The invention discloses a multifunctional air purification filter screen, which comprises a primary filter module, an HEPA filter module, and a gas adsorption and catalytic degradation module. The multi-module structures are connected and fixed into an integral filter screen from the outside in, the filter screen can achieve effective interception of fine particulate matters (PM2.5), bacteria, viruses and other particulate pollutants and thorough decomposition and purification of formaldehyde, ozone, toluene and other gaseous pollutants, also has deodorization, bacteriostasis and sterilization effects, is a multifunctional air purification filter screen integrating air filtration, purification, antibacterial efficacy, etc. With the characteristics of small wind resistance, long service life and good stability, the multifunctional air purification filter screen provided by the invention has great application prospects in air purifiers, central ventilation systems and other air purification devices, also is low in cost, and can realize large-scale continuous production.