8 results about "Antibiotics therapy" patented technology

Compounds and methods for combinatorial drug discovery in nanoliter droplets are described herein. More particularly, novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infections are described.

This invention provides the application of gonococcal ferritin in the preparation of anti-gonococcal products, relating to the field of antibody technology. The application of gonococcal ferritin subunits in the preparation of antibodies against gonococcal ferritin inhibits gonococcal infection by intervening in the iron metabolism pathway of gonococci, without inducing classic drug resistance mutations. This overcomes the limitations of existing technologies that rely on antibiotics, achieving broad-spectrum inhibition of drug resistance lineages. It solves the technical problem in existing technologies where multidrug / pan-drug resistance of gonococci leads to complete failure of antibiotic treatment, and the lack of therapeutic targets targeting its core survival mechanisms.

This invention discloses a method for preparing TCPP / Emodin composite photocatalysts and their antibacterial applications, belonging to the field of pharmaceutical antibacterial medicine. Addressing the issues of drug resistance easily induced by traditional antibiotics in treating bacterial infections, performance defects in existing photocatalysts, and insufficient antibacterial capacity of single antibacterial materials, this invention leverages the advantages of tetracarboxyphenylporphyrin (TCPP)—strong visible light capture ability and low photogenerated electron-hole recombination rate—and complements emodin's π-conjugated system and its structural advantage of promoting carrier migration. The two are covalently linked through a chemical coupling mechanism involving EDC / NHS synergistic activation of the carboxyl group. Through steps such as dissolution, mixing reaction, dialysis purification, and freeze-drying, spherical TCPP / Emodin composite nanomaterials with a particle size of 100-500 nm are obtained. This composite material reduces the photogenerated electron-hole recombination rate and improves carrier migration efficiency, efficiently generating ROS under visible light irradiation, and exhibits excellent photodynamic antibacterial properties.

The present application relates to a kind of microwave response antibacterial promotes the repair of bismuth telluride-based thermoelectric material and preparation and application, belong to biological medicine technical field.The microwave response antibacterial promotes the repair of bismuth telluride-based thermoelectric material includes zinc oxide-bismuth telluride.The preparation method of the microwave response antibacterial promotes the repair of bismuth telluride-based thermoelectric material, including the following steps: bismuth nitrate pentahydrate and polyvinylpyrrolidone are dissolved in ethylene glycol to obtain solution A;Sodium hydroxide and sodium tellurite are dissolved in ethylene glycol to obtain solution B;Zinc oxide is dissolved in ethylene glycol to obtain solution C;Solution A, solution B and solution C are mixed, and the mixed solution is heated, and reaction product is prepared by reaction;The reaction product is treated, and zinc oxide-bismuth telluride is prepared.The microwave response antibacterial promotes the repair of bismuth telluride-based thermoelectric material provided by the present application can not only avoid the related risk of antibiotic treatment when being used for wound infection treatment, but also effectively remove bacterial film and continuously promote wound repair.

This invention belongs to the food or pharmaceutical field, specifically relating to a probiotic and prebiotic composition, its preparation process, and its application. The composition includes probiotics, resistant dextrin, xylooligosaccharides, fructooligosaccharides, stachyose, erythritol, and cranberry powder, prepared using a fluidized bed spray granulation process. As an adjuvant to antibiotics, this composition has been verified in animal and clinical trials to synergistically treat upper / lower respiratory tract infections and urinary tract infections, shorten symptom duration, accelerate recovery from the primary disease, maintain intestinal flora diversity, increase the abundance of beneficial bacteria such as Bifidobacteria, reduce the incidence of adverse reactions, and alleviate antibiotic-associated diarrhea. This invention provides a microecological restoration solution for antibiotic treatment, possessing clear clinical value and technological feasibility.

The application discloses a multimodal antibacterial biological heterojunction, a preparation method and application thereof, and comprises the following steps: S1, preparing a dispersion liquid of single-layer Ti3C2 nanosheet; S2, preparing Fe and Cu doped metal organic framework material: FeCu-MOF; S3, compounding the single-layer Ti3C2 nanosheet and the FeCu-MOF to prepare the multimodal antibacterial biological heterojunction. The MXene / FeCu-MOF heterojunction is innovatively constructed, the band structure and near-infrared plasmonic effect are regulated, the directional transfer of electric charges is effectively promoted, the chemical dynamic therapy (CDT) and photodynamic therapy (PDT) effects are significantly enhanced, and the synergistic effect with photothermal therapy (PTT) is generated. The application designs a new multimodal non-antibiotic treatment strategy, which can realize efficient killing and removal of methicillin-resistant Staphylococcus aureus.

This invention discloses a traditional Chinese medicine monomer for treating necrotizing enteritis in poultry and its application, belonging to the field of traditional Chinese veterinary medicine technology. This monomer is composed of resveratrol, with a dosage of 125-500 mg per kilogram of feed, preferably 250 mg. The resveratrol of this invention treats necrotizing enteritis in chickens through a synergistic effect of direct in vitro antibacterial activity and in vivo intestinal barrier protection: the MIC against Clostridium perfringens in vitro is 0.16 mg / mL, exerting its antibacterial effect through multiple targets including inhibition of cell wall synthesis, energy metabolism, and virulence regulation; in vivo, it significantly improves the growth performance of NE broilers, reduces intestinal lesion scores, repairs the intestinal barrier, regulates immune inflammatory responses, and enhances antioxidant capacity. This invention provides theoretical and experimental basis for the development of natural control agents against intestinal pathogens in livestock and poultry, possessing the characteristics of high efficiency, safety, and no residue, and providing a new approach to replace antibiotics in the treatment of necrotizing enteritis in chickens.

The application discloses application of fuscocerine in preparation of products for relieving intestinal injury of chicks induced by salmonella, and belongs to the technical field of veterinary drugs. In a model of intestinal inflammation salmonella infected chicks, the chicks are orally administered with 20 mg / kg BW fuscocerine. The experimental results show that the fuscocerine can significantly relieve the growth performance of the chicks, improve the diarrhea condition and fecal state of the chicks, and improve the intestinal structure and permeability of the chicks through ileal M cells, thereby relieving the intestinal injury of the chicks caused by intestinal inflammation salmonella. The method for resisting intestinal inflammation salmonella of the chicks is beneficial to replacing the traditional antibiotic treatment method, and helps the development of poultry breeding.