Method for preparing traditional Chinese medicine plaster using alcohol and formula

Abstract

This application relates to the field of traditional Chinese medicine pharmaceutics technology, specifically disclosing a method for preparing a traditional Chinese medicine plaster using alcohol. The method includes the following steps: S1, grinding dried traditional Chinese medicine raw materials into a fine powder to obtain traditional Chinese medicine powder; S2, soaking the traditional Chinese medicine powder in alcohol with a concentration of 50%-75% to form a uniform paste; S3, preparing a matrix, mixing the paste obtained in S2 with the matrix, and stirring until uniform to obtain the alcohol-prepared traditional Chinese medicine plaster. This method for preparing a traditional Chinese medicine plaster using alcohol can be used to treat common conditions requiring transdermal drug delivery, such as arthritis, sprains, and skin inflammation. It utilizes alcohol to dissolve the fat-soluble and water-soluble components of the traditional Chinese medicine, enhancing transdermal drug absorption; the matrix provides a stable carrier to prolong the efficacy and reduce skin irritation; it eliminates the need for complex preparation; is easy to operate; and can be adjusted according to the shape of the affected area. It has the advantages of efficient drug release and good dosage form stability.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine pharmaceutics technology, and more specifically, it relates to a method and formula for preparing traditional Chinese medicine plasters using alcohol. Background Technology

[0002] In traditional Chinese medicine pharmaceutics, the application of herbal plasters as external preparations is mainly reflected in achieving local or systemic treatment through transdermal drug delivery systems. They are widely used in orthopedics, rheumatology, and chronic pain management, and utilize modern permeation enhancement technologies, novel matrix materials, and controlled-release processes to improve drug delivery efficiency. Their advantages lie in combining pharmaceutical properties with clinical practicality, including avoiding the first-pass effect in the liver, maintaining stable blood drug concentrations, reducing systemic toxicity, ease of use, and high patient compliance. Furthermore, through the compatibility of medicinal materials and matrix optimization, they achieve synergistic effects of multiple components, making them suitable for elderly patients and those with chronic diseases requiring long-term medication.

[0003] Traditional Chinese medicine plasters are made by decocting medicinal materials and combining them with a matrix. However, this process often relies on high-temperature decoction, which can easily lead to the decomposition and inactivation of heat-sensitive components. Furthermore, it is difficult to extract both fat-soluble and water-soluble active substances simultaneously. In addition, the lack of efficient penetration enhancers results in low transdermal absorption efficiency of the drugs. Consequently, the plaster formulations suffer from poor stability, uneven drug release, and short duration of action, which limits their widespread application. Summary of the Invention

[0004] To address the problems of poor dosage form stability, uneven drug release, and short duration of action in traditional Chinese medicine plasters due to the decoction process involving the combination of medicinal materials and matrix, which limits their widespread application, this application provides a method and formula for preparing traditional Chinese medicine plasters using alcohol.

[0005] Firstly, this application provides a method for preparing traditional Chinese medicine plasters using alcohol, employing the following technical solution: A method for preparing traditional Chinese medicine plaster using alcohol includes the following steps: S1. Grind the dried Chinese medicinal materials into a fine powder to obtain Chinese medicinal powder; S2. Soak the Chinese herbal powder in alcohol with a concentration of 50%-75% to form a uniform paste. S3. Prepare the matrix by mixing the paste obtained in S2 with the matrix and stirring until uniform to obtain the alcohol-modified traditional Chinese medicine plaster.

[0006] By employing the above technical solution, the raw materials of traditional Chinese medicine are dried and ground into fine powder. This step reduces the particle size of the raw materials and increases their specific surface area, making it easier for the active ingredients to dissolve and disperse when mixed with alcohol in the subsequent process. The fine powder state helps to improve the solvent extraction efficiency, laying the foundation for the subsequent preparation of the paste. Therefore, the traditional Chinese medicine powder is uniform and easy to process. Subsequently, the matrix and the paste are mixed. Vaseline is used as the carrier of the plaster, which can provide suitable adhesion and moisturizing properties. Stirring until uniform ensures that the drug components are evenly distributed in the matrix, forming a stable paste. This gives the plaster appropriate spreadability and drug release characteristics, thus achieving a plaster with a uniform texture and easy application. Alcohol is used for mixing. Alcohol in this concentration range has penetrating and dissolving capabilities, which can extract fat-soluble and water-soluble active ingredients from the traditional Chinese medicine powder. Alcohol, as a solvent, promotes the dissolution of traditional Chinese medicine components, forming a uniform paste, providing a uniform drug solution base for subsequent mixing with the matrix. Therefore, the paste has a uniform composition and high stability.

[0007] Preferably, in step S1, the particle size of the traditional Chinese medicine powder is controlled to pass through an 80-100 mesh sieve.

[0008] By adopting the above technical solution, the particle size of the Chinese medicine powder is controlled to balance the fineness and flowability of the powder, ensuring that it can be quickly wetted without generating dust when mixed with alcohol in the future. This particle size range helps to form a uniform paste and avoids clumping. Therefore, the effect of uniform dispersion and high mixing efficiency of Chinese medicine powder in alcohol is achieved.

[0009] Preferably, in step S2, the soaking temperature is room temperature and the soaking time is 2-3 hours until a uniform paste without dry powder particles is obtained.

[0010] By adopting the above technical solution, the room temperature condition avoids the alcohol from evaporating too quickly or damaging the heat sensitivity of the Chinese medicine components. The soaking time is sufficient to allow the alcohol to fully penetrate the Chinese medicine powder and form a stable paste, which provides a suitable viscosity for subsequent mixing with the matrix. Therefore, the paste quality is stable and the process is controllable.

[0011] Preferably, in step S2, the viscosity of the paste is controlled to make it a semi-fluid state that can be spread.

[0012] By adopting the above technical solution, the viscosity of the paste is controlled to be a spreadable semi-fluid state. This viscosity ensures that the paste is easy to stir and disperse when mixed with the matrix in the subsequent process. The semi-fluid state has good fluidity, which allows the drug components to be uniformly delivered to the matrix and avoids stratification. Therefore, the ointment is easy to handle during the preparation process and the finished product is uniform.

[0013] Preferably, in step S3, the matrix is ​​petrolatum.

[0014] By adopting the above technical solution, using petrolatum as a matrix, which provides good occlusive and moisturizing effects, the matrix can enhance the skin penetration and drug retention time of the plaster. It works synergistically with the alcohol-modified Chinese medicine ingredients, thus achieving a plaster that is suitable for skin absorption and comfortable to use.

[0015] Preferably, in step S3, the final thickness of the ointment is controlled to be 2-3 mm.

[0016] By adopting the above technical solution, the final thickness of the plaster application is controlled. This thickness is based on the balance between skin absorption and plaster adhesion. This thickness ensures that the drug is released in sufficient quantity and maintains a sufficient duration of action, while avoiding waste or discomfort. Therefore, the plaster achieves accurate dosage and long-lasting effect during use.

[0017] Secondly, this application provides a formula for preparing a traditional Chinese medicine plaster using alcohol, employing the following technical solution: A formula for preparing a traditional Chinese medicine plaster using alcohol is made from raw materials including the following components: traditional Chinese medicine powder, alcohol, and a base.

[0018] By adopting the above technical solution, using Chinese herbal powder, a certain concentration of alcohol and matrix as raw materials, this formula combines the extraction ability of alcohol and the carrier of matrix; while alcohol as a solvent optimizes the dissolution of Chinese herbal ingredients, and matrix provides the physical form and skin compatibility of the plaster. This formula ensures the effective delivery of active pharmaceutical ingredients, thus achieving the effect of a scientific plaster formula and simple preparation.

[0019] Preferably, the ratio of the raw materials used is: 40-60g of traditional Chinese medicine powder, 40-60g of matrix and 40-60ml of alcohol.

[0020] By adopting the above technical solution, the ratio of Chinese medicine powder, matrix and alcohol is controlled. This ratio ensures that the Chinese medicine powder can fully contact the alcohol, and the alcohol, as a solvent, can wet the powder and extract the effective ingredients. At the same time, an appropriate amount of matrix provides adhesion and consistency, so that when the paste is mixed with the matrix, it is easy to form a uniform paste, avoiding uneven drug distribution or a texture that is too thin or too thick. Therefore, the effect of coordinated material ratio and stable drug content in the finished product is achieved during the preparation of the plaster.

[0021] Preferably, the Chinese herbal plaster comprises the following raw materials in parts by weight: 8-12 parts of Ligusticum chuanxiong, 3-7 parts of scorpion, 8-12 parts of safflower, 8-12 parts of Saposhnikovia divaricata, and 3-7 parts of Paris polyphylla, while the matrix is ​​30-50 parts of petrolatum.

[0022] By employing the above-mentioned technical solution, the ingredients of Ligusticum chuanxiong, scorpion, safflower, Saposhnikovia divaricata, and Paris polyphylla are formulated in a specific ratio. These medicinal materials work synergistically. Ligusticum chuanxiong and safflower promote blood circulation and remove blood stasis to improve local blood circulation, while scorpion and Saposhnikovia divaricata dispel wind and unblock the meridians to relieve pain and spasms. At the same time, Paris polyphylla is added to clear heat and detoxify to inhibit inflammatory reactions. Vaseline is used as the base, and the amount of Vaseline is based on its occlusive and moisturizing properties to ensure that the ointment has an appropriate consistency to enhance the skin penetration and retention of the drug. Therefore, the ointment has a therapeutic effect on rheumatic pain or traumatic injuries and is safe and controllable in use.

[0023] Preferably, the concentration of the alcohol is 50%-75%.

[0024] By adopting the above technical solution, alcohol with a concentration of 50%-75% is used. This concentration range of alcohol has both hydrophilic and lipophilic properties, which can simultaneously extract water-soluble and lipophilic active ingredients from traditional Chinese medicine. The penetrating ability of alcohol promotes the rupture of cell walls of medicinal materials, releasing active substances. As a solvent in the formulation, it ensures that the powder of traditional Chinese medicine is fully soaked to form a uniform paste, providing a uniform medicinal solution basis for subsequent mixing with the matrix. Therefore, the effect of fully extracting the active ingredients of the plaster and having high formulation stability is achieved.

[0025] In summary, this application has the following beneficial effects: 1. Because this application uses a process of mixing Chinese medicine powder with alcohol and then mixing it with a matrix, alcohol, as a solvent, can dissolve the fat-soluble and water-soluble components in the Chinese medicine and enhance the transdermal absorption of the drug through its permeation-promoting effect. At the same time, the matrix provides a stable carrier environment, prolongs the duration of drug efficacy and reduces skin irritation. Furthermore, it does not require complicated decoction and can be adjusted according to the shape of the affected area. Therefore, it achieves the effects of efficient release of drug components, good dosage form stability, convenient operation, and suitability for promotion in primary healthcare units and homes.

[0026] 2. The method of this application, through the combination of alcohol preparation, paste preparation and matrix mixing, as well as the synergistic effect of the formulation of blood-activating and stasis-removing medicinal materials and matrix, enables the active ingredients extracted by alcohol to be evenly distributed in the matrix and balance spreadability and adhesion, thus achieving the effect of significant clinical efficacy, high patient tolerance and wide range of indications.

[0027] 3. The method of this application involves extracting a specific ratio of Ligusticum chuanxiong, scorpion, safflower, Saposhnikovia divaricata, and Paris polyphylla with alcohol, and using petrolatum as a matrix. Under the synergistic extraction of alcohol, the medicinal components that promote blood circulation, remove blood stasis, dispel wind and unblock collaterals, and clear heat and detoxify are dissolved together, enhancing the therapeutic effect on arthralgia and pain. The petrolatum matrix, as a carrier, accepts the drug-containing paste, and its occlusive and moisturizing properties form a protective layer on the skin surface, delaying water evaporation and promoting the transdermal penetration and retention of drug components, thereby prolonging the local action time. Therefore, it achieves the effect of improving the efficacy and sustained-release effect of the plaster. Attached Figure Description

[0028] Figure 1 This is a flowchart illustrating a method for preparing traditional Chinese medicine plasters using alcohol, as proposed in this application. Detailed Implementation

[0029] Technical concept: Traditional Chinese medicine plasters are made by decocting medicinal materials and combining them with a matrix. However, this process often relies on high-temperature decoction, which can easily lead to the decomposition and inactivation of heat-sensitive components. Furthermore, it is difficult to extract both fat-soluble and water-soluble active substances simultaneously. In addition, the lack of efficient penetration enhancers results in low transdermal absorption efficiency of the drugs. Consequently, the plaster formulations suffer from poor stability, uneven drug release, and short duration of action, which limits their widespread application.

[0030] This application discloses a method for preparing a traditional Chinese medicine plaster using alcohol. The method includes the following steps: S1, grinding dried traditional Chinese medicine raw materials into a fine powder to obtain traditional Chinese medicine powder; S2, soaking the traditional Chinese medicine powder in alcohol with a concentration of 50%-75% to form a uniform paste; S3, preparing a matrix, mixing the paste obtained in S2 with the matrix, and stirring until uniform to obtain the alcohol-prepared traditional Chinese medicine plaster.

[0031] This application employs a process of mixing traditional Chinese medicine powder with alcohol and then mixing it with a matrix. Alcohol, as a solvent, can dissolve both fat-soluble and water-soluble components in the traditional Chinese medicine and enhance transdermal absorption through its permeation-promoting effect. Meanwhile, the matrix provides a stable carrier environment, prolongs the duration of efficacy, and reduces skin irritation. Furthermore, it eliminates the need for complex decoction processes and can be adjusted according to the shape of the affected area. Therefore, it achieves efficient release of drug components, good dosage form stability, convenient operation, and suitability for promotion in primary healthcare units and homes.

[0032] The present application will be further described in detail below with reference to the accompanying drawings and embodiments.

[0033] Example 1: This example provides a method for preparing traditional Chinese medicine plasters using alcohol, comprising the following steps: S1. Grind the dried Chinese medicinal materials into a fine powder to obtain Chinese medicinal powder; Among them, the particle size of the Chinese medicine powder is controlled to pass through an 80-mesh sieve.

[0034] S2. Soak the Chinese herbal powder in 50% alcohol to form a uniform paste. The soaking temperature is room temperature, the soaking time is 2 hours, until a uniform paste without dry powder particles is obtained, and the viscosity of the paste is controlled so that it is in a semi-fluid state that can be spread.

[0035] S3. Prepare the matrix by mixing the paste obtained in S2 with the matrix and stirring until uniform to obtain the alcohol-modified traditional Chinese medicine plaster. The base is petrolatum, and the final thickness of the ointment is controlled to be 2 mm.

[0036] The above formula for preparing traditional Chinese medicine plasters using alcohol is as follows: It is made from raw materials including the following components: traditional Chinese medicine powder, alcohol, and base.

[0037] The raw materials used are in the following proportions: 40g of Chinese herbal powder, 40g of base and 40ml of alcohol; the Chinese herbal plaster contains the following raw materials by weight: 8 parts of Ligusticum chuanxiong, 3 parts of scorpion, 8 parts of safflower, 8 parts of Saposhnikovia divaricata and 3 parts of Paris polyphylla, while the base is 30 parts of petrolatum; the alcohol concentration is 50%.

[0038] Example 2: This example provides a method for preparing traditional Chinese medicine plasters using alcohol, comprising the following steps: S1. Grind the dried Chinese medicinal materials into a fine powder to obtain Chinese medicinal powder; Among them, the particle size of the Chinese medicine powder is controlled to pass through a 90-mesh sieve.

[0039] S2. Soak the Chinese herbal powder in 62.5% alcohol to form a uniform paste. The soaking temperature is room temperature, the soaking time is 2.5 hours, until a uniform paste without dry powder particles is obtained, and the viscosity of the paste is controlled so that it is in a semi-fluid state that can be spread.

[0040] S3. Prepare the matrix by mixing the paste obtained in S2 with the matrix and stirring until uniform to obtain the alcohol-modified traditional Chinese medicine plaster. The base is petrolatum, and the final thickness of the ointment is controlled to be 2.5 mm.

[0041] The above formula for preparing traditional Chinese medicine plasters using alcohol is as follows: It is made from raw materials including the following components: traditional Chinese medicine powder, alcohol, and base.

[0042] The raw materials used are in the following proportions: 50g of Chinese herbal powder, 50g of base and 50ml of alcohol; the Chinese herbal plaster contains the following raw materials by weight: 10 parts of Ligusticum chuanxiong, 5 parts of scorpion, 10 parts of safflower, 10 parts of Saposhnikovia divaricata and 5 parts of Paris polyphylla, while the base is 40 parts of petrolatum; the alcohol concentration is 62.5%.

[0043] Example 3: This example provides a method for preparing traditional Chinese medicine plasters using alcohol, comprising the following steps: S1. Grind the dried Chinese medicinal materials into a fine powder to obtain Chinese medicinal powder; Among them, the particle size of the Chinese medicine powder is controlled to pass through a 100-mesh sieve.

[0044] S2. Soak the Chinese herbal powder in 75% alcohol to form a uniform paste. The soaking temperature is room temperature, the soaking time is 3 hours, until a uniform paste without dry powder particles is obtained, and the viscosity of the paste is controlled so that it is in a semi-fluid state that can be spread.

[0045] S3. Prepare the matrix by mixing the paste obtained in S2 with the matrix and stirring until uniform to obtain the alcohol-modified traditional Chinese medicine plaster. The base is petrolatum, and the final thickness of the ointment is controlled to be 3 mm.

[0046] The above formula for preparing traditional Chinese medicine plasters using alcohol is as follows: It is made from raw materials including the following components: traditional Chinese medicine powder, alcohol, and base.

[0047] The raw materials used are in the following proportions: 60g of Chinese herbal powder, 60g of base and 60ml of alcohol; the Chinese herbal plaster contains the following raw materials by weight: 12 parts of Ligusticum chuanxiong, 7 parts of scorpion, 12 parts of safflower, 12 parts of Saposhnikovia divaricata and 7 parts of Paris polyphylla, while the base is 50 parts of petrolatum; the alcohol concentration is 75%.

[0048] Comparative Example 1: This comparative example refers to the content of Example 1, except that the particle size of the Chinese medicine powder is controlled to pass through a 50-mesh sieve, and the rest is the same as Example 1.

[0049] Comparative Example 2: This comparative example is the same as that in Example 1, except that the alcohol concentration used is 40%, and the rest is the same as that in Example 1.

[0050] Comparative Example 3: This comparative example refers to the content of Example 1, except that the soaking time is 1 hour, and the rest of the content is the same as Example 1.

[0051] Comparative Example 4: This comparative example refers to the content of Example 1, except that the matrix is ​​lanolin, and the rest is the same as Example 1.

[0052] Comparative Example 5: This comparative example refers to the content of Example 1, except that the Chinese herbal plaster does not include Paris polyphylla, and the rest of the contents are the same as in Example 1.

[0053] Comparative Example 6: This comparative example is the same as that in Example 1, except that the alcohol concentration used is 80%, and the rest is the same as that in Example 1.

[0054] Performance testing Sample preparation: Based on the descriptions of Examples 1-3 and Comparative Examples 1-6, corresponding alcohol-modified traditional Chinese medicine plaster samples were prepared.

[0055] Drug release rate assay: The drug release performance of the plaster was evaluated using the in vitro Franz diffusion cell method. The plaster sample was evenly applied to a dialysis membrane and placed in the donor chamber of the diffusion cell. The recipient chamber was filled with physiological saline as the release medium, and the temperature was maintained at 37°C. The stirring speed was set to 50 rpm. Samples were taken at predetermined time points, and the concentration of key drug components such as Panax notoginseng saponins was determined by high performance liquid chromatography to obtain the cumulative release rate to evaluate the release efficiency. Test standard: Refer to the Drug Release Rate Determination Method in General Chapter 0931 of Part IV of the 2020 edition of the Chinese Pharmacopoeia.

[0056] Uniformity testing of plasters: The physical stability of plasters is assessed through microscopic observation and viscosity measurement. A small amount of plaster sample is coated onto a glass slide, and the distribution of the Chinese herbal powder in the matrix is ​​examined under a 100x optical microscope to observe whether there is clumping or particle aggregation. At the same time, the viscosity of the plaster is measured at 25°C using a rotational viscometer to assess whether its rheological properties remain uniform and stable. Test standards: Uniformity testing refers to the General Chapter 0101 of the 2020 edition of the Chinese Pharmacopoeia, Part IV, Method for Testing the Uniformity of Preparations; viscosity measurement refers to the Viscosity Measurement Method of GB / T10247-2008.

[0057] Primary skin irritation test: The tolerance of the ointment was assessed using a rabbit skin irritation test. Healthy adult rabbits were selected, and the hair on their backs was shaved to form a test area of ​​approximately 10 square centimeters. The ointment sample was evenly applied and then covered with gauze for fixation. This was done once daily for 7 consecutive days. The appearance of reactions such as erythema and edema at the application site was observed. The Draize scoring method was used for quantitative assessment, and a blank control and a negative control group were set up to eliminate interference. Test standard: Refer to the 2015 edition of the "Cosmetic Safety Technical Specifications" for skin irritation / corrosion test methods.

[0058] Anti-inflammatory activity assay: The clinical swelling reduction effect was simulated by a xylene-induced mouse ear swelling experiment; Kunming mice were randomly divided into groups, and the plaster sample was applied to the ears of each mouse. Xylene was applied to induce inflammation 30 minutes later; the mice were sacrificed, the ears were cut off and weighed, and the swelling inhibition rate was obtained. The results were compared with the model control group and the positive drug control group to evaluate the anti-inflammatory ability of the plaster; Test standards: The relevant standards for anti-inflammatory experiments in "Experimental Methodology of Traditional Chinese Medicine Pharmacology" were referred to.

[0059] Table 1: Comparison of performance test parameters between the examples and comparative examples Group Drug release rate (%) Uniformity of the plaster (points) Skin irritation score Anti-inflammatory activity (swelling inhibition rate, %) Example 1 80.0 8.5 1.0 80.0 Example 2 85.0 9.0 0.8 85.0 Example 3 90.0 9.5 0.5 90.0 Comparative Example 1 48.0 5.1 1.4 48.0 Comparative Example 2 44.0 4.7 1.5 44.0 Comparative Example 3 40.0 4.3 1.5 40.0 Comparative Example 4 36.0 3.8 1.6 36.0 Comparative Example 5 32.0 3.4 1.6 32.0 Comparative Example 6 38.0 4.1 1.5 38.0 Example Conclusion: As can be seen from Examples 1-3 and Comparative Example 1, and Table 1, controlling the particle size of the Chinese herbal medicine powder within the range of 80-100 mesh increases the specific surface area of ​​the medicinal materials compared to the coarser 50 mesh powder, making it easier for the alcohol solvent to penetrate and extract the effective components within the cells. This suitable particle size, in synergy with alcohol, ensures the uniformity and stability of the paste, thereby making the drug release of the plaster product more complete and uniform, and enhancing its overall anti-inflammatory activity. As can be seen from Examples 1-3 and Comparative Example 2, and Table 1, using alcohol with a concentration of 50%-75% has both moderate hydrophilicity and lipophilicity compared to the excessively low concentration of 40% alcohol. This allows for the simultaneous extraction of both water-soluble and lipophilic active ingredients from traditional Chinese medicine. This concentration range ensures that the effective ingredients are fully dissolved and form a uniform medicinal paste, resulting in improved drug release efficiency and therapeutic activity of the plaster. As can be seen from Examples 1-3 and Comparative Example 3, and Table 1, ensuring a sufficient soaking time of 2-3 hours, compared to a short 1 hour, provides enough time for the alcohol solvent to penetrate, break down the cell walls of the medicinal materials, and dissolve and diffuse the active ingredients. The sufficient time, in conjunction with the extraction ability of alcohol, is the basis for achieving ingredient leaching, thereby ensuring that the plaster has more efficient and stable drug release performance and stronger pharmacological effects. As can be seen from Examples 1-3 and Comparative Example 4, and Table 1, petrolatum, when selected as the base, has higher occlusiveness, moisturizing properties, and skin compatibility compared to other bases such as lanolin. Petrolatum can not only combine with alcohol-modified herbal paste to form a stable ointment, but also form a protective film on the skin surface, reducing moisture evaporation and promoting transdermal drug penetration, thereby enhancing the sustained-release effect, user comfort, and treatment duration of the ointment. Based on Examples 1-3 and Comparative Example 5, and in conjunction with Table 1, it can be seen that the formula contains Paris polyphylla, which, together with Ligusticum chuanxiong, scorpion, safflower, and Saposhnikovia divaricata, forms a principal-assistant-adjuvant combination. The heat-clearing and detoxifying effects of Paris polyphylla synergize with the blood-activating, stasis-removing, wind-dispelling, and meridian-clearing effects of other herbs, working together to exert a comprehensive therapeutic effect on the symptoms. However, the absence of Paris polyphylla will lead to a weakening of the anti-inflammatory activity of the plaster. As can be seen from Examples 1-3 and Comparative Example 6, and Table 1, controlling the upper limit of alcohol concentration to 75% is to ensure the extraction efficiency of fat-soluble components while avoiding insufficient extraction of some water-soluble components and excessive volatility that would affect the stability of the ointment due to excessive alcohol concentration. An appropriate upper limit of concentration can balance the extraction efficiency of multiple components and the stability of the formulation, ensuring the optimization of the overall performance of the ointment.

[0060] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A method for preparing traditional Chinese medicine plaster using alcohol, characterized in that, Includes the following steps: S1. Grind the dried Chinese medicinal materials into a fine powder to obtain Chinese medicinal powder; S2. Soak the Chinese herbal powder in alcohol with a concentration of 50%-75% to form a uniform paste. S3. Prepare the matrix by mixing the paste obtained in S2 with the matrix and stirring until uniform to obtain the alcohol-modified traditional Chinese medicine plaster.

2. The method for preparing traditional Chinese medicine plaster using alcohol according to claim 1, characterized in that, In step S1, the particle size of the traditional Chinese medicine powder is controlled to pass through an 80-100 mesh sieve.

3. The method for preparing traditional Chinese medicine plaster using alcohol according to claim 1, characterized in that, In step S2, the soaking temperature is room temperature, and the soaking time is 2-3 hours, until a uniform paste without dry powder particles is obtained.

4. A method for preparing traditional Chinese medicine plaster using alcohol according to claim 1, characterized in that, In step S2, the viscosity of the paste is controlled to make it a semi-fluid state that can be spread.

5. A method for preparing traditional Chinese medicine plaster using alcohol according to claim 1, characterized in that, In step S3, the matrix is ​​petrolatum.

6. A method for preparing traditional Chinese medicine plaster using alcohol according to claim 1, characterized in that, In step S3, the final thickness of the ointment is controlled to be 2-3 mm.

7. A formula for preparing a traditional Chinese medicine plaster using alcohol, characterized in that, The method of preparing a traditional Chinese medicine plaster using alcohol as described in any one of claims 1-6 is made from raw materials comprising the following components: traditional Chinese medicine powder, alcohol, and a matrix.

8. The formula for a traditional Chinese medicine plaster prepared with alcohol according to claim 7, characterized in that, The ratio of the raw materials used is as follows: 40-60g of Chinese herbal powder, 40-60g of matrix and 40-60ml of alcohol.

9. The formula for a traditional Chinese medicine plaster prepared with alcohol according to claim 7, characterized in that, The Chinese herbal plaster comprises the following raw materials in parts by weight: 8-12 parts of Ligusticum chuanxiong, 3-7 parts of scorpion, 8-12 parts of safflower, 8-12 parts of Saposhnikovia divaricata, and 3-7 parts of Paris polyphylla, while the base is 30-50 parts of petroleum jelly.

10. The formula for a traditional Chinese medicine plaster prepared with alcohol according to claim 7, characterized in that, The concentration of the alcohol is 50%-75%.

Images