861 results about "Skin irritant" patented technology

Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the alpha -hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one calcitonin gene related peptide ("CGRP") antagonist, e.g., CGRP 8-37 or an anti-CGRP antibody.

The invention relates to the high degree of exchange Ca-A type zeolite hemostasis dressing and the preparation method and the purpose. The zeolite hemostasis dressing of the invention containing the zeolite has fast hemostasis speed, and has no bacterium, no pyrogen, no cell toxicity, no hypersensitive reaction and no skin irritation, the using is convenient and the cost is low.

A regulated heat source is described that can be applied to a skin lesion, such as pustular-form eruption or localized abscess, in order to accelerate the death of invading bacteria, fungi or viral particles, or to assist in the breakdown of a skin irritant and thereby speed the recovery process.

The invention provides a nail polish with low stimulation, which belongs to the cosmetic technical field. The nail polish solves the problems of strong stimulation and easy shedding meeting water of the current nail polishes. The nail polish comprises the following components by weight part: 30-85 parts of alcohols solvent, 10-40 parts of alcohol soluble film forming agent, 1-10 parts of plasticizer, 1-10 parts of thickening agent, 1-10 parts of suspending agent, 0-5 parts of pigment, 0-5 parts of essence and 0-30 parts of solvents besides alcohol. The invention has the advantages that 1, the smell is light, only slight alcohol smell is provided, various essences are added to obtain the fragrance which is analogous with the perfume; 2, the stimulation on nail and skin of the human body is small; 3, dissolvability corrosion can not be caused when the nail polish is contacted with chemical fiber clothes and plastics; 4, the water resistance is excellent, the adhesion of the nail polish of the invention is equivalent with the ester solvent type nail polishes; 6, returning-viscosity is not generated after the nail polish is dried; and 7, the surface brightness of the nail polish of the invention is equivalent with the ester solvent type nail polishes.

Disclosed is a polyfunctional hydrocarbon oil composition containing a hydrocarbon oil which has a density at 15 DEG C of 0.7-0.8 g/cm<3>, while having an n-paraffin content of 10-90% by mass, an aromatic content of 0-3% by volume and a naphthene content of 0-20% by volume. Also disclosed is a metalworking oil composition, electrical discharge machining oil composition, rust preventive oil composition and cleaning composition, each composed of the hydrocarbon oil composition. The hydrocarbon oil composition is improved in safety such as volatility, inflammability, odor and skin irritation as well as working environment, and performs many functions.

The invention discloses an APG (alkyl polyglucoside) plant environmentally-friendly shampoo which comprises APG (alkyl polyglucoside), coconut oil 6501, water-soluble wool grease, cocamidopropylamine oxide, emulsified silicon oil softener, EDTA (ethyle, diamine tetraacetic acid), citric acid, sodium alginate, Germall, plant additive and water. The APG plant environmentally-friendly shampoo has the effects of effectively resisting hair dropping, blacking hair, shinning hair, nourishing hair, sterilizing, removing dandruff and relieving itching, has small skin irritation, and does not produce drug resistance after being used for long term.

A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and/or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35° C. and less than 150° C., and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.

The invention discloses a multifunctional moist towelette which comprises a flexible platy fiber carrier, wherein the flexible play fiber carrier is rich in multifunctional liquid medicine, and the multifunctional liquid medicine contains the following components according to weight percentage: 8-10% of deodorized ethanol, 1.5-2.7 % of humectant, 0.1-0.3 % of solubilizer, 0.2-0.4 % of emulsifier, 0.3-0.4 % of preservative, 84.28-76.59 % of purified water, 5-8 % of dimethyl phthalate, 0.3-0.5 % of mosquito repelling plant extract, 0.02-0.03 % of menthol crystal, 0.2-0.5 % of vitamin E, and 0.1-0.5 % of aloe vera gel; the pH value of the multifunctional liquid medicine is 5.6-6.5; the mosquito repelling plant extract is an extract obtained in a way that one or multiple of citronella, folium artemisiae argyi and mozzie buster is subjected to supercritical carbon dioxide extraction or an essential oil extractor method or a physical soaking and extracting method. The multifunctional moist towelette has less irritation to skin, is suitable for sensitive skins, has lasting mosquito repelling effect and has various health-care functions to skin, such as diminishing inflammation, preserving moisture, resisting ageing, easing pain and relieving itching.

The invention discloses a Chinese medicinal shinyleaf prickly ash root nourishing and itch-relieving shower gel, and relates to the technical field of daily chemical products. The shower gel is prepared from a cationic surfactant, an anionic surfactant, a conditioner, a nonionic surfactant, an ampholytic surfactant, a polyol moistening agent, a pearling agent, shinyleaf prickly ash root extract, natural tea extract, high-efficiency nourishing components, citric acid, sodium citrate, sodium chloride, essence, Kathon and proper water. The shower gel has basic cleaning effect, mild performance, low irritation to skin, and can be used for effectively nourishing skin, eliminating skin tension after shower and effectively relieving itch.

The invention belongs to the field of environmental protection machinery which discloses a domestic organic refuse treatment machine for disposal of refuse by YB microbiological functional bacterium, wherein the functional bacterium has no toxicity and skin excitation but possesses strong degradation capability. The refuse treatment machine provided by the invention is easy to operate, it is safe and reliable and can degrade domestic organic refuse quickly.

The transfer of antimicrobial agent from a cleaning substrate to the skin can be reduced resulting in reduced skin irritancy when the viscosity of the cleaning composition containing the antimicrobial is increased in viscosity. The transfer is measured by the Simulated Hand Transfer Method. The cleaning substrate is used to clean hard surfaces, especially bathroom surfaces such as toilets, and is attached to a cleaning implement. Also provided is a method of promoting a product having reduced skin irritancy.

An antimicrobial composition is provided in which the skin irritation of isothiazolone type compound is decreased and the injection operation properties thereof is improved by forming it as an uniform solution. The composition contains isothiazolone type compound and a compound which decreases the skin irritation of the former in a molar ratio of 1:0.1-50 and is dissolved in a solvent.

Botanically derived anti-irritants for prophylactic and therapeutic treatment of adverse skin reactions from application of transdermal or topical drug delivery system, permits the effective administration of a drug from a delivery system in which the drug, of a component of the delivery system comprises a skin irritant; and the delivery systems formed thereby.

The invention provides a facial make-up with excellent effect on moisturizing, whitening and nourishing and small irritation to skin. The facial make-up consists of make-up substrate and make-up active substances, wherein the make-up active substances comprise glycolic acid, kojic acid, arbutin, aloin, baicalin, paeoniflorin, glycyrrhizic acid, squalane, hyaluronic acid and chitin to be prepared into toner, facial cream, facial cleanser, facial mask, gel and external soft capsule preparations.

The invention relates to a pigment-containing artificial skin detection model and a preparation method thereof. The artificial skin detection model is an epidermal layer structure with activity, which is constructed by compositely inoculating cutin formative cells and melanophores to the surface of a support membrane made from a biodegradable material through culture and comprises a stratum basale, a stratum spinosum, a stratum granulosum and a stratum corneum, and a basilar membrane structure is formed between the epidermal layer and the biodegradable material positioned below the epidermal layer. Compared with the conventional product, the invention can better simulate the pigment components of natural skin and more accurately reflect the whitening and sunscreen effect of cosmetics because of containing the melanophores, nourish the cutin formative cells by using the support membrane made from the biodegradable material as an enderonic layer, control the contraction of the epidermal layer with the strength and enhance the stability of the detection model and has low raw material cost, short manufacturing period and mass production; and in addition, the prepared artificial skin detection model can be directly used for the efficacy detection of the cosmetics and the skin irritation detection of textiles, the cosmetics and chemicals.

The invention provides a cleaning agent composition and a preparation method thereof. The cleaning agent composition comprises the following components in percentage by weight: 1 to 10 percent of fatty acid salt anionic surfactant, 1 to 10 percent of polyoxyethylene type nonionic surfactant, 1 to 10 percent of quaternary ammonium salt cationic surfactant, 1 to 5 percent of sodium hydroxide or potassium hydroxide, 20 to 50 percent of glycol ether solvent and 20 to 50 percent of water. The product has the advantages of reasonable formula, good cleaning effect on heavy oil dirt, low alkali and organic solvent content, low irritation to the skin, high safety and low cost. The preparation method for the cleaning agent composition comprises the following steps of: weighing the sodium hydroxide or the potassium hydroxide, and adding the sodium hydroxide or the potassium hydroxide into the water for dissolving with stirring to form alkali solution; and adding the fatty acid salt anionic surfactant into the prepared alkali solution, dissolving the anionic surfactant with stirring, then adding the polyoxyethylene type nonionic surfactant and the quaternary ammonium salt cationic surfactant into the solution in turn, adding the glycol ether solvent into the solution, and stirring the solution uniformly.

The invention discloses biological environment-friendly hair-darkening and hairloss-preventing shampoo and a preparation method thereof. The shampoo contains alkyl polyglucoside (APG), coconut oil, water soluble wool oil, cocoamido propyl betaine, tea seed oil, ethylenediaminetetraacetic acid (EDTA) disodium, citric acid, sodium alginate, genma and plant hair-darkening and hairloss-preventing essence. The shampoo can effectively prevent hair loss, darken and brighten hair, remove dandruff and relieve itching, is less irritant to skin and can be used for a long time without causing medicine resistance.

The invention belongs to the technical field of cosmetics, and relates to a skin care product with sunscreen and sun repair functions and a preparation method thereof. The skin care product with the sunscreen and sun repair functions comprises the following components: sodium copper chlorophyllin, cytokine complex liposome, an asparagus extract, a flos lonicerae extract, an ash bark extract, dipotassium glycyrrhizinate, shea butter, butanediol, beta-glucan, sodium hyaluronate, xanthan gum, trehalose, hydrogenated jojoba oil, squalane, cyclopentasiloxane, cetearyl glucoside, cetearyl alcohol, PEG-100 stearate, tocopheryl acetate, bisabolol, a preservative, essence and deionized water. The skin care product with the sunscreen and sun repair functions, provided by the invention, is reasonable in formula, stable in property, mild in effect and free from skin irritation and has the obvious sunscreen and sun repair functions under the synergistic action of the various effective components.

Provided is a transdermal preparation having low skin irritation as well as a sufficient skin permeability rate of donepezil, which comprises one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof. Also provided are a manufacturing method thereof, and a method for reducing skin irritation of a transdermally absorbable donepezil-containing preparation. An embodiment is a transdermal preparation comprising one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof, and a skin irritation-reducing agent.

The invention discloses a skin care composition with a wrinkle removing and resisting function. The composition comprises a phase A and a phase B, wherein the phase A comprises oil, and the phase B comprises traditional Chinese medicine extracts. In the invention, raw materials are all selected from natural soothing components, have little stimulation to the skin, permeate into the skin stratum basale through various approaches and can be used for recovering skin activity and removing free radicals so as to fundamentally play the roles of removing and resisting wrinkles. Experiments prove that the preparation of the skin care composition has an obvious wrinkle removing function, and can obviously improve the texture of the skin, make the texture fine and smooth, simultaneously enhance skin glossiness and make the skin fin, mellow and white after being used for 30 days. The skin care composition disclosed by the invention is prepared from the raw materials which are easy to obtain by a convenient preparation method, is easy to accept by the massive consumers and has good application prospects and market prospects.

It has been discovered that certain combinations compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) at least one active agent; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.

The invention discloses pentacyclic triterpenoid cyclodextrin clathrate compound proliposome and a preparation method thereof. The main component comprises one or more of pentacyclic triterpenoid compound series, for example, ursolic acid, oleanolic acid, betulonic acid, beta-masticinic acid, cyclodextrin clathrate compound, phospholipid material and cholesterol. According to the pentacyclic triterpenoid cyclodextrin clathrate compound proliposome, the pentacyclic triterpenoid compound is clathrated through cyclodextrin to improve the hydrophilicity; the liposome is used as a carrier to clad, and the proliposome is obtained by freezing and drying. According to the pentacyclic triterpenoid cyclodextrin clathrate compound proliposome, the bioavailability and the stability of the pentacyclic triterpenoid compound can be improved; transdermal absorption is promoted, and the skin irritation is reduced. In addition, the cyclodextrin clathrate compound proliposome is of a powder shape, good in stability and rehydration reconstruction and convenient to use, and can be applied to a plurality of cosmetic dosage forms such as cream, emulsion, gel and essence.

The invention discloses a Chinese medicinal composition with acne treatment and anti-inflammation effects. The composition is mainly prepared from the following raw materials in part by weight: 35 to 45 parts of root of red-rooted salvia, 15 to 20 parts of honeysuckle flower, 15 to 25 parts of clove, 10 to 15 parts of officinal magnolia bark and 10 to 15 parts of rhubarb. The raw materials contain natural soothing components, have low skin irritation and realize an acne treatment effect in various ways. Compared with the same type of products in the conventional market, the composition is safer, efficient and independent (without antibiotics or chemical medicament components); and raw materials are readily available, different dosage forms can be taken as carriers and a preparation methodis convenient. The composition has low cost, good effect, good application prospect and market prospect, and is easily accepted by customers.

The invention discloses iodine disinfection liquid and a preparation method thereof. The iodine disinfection liquid comprises the following medical raw materials in proportion by weights: 4-65 g of povidone iodine, 0.05-0.15 g of potassium iodate, 4-8 g of sodium dihydrogen phosphate, 1-3 g of disodium hydrogen phosphate, suitable amount of 10% sodium hydroxide and purified water added to 1000 mL. The iodine disinfection liquid disclosed by the invention is suitable for skin disinfection and mucous membrane (oral cavity and the like) disinfection, disinfection of surgical hand washing and healthy hand washing, disinfection of fire burn and wound and disinfection of surfaces of common objects. The iodine disinfection liquid disclosed by the invention has the advantages of low skin irritation, low toxicity, action durability, safety, convenience and simpleness for use as well as steady quality.