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Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application

A technology for povidone-iodine and mastitis, which is applied in the field of compound povidone-iodine gel for treating dairy cow mastitis and its preparation, and achieves the effects of convenient operation, no sensitization and high drug concentration

Inactive Publication Date: 2009-05-27
HUAZHONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There is no report on the preparation method of compound povidone-iodine gel for the treatment of cow mastitis

Method used

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  • Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application
  • Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application
  • Compound povidone iodine gel for treating mastitis of milk cattle as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Prepare the physical addition of 100Kg compound povidone-iodine gel finished product component as follows:

[0071] Carbomer—940 0.1Kg

[0072] 4% povidone iodine 0.2Kg

[0073] Hydrocortisone 1Kg

[0074] Sodium hydroxide 0.05Kg

[0075] Potassium iodate 0.1Kg

[0076] Propylene Glycol 5Kg

[0077] Add 93.55Kg of pure water.

[0078] Prepared as follows:

[0079] According to recipe quantity:

[0080] (1) Stir the carbomer with a little water to fully swell;

[0081] (2) Sodium hydroxide is added in the carbomer of step (1) to obtain a gel matrix;

[0082] (3) Povidone-iodine is added in the gel matrix that step (2) obtains, stir;

[0083] (4) Potassium iodate is made into solution with a little water and hydrocortisone and propylene glycol are mixed and added in the product of step (3) gained;

[0084] (5) Add pure water and mix well to get the finished product.

[0085] In the gel complex finished product that present embodiment produces, every bottle of g...

Embodiment 2

[0087] According to the described step of embodiment 1, in the present embodiment, the physical addition of each component of preparing 100Kg compound povidone-iodine gel is as follows:

[0088] Carbomer—940 0.2Kg

[0089] 4% povidone-iodine 1Kg

[0090] Hydrocortisone 2Kg

[0091] Sodium hydroxide 0.06Kg

[0092] Potassium iodate 0.2Kg

[0093] Propylene glycol 10Kg

[0094] Add 86.54Kg of pure water.

[0095] In the gel compound finished product that present embodiment produces, every bottle of gel agent 500g, every bottle of gel component content: carbomer-940 is 1g, 4% povidone iodine 5g, hydrocortisone 10g, hydroxide Sodium 0.3g, potassium iodate 1.25g, propylene glycol 50g, the total weight of each bottle of gel is 500g.

Embodiment 3

[0097] According to the described step of embodiment 1, in the present embodiment, the physical addition of each component of preparing 100Kg compound povidone-iodine gel is as follows:

[0098] Carbomer—940 0.4Kg

[0099] 4% povidone iodine 2Kg

[0100] Hydrocortisone 3Kg

[0101] Sodium hydroxide 0.06Kg

[0102] Potassium iodate 0.3Kg

[0103] Glycerol 10Kg

[0104] Add 84.24Kg of pure water.

[0105] In the gel complex finished product that present embodiment produces, every bottle of gel agent 500g, every bottle of gel component content: carbomer-940 is 2g, 4% povidone iodine 10g, hydrocortisone 15g, hydroxide Sodium 0.3g, potassium iodate 1.5g, glycerol 50g, the total weight of each bottle of gel is 500g.

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Abstract

The invention belongs to the technical field of animal remedy preparation and in particular relates to a pharmaceutical composition for curing dairy cow mastitis and a preparation method and a usage of the pharmaceutical composition. The remedy comes into being by mixing carbomer-940, povidone iodine, hydrocortisone, potash iodate, propylene glycol or glycerol, sodium hydroxide and purified water. The povidone iodine in the preparation has great sterilizing power, no odor or stimulation or sensitization and low toxicity and leads to no residuals which are formed in milk and harmful to human body, no withdrawal period is required during the course of medication, and no milk drinking stop is required; a prepared gel preparation is injected into breasts, a relatively high drug concentration can be achieved in the breasts in a short time, and the treatment cycle is short. Results of clinical trials show that the cure rate of recessive mastitis of the diary cow is up to 86.43 percent, and the effective rate is up to100 percent; and the cure rate of clinical mastitis of the diary cow is up to 78.03 percent, and the effective rate is up to 93.75 percent.

Description

technical field [0001] The invention belongs to the technical field of preparation of veterinary drugs, in particular to a compound povidone-iodine gel for treating cow mastitis, a preparation method and application thereof. Background technique [0002] Mastitis is the most common and frequently-occurring mammary gland disease in dairy cows. It is common in the early stage of lactation or the period of high milk production in high-yield cows. Mastitis not only affects the quality of milk, but also reduces milk production, causing serious damage to the development of the dairy industry. hazards. Cow mastitis is mainly caused by pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, Streptococcus dysgalactiae, Streptococcus agalactiae, and Klebsiella pneumoniae. In the past, antibiotics or traditional Chinese medicine were used for treatment. However, antibiotic treatment can easily lead to drug resistance of bacteria, and Chinese medicine treatment has a slow ...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K31/787A61K31/573A61P29/00A61P31/04
Inventor 杨利国江喜春滑国华张华林
Owner HUAZHONG AGRICULTURAL UNIVERSITY
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