrument skin stimulation test data processing method based on an artificial skin model, and relates to the technical field of skin stimulation tests. Collecting the original OD value of each pore in the 96-pore plate under the wavelength of 570nm; calculating the survival rate and the standard deviation of the positive control group and the test sample group; verifying the data validity of the negative control group and the positive control group; and performing skin irritation judgment according to the average survival rate of the test sample group to obtain a skin irritation type. According to the method, the in-vitro skin model based on HTWSkinRHE is established, strict standardized culture conditions and grouping design are adopted, the batch-to-batch consistency and data comparability of the experimental model are remarkably improved, and the model can better meet more medical instrument requirements; the cell activity is detected by simulating a complete skin layered structure and combining an MTT method, and the judgment threshold value is highly matched with the in-vivo stimulation response.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The invention discloses clobetasol propionate liniment and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The clobetasol propionate liniment provided by the invention consists of clobetasol propionate and dipotassium glycyrrhizinate which serve as effective components, absolute ethyl alcohol serving as a cosolvent and a novel eutectic solvent aqueous solution. The eutectic solvent aqueous solution is prepared by heating a citric acid aqueous solution and a tartaric acid aqueous solution under specific conditions. The invention also provides a method for preparing the clobetasol propionate liniment. A eutectic solvent formed by citric acid and tartaric acid is used as a main solvent, so that the use amount of absolute ethyl alcohol is reduced, and the use irritation is reduced. According to the liniment, the solubility and stability of clobetasol propionate which is extremely difficult to dissolve in water in a liniment system are improved, meanwhile, the formula system is mild, skin irritation caused by ethyl alcohol is reduced, and the liniment has good safety and application prospects.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The invention discloses a low-sensitivity whitening recombinant humanized collagen composition and a preparation method thereof. The low-sensitivity whitening recombinant humanized collagen composition is prepared from modified recombinant humanized collagen, tetrahydrocurcumin, ethyl ascorbic acid ether and dipotassium glycyrrhizinate, the modified recombinant humanized collagen comprises a recombinant humanized collagen chain segment, a polyethylene glycol chain segment modified on the recombinant humanized collagen chain segment, and tetrahydromethyl pyrimidine formyl modified at the other end of the polyethylene glycol chain segment. The modified recombinant humanized collagen can provide proper steric hindrance to achieve the effects of shielding residual antigen epitopes and improving the efficiency of combining target spot cell surface receptors, and cooperates with other mild whitening components to act on various pathways (including oxidation resistance, transport inhibition, enzyme inhibition and inflammation resistance), so that synergistic interaction and irritant hedging are realized, and the skin whitening effect is improved. Therefore, the whitening effect is achieved under low skin irritation.

An iontophoresis device capable of reducing skin irritability due to an applied current while enhancing skin permeability of a drug is provided. The iontophoresis device includes a power supply, an electrode electrically connected to the power supply, a drug disposed between skin and the electrode, and a control unit configured to control a current applied to the skin via the electrode. The control unit controls the current so that a pulse current having a pulse frequency of 0.5 Hz or more and 50 Hz or less is applied to the skin.

The invention discloses an agilawood plaster composite formula and a preparation method, and relates to the technical field of external medicine preparations, the agilawood plaster composite formula comprises, by weight, 5-20 parts of an agilawood extraction component, 40-80 parts of a plaster matrix, 3-15 parts of a natural active component, and an odor blending component and a skin affinity regulator can be added. Wherein the agilawood extraction component is a mixture of agilawood volatile oil and an alcohol extract in a ratio of 1: (2-5), and the natural active components are at least two analgesic and anti-inflammatory plant extracts. The preparation method comprises the following steps: preparing the agilawood extract component, melting and mixing the plaster matrix, stirring and forming multiple components under a vacuum condition and the like. Through the synergistic effect of multiple components, the analgesic and anti-inflammatory effects are enhanced, the skin irritation is reduced, the odor comfort level and the adhesion performance are optimized, the process is scientific and reasonable, and the preparation method is suitable for large-scale production.

The invention relates to an ibuprofen-containing transdermal patch as well as a preparation method and application thereof. The ibuprofen-containing transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises ibuprofen, a compound at least containing one amino group and a pressure-sensitive adhesive, and based on the weight of the polymer matrix layer, the ibuprofen accounts for 10-30% by weight, the compound at least containing one amino group accounts for 0.1-5% by weight, and the pressure-sensitive adhesive accounts for 0.1-5% by weight. The weight content of the pressure-sensitive adhesive is 45%-84%, the pressure-sensitive adhesive is composed of a silicone pressure-sensitive adhesive and an acrylate pressure-sensitive adhesive, and the weight ratio of the silicone pressure-sensitive adhesive to the acrylate pressure-sensitive adhesive is 1: 1-15: 1. According to the transdermal patch, the penetration capacity of ibuprofen is remarkably improved, particularly, the early-stage medicine penetration rate is higher, the medicine utilization rate is greatly improved, meanwhile, the patch is good in application performance, free of skin irritation, free of crystallization in the long-term storage process, good in stability and capable of better meeting the clinical medication requirement.

The invention discloses a safe and long-acting mosquito-repelling compound, a mosquito-repelling nano-carrier and a mosquito repellent. The mosquito-repelling compound is prepared by chemical crosslinking or non-covalent binding of mosquito-repelling active substances and biological macromolecules, high-molecular polymers or skin-friendly micromolecules. The mosquito repelling compound effectively prolongs the action time, and experiments show that the super-high mosquito repelling rate larger than or equal to 99.4% is always kept within the period as long as 24 h. In addition, compared with a free mosquito-repelling active substance, the mosquito-repelling compound is large in molecular weight and only adheres to the skin cuticle but does not permeate into the skin barrier, so that the mosquito-repelling compound has lower biotoxicity and skin irritation.

The present invention belongs to the technical field of cosmetics, and relates to an organosilicon compound derived from ascorbic acid or retinoic acid, and a preparation method therefor and the use thereof. The ascorbic-acid-derived organosilicon compound prepared from ascorbic acid in the present invention shows higher cell proliferation-promoting activity on human immortalized keratinocyte cell line HaCaT and better skin anti-aging activity while maintaining anti-oxidant activity, and has good application potential in improving skin condition. Compared with retinoic acid, retinyl retinoate and pinacolone retinoate, the retinoic-acid-derived organosilicon compound prepared from retinoic acid has better proliferation-promoting activity on fibroblasts and human immortalized keratinocyte cell line HaCaT, has good light / thermal stability, potentially better transdermal absorption and causes less skin irritation, and has great development prospects.

Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and / or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

The present application relates to the technical field of plant essential oil, and particularly discloses an essential oil composition and application thereof.The essential oil composition comprises the following components: carvacrol, thymol, lemon oil, peppermint oil, bay leaf oil, patchouli oil, geranium oil, perilla oil, cinnamon oil, clove oil and boldo oil.The essential oil composition provided by the present application is natural, environment-friendly, has good sterilization effect, comfortable smell, no obvious skin irritation, harmless to human body, and friendly to the environment, and can be applied to the preparation of antimicrobial products.

This invention discloses a medical eye dressing and its preparation method, belonging to the field of medical biological dressing material preparation technology. The method includes the following steps: mixing and stirring graphene oxide-sodium hyaluronate oxide, graphene oxide-trehalose oxide, glycerin, emulsifier, moisturizer, chelating agent, calcium chloride, and deionized water to form a dilute viscous matrix material; filling the dilute viscous matrix material into an aluminum-plastic film bag lined with non-woven fabric and sealing it to obtain the medical eye dressing. This invention directly fills the medical eye dressing into an aluminum-plastic film bag lined with non-woven fabric after mixing and stirring graphene oxide-sodium hyaluronate oxide, graphene oxide-trehalose oxide, glycerin, carbomer, Tween-80, polyglutamic acid, disodium edetate, calcium chloride, and deionized water, thereby improving the breathability of the eye dressing and reducing skin irritation.

The invention provides a long-acting bromhidrosis-removing nano composition and a preparation method thereof, and relates to the field of traditional Chinese medicine preparations. The long-acting bromhidrosis removal nano composition capable of treating both symptoms and root causes is obtained by fusing the traditional Chinese medicine sweating syndrome treatment theory and the nano transdermal technology, fundamental regulation and control of the armpit microenvironment are achieved through the triple mechanism of eliminating evil and strengthening the body resistance, transdermal synergism and ecological balance, and the drug effect durability is improved; the in-vitro half-life period of active ingredients such as ellagic acid is prolonged; preferably, the particle size of the nano silicon dioxide can convey the active ingredients to an apocrine duct, so that the effect of removing the active ingredients such as bromhidrosis berberine and ellagic acid is improved; according to the long-acting bromhidrosis-removing nano composition, fractionated coconut oil is adopted to neutralize the bitter cold property of coptis chinensis or berberine, and the skin irritation index is reduced to 0.32 (the traditional preparation is greater than or equal to 1.05), so that the long-acting bromhidrosis-removing nano composition has excellent long-acting antibacterial and bromhidrosis-removing effects and is small in skin irritation.