6 results about "Neurochemistry" patented technology

Failures in establishing trust during international conflict negotiations frequently result in warfare, as ideological differences often cannot be resolved through rational discourse alone. Empathy between opposing parties is essential for building trust, and oxytocin is recognized for its critical role in facilitating empathy, trust, inter-brain synchrony, and cooperative decision-making. However, prevailing scientific studies typically do not differentiate between the cis and trans isomers of oxytocin, despite evidence that only the trans isomer is pharmacologically active. The present invention provides methods for the separation and quantification of oxytocin isomers, with particular emphasis on the trans isomer's function in social synchrony and decision-making within conflict negotiation contexts. Additionally, the invention explores the role of extremely low frequency electromagnetic radiation permeating the human central nervous system interconnecting neurochemical changes among groups. These advances clarify the unique neuropeptide functions of oxytocin and enhance understanding of its impact on cooperation and conflict resolution.

The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and / or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same.

The application discloses a hydrogel, a sensor and a preparation method and application thereof. The hydrogel is PEDOT:PSS / EMIM-Cl / Fc + PF6 ‑ The hydrogel comprises a poly 3,4-ethylenedioxythiophene: polystyrene sulfonate conductive polymer, 1-ethyl-3-methyl imidazole chloride and ferrocene hexafluorophosphate. The application can accurately control the inherent potential of the gel interface by doping 1-ethyl-3-methyl imidazole chloride and ferrocene hexafluorophosphate in the hydrogel, and realizes potential type analysis of various neurochemical molecules in the brain.

Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of ATXN1 RNA in a cell or subject and, in certain cases, reducing the amount of ATXN1 in a cell or subject. Such compounds, methods, and pharmaceutical compositions can be used to improve at least one symptom or marker of a neurodegenerative disease. Such symptoms and markers include gait and limb ataxia, cognitive impairment, difficulty speaking and swallowing, atrophy of the cerebellum and brainstem in magnetic resonance imaging (MRI), neurochemical abnormalities in the cerebellum and brainstem detected via magnetic resonance spectroscopy (MRS), and death within 10-15 years after symptom onset. Such neurodegenerative diseases include spinocerebellar ataxia type 1.

The present application relates to a kind of mouse sleep fragmentation research system based on electrophysiological electrochemical synchronous recording, belong to animal experiment equipment technical field, solve the lack of electrophysiological, electrochemical signal synchronous recording function in the prior art in the process of modeling;Cannot assess the influence of modeling degree and neurochemistry level one of the problems etc..The present application includes sleep fragmentation modeling module, signal measurement and acquisition control module and analysis module;Sleep fragmentation modeling module provides sleep space for mouse, and interval predetermined time is carried out to mouse sleep interference;Signal measurement and acquisition control module is used to measure and collect the electrophysiological signal and electrochemical signal of disturbed mouse;Analysis module is used to assess sleep quality and modeling effect.The present application realizes the integrated design of mouse sleep fragmentation modeling, electrophysiological signal recording, electrochemical signal detection, provides complete experimental system for the neurochemical mechanism research of sleep fragmentation.

A dental composition for expediting recovery from dental anesthesia comprises Vitamin C (75-2,000 mg), caffeine (30-400 mg), and beet root extract (250-7,000 mg) in synergistic combination. The composition addresses prolonged numbness following dental procedures by employing multiple complementary mechanisms: Vitamin C counteracts anesthetic effects through neurochemical pathways, beet root extract enhances vascular delivery via increased blood flow, and caffeine accelerates metabolic clearance. Administered as capsules immediately after or during dental procedures, the composition reduces post-procedural numbness duration, prevents soft tissue injuries from inadvertent biting, restores normal speech and eating function sooner, and promotes wound healing. The invention provides a safe, effective solution to a long-standing problem in dental anesthesia management.