78 results about "Potential toxicity" patented technology

The present invention relates to a neurochemical formulation comprising a supplement for improving function of neurons, improving memory and cognitive abilities, and reversing free radical damage caused by aging or neurodegenerative disease. The formulation comprises phosphoesters and antioxidants. Components may have antioxidant properties or enhance properties of other components. The synergistic combinations allow individual component dosages to be reduced, thereby minimizing potential toxicity.

A method and apparatus for inactivating contaminants, particularly nonenveloped viruses, in blood products without the need for quenchers in the blood products. The blood product is flowed through a flow meter at a controlled flow rate and subjected to type C ultraviolet radiation, where the irradiation dose received by the blood product is less than 640 joules/m2. The blood product does not contain quenchers when being irradiated, and the blood product retains more than 85% of its Factor VIII activity after being subjected to the radiation. The produced blood product is free of viruses and quenchers, avoiding potential toxicity due to the quenchers. The apparatus includes a source of UVC light, a quartz tube containing the blood product while it is exposed to the UVC light, a flow meter for controlling the flow rate of the blood product to be treated, and a pump. The UV light preferably emits light at 254 nm.

The invention discloses an application of carbon nanodots as a water-soluble ratiometric fluorescent probe and solves the problems that the existing ratiometric fluorescent probes are high in preparation cost, poor in luminescent stability and provided with potential toxicity. According to the application, the carbon nanodots are dissolved in a solution to be measured, an excitation wavelength is fixed at 360-400nm,the solution to be measured dissolved with the carbon nanodots is subjected to fluorescence spectrum detection at a fixed temperature, intensities of a blue maximum fluorescence-emission peak and a green maximum fluorescence-emission peak are measured, the ratios of the blue maximum fluorescence-emission peak intensity and the green maximum fluorescence-emission peak intensity are calculated, so that the detection of the objective to be measured is achieved. The application has the advantages of being low in cost, good in luminescent stability, non-toxic, high in sensitivity and capable of achieving detection for temperature, pH of water solution, ethanol concentration in ethanol water and Fe3+ concentration in Fe3+-containing neutral water solution simply, accurately and quickly.

The invention relates to a nutritional supplement with functions of oxidation resistance and fatigue resistance, which is prepared from active ingredients and auxiliary materials such as multiple vitamins, mineral substances, siberian ginseng extracts, astragalus mongholicus extracts, medlar extracts, grape seed extracts and the like. The active ingredients in the supplement have a special proportion; the nutritional supplement can achieve the same effects of oxidation resistance and fatigue resistance by using a dose of traditional Chinese medical extracts smaller than the conventional dose;and the nutritional supplement has the characteristics of low potential toxicity, low production cost, obvious treatment effect and low price, thereby being suitable for long-time use.

The invention relates to a hydrophobically associating hydroxyethylcellulose oil displacement agent. The hydrophobically associating hydroxyethylcellulose has the constitutional unit shown in the formula I. In the formula I, R is -C12H25, -C14H29 or -C16H33. The hydrophobically associating hydroxyethylcellulose is used to prepare 2000-8000mg/L of solution and the solution is injected in formationor core so as to increase the oil recovery. In the oil displacement agent, the modified natural polymer-hydrophobically associating hydroxyethylcellulose is used to replace the refractory polyacrylamide oil displacement agent with potential toxicity.

The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.

The invention relates to a fluorescent bioprobe for upconverting nanoparticle-labeled aptamers, which belongs to the technical field of biomolecular detection. In order to overcome the technical problems of existing QDs-labeled aptamer biological probes, including damage to the nucleic acid of the organism where the target molecule is located, high background signal of QDs, potential toxicity, "blinking" effect and chemical instability, provide A fluorescent bioprobe for up-conversion nanoparticle-labeled aptamers, including aptamers labeled with up-conversion nanoparticles as fluorescent donors, and DNA strands complementary to the aptamers, which are connected with fluorescent The donor undergoes a FRET effect as the fluorescent acceptor dye molecule. The fluorescent donors used in the present invention are UCNPs, which have the advantages of low background signal, non-toxicity, no "blinking" effect and strong chemical stability.

The invention discloses a pure-organic long-afterglow composite material and a preparation method thereof, belongs to the technical field of luminescent materials and is used for solving the problems that the preparation process of a long-afterglow luminescent material is complex, potential toxicity exists in the preparation process, and preparation raw materials are scarce in the prior art. The preparation method comprises the following steps of pyrolyzing ethylene diamine tetraacetic acid disodium for 2-4 hours at 200-400 DEG C in inert atmosphere so as to obtain black fluffy solids, carrying out ultrasonic dissolving on the black fluffy solids, carrying out centrifuging to remove black precipitates, taking an upper-layer tan clear solution as a water solution of carbon nanodots, finally adequately mixing the water solution of the carbon nanodots with a polyvinyl alcohol water solution, and drying to obtain the pure-organic long-afterglow composite material. The pure-organic long-afterglow composite material has the advantages that the afterglow decay time can reach multiple seconds, and the material is non-toxic, is good in biocompatibility and can be applied to the field of biological medicines.

The invention discloses a clean sterile high-barrier medical rubber plug and a preparation method thereof, and relates to a medical rubber plug which is free of potential toxicity on medicines and human tissues and has bacteria restraining and sterilizing performance and high barrier performance and a preparation method thereof, belonging to the technical field of medical rubber accessories. The preparation method for the clean sterile high-barrier medical rubber plug comprises the following steps: performing processes such as mixing medical raw rubber, natural aloe extract powder, medical-level sheet micro nano filler, processing auxiliaries and a radiation sensitizer in proportion, performing mould base pressing and molding, radiation vulcanizing, trimming, and drying, thereby preparing the medical rubber plug. The sterile high-barrier medical rubber plug is simple in formula system, adopts normal-temperature radiation vulcanization, is free of high-temperature decomposition products and free of potential toxicity on medicines and human tissues, and can be used for medical rubber accessories such as a medical injector rubber piston and a medical rubber plug which directly contact with the medicines.

Methods and apparatus to identify a potential toxicity of a therapy in a biological system are described. In one embodiment, a method uses a computer model that represents a set of biological processes of the biological system. The method includes executing the computer model to identify a first set of biological processes contributing to the occurrence of a toxic state of the biological system. The method also includes identifying a set of biological assays based on the first set of biological processes and testing the therapy in the set of biological assays to identify a second set of biological processes modified by the therapy. The method further includes identifying the potential toxicity of the therapy based on the second set of biological processes.

The invention relates to a safety evaluation method of transferring Bt gene insect-resistant paddy for predator paederus fuscipes. The method comprises three parts which are three-level nutrition test, protein transfer rule and Tier-1 toxicity determination test, wherein each part evaluates the influence on the paederus fuscipes by the transferring Bt gene insect-resistant paddy through prey mediation, the approach and degree of the paederus fuscipes exposed to Bt protein, and the potential toxicity of the Bt protein expressed by the transferring Bt gene insect-resistant paddy to the paederus fuscipes, and finally ecological results to non-target organism by the transferring Bt gene insect-resistant paddy are comprehensively evaluated according to data on the three aspects. The evaluation method is systematic and scientific, and has important significance on perfecting the research on the influence of transferring Bt gene crop on non-target organisms and confirming the ecological safety of transferring Bt gene crop planting.

An electrochemical method employing DNA as a probe to detect environmental pollutants. A biosensor detector comprises a working electrode, an auxiliary electrode, a reference electrode, a detection cell and an electrochemical working station. The working electrode is modified with nucleic acid probes on a surface thereof, and a genotoxicity compound in an environment sample is detected in a buffer system. When a detection result is positive, a signal of the sensor is changed obviously. Compared with an existing biosensor, the method has main advantages of: 1. high sensitivity; combination of an electrical active molecule and nucleic acid probes to increase a response current; 2. miniature and cheap apparatus and equipment, large detection flux, simple sample pre-treatment, and suitabilityfor on spot rapid screening detection. The method can not only carry out screening detection on a known genotoxicity compound but also evaluate potential toxicity effect of a newly synthesized compound; and the method can screen whether an actual sample contains a genotoxicity compound.

The invention provides a method for determining influence of insecticidal compounds on potential toxicity of Laodelphax striatellus, which includes: determining artificial feed effective to a determination system of toxicity on Laodelphax striatellus; developing a technique and a method for adding different organic or inorganic insecticidal compounds into the artificial feed; screening positive comparative compounds (protease inhibitor E-64 or inorganic compound, PA (potassium dihydrogen arsenate)) suitable for the determination system; providing suitable toxicity influence evaluation indexes for Laodelphax striatellus by experimental research; using E-64 and PA as modal compounds; verifying effectiveness and sensitiveness of the built method of toxicity determination for Laodelphax striatellus by dose-reaction bioassay; and finally building the systematic and sensitive method for determining potential toxicity influence of insecticidal compounds on Laodelphax striatellus. The method can be used for evaluating potential toxicity of exogenous insecticidal protein expressed in insect-resistant transgenic crops on Laodelphax striatellus and screening novel insecticidal protein genes resistant to Laodelphax striatellus, and can also be used for determining potential influence of different insecticides on Laodelphax striatellus.

The invention relates to a traditional Chinese medicine component micro emulsion nano delivery system as well as a preparation method and an application thereof in preparing a pharmaceutical preparation. The system consists of oil components, saponin components and insoluble components of traditional Chinese medicines, and is characterized by further comprising a co-emulsifier and water, wherein the weight ratio of the oil components to the saponin components to the insoluble components to the co-emulsifier to water is 40:(20-40):(1-4):(10-20):(80-200). The micro emulsion constructed by active components of traditional Chinese medicines can be used for solubilizing the insoluble components on one hand to control drug release and further form a nanoscale emulsion in water; on the other hand, by virtue of in vivo absorptive characteristics of the nano emulsion, the oral absorptive availability of the traditional Chinese medicine components is remarkably enhanced. The drug loading capacity can be greatly improved, and the potential toxicity in vivo can be reduced. Saponins and oils are combined to further have the synergic antitumor effect.

The invention discloses aerobic active marine bacteria and a preparation method of a decolorizing flocculant of the aerobic active marine bacteria. The aerobic active marine bacteria is formed by performing isolation and screening on mud disgorged by ruditapes philippinarum bred in a sea farm in a Zhujiajian, Zhoushan, Zhejiang in China, and is authenticated to be pseudoalteromonas ((i) Pseudoalteromonas (/i)sp.). The decolorizing flocculant has the beneficial effects that the formed adecolorizing flocculant has good decoloration effect, and the flocculation rate of the decolorizing flocculant to kaolin reaches greater than 90 percent; the decolorizing flocculant has high activity for performing decoloration on high-concentration waste water, and the flocculation rate of the decolorizing flocculant to methylene blue, malachite green and crystal violet reaches greater than 92 percent, 99 percent and 98 percent; the decolorizing flocculant does not have potential toxicity for organisms, and is green and healthy.

The existing PAM (polyacrylamide) dewatered sludge has poor digestion efficiency due to oversize flocs in the anaerobic digestion process, thereby inhibiting the high-molecular organic matrix in the sludge from leaching, prolonging the retention time of the sludge, and providing possibility for degradation of PAM into the monomer acrylamide. The invention provides a recycling harmless system and method for promoting hydrolysis of residual PAM in dewatered sludge and simultaneously producing short-chain fatty acids, belonging to the field of sludge treatment and disposition. The method comprises the following steps: PAM dewatered sludge is subjected to pyrohydrolysis treatment to promote PAM flocs in dewatered sludge to dissociate; alkaline conditioning is carried out to sufficiently destroy the pyrohydrolysis sludge zoogloea floc structure; and the sludge is sent into an anaerobic fermentation tank to produce short-chain fatty acids. The method enhances the PAM hydrolysis rate, lowers the PAM potential toxicity, and implements recycling harmless utilization of PAM dewatered sludge.

The invention relates to preparation of a bismuth-containing compound, in particular to bismuth alginate and a preparation method and application thereof. The structure of the bismuth alginate is shown as Formula 1, wherein n is equal to 200-250. The bismuth alginate is prepared via reaction of algin and bismuth salt or bismuth alkali in alkaline aqueous solution, and the alginic acid is prepared via ethanol precipitation and separation, dehydration, drying and grinding. The bismuth alginate is synthesized with alginic acid as a bismuth carrier, the bismuth content of the bismuth-containing compound is lower than the bismuth content of bismuth preparations universally applied in clinics at present, and the potential toxicity of long-term administration of the bismuth can be reduced. Moreover, the bismuth-containing compound has the biological activity of both bismuth preparations and alginic acid and has multi-functions of protecting the gastric mucosa, neutralizing the gastric acid, reducing the activity of pepsin, killing Hp, and promoting healing of peptic ulcer wounds. Therefore, the bismuth-containing compound has good values in new drug development. Formula I is shown below.

A method of screening an organic salt for potential toxicity if used as a stabilizing agent for live cells or viruses, the method comprising: (a) providing a composition of unilamellar vesicles; then (b) contacting an organic salt to the unilamellar vesicles; and then (c) detecting a change in at least one thermal parameter of the unilamellar vesicles caused by the organic salt at said known concentration. A change in the at least one thermal parameter indicates the organic salt is potentially toxic for use as a stabilizing agent for live cells or viruses. Compositions of organic salts identified by such methods, along with methods of using the same in stabilizing live cells or viruses, are also described.

The invention discloses an extraction method for a material with antioxidant activity in peony leaves and a method for preparing material into powder, which comprise the following steps: firstly, thematerial with antioxidant activity is extracted from peony leaves, the extracted material with antioxidant activity is then purified, and finally, powder is prepared from the purified material. The extraction method for the material with antioxidant activity in peony leaves and the method for preparing powder which are disclosed by the invention solve the problem that antioxidants synthesized by the prior art have potential toxicity and carcinogenic effect; the methods are easy to operate, and has good repeatability; by applying the methods disclosed by the invention, a natural, highly effectively and low-toxicity antioxidant can be obtained, moreover, the comprehensive utilization of oil peony resource is also increased, and certain social benefit is generated.

The invention discloses a nutritional agent with noise reduced hearing loss resistance. The nutritional agent is prepared from the following raw materials in parts by weight: 600-1000 parts of N-acetyl-L-cysteine, 1-4 parts of vitamin A, 1-5 parts of vitamin B1, 1-5 parts of vitamin B2, 1-10 parts of vitamin B6, 0.01-0.05 part of vitamin B12, 60-1000 parts of vitamin C, 15-300 parts of vitamin E which is based on alpha-totaxin, 50-400 parts of magnesium and 79-3175 parts of food acceptable accessories. Experiment data displays that the nutritional agent has remarkable effect of preventing and controlling the noise induced hearing loss. The nutritional agent can be used for enhancing the anti-oxidation ability of the organism and lightening the exitotoxicity damage, has the characteristics of being remarkable in curative effect, low in potential toxicity and low in cost, and is suitable for the noise reduced hearing loss protection and daily nutrient supplementation of people who live and work in the environment with continuous exposed high-intensity noise.

The invention provides a polypeptide for preparing hydrogel. The amino acid sequence of the polypeptide is SEQ ID NO: 1. The polypeptide is used for preparing the hydrogel. The prepared hydrogel can be used for producing cell culture holders. The polypeptide has the advantages that enzymes of organisms are catalyzed under physiological conditions to form the hydrogel, and accordingly, damage of external chemical agents, ultraviolet light and the like to tissues is avoided; the biological enzymes can be degraded, the hydrogel is degraded by endogenous substances in the organisms, and accordingly, potential toxicity and immunogenicity risks caused by introduction of exogenous chemical agents are avoided; the polypeptide is an ideal tissue engineering material and is significant to human life health.