A composition with soothing redness-reducing and barrier repair functions and uses thereof

Abstract

The application discloses a composition with soothing redness and barrier repair functions and application thereof, and relates to the cosmetic field. The composition comprises the following components in mass parts: sea buckthorn fruit extract 0.01-0.1 parts, gardenia flower extract 0.01-1 part, and egg yolk oil 1-5 parts. The composition can be applied to cosmetics. The sea buckthorn fruit extract, the gardenia flower extract and the egg yolk oil are compounded according to a certain mass ratio to be used as effective components of the cosmetics. The composition has the effects of increasing the epidermal water content, soothing redness and repairing the skin barrier. The components of the composition are natural and green, safe, mild and non-irritating, have good smearing and absorption performance, can effectively improve the skin feeling of the skin care product, improve the extensibility of the product after smearing and the softness of the skin after drying, and reduce the sticky feeling of the product. The composition can not only effectively relieve the skin sensitivity and discomfort of adults, but also be used for relieving the problems of infantile eczema, dry and red skin and the like.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a composition having soothing and redness-reducing and barrier-repairing functions and its application. Background Technology

[0002] Skin redness is usually caused by factors such as thin and delicate skin, temperature changes, allergic reactions, inflammation, drug side effects, and diseases. Occasional redness can be relieved by keeping the skin clean, moisturized, and protected from the sun. However, if it persists for a longer period or is accompanied by other symptoms, it generally requires the use of specialized cosmetics or specific medications for improvement or treatment. Currently, most repair cosmetic products on the market focus on single-pathway repair or rely on high concentrations of active ingredients, which carries a high risk of irritation and low repair efficiency, and may be problematic for addressing issues such as skin redness, damaged skin barrier, and exacerbated inflammation.

[0003] Therefore, developing a gentle and safe cosmetic composition that combines the dual effects of redness reduction and barrier repair has significant market value and application prospects. Summary of the Invention

[0004] This invention provides a composition with soothing and redness-reducing and barrier-repairing functions and its application, aiming to overcome the above-mentioned problems existing in the prior art to a certain extent.

[0005] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: a composition with soothing redness reduction and barrier repair functions, comprising the following raw materials in parts by weight: 0.01-0.1 parts of sea buckthorn fruit extract, 0.01-1 parts of magnolia flower extract, and 1-5 parts of egg yolk oil.

[0006] It should be noted that sea buckthorn fruit extract contains various active substances such as fatty acids, fat-soluble vitamins, proanthocyanidins, and vitamin C, all essential for the skin. These components give sea buckthorn fruit extract an excellent effect in reducing IL-6 and TNF-α gene expression. Sea buckthorn proanthocyanidins not only have excellent anti-inflammatory effects but also possess antioxidant properties, increasing superoxide dismutase (SOD) expression, reducing malondialdehyde (MDA) and reactive oxygen species (ROS) levels, repairing damaged skin's active monomers, and are easily absorbed through the skin, leaving a smooth, moisturizing, and non-sticky feel. Magnolia flower extract contains magnolin, which can… It effectively inhibits the migration of HMGB1 from the nucleus to the extracellular space, enhances HSP27 expression, strengthens cellular stress protection, significantly inhibits ET-1 and ICAM-1, reduces inflammatory cell migration and vasodilation, and significantly inhibits the release of IL-8 and PEG-2-induced inflammatory factors. It has excellent soothing and redness-reducing effects, and its skin feel is smooth and non-sticky. Egg yolk oil contains a variety of unsaturated fatty acids, phospholipids, vitamins and minerals, which have antibacterial and anti-inflammatory effects. It can reduce the secretion of inflammatory factors and has a significant soothing and antipruritic effect. At the same time, it has a sebum-like structure that can promote skin barrier repair.

[0007] Based on the above technical solutions, the present invention may have the following further specific options or better options.

[0008] Preferably, the mass ratio of the sea buckthorn fruit extract, the magnolia flower extract and the egg yolk oil is (0.01-0.05):(0.05-0.5):(1-2).

[0009] Optimally, the mass ratio of the sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil is 0.04:0.1:1.2.

[0010] Specifically, the sea buckthorn fruit extract is obtained from sea buckthorn fruit by water extraction and macroporous resin chromatography.

[0011] Preferably, the proanthocyanidin content in the sea buckthorn fruit extract is 0.05-0.5 wt%.

[0012] Specifically, the extract of Magnolia officinalis flower is obtained from Magnolia officinalis flower by water extraction or alcohol extraction.

[0013] Specifically, the magnolin content in the Magnolia flower extract is above 70 wt%.

[0014] The present invention also provides the application of the above-mentioned composition having soothing and redness-reducing and barrier-repairing functions in cosmetics.

[0015] Specifically, the cosmetics include serums, lotions, creams, masks, toners, or skin gels.

[0016] Preferably, the composition is present in the cosmetic at a concentration of 0.5-8 wt%.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] This invention combines sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil in a specific mass ratio for use in cosmetics. It improves skin's epidermal moisture content, soothes redness, and repairs the skin barrier. The three components exhibit a significant synergistic effect in achieving these functions. Furthermore, the raw materials in this composition are all-natural and environmentally friendly, highly safe, gentle, and non-irritating. It has good absorption properties, effectively improving the skin feel of skincare products, enhancing spreadability and skin softness after drying, and reducing stickiness. In addition, it not only effectively relieves sensitive skin discomfort in adults but can also alleviate eczema, dry and red skin in infants and young children. Attached Figure Description

[0019] Figure 1 This is a bar chart showing the rate of increase in skin epidermal moisture content by the face cream products corresponding to Examples 1-3 and Comparative Examples 1-6 of the present invention;

[0020] Figure 2 This is a bar chart showing the reduction rate of skin hemoglobin content by the face cream products corresponding to Examples 1-3 and Comparative Examples 1-6 of the present invention;

[0021] Figure 3 This is a bar chart showing the rate of decrease in skin TEWL of the face cream products corresponding to Examples 1-3 and Comparative Examples 1-6 of the present invention. Detailed Implementation

[0022] The technical solutions provided by the present invention will be clearly and completely described below with reference to the accompanying drawings and specific embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] To avoid unnecessary details, unless otherwise specified, all raw materials used in the following examples are commercially available products, and all methods used are conventional methods in the art.

[0024] The sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil used in the following examples and comparative examples are all commercially available products: the sea buckthorn fruit extract is commercially available Tangola™-OPC sea buckthorn proanthocyanidins (manufacturer: Guangzhou Shunqi), with a proanthocyanidin content of 0.05-0.5wt%; the magnolia flower extract is commercially available Youweishu (manufacturer: Shanghai Jiakai), with a magnolol content of over 70wt%; the egg yolk oil is commercially available egg yolk oil (low odor) product (manufacturer: Guangzhou Junmu), with a purity of over 99%.

[0025] Furthermore, the cosmetics prepared in the following embodiments and comparative examples of the present invention are compounded from a base material and a composition having soothing, redness-reducing, and barrier-repairing functions. Taking each embodiment as an example, the sum of the mass percentage of the base material in the corresponding cosmetic and the mass percentage of the composition composed of the three components in each embodiment in the corresponding cosmetic is 100%.

[0026] The sources of the base ingredients and the mass percentage of each ingredient in the cosmetics (such as face creams) prepared by this invention are shown in Table 1.

[0027] Table 1:

[0028] raw material components factory Product Model mass percentage / % Polyglycerol-3-methylglucose distearate Evonik TEGO CARE 450 MB 1-3 Glyceryl stearate citrate Evonik AXOL C 62 0.2-1 Indian Garcinia Cambogia Seed Oil Hallstar Biochemica Kokum Butter Ultra 1-4 Shea butter French OLVEA PRESSED AND REFINED SHEA BUTTER TrueShea 5-10 Cetearyl alcohol Guangzhou Kete Chemical Co., Ltd. EMERCOL® C16-18 30:70 MY 2-6 C13-16 isoparaffins Givaudan France SAS Neossance Hemisqualane 1-5 Caprylic / Capric Triglyceride British Waldner CRODAMOL GTCC - LQ -(SG) 6-15 p-Hydroxyacetophenone Sampdoria Sampo® PHA 0.1-2 diglycerides Sakamoto Pharmaceutical Co., Ltd. Diglycerin S 0.5-3 Butylene glycol Daicel Japan 1,3-Butylene Glycol 1-4 glycerin Wilmar Oils Refined Glycerin 2-6 Sodium acrylate copolymer LUCAS MEYER COSMETICS SAS LECIGEL 0.1-0.4 Sodium polyacrylamide dimethyl taurate Clariant Aristoflex Silk 0.1-0.4 Ethylhexylglycerin Sampdoria Sampo® E100 0.01-0.1 distilled water / / 32.1-79.49

[0029] The following examples and comparative examples all use the above-mentioned base material and the composition with soothing and redness-reducing and barrier-repairing functions provided by the present invention (in the comparative examples, it is a composition of two components or a single component) to prepare face cream products. To highlight the synergistic effects of the composition provided by the present invention in soothing and redness-reducing and barrier-repairing, the examples and comparative examples use the same base material with the same mass percentage of the base material in the face cream product (97.153%), with the remainder being the composition (2.847%). The specific composition of the base material is shown in Table 2.

[0030] Table 2:

[0031] raw material components factory Product Model mass percentage / % Polyglycerol-3-methylglucose distearate Evonik TEGO CARE 450 MB 2 Glyceryl stearate citrate Evonik AXOL C 62 0.5 Indian Garcinia Cambogia Seed Oil Hallstar Biochemica Kokum Butter Ultra 2 Shea butter French OLVEA PRESSED AND REFINED SHEA BUTTER TrueShea 8 Cetearyl alcohol Guangzhou Kete Chemical Co., Ltd. EMERCOL® C16-18 30:70 MY 4 C13-16 isoparaffins Givaudan France SAS Neossance Hemisqualane 3 Caprylic / Capric Triglyceride British Waldner CRODAMOL GTCC - LQ -(SG) 10 p-Hydroxyacetophenone Sampdoria Sampo® PHA 1 diglycerides Sakamoto Pharmaceutical Co., Ltd. Diglycerin S 2 Butylene glycol Daicel Japan 1,3-Butylene Glycol 2.5 glycerin Wilmar Oils Refined Glycerin 3 Sodium acrylate copolymer LUCAS MEYER COSMETICS SAS LECIGEL 0.3 Sodium polyacrylamide dimethyl taurate Clariant Aristoflex Silk 0.2 Ethylhexylglycerin Sampdoria Sampo® E100 0.05 distilled water / / 58.603

[0032] In the preparation of face cream products using compound formulations in Examples 1-3, the mass fractions of sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil in the compositions with soothing and redness-reducing and barrier-repairing functions are shown in Table 3.

[0033] Table 3:

[0034] Examples 1-3 Sea buckthorn fruit extract Magnolia flower extract Egg yolk oil 1 0.04 0.1 1.2 2 0.05 0.05 1 3 0.1 0.5 2

[0035] In the preparation of face cream products by compounding Comparative Examples 1-3, each was based on Example 1. The compounded components were any two of the following: sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil (i.e., the composition was missing any one component, and the remaining two components together accounted for 2.847% of the face cream product by mass). The mass percentages of the remaining two components are shown in Table 4.

[0036] Table 4:

[0037] Comparative Example Sea buckthorn fruit extract Magnolia flower extract Egg yolk oil 1 - 0.1 1.2 2 0.04 - 1.2 3 0.04 0.1 -

[0038] In the preparation of face cream products using the compounding method in Comparative Examples 4-6, based on Example 1, one of the following was compounded with the base material: sea buckthorn fruit extract, magnolia flower extract, and egg yolk oil. Specifically, in the face cream product corresponding to Comparative Example 4, sea buckthorn fruit extract (accounting for 2.847% of the face cream product by mass) was compounded with the base material; in the face cream product corresponding to Comparative Example 5, magnolia flower extract (accounting for 2.847% of the face cream product by mass) was compounded with the base material; and in the face cream product corresponding to Comparative Example 6, egg yolk oil (accounting for 2.847% of the face cream product by mass) was compounded with the base material.

[0039] The following are test examples of performance testing of the face cream products obtained in Examples 1 to 3 and Comparative Examples 1 to 6.

[0040] Test Example 1: Epidermal Moisture Content Test

[0041] 1.1 Experimental Method Details

[0042] Testing instrument: Skin moisture meter (Cornemeter CM825, Courage + Khazaka, Germany).

[0043] Subjects: Thirty healthy volunteers (20 women and 10 men) aged 25–45 years with dry to combination skin and no history of systemic diseases or dermatological conditions were recruited to meet the criteria for sensitive skin. Informed consent was obtained before the trial.

[0044] Test area: Both sides of the cheek area, marked with 3 fixed test points (2 cm in diameter).

[0045] Test conditions: ambient temperature 22±2°C, relative humidity 50±5%, subjects sat quietly in this environment for 30 minutes before the test.

[0046] Test procedure: On day 0, the initial stratum corneum moisture content (AU) was measured; after cleansing in the morning and evening, 0.1 g of the cream from the example or comparative example was applied evenly to the test area, and the moisture content was measured at the same time point on days 7, 14, and 28. Each test point was measured 3 times, and the average value was taken.

[0047] Data calculation: Moisture content increase rate (%) = (Moisture content after test - Initial moisture content) / Initial moisture content × 100%.

[0048] 1.2 Statistical Analysis

[0049] Data analysis was performed using SPSS 26.0 software. Data are expressed as mean ± standard deviation (Mean ± SD). Paired-samples t-tests were used for within-group comparisons, and one-way ANOVA was used for between-group comparisons. If significant differences were found, Tukey multiple comparisons were performed. The significance level was set at P < 0.05.

[0050] 1.3 Test Results

[0051] After using the face cream products prepared in Examples 1-3 and Comparative Examples 1-6, the increase rate of skin stratum corneum moisture content after using the lotion containing the composition of the present invention was measured using a skin moisture meter. The increase rate of epidermal moisture content (after 28 days of use) is shown in Table 5. Figure 1 As shown.

[0052] Table 5:

[0053] Group Sea buckthorn fruit extract (per serving) Magnolia flower extract (per serving) Egg yolk oil (serves) Moisture content increase rate (%) Average data deviation Example 1 0.04 0.1 1.2 35.0*# 0.52 Example 2 0.05 1 1 33.5*# 0.46 Example 3 0.1 0.5 2 34.2*# 0.60 Comparative Example 1 - 0.1 1.2 22.0* 0.88 Comparative Example 2 0.04 - 1.2 23.0* 0.73 Comparative Example 3 0.04 0.1 - 21.5* 1.05 Comparative Example 4 0.04 – – 9.0* 1.15 Comparative Example 5 – 0.1 – 7.5* 1.32 Comparative Example 6 – 1.2 10.0* 1.10 Blank control group – – – 4.0

[0054] Note: * indicates a significant difference compared to the blank control group (P < 0.05); # indicates a significant difference compared to comparative examples 1-3 (P < 0.05).

[0055] From Table 5 and Figure 1 It can be seen that the face cream products corresponding to Examples 1-3 have a significantly higher rate of improvement in skin epidermal moisture content than Comparative Examples 1-6. Analysis of the specific improvement rate data shows that sea buckthorn fruit extract, magnolia flower extract and egg yolk oil have a significant synergistic effect in improving skin moisture content.

[0056] Test Example 2: Soothing and Redness Reduction Test

[0057] 2.1 Experimental Method Details

[0058] Testing instruments: Skin hemoglobin meter (Mexameter MX18, Courage + Khazaka, Germany); patch test materials (Finn Chambers, SmartPractice).

[0059] Subjects: 30 volunteers from the same test case 1.

[0060] Test areas: For heme testing, the test site is a 2 cm × 2 cm area on the inner side of the forearm; for patch testing, the test site is healthy skin on both sides of the spine on the back.

[0061] Test process:

[0062] A. Heme content determination:

[0063] On day 0, the initial heme content (AU) was measured. The test sample was applied every morning and evening for 14 consecutive days. The heme content was measured at the same time point on days 7 and 14.

[0064] B. 48-hour closed patch test:

[0065] Add 20 mg of sample to each well, cover the skin, remove after 48 hours, and observe the skin reaction (erythema, edema) at 0.5, 24, and 48 hours. Score according to the "Technical Specifications for Safety Evaluation of Cosmetics" (0–4 points).

[0066] Data calculation: Heme reduction rate (%) = (initial value - post-test value) / initial value × 100%.

[0067] 2.2 Statistical Analysis:

[0068] Heme data were analyzed using repeated measures ANOVA, and patch test stimulation rates were analyzed using the chi-square test (χ²).

[0069] P < 0.05 is considered statistically significant.

[0070] 2.3 Test Results

[0071] Table 6 shows the reduction rate of skin hemoglobin content and irritation rate (after 14 days of use) after subjects used the face cream products prepared in Examples 1-3 and Comparative Examples 1-6. A bar chart was also created to show the data on the reduction rate of skin hemoglobin content. Figure 2 As shown.

[0072] Table 6:

[0073] Group Heme content reduction rate % Average data deviation Irritation rate (number of people experiencing erythema / edema) Example 1 30.0*# 0.38 0 / 30 Example 2 28.5*# 0.55 0 / 30 Example 3 29.2*# 0.44 0 / 30 Comparative Example 1 18.0* 0.95 2 / 30 Comparative Example 2 19.0* 0.82 3 / 30 Comparative Example 3 17.5* 0.77 2 / 30 Comparative Example 4 7.0* 1.23 2 / 30 Comparative Example 5 6.0* 1.18 2 / 30 Comparative Example 6 8.0* 1.27 1 / 30 Blank control group 3.1 - 1 / 30

[0074] Note: * indicates a significant difference compared to the blank control group (P < 0.05); # indicates a significant difference compared to comparative examples 1-3 (P < 0.05).

[0075] From Table 6 and Figure 2 It can be seen that, through the determination of skin hemoglobin content and patch test, the improvement of skin redness after use was evaluated. The example group showed better redness reduction effect and lower irritation rate. Moreover, the test data analysis showed that sea buckthorn fruit extract, magnolia flower extract and egg yolk oil had a significant synergistic effect in reducing skin redness.

[0076] Test Example 3: Barrier Repair Test

[0077] 3.1 Experimental Method Details

[0078] Testing instrument: Transdermal moisture loss meter (Tewameter TM300, Courage + Khazaka, Germany).

[0079] Subjects: 30 volunteers diagnosed with impaired barrier function (initial TEWL value ≥15 g / h·m²) aged 28-50 years.

[0080] Test area: Both sides of the cheek area, marked with 3 fixed test points.

[0081] Test conditions: Same as test example 1.

[0082] Test procedure: Measure the initial TEWL value (g / h·m²) on day 0. Use the test sample every morning and evening for 28 consecutive days. Measure the TEWL value on days 7, 14 and 28. Repeat the measurement 3 times for each test point and take the average value.

[0083] Data calculation: TEWL decline rate (%) = (Initial TEWL - Post-test TEWL) / * Initial TEWL * 100%

[0084] 3.2 Statistical analysis: Repeated measures ANOVA was used, and Bonferroni correction was used for comparisons between groups. P < 0.01 was considered highly significant.

[0085] 3.3 Test Results

[0086] The rate of decrease in transdermal water loss (TEWL) after subjects used the face cream products prepared in Examples 1-3 and Comparative Examples 1-6 (after 28 days of use) is shown in Table 7. Figure 3 As shown.

[0087] Table 7:

[0088] Group TEWL decrease rate (%) Average data deviation Example 1 45.0*# 0.64 Example 2 43.0*# 0.41 Example 3 44.0*# 0.49 Comparative Example 1 28.0* 0.79 Comparative Example 2 30.0* 0.91 Comparative Example 3 27.0* 0.84 Comparative Example 4 12.0* 1.08 Comparative Example 5 10.0* 1.25 Comparative Example 6 13.0* 1.20 Blank control group 5.0

[0089] Note: * indicates P < 0.05; # indicates a significant difference compared to comparative examples 1-3 (P < 0.05).

[0090] From Table 7 and Figure 3 It can be seen that the TEWL value of the example group decreased significantly, and the barrier repair effect was better than that of the control group. The analysis of the test data shows that sea buckthorn fruit extract, magnolia flower extract and egg yolk oil have a significant synergistic effect in improving skin barrier repair.

[0091] In summary, the combination of sea buckthorn fruit extract, magnolia flower extract and egg yolk oil provided by this invention has a synergistic effect in improving skin epidermal moisture content, soothing redness and repairing the skin barrier. It is suitable for various skin care products, especially for sensitive skin and skin with a damaged barrier.

[0092] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition having soothing and redness-reducing properties and a barrier-repairing function, characterized in that, The ingredients include the following parts by weight: 0.01-0.1 parts sea buckthorn fruit extract, 0.01-1 parts magnolia flower extract, and 1-5 parts egg yolk oil; Among them, the sea buckthorn fruit extract uses commercially available Tangola™-OPC sea buckthorn proanthocyanidins, with a proanthocyanidin content of 0.05-0.5wt%; the magnolia flower extract uses commercially available Youweishu, with a magnolia lipoprotein content of over 70wt%; and the egg yolk oil uses commercially available egg yolk oil products with a purity of over 99%.

2. The composition with soothing redness-reducing and barrier-repairing functions according to claim 1, characterized in that, The mass ratio of the sea buckthorn fruit extract, the magnolia flower extract, and the egg yolk oil is (0.01-0.05):(0.05-0.5):(1-2).

3. The composition with soothing redness-reducing and barrier-repairing functions according to claim 2, characterized in that, The mass ratio of the sea buckthorn fruit extract, the magnolia flower extract, and the egg yolk oil is 0.04:0.1:1.

2.

4. The use of a composition having soothing redness-reducing and barrier-repairing functions as described in any one of claims 1 to 3 in the preparation of cosmetics.

5. The application according to claim 4, characterized in that, The cosmetics include serums, lotions, creams, masks, toners, or skin gels.

6. The application according to claim 4, characterized in that, The composition is present in cosmetics at a concentration of 0.5-8 wt%.

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