31 results about "Skin irritant" patented technology

The present application relates to the cosmetic technical field, specifically, it relates to a kind of lipid-polymer composition comprising retinol and its preparation method and application.The component includes retinol 1-15%, solvent oil 10-20%, antioxidant 0.1-1%, emulsifier 1-4.5%, lipid 1-2%, polyol 10-20%, polymer 0.05-0.5% by mass percentage, and the balance is water.The present application can significantly improve the stability of retinol and system by the compounding of specific retinol, solvent oil, antioxidant, emulsifier, lipid, polyol and polymer, solve the problem of easy oxidative degradation of retinol;By limiting the emulsifier to be polyglycerol emulsifier, combined with lipid and polymer hybridization wrapping, the skin irritation of retinol can be effectively reduced, and the defects of strong irritation of retinol and limited application population can be effectively solved.

The application discloses a sunscreen composition based on the ultraviolet absorption characteristics of yellow water of liquor, and a preparation method and application thereof. The sunscreen composition comprises 10-60 parts by weight of a yellow water extract of a strong-flavor liquor, 20-70 parts by weight of a yellow water extract of a Maotai-flavor liquor, and 0-40 parts by weight of a yellow water extract of a light-flavor liquor. It is found that the yellow water of different flavor liquors has characteristic ultraviolet absorption spectrum, wherein the yellow water of the strong-flavor liquor has strong absorption in the UVB band (290-320 nm), the yellow water of the Maotai-flavor liquor has strong absorption in the UVA band (340-380 nm), and the yellow water of the light-flavor liquor has relatively uniform absorption in a wide band. According to the spectral complementarity, the natural sunscreen composition is obtained. The sunscreen composition has an in-vitro SPF value of 15-35, a PA value of ++~++++, good light stability and low skin irritation.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

Disclosed is an efficacious, low-pH skin care composition that provides good sensory properties and has a low skin irritation potential. The low-pH composition includes an effective amount of a vitamin B3 compound and, optionally, one or more additional skin care actives to provide a skin health and / or appearance benefit. The low-pH composition also includes a pH buffer comprising lactic acid and sodium lactate, a polymer thickener comprising polyacrylate crosspolymer-6, and a silicone fluid having a kinematic viscosity of 100 cSt or less at 25° C. The pH of the low-pH composition can range from 2.0 to 5.0.

The present application relates to a kind of high-efficiency targeted penetration supermolecular oil-tea camellia seed oil and its preparation method and application, the supermolecular oil-tea camellia seed oil is to use palmitoyl tripeptide-1 and the specific interaction of tea saponin in oil-tea camellia seed oil constructs hydrogen bond and π-π stacking double action ordered self-assembly supramolecular system, the supramolecular has water oil amphiphilic structure characteristics, can be spontaneously emulsified, realize targeted delivery and slow-release balance, simultaneously avoid the skin irritation problem caused by adding emulsifier;And based on the amphiphilic characteristics of supramolecular core structure, it can be used to simultaneously adapt oil-soluble, water-soluble skin care formulations, respectively adapt polar and non-polar functional components, break through the penetration limit problem of traditional single carrier, greatly widen the application scene of oil-tea camellia seed oil in cosmetic field.

The application provides a long-acting hydrogen slow-release sanitary napkin and a preparation method thereof, and relates to the technical field of sanitary products. The long-acting hydrogen slow-release sanitary napkin comprises a skin-friendly surface layer, a long-acting hydrogen slow-release functional layer, a flow guide layer, an absorbent core, an anti-seepage bottom film, a back adhesive layer and release paper, and the skin-friendly surface layer, the long-acting hydrogen slow-release functional layer, the flow guide layer, the absorbent core, the anti-seepage bottom film, the back adhesive layer and the release paper are sequentially stacked from top to bottom. The long-acting hydrogen slow-release functional layer is composed of a flexible carrier substrate loaded with long-acting hydrogen slow-release microcapsules. The application solves the problems of existing hydrogen functional sanitary products, such as easy hydrogen escape, poor storage stability, short slow-release time, uncontrollable hydrogen production, strong skin irritation and unreasonable structure design, while guaranteeing the biological safety of the product. On the premise of not affecting the basic absorption and anti-seepage performance of the sanitary napkin, the product is endowed with excellent antioxidant, anti-inflammatory, antibacterial and pain relief effects.

The application belongs to the technical field of bioengineering, and relates to a marine-derived antibacterial peptide FP2606 and a use of the marine-derived antibacterial peptide FP2606 in preparation of a skin antibacterial drug. Streptomyces globisporus The application also provides a DNA molecule encoding the antibacterial peptide, a recombinant expression vector and an engineering strain, and realizes high-efficiency heterologous expression of the FP2606 in vitro. Experimental verification shows that the antibacterial peptide FP2606 has strong bacteriostatic activity on common pathogenic bacteria causing skin infection of children, has extremely high biological safety, has no hemolytic activity, no skin cell toxicity and no skin irritation, perfectly adapts to the physiological characteristics of the tender skin of children, and can be widely applied to preparation of a skin external antibacterial preparation for children, a skin infection prevention and treatment drug for children and a skin barrier care product for children.

This invention belongs to the field of pharmaceutical formulation technology, specifically disclosing a gastrodin transdermal patch and its preparation method. The patch consists of a backing layer, a drug-containing matrix layer, and an anti-adhesive layer, using gastrodin as the active ingredient. It employs HP-β-CD inclusion technology, combined with an HPMC and PVP polymer backbone and an oleic acid-menthol composite transdermal enhancement system. The preparation utilizes solvent casting and low-temperature vacuum drying processes, which are mild and controllable. This invention effectively solves the problems of difficult transdermal absorption, easy recrystallization, and low bioavailability of gastrodin. The resulting patch has excellent adhesion, no skin irritation, high transdermal penetration, and good skin biocompatibility. It can efficiently cross the blood-brain barrier, regulate the neuroinflammatory microenvironment in the brain, significantly inhibit the colonization and progression of non-small cell lung cancer brain metastases, and strongly reverse tumor-related anxiety and depression-like mood disorders. It provides a novel drug delivery regimen with great clinical translational potential for the non-invasive synergistic treatment of brain tumors and their associated mood disorders.

The present application relates to the technical field of wet wipes, and specifically discloses a mild bacteriostatic non-irritating wet wipe, which comprises a non-woven fabric substrate and a bacteriostatic liquid loaded thereon, and the bacteriostatic liquid is composed of a composite bacteriostatic material, a free bacteriostatic component, a humectant, a bactericide, a pH regulator and deionized water; wherein the composite bacteriostatic material is obtained by loading gold anoectochilus alcohol extract, forsythia suspense alcohol extract or red peony root alcohol extract on UiO-66-NH2, and then grafting bacteriostatic polysaccharide and a moisturizing component through amidation reaction; the present application provides rapid bacteriostatic effect during wiping through the free bacteriostatic component and the bactericide, utilizes the slow release of the alcohol extract by the porous framework of UiO-66-NH2 and the surface grafting of the moisturizing chain segment to maintain a moist microenvironment of the material, realizes long-acting bacteriostasis on the surface of the skin, and the grafted polysaccharide and the moisturizing component cooperate with the humectant to form a film on the skin and prolong the moisturizing time; the formula does not contain ethanol and the pH is maintained in the weakly acidic range, and the skin irritation is low.

A transdermal sustained-release patch for buspirone hydrochloride comprises a polyester film carrier as the backing layer, a pressure-sensitive adhesive reservoir layer prepared on the surface of the backing layer, and finally covered with a polyethylene protective film to obtain the sustained-release patch. The pressure-sensitive adhesive reservoir layer consists of a drug solution layer and an adhesive layer matrix. The drug solution layer is composed of buspirone hydrochloride, triethylamine, and glycerin, while the adhesive layer matrix is ​​composed of polyacrylate, triethylamine, a penetration enhancer, and glycerin. This invention's transdermal sustained-release patch for buspirone hydrochloride achieves a transdermal bioavailability of over 60% within 24 hours. A dose of 1.5 mg / patch achieves the equivalent effect of 10 mg orally, reducing the dosing frequency from 2-3 times daily to once daily, significantly improving patient compliance. The patch's pH value is controlled at 7.2-7.5, resulting in low skin irritation (HRIPT score ≤1.0). The process is simple, requiring no added sustained-release materials, only standard transdermal patch excipients, making production straightforward.

This invention belongs to the field of personal care product technology, specifically relating to a male genital mousse wash containing PHMB and its preparation method. The wash uses polyhexamethylene biguanide hydrochloride (PHMB) as the core antibacterial agent, combined with cocoylpropyl betaine and sodium lauroyl sarcosinate as the cleansing surfactant system, compounded with sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, supplemented with propylene glycol, glycerin, disodium EDTA, and phenoxyethanol. The pH is adjusted to 5.0–6.0 with L-lactic acid, and the remainder is water for injection. The preparation employs a low-temperature stepwise feeding process to obtain a weakly acidic mousse foam. The product exhibits an antibacterial rate of ≥99.99% against Escherichia coli, Staphylococcus aureus, and Candida albicans, is non-irritating to the skin, produces a dense and stable foam that is easy to rinse, and has good high and low temperature stability. It combines cleansing, antibacterial, and mucosal repair effects, solving the problems of traditional feminine hygiene products such as high irritation, easy allergy, and poor dosage form experience. It is suitable for daily cleaning and care of the male genitalia.

This invention relates to a compound gel for treating joint inflammation based on a modified ancient Chinese medicine formula, belonging to the fields of pharmaceutical preparations and traditional Chinese medicine. The compound gel consists of active ingredient extracts, a poloxamer thermosensitive gel matrix, a penetration enhancer, a humectant, and deionized water. The active ingredient extracts are obtained from *Terminalia chebula*, *Amla emblica*, lavender, wild watermelon, *Artemisia annua*, and chamomile through ultrasonic-microwave coupling extraction. Using ultrasonic-microwave coupling extraction combined with a low-temperature drying process, small-molecule active ingredients are obtained. A body temperature-responsive gel is constructed based on poloxamer 407 / 188, achieving in-situ phase transition on the skin surface and stable sustained release over 6-8 hours, significantly improving transdermal absorption. The gel is combined with an integrated medication container and biomimetic protective gear to form a synergistic drug delivery system, achieving closed-loop controlled release, leak-proof design, and motion adaptation. This gel is non-irritating and non-allergenic, suitable for topical treatment of osteoarthritis, rheumatoid arthritis, and soft tissue injuries caused by cold and dampness in high-altitude regions.

The application discloses a kind of recombinant humanized collagen composition for removing freckle and preparation method and application thereof, and composition includes recombinant humanized collagen and histidine;The recombinant humanized collagen includes unit A and unit B, the unit A is the amino acid sequence of the 168~554 fragment of human source III collagen chain alpha-1 chain;The unit B is the amino acid sequence of the 1127~1163 fragment of human source III collagen chain alpha-1 chain, the unit A and the unit B are connected using linker.The recombinant humanized collagen has the effect of promoting keratinocyte proliferation and inhibiting tyrosinase;Further, the recombinant humanized collagen is compounded into composition with histidine, sponge bone needle and allantoin, the composition has good whitening and freckle-removing effect and low skin irritation, and users are widely applicable.

This invention discloses the application of dermal ethylsin in the preparation of antibacterial and repairing cosmetics or pharmaceuticals, and compositions containing it. Dermal ethylsin can inhibit Propionibacterium acnes, Staphylococcus aureus, and / or Staphylococcus epidermidis, and can promote keratinocyte migration and / or upregulate the expression of repair-related genes. Cytotoxicity tests show that dermal ethylsin has good safety. Human efficacy evaluation shows that serums containing dermal ethylsin can significantly reduce inflammatory papules, improve skin redness, and improve barrier function. Therefore, dermal ethylsin can be used as a dual-action antibacterial and repairing active agent in cosmetics or pharmaceuticals for acne skin care, sensitive skin repair, and / or post-medical aesthetic repair. Dermal ethylsin is derived from *Gnaphalium affine*, has good safety, and is non-irritating to the skin.

The present invention relates to a medical patch for the administration of an active agent comprising an active agent-containing layer structure, said active agent-containing layer structure comprising a backing layer, an active agent-containing layer and a skin contact layer, wherein the skin contact layer is an adhesive layer which is directly attached to the active agent-containing layer, and wherein the saturation concentration of the active agent in the skin contact layer is less than 0.1 % by weight, as well as to such a medical patch for use in a method of treatment and to a process of manufacture of such a medical patch.

This invention belongs to the field of biomedical technology and relates to an ultrasound-responsive microneedle for acne treatment, specifically a PVDF / curcumin hyaluronic acid microneedle for ultrasound-responsive acne treatment and its preparation method. It is prepared by mixing sodium hyaluronate, PVDF, and curcumin. The PVDF in the microneedle triggers the targeted release of curcumin under ultrasound stimulation, increasing the drug concentration at the lesion site; the antibacterial and anti-inflammatory effects of curcumin synergistically enhance the therapeutic effect of acne treatment with the repair function of hyaluronic acid; the hyaluronic acid matrix reduces skin irritation, making it suitable for long-term use; the preparation process is simple, reproducible, and easy to scale up.

This invention relates to the fields of cosmetics and pharmaceutical chemistry, and discloses a glycyrrhizin salicylate ester and its applications. The structural formula of the glycyrrhizin salicylate ester is shown in Formula I. The glycyrrhizin salicylate ester of this application uses glycyrrhizin and salicylic acid as starting materials, and combines the two active molecules into one through dehydration ester condensation, fundamentally solving the problem of easy oxidation and inactivation of glycyrrhizin, and significantly improving chemical stability. At the same time, this structure cleverly masks the strongly acidic carboxyl group of salicylic acid, resulting in a significant reduction in skin irritation of the final product, making it far milder than physical mixtures, with better tolerance and suitability for a wider range of skin types. The glycyrrhizin salicylate ester of this application combines the excellent whitening and antioxidant effects of glycyrrhizin with the excellent keratin-regulating and anti-inflammatory capabilities of salicylic acid, and has broad application prospects in the preparation of topical products for skin whitening, spot fading, anti-inflammation, anti-acne, and anti-photoaging.

This invention discloses a preparation method and application of a compound biological enzyme quaternary ammonium salt formulation for pet disinfection. The formulation comprises a compound quaternary ammonium salt, peony bud extract, lysozyme, lysostaphylococcal enzyme, lactic acid, sodium hyaluronate, and water. This invention scientifically combines the compound quaternary ammonium salt with various biological enzymes (lysozyme and lysostaphylococcal enzyme), plant extracts (peony bud extract), and organic acids (lactic acid), fully leveraging the synergistic effect of each component and overcoming the shortcomings of single-component formulations, such as narrow bactericidal spectrum, easy development of drug resistance, and high skin irritation. This formulation exhibits rapid and efficient killing effects against various microorganisms, including Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Candida albicans, Trichophyton mentagrophytes, and poliovirus.

The application provides a preparation method of high-stability mechlorambal hydrochloride tincture, and specifically comprises the following steps: under the condition of stirring at 20-25 DEG C, anhydrous hydrogen chloride gas is introduced into first anhydrous ethanol to prepare an acidified anhydrous ethanol solution with a hydrogen chloride mass concentration of 1-2 g / L; under the protection of nitrogen, mechlorambal hydrochloride is added into the prepared solution, and the solution is stirred and dissolved in the dark; second anhydrous ethanol is continuously added, and the solution is uniformly stirred in the dark; the obtained solution is filtered, filled and sealed in the dark to obtain the high-stability mechlorambal hydrochloride tincture. The application can significantly reduce the degradation rate of mechlorambal hydrochloride in anhydrous ethanol, and due to the reduction of degradation products, the skin irritation after external administration is reduced, and the patient's medication compliance is better. In addition, the application does not need to change the original tincture dosage form, does not introduce complex adjuvants or gel matrix, and can be realized only by acidifying the solvent, and the operation is simple and easy to industrialize and scale up. After the acidified solvent is prepared, it can be used as a standardized intermediate, and the quality controllability is strong.

The application discloses a microneedle co-loading asiaticoside and near-infrared photothermal agents, and a preparation method and application thereof. The microneedle adopts a layered structure, and hyaluronic acid and polyvinylpyrrolidone are used as a skeleton matrix. Asiaticoside, near-infrared photothermal agent IR1048 and octa-arginine are loaded on the needle tip, and asiaticoside is loaded on the base. The mechanical strength of a single needle is about 0.46 N, the needle can smoothly penetrate into the dermis layer and is basically dissolved within 10 min, and in-situ precise release of active ingredients is realized. In combination with 1064 nm laser irradiation, the application degrades amyloid in the dermis layer through the photothermal effect of IR1048, and cooperates with asiaticoside to inhibit abnormal cell proliferation and promote collagen regeneration, so that the lesion is effectively removed and the skin microenvironment is reshaped. The microneedle has no obvious skin irritation, has good blood compatibility, and has no systemic toxicity. The application provides a safe and efficient transdermal delivery new strategy with clinical conversion potential for skin amyloidosis.

This invention provides a novel anti-hair loss and hair growth composition, and an essence containing anti-hair loss and hair growth effects, as well as a method for preparing the same. The anti-hair loss and hair growth composition comprises adenosine, acetyl tetrapeptide-3, and Platycladus orientalis leaf extract. The anti-hair loss and hair growth essence comprises the anti-hair loss and hair growth composition, a hair conditioning agent, a solvent, a moisturizer, a solubilizer, a preservative, a fragrance, and water. The anti-hair loss and hair growth composition or essence of this invention can promote hair growth and improve the scalp environment, thereby effectively preventing and treating hair loss problems. Furthermore, the composition or essence of this invention has no or minimal skin irritation.

The application discloses a kind of external use traditional Chinese medicine formula for mastalgia and preparation method, belong to traditional Chinese medicine compound preparation field.This formula is composed of Raphanus sativus L., perilla seed, white mustard seed, Evodia rutaecarpa, cyperus rotundus and bupleurum.The subcritical fluid extraction method is used to extract mixed seed oil from Raphanus sativus L., perilla seed and white mustard seed, and then alcohol reflux extraction is used to obtain alcohol extraction infusion from cyperus rotundus, bupleurum and Evodia rutaecarpa.The mixed seed oil is made into microemulsion with surfactant and cosurfactant, and then the alcohol extraction infusion is mixed with gel matrix.Finally, the microemulsion is mixed with gel matrix to be homogeneous, defoamed, and microemulsion gel is prepared.The traditional Chinese medicine extract is prepared into microemulsion gel in the application, which combines high transdermal absorption rate of microemulsion and good spreadability of gel, has the effects of soothing liver and regulating qi, warming meridians and dispelling cold, resolving phlegm and resolving mass, can effectively relieve mastalgia, and the preparation method is stable and reliable with little skin irritation.

This utility model discloses a 40mm tear gas smoke-generating riot control round for riot guns, relating to the field of riot control ammunition technology. The utility model includes a projectile assembly with a launching component at its bottom, and the projectile assembly includes an upper projectile body. By employing a high-low pressure chamber staged pressurization structure, the high-pressure chamber first accumulates energy during propellant combustion, then releases it to the low-pressure chamber through a pressure relief hole, propelling the projectile assembly to embed in the rifling and fly at high speed, increasing the range to ≥200m, with a maximum of 400m. This solves the problems of insufficient chamber pressure and limited range caused by the single high-pressure chamber design in existing technologies, meeting the needs of long-range law enforcement. It uses CS instead of CN as the irritant; CS is chemically stable, non-carcinogenic after combustion, has low skin irritation, and degrades quickly, resulting in minimal environmental impact. This solves the problems of toxic residues and health hazards associated with CN irritants in existing technologies, improving the safety of weapon use.

The present invention provides an anhydrous formulation composition comprising bakuchiol and sphingolipid, and a composition for improving skin irritation of bakuchiol comprising sphingolipid as an active ingredient. Specifically, the anhydrous formulation composition of the present invention may improve skin irritation caused by bakuchiol while maintaining excellent effects of bakuchiol by including sphingolipid.

The present application provides a programmed drug release composite microneedle, which is composed of a drug-loaded needle tip layer and a base layer, can realize rapid release of analgesic drugs and slow release of sedative drugs, and the two drugs synergistically play the roles of analgesia, sedation and improvement of mood; through a plurality of experiments, it is verified that the microneedle has good biocompatibility, no skin irritation, no long-term toxicity to main organs, and non-invasive and convenient operation, solves many defects of traditional analgesic and sedative dosage forms, and provides a new effective path for long-term home intervention of chronic pain patients.

This application relates to the field of skin care technology, and particularly to a keratin plug removal composition, a keratin plug removal cosmetic, and a method for removing keratin plugs from the skin. The composition of the keratin plug removal component is selected from any of the following combinations: (i) component A and component B; (ii) component A and component C; (iii) component B and component C; and (iv) component A, component B, and component C; component A comprising a fatty acid arginine salt; component B comprising a fatty acid taurine salt; and component C comprising one or more of N-acylaminopropionate, N-acylmethyl taurine taurine, and N-acylglutamate. The keratin plug removal composition and cosmetic have low skin irritation and good keratin plug removal effect.

This invention relates to a method for preparing mulberry leaf extract through multiple fermentation, and the mulberry leaf extract and its applications, belonging to the field of cosmetic raw material extraction technology. This method, through a complex enzymatic pretreatment, three-stage specific fermentation, and ultrafiltration purification process, produces a mulberry leaf extract that is non-irritating to the skin, exhibits good safety, high bioavailability, and excellent skin penetration, demonstrating significant effects in enhancing the skin barrier, moisturizing, and reducing wrinkles.

The application discloses a preparation process of high-activity supramolecular assembly microspheric PDRN and belongs to the field of cosmetic raw material preparation, and contains two stages of PDRN biosynthesis-enzymatic decoupling extraction refinement and supramolecular assembly microspherization. First, PDRN precursors are synthesized through fermentation of genetically engineered Escherichia coli, combined with salmon testis enzyme-assisted extraction, and purified through macroporous resin-ultrafiltration membrane combination to obtain high-purity PDRN pure product; then, through intermolecular hydrogen bonds and hydrophobic interaction, self-assembly is realized by using amphiphilic cyclodextrin derivatives and PEG-PLA as carriers to realize PDRN microspherization, and a crosslinking agent is not needed in the whole process. The prepared microspheric PDRN has a purity of 95%, a particle size of 100-300 nm, an encapsulation rate of 85%, an activity retention rate of 90%, excellent sustained release and stability, no skin irritation, and is suitable for various cosmetic formulations, and the process equipment is conventional, easy to be industrialized, the raw material utilization rate is high, and the process is green and environmentally-friendly.