144 results about "Microbial disease" patented technology

The invention discloses a novel compound microorganism living bacteria agent. The agent comprises probiotics such as pediococcus, saccharomyces, bacillus and the like, wherein the total bacterial quantity is above 107 colony-forming units (cfu)/gram. The invention further discloses a method for preparing the novel compound microorganism living bacteria agent and applications of the novel compound microorganism living bacteria agent in preparation of organic sewage purification additives, deodorization fly dispelling agents, degreasing agents, pipeline blockage removing agents, feed additives and microorganism disease prevention agents. The novel compound microorganism living bacteria agent has the comprehensive effects of high removal rates to ammonia nitrogen, total nitrogen and total phosphorus, small sludge residues, energy saving, environmental friendliness and the like and the characteristics of convenience in use, safety and quickness in function, no secondary pollution, benefits to ecological protection, low treatment cost, good comprehensive profit and the like.

The present invention relates to the use of the cyclic dinucleotide c-di-GMP and cyclic dinucleotide analogues thereof in a method for attenuating virulence of a microbial pathogen or for inhibiting or reducing colonization by a microbial pathogen. This method further inhibits microbial biofilm formation and is capable of treating bacterial infections. The microbial colonization or biofilm formation inhibited or reduced may be on the skin or on nasal or mucosal surface. The microbial colonization or biofilm formation inhibited can also be on the surfaces of medical devices, especially those in close contact with the patient, as well on the surfaces of industrial and construction material where microbial colonization and biofilm formation is of concern.

Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 μm in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.

Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present invention include, particularly, those caused by microbial pathogens such as bacteria and viruses.

A method for in situ detection of viable pathogenic bacteria in a selective medium by measuring cathodic peak current of oxygen on cyclic voltammograms during bacterial proliferation with an electrochemical voltammetric analyzer. The rapid oxygen consumption at a time during the growth of bacteria resulted in a sharp decline of the cathodic peak current curves. The detection times (threshold values) obtained from the cathodic peak current curve were inversely related to the concentrations of the pathogenic bacteria in the medium. This method for detection of pathogenic bacteria is more sensitive than nucleic acid-based polymerase chain reaction (PCR) methods and any of antibody-based methods such as enzyme-linked immunosorbent assay (ELISA) technology, electrochemical immunoassays, immunosensors, and it has a sensitivity similar to conventional culture methods and impedimetric methods but is more rapid than both of them. A calibration curve was obtained by plotting initial cell concentrations (CFU/ml) determined by conventional plate counting, as a function of the detection time.

The invention discloses fragrant grass vagina cleaning liquid and a preparation process thereof, and relates to the fragrant grass vagina cleaning liquid for preventing and treating gynecological inflammation and the preparation process thereof. The fragrant grass vagina cleaning liquid is prepared by processing glossy privet fruit, angelica dahurica, Chinese ligusticum rhizome, mint, divaricate saposhnikovia root, ash bark, amur corktree bark, yerbadetajo herba ecliptae, baical skullcap root, gardenia, lightyellow sophora root, motherwort herb, white paeony root, heartleaf houttuynia herb, nutgrass galingale rhizome, common cnidium fruit, rhubarb, spreading hedyotis herb, honeysuckle flower, dandelion, weeping forsythiae, belvedere fruit, borneol, borax, alum, citric acid, royal jelly, sorbic acid, sodium bicarbonate, glycerol, ethyl cellulose, vitamin C, sodium salt, citric acid and sodium hydroxide serving as raw materials. A product does not have stimulus or dependency, is not influenced by much secretion, and can kill bacteria and microorganism pathogen in vagina, protect mucosal tissues in the vagina, improve the physiological function of female genital organs and prevent and treat diseases.

A long-acting compound biologic organic-inorganic fertilizer is prepared from useful microbial bacteria (EV preparation), long-acting agent, organic substance, N, P, K, Zn, B, Mn, Mo, Fe, S, Ca and zeolite powder through proportionally mixing, stirring, and granulating. Its advantages are long acting time (160 days), high utilization rate increased by 25%, and high yield of agricultural crops.

The invention discloses a microbial-disease relation prediction method based on the similarity and the double random walk. According to the method, firstly, the disease function similarity is constructed by utilizing the disease gene relation and the gene function similarity information. Secondly, the disease Gaussian kernel similarity is constructed according to the known microbial disease relation. On the basis of the disease function similarity and the Gaussian kernel similarity, a final similarity of diseases is integrated. The similarity of microorganisms is derived from the Gaussian kernel similarity of the known microbial disease relation. The microorganism similarity information, the disease similarity information and the known microbial disease relation information are integratedinto a double-layer heterogeneous network. In this way, the microbial disease relation prediction is carried out in the heterogeneous network by utilizing the double-random walk method. According to the method, the relation between microbial diseases can be predicted. The method provides a foundation basis for biological experiments. By adopting the method, the manpower and the material cost are saved.

The present invention relates to disinfection of water polluted by microbial pathogens through the use of photosensitizers. The photosensitizer is a porphyrinoid which is part of an adduct comprising a resin, a spacer and said porphyrinoid. An apparatus wherein said adduct is excited by light sources and water is disinfected while flowing inside the apparatus is also provided. A system for the disinfection of water comprising said apparatus and further elements is also within the scope of the invention.

The present invention relates to a new strain of coronavirus and its application. Said invention utilizes the throat-swabbed cell colture of SARS patient to separate out a new type coronavirus, called by name of SARS coronavirus Fudan I strain. By infecting Vero E 6 cell and patient's serum the indirect FA display is positive, after the influenza virus A and B, RS virus and pathogens of pneumococcus, etc. are excluded, the tests show that said separated coronavirus is a variant strain of new coronavirus. Said strain can be used for providing basis for preparing SARS diagnosis reagent and researchnig and producing medicine for resisting and curing SARS disease.

The present invention concerns a method for identifying biologically active structures which are coded by the genome of microbial pathogens, using genomic pathogen nucleic acids.

The invention discloses a broad-spectrum composite microbial fungicide and a preparation method thereof. Original composite conidial powder consists of the following three microorganisms: bacillusthuringiensis GSICC32807, bacillus amyloliquefaciens GSICC32826 and pythiumoligandrum GSICC61615. Two types of bacterial spore powder and a type of fungal spore powder are mixed according to the weight ratio of 1:1:1 to prepare a broad-spectrum composite microbial fungicide product. The broad-spectrum composite microbial fungicide product provided by the invention can be quickly planted around the root of a plant to obviously prevent, resist and kill microbial diseases of various crops by competing infection sites with pathogenic bacteria, implementing the hyperparasitism action, secreting auxin, promoting nutrient absorption of the plant and the like; furthermore, the road-spectrum composite microbial fungicide has the effects of promoting the growth of the crops, increasing the yield and improving the quality.

The invention provides a composite microbial disease/insect-resistant agent for green vegetables and a manufacturing method thereof. The composite microbial disease/insect-resistant agent for green vegetables comprises a composite microbial inoculant and a fertilizer, wherein the composite microbial inoculant is a mixed microbial inoculant formed by fermenting Bacillus and Rhodospirillum in a culture medium; the fertilizer comprises a potassium fertilizer and a pH regulator; the mass ratio of the composite microbial inoculant to the fertilizer is (30-50):(50-70); and the mass ratio of the Rhodospirillum microbial inoculant to the Bacillus microbial inoculant is (1-3):1. By adopting the composite microbial inoculant, the agent has the advantages of sufficient nutrients and reasonable supply, can enhance the nutrient absorption capacity of the plant root, and effectively inhibits harmful bacteria from growth and reproduction. When being used for a long time, the agent can improve the soil and avoid multiple diseases and insects due to deficiency of nutrient elements.

A disinfectant for skin and mucosa comprises ketone extracts of radix sophorae flavescentis, fructus cnidii, honeysuckles and liquorice; powder is obtained after shells are calcinated; double-chain quaternary ammonium salt is obtained; and the ketone extracts of the radix sophorae flavescentis, the fructus cnidii, the honeysuckles and the liquorice, the powder obtained after the shells are calcinated and the double-chain quaternary ammonium salt are mixed in an aqueous solution, and then the mixture is prepared into a needed dosage form. The disinfectant has the functions of quick acting, long acting and broad-spectrum killing of bacteria and viruses (such as influenza viruses), adenoviruses and malignant bacteria, the skin and mucosa tissues cannot be damaged, and no irritability or stimulation is caused to normal skin and mucosa tissues. The disinfectant can kill 99% of pathogenic microorganisms (viruses and bacteria) in 5 seconds, the continuous anti-bacteria time is long, the amount of quaternary ammonium salt in the disinfectant is 10-20% of that of quaternary ammonium salt in a conventional disinfectant, and the disinfectant is safer when used on the mucosa. Compared with a quaternary ammonium salt disinfectant for single application, the effect is improved by 10-15 times, and the product LD50 is improved by more than 5-10 times.

The invention relates to the field of microbial disease control and in particular relates to a probiotic with bacteriostatic ability. The probiotic is Enterobacter ludwigii-PC88, is collected in China General Microbiological Culture Collection Center (CGMCC) on June 24, 2013, and has a collection number of CGMCC No.7814. The probiotic is separated from intestinal tracts of healthy flounders. The pure culture of the probiotic has relatively strong inhibitory effects on aquatic pathogens such as vibrio splendidus, vibrio harveyi, vibrio parahaemolyticus, pseudomonas aeruginosa and vibrio anguillarum, also can inhibit growth of known human pathogens such as tritirachium album, staphylococcus aureus and klebsiella pneumoniae, and has resistance to ampicillin. The pure culture or composition of the probiotic can be used for control of aquaculture diseases and development of novel antibacterial materials, and has good application prospects.

The functions of IFNgamma-induced GTPases of the IGTP-family as strong anti-infective agents, and more particularly a strong anti-parasite and/or anti-bacterial agents, are disclosed. These molecules (in both protein and nucleic acid forms) are effective to modify anti-microbial e.g., anti-bacterial and/or anti-parasitic) immune responses in a subject, to prevent or inhibit replication or infectivity of microbe, to treat microbial diseases, and to detect susceptibility of a subject to microbial infection. This invention also provides kits and compounds useful in such methods. Also provided are transgenic non-human animals in which IGTP-family member gene expression has been altered, and the use of such animals to screen for anti-microbial agents.

The invention discloses a fruit and vegetable fungicide containing a camellia oleifera cake extracting solution. Effective components are extracted from a camellia oleifera cake and are compounded with a biological fungicide; a mixture is applied to microbial disease and pest control over fruits and vegetables; the camellia oleifera cake extracting solution is compounded with one or several of a trichoderma agent, lactic streptococci and natamycin, and a mixture is diluted for use. The preparation method of the camellia oleifera cake extracting solution comprises the following steps: taking a certain amount of camellia oleifera cake, and adding an extracting agent according to the solid-liquid ratio of 1:(10 to 20) kg/L; carrying out ultrasonic extraction at the temperature of 50 to 80 DEG C for 1 to 4 hours, extracting for two times, then combining the extracting solution, and carrying out vacuum concentration at the temperature of 40 to 70 DEG C, wherein the extracting agent is one or a mixture of acetone, methanol and ethanol, and the concentration is 60 to 90 percent. The fruit and vegetable fungicide disclosed by the invention is formed by compounding a plant source with a biological source; the broad spectrum of the fungicide can be improved, drug resistance of pathogenic bacteria is overcome, the use amount of chemical pesticide can be effectively reduced, and the safety of fruit and vegetable products is improved, so the fruit and vegetable fungicide is a fungicide for effectively preventing and controlling microbial diseases and pests of the fruits and vegetables.

The invention relates to the field of microbial disease control and in particular relates to a probiotic separated from intestinal tracts of turbots and an application thereof. The probiotic is Leclercia adecarboxylata P115, is collected in China General Microbiological Culture Collection Center (CGMCC) on June 24, 2013, and has a collection number of CGMCCNo.7813. The probiotic is separated from the intestinal tracts of healthy turbots. The probiotic and the pure culture thereof have obvious bacteriostatic effects on tritirachium album, klebsiella pneumoniae, staphylococcus aureus, vibrio parahaemolyticus, vibrio harveyi and vibrio anguillarum. The pure culture or composition of the probiotic can be used for control of aquaculture diseases and development of novel antibacterial materials, and has good application prospects.

The present invention provides proteins with antimicrobial activity, and methods for treating subjects by administering the proteins. In particular, the invention provides methods for treating and/or preventing microbial diseases and infections. The present invention further provides the target for these antimicrobial agents, as well as assays for identifying regulators of the target.