Traditional Chinese medicine body milk and preparation method thereof

Abstract

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a traditional Chinese medicine body lotion and its preparation method. Background Technology

[0002] The elderly population commonly suffers from sebaceous gland atrophy and declining skin barrier function, with approximately 75% experiencing chronic dry skin and persistent itching. Furthermore, up to 40% of patients with chronic diseases such as diabetes develop dermatitis and have slow-healing wounds. Existing body lotion products on the market suffer from three main deficiencies: First, a lack of specialized products; globally, there is only one clinically validated product specifically for elderly patients with chronic diseases, resulting in a severe lack of targeted treatment. Second, weak efficacy; itching relief rates are below 40%, repair cycles exceed 4 weeks, and the effects are slow to take hold and poor in lasting effects. Third, poor user experience; product sensitization rates exceed 35%, continuous use rates are less than 20%, and the skin feel is unpleasant and highly irritating.

[0003] Traditional Chinese medicine (TCM) has a long history of treating skin problems caused by "blood deficiency and wind-dryness." The "Dang Gui Yin Zi" formula recorded in the Song Dynasty's *Yan Shi Ji Sheng Fang* is a classic prescription for nourishing blood, moisturizing dryness, dispelling wind, and relieving itching. Based on the TCM theory that "external treatment is the same as internal treatment," there is great potential in transforming ancient internal prescriptions into external preparations. However, how to combine traditional ancient prescriptions with modern pharmaceutical technology to develop a TCM-based body lotion for the elderly that is highly effective, gentle, and has a superior skin feel is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine body lotion and its preparation method to solve the above-mentioned technical problems.

[0005] The above-mentioned technical objective of the present invention is achieved through the following technical solution: A traditional Chinese medicine body lotion comprises the following components by weight: 5-15 parts of active ingredients derived from the ancient formula of Dang Gui Yin Zi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity ≥95%, and 0.1-0.5 parts of natural borneol with a purity ≥99%, with the remainder being an oil phase matrix, an aqueous phase matrix, and an emulsifier. The active ingredients derived from the ancient formula of Danggui Yinzi include Danggui extract, Astragalus polysaccharide, Matrine and Glycyrrhiza flavonoids, and these active ingredients are obtained through a low-temperature warm-heat extraction process at 40-45℃.

[0006] Furthermore, the specific parameters of the low-temperature hot extract process are as follows: material-to-liquid ratio 1:12, extraction time 2 hours, stirring once every 15 minutes during extraction; the extract is filtered through a 100-mesh + 200-mesh double-layer filter cloth gradient, and then purified by centrifugation at 3000 r / min for 15 minutes.

[0007] Furthermore, the herbal body lotion is a water-in-oil emulsion with a volume ratio of oil phase to water phase of 1:3, and is prepared by homogenization at 45°C and 180 r / min for 30 minutes.

[0008] Furthermore, the herbal body lotion meets the following performance indicators: skin irritation level <0.3, 24-hour moisturizing power ≥78%, herbal active ingredient retention rate ≥83.2%, and absorption within 5 minutes after application.

[0009] This invention also provides a method for preparing the above-mentioned traditional Chinese medicine body lotion, comprising the following steps: S1. Raw material pretreatment: Select authentic medicinal materials from the ancient formula of Dang Gui Yin Zi, wash and dry them, and then pulverize them to 60 mesh; grind natural borneol into fine powder for later use. S2. Warm extraction of extract: A constant temperature sealed extraction process of 40-45℃ is adopted, with a material-to-liquid ratio of 1:12, and extraction is carried out continuously for 2 hours, with stirring once every 15 minutes during the process, so that the retention rate of herbal active ingredients is ≥83.2%; S3. Filtration and purification: Double-layer filter cloth gradient filtration is used, with the first layer being 100 mesh and the second layer being 200 mesh, to remove raw material residue; then centrifugation is performed at a speed of 3000 r / min for 15 minutes to obtain Angelica sinensis extract. S4. Precise formulation and blending: Cool the extract obtained in step S3 to 35°C, add borneol powder, vitamin E and ceramide NP with a purity of ≥95% according to the optimized ratio, and stir continuously for 15 minutes to ensure that each component is evenly dispersed. S5. Emulsification and molding: Mix the mixture from step S4 with the oil phase and water phase components, and use a low-temperature and low-speed homogenization process at 45℃ and 180r / min for 30 minutes. The volume ratio of the oil phase to the water phase is 1:3 to ensure uniform oil-water dispersion. S6. Cooling and filling: Cool the emulsified product to room temperature and fill it in a sterile environment. Perform microbial testing before packaging to ensure that the total number of colonies is ≤1000 CFU / g.

[0010] Furthermore, the retention rate of herbal active ingredients in step S2 is achieved through low-temperature constant-temperature extraction, avoiding the destruction of effective components of traditional Chinese medicine by high temperatures.

[0011] In summary, the present invention has the following beneficial effects: Firstly, this invention is the first to successfully transform the ancient oral formula "Dang Gui Yin Zi" into a topical body lotion specifically formulated for the elderly, precisely targeting the pathogenesis of "blood deficiency and wind-dryness" in the elderly. The formula contains Angelica sinensis extract, Astragalus polysaccharide, Matrine, and Glycyrrhiza flavonoids, combined with Vitamin E and ceramide NP, while eliminating alcohol, fragrances, and traditional preservatives. Testing shows a skin irritation level of <0.3, far superior to commercially available products (typically 0.8-1.2), making it extremely gentle on the delicate skin of the elderly.

[0012] Secondly, this invention utilizes the synergistic effect of the traditional Chinese medicine mechanism of "nourishing blood and moisturizing dryness, dispelling wind and relieving itching" and the modern barrier repair ingredient (ceramide NP). Through experimental verification, it has been shown to improve the symptoms of dry and itchy skin in the elderly by 85.2%, with a 24-hour moisturizing power of ≥78%, thus solving the problem of stubborn itching and dryness and peeling of the elderly skin.

[0013] Thirdly, this invention uses natural borneol as a "guide drug" to promote the transdermal absorption of active ingredients. Combined with an optimized low-temperature homogenization process for water in oil (oil-to-water ratio 1:3, 45℃, 180r / min), the product has a delicate and light texture, is absorbed within 5 minutes after application, and is not sticky or stains clothing. This overcomes the shortcomings of traditional oily products, such as stickiness and difficulty in consistent use.

[0014] Fourth, the 40-45℃ low-temperature warm-heat extraction process of this invention, combined with a material-to-liquid ratio of 1:12, extraction for 2 hours, and regular stirring during the process, avoids the destruction of heat-sensitive active ingredients (such as volatile oils, polysaccharides, and flavonoids) by high temperatures. The retention rate of herbal active ingredients can reach more than 83.2%, far exceeding the traditional high-temperature extraction process, thus ensuring the efficacy of the product. Attached Figure Description

[0015] Figure 1 This is a flowchart of the preparation process of the herbal body lotion of this invention. Detailed Implementation

[0016] The present invention will be described in detail below through specific embodiments, but the scope of protection of the present invention is not limited to the following embodiments.

[0017] Example 1: Preparation of Traditional Chinese Medicine Body Lotion Formula (by weight, total weight calculated as 100 parts): 10 parts of active Chinese herbal ingredients derived from the ancient formula of Dang Gui Yin Zi (in extract form, containing approximately 20% raw herbs), 2 parts of Vitamin E, 1 part of Ceramide NP (purity ≥95%), 0.3 parts of Natural Borneol (purity ≥99%), 8 parts of Oil Phase Matrix: Hydrogenated Polyisobutylene, 5 parts of Squalane, 100 parts of Aqueous Phase Matrix: Deionized Water, 5 parts of Glycerin, 3 parts of 1,3-Butanediol, 2 parts of Emulsifier: PEG-100 Stearate, 0.5 parts of Low-Irritant Preservative (p-hydroxyacetophenone).

[0018] like Figure 1 As shown, the preparation process is as follows: S1. Raw material pretreatment: Take Angelica sinensis, Astragalus membranaceus, Sophora flavescens, Glycyrrhiza uralensis and other medicinal materials (according to the original formula of Dang Gui Yin Zi), wash and dry them, and then pulverize them to 60 mesh; grind natural borneol into fine powder for later use.

[0019] S2. Warm extraction of extract: Place the pulverized medicinal material in an extraction tank, add 12 times the amount of purified water (material-liquid ratio 1:12), seal, heat to 42±2℃, and extract at a constant temperature for 2 hours, stirring once every 15 minutes during the process.

[0020] S3. Filtration and Purification: The extract is filtered through a double-layer filter cloth of 100 mesh and 200 mesh to remove raw material residue; then centrifuged at 3000 r / min for 15 minutes, and the supernatant is collected to obtain Angelica sinensis extract. The retention rate of herbal active ingredients was found to be 84.1%.

[0021] S4. Precise formulation and blending: Cool the above extract to 35°C, add borneol powder, vitamin E and ceramide NP according to the formula, and stir continuously for 15 minutes until evenly dispersed.

[0022] S5. Emulsification and Molding: Heat the oil phase matrix (hydrogenated polyisobutylene, squalane, emulsifier) ​​to 45°C, and the aqueous phase matrix (deionized water, glycerol, 1,3-butanediol) to 45°C. Add the mixture from step S4 to the oil phase while stirring, then slowly add the aqueous phase, controlling the volume ratio of the oil phase to the aqueous phase to be approximately 1:3. Homogenize at 45°C and 180 r / min for 30 minutes.

[0023] S6. Cooling and Filling: Stop heating, continue slow stirring to cool to room temperature, add preservative, stir evenly, and fill under aseptic conditions. Perform microbial testing before filling to ensure that the total bacterial count is ≤1000 CFU / g. This yields the herbal body lotion of this invention.

[0024] Example 2: The parts that are the same as in Example 1 will not be repeated here. The difference is that: The formula contains 5 parts of active Chinese herbal ingredients derived from the ancient formula of Dang Gui Yin Zi, 1 part of vitamin E, 0.5 parts of ceramide NP with a purity of ≥95%, and 0.1 parts of natural borneol with a purity of ≥99%. Other ingredients can be adjusted accordingly.

[0025] Example 3: The parts that are the same as in Example 1 will not be repeated here. The differences are as follows: The formula contains 15 parts of active Chinese herbal ingredients derived from the ancient formula of Dang Gui Yin Zi, 3 parts of vitamin E, 2 parts of ceramide NP with a purity of ≥95%, and 0.5 parts of natural borneol with a purity of ≥99%. Other ingredients can be adjusted accordingly.

[0026] Example 4: Performance Testing Test subjects: 30 elderly subjects aged 60-75 years with symptoms of dry and itchy skin on their lower legs were recruited, including 10 patients with type 2 diabetes and pruritus.

[0027] Test method: Subjects used the herbal body lotion prepared in Example 1 twice daily, morning and evening, applying it to dry and itchy areas for two consecutive weeks. Skin parameters were assessed before use, after one week of use, and after two weeks of use.

[0028] Evaluation indicators and results: Skin irritation: Human skin patch tests were conducted in accordance with the "Cosmetic Safety Technical Specifications". The results showed that none of the subjects experienced adverse reactions such as erythema or edema, and the skin irritation score was 0.1, which meets the requirement of <0.3.

[0029] 24-hour moisturizing power: Measured using a Corneometer skin moisture analyzer. After 2 weeks of use, the average moisture content of the subjects' stratum corneum increased by 58.3%, and the calculated 24-hour moisturizing power was 78.5%, meeting the requirement of ≥78%.

[0030] Retention rate of active ingredients in herbs: Samples were taken from the extraction process step S2, and the content of the index components was determined by high performance liquid chromatography. The results showed that, compared with the theoretical value, the retention rate of active ingredients in Angelica sinensis extract was 84.1%, which meets the requirement of ≥83.2%.

[0031] Absorption speed: Subjective evaluations and instrumental tests (changes in skin gloss after application) showed that the product was completely absorbed within an average of 4.5 minutes after application, without any stickiness, which meets the requirement of absorption within 5 minutes.

[0032] Antipruritic effect: The visual analog scale (VAS, 0-10) was used. The average VAS pruritus score of the subjects decreased from 7.2 points before use to 1.1 points after 2 weeks, with an pruritus relief rate of 85.2%.

[0033] Example 5: Comparative Test The product of this invention (Example 1) was compared with a representative commercially available body lotion, and the results are shown in the table below: The comparative results show that the present invention is significantly superior to existing commercially available products in terms of low irritation, high moisturizing power, high retention rate of active ingredients, and optimized skin feel and absorption speed.

[0034] Industrial applicability The herbal body lotion and its preparation method provided by this invention can be widely used in the field of skin care for the elderly and those with chronic diseases. Its preparation process is simple, with clearly defined parameters, making it easy to achieve standardized mass production on cosmetic production lines. The product has advantages such as low irritation, high-efficiency moisturizing, and rapid absorption, effectively solving problems such as dry skin, itching, and slow wound healing in the elderly and those with chronic diseases. It fills a market gap and has extremely high industrial applicability and socio-economic value.

[0035] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine body lotion, characterized in that, It includes the following components by weight: 5-15 parts of active Chinese herbal ingredients derived from the ancient formula of Dang Gui Yin Zi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity ≥95%, and 0.1-0.5 parts of natural borneol with a purity ≥99%, with the remainder being an oil phase matrix, an aqueous phase matrix, and an emulsifier. The active ingredients derived from the ancient formula of Danggui Yinzi include Danggui extract, Astragalus polysaccharide, Matrine and Glycyrrhiza flavonoids, and these active ingredients are obtained through a low-temperature warm-heat extraction process at 40-45℃.

2. The herbal body lotion according to claim 1, characterized in that, The specific parameters of the low-temperature hot-temperature extract process are as follows: material-to-liquid ratio 1:12, extraction time 2 hours, stirring once every 15 minutes during extraction; the extract is filtered through a 100-mesh + 200-mesh double-layer filter cloth gradient, and then purified by centrifugation at 3000 r / min for 15 minutes.

3. The herbal body lotion according to claim 1, characterized in that: The herbal body lotion is a water-in-oil emulsion with a volume ratio of oil to water of 1:3, and is prepared by homogenization at 45°C and 180 r / min for 30 minutes.

4. The herbal body lotion according to claim 1, characterized in that, The herbal body lotion meets the following performance indicators: skin irritation level <0.3, 24-hour moisturizing power ≥78%, herbal active ingredient retention rate ≥83.2%, and absorption within 5 minutes after application.

5. A method for preparing a traditional Chinese medicine body lotion according to any one of claims 1-4, characterized in that, Includes the following steps: S1. Raw material pretreatment: Select authentic medicinal materials from the ancient formula of Dang Gui Yin Zi, wash and dry them, and then pulverize them to 60 mesh; grind natural borneol into fine powder for later use. S2. Warm extraction of extract: A constant temperature sealed extraction process of 40-45℃ is adopted, with a material-to-liquid ratio of 1:12, and extraction is carried out continuously for 2 hours, with stirring once every 15 minutes during the process, so that the retention rate of herbal active ingredients is ≥83.2%; S3. Filtration and purification: Double-layer filter cloth gradient filtration is used, with the first layer being 100 mesh and the second layer being 200 mesh, to remove raw material residue; then centrifugation is performed at a speed of 3000 r / min for 15 minutes to obtain Angelica sinensis extract. S4. Precise formulation and blending: Cool the extract obtained in step S3 to 35°C, add borneol powder, vitamin E and ceramide NP with a purity of ≥95% according to the optimized ratio, and stir continuously for 15 minutes to ensure that each component is evenly dispersed. S5. Emulsification and molding: Mix the mixture from step S4 with the oil phase and water phase components, and use a low-temperature and low-speed homogenization process at 45℃ and 180r / min for 30 minutes. The volume ratio of the oil phase to the water phase is 1:3 to ensure uniform oil-water dispersion. S6. Cooling and filling: Cool the emulsified product to room temperature and fill it in a sterile environment. Perform microbial testing before packaging to ensure that the total number of colonies is ≤1000 CFU / g.

6. The method for preparing a traditional Chinese medicine body lotion according to claim 5, characterized in that: The retention rate of herbal active ingredients in step S2 is achieved through low-temperature constant-temperature extraction, avoiding the destruction of effective components of traditional Chinese medicine by high temperature.

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