Health-care liquid for rheumatic and bone pain and its preparation method
By constructing a microemulsion dispersion system using arginine acetylpropionate and alcohol ether cosolvents in traditional Chinese medicine compound external preparations, the problem of polar components being difficult to co-dissolve and gelling during the extraction process of traditional Chinese medicine compound external preparations was solved, thereby improving the stability of drug components and the transdermal absorption rate.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 陈丽波
- Filing Date
- 2026-04-02
- Publication Date
- 2026-07-17
AI Technical Summary
In the existing technology, there is a solubility conflict between components of different polarities in the extraction process of traditional Chinese medicine compound external preparations, making it difficult to co-dissolve and extract. Furthermore, under physical stress, demulsification or gelation is prone to occur, making it difficult for the drug components to exist stably and be absorbed through the skin.
Arginine levulinate, generated from L-arginine and levulinic acid, is used as an interfacial stabilizing medium. Combined with alcohol ethers or alcohol co-solvents, a microemulsion dispersion system is constructed. Through stepwise mixing of alkaline and acidic extracts and high-shear homogenization, a stable nano-microemulsion dispersion system is formed, which encapsulates the traditional Chinese medicine components and avoids polarity conflict and gelation.
This method enables the co-extraction and retention of components with different polarities within the same system, improving the transdermal absorption rate and stability of drugs, overcoming the problems of easy component separation and gelation in traditional methods, and enhancing the transdermal effect of drugs.
Smart Images
Figure CN122398933A_ABST