11 results about "Neurochemistry" patented technology

The invention relates to an implantable gamma-aminobutyric acid detection system, which belongs to the technical field of neurochemical detection and comprises an implantable microelectrode array device, a signal detection circuit module, a first wireless data transceiving module, a second wireless data transceiving module and a detection terminal. The invention also provides a dynamic real-time calibration method. The method comprises the following steps: implanting the implanted microelectrode array device into an animal body; measuring two paths of electrochemical impedance data between the working electrode and the reference electrode and between the calibration electrode and the reference electrode by using a signal detection circuit module; calculating an estimated value of the concentration of gamma-aminobutyric acid by adopting an improved Randles circuit model; estimating the measurement error of the gamma-aminobutyric acid concentration by using an artificial neural network; and calibrating the measurement error to obtain a gamma-aminobutyric acid concentration detection value.

The invention discloses an electrode for neurochemical detection of a deep brain region and a preparation method thereof, and relates to the technical field of electrochemical analysis, and the key point of the technical scheme is that the electrode comprises carbon fibers, a fused quartz capillary tube and a glass capillary tube; the carbon fiber penetrates into the fused quartz capillary tube, and one end of the fused quartz capillary tube penetrates into the glass capillary tube. The low-damage implantable cranial nerve chemical electrode provided by the invention has the advantages of small implantation cross section, good biocompatibility and the like, greatly reduces the damage of the implanted electrode to brain tissues and possible inflammatory reactions, is beneficial to realizing long-term implantation, supports electrochemical analysis methods such as cyclic voltammetry, oxidation-reduction potential method and the like, and has good application prospects. In-situ high-sensitivity detection of neurochemical substances such as ascorbic acid and dopamine can be realized, and the method has a relatively good application value in the research field of various neurophysiology and pathology processes.

Failures in establishing trust during international conflict negotiations frequently result in warfare, as ideological differences often cannot be resolved through rational discourse alone. Empathy between opposing parties is essential for building trust, and oxytocin is recognized for its critical role in facilitating empathy, trust, inter-brain synchrony, and cooperative decision-making. However, prevailing scientific studies typically do not differentiate between the cis and trans isomers of oxytocin, despite evidence that only the trans isomer is pharmacologically active. The present invention provides methods for the separation and quantification of oxytocin isomers, with particular emphasis on the trans isomer's function in social synchrony and decision-making within conflict negotiation contexts. Additionally, the invention explores the role of extremely low frequency electromagnetic radiation permeating the human central nervous system interconnecting neurochemical changes among groups. These advances clarify the unique neuropeptide functions of oxytocin and enhance understanding of its impact on cooperation and conflict resolution.

The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and / or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same.

The application discloses a hydrogel, a sensor and a preparation method and application thereof. The hydrogel is PEDOT:PSS / EMIM-Cl / Fc + PF6 ‑ The hydrogel comprises a poly 3,4-ethylenedioxythiophene: polystyrene sulfonate conductive polymer, 1-ethyl-3-methyl imidazole chloride and ferrocene hexafluorophosphate. The application can accurately control the inherent potential of the gel interface by doping 1-ethyl-3-methyl imidazole chloride and ferrocene hexafluorophosphate in the hydrogel, and realizes potential type analysis of various neurochemical molecules in the brain.

Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of ATXN1 RNA in a cell or subject and, in certain cases, reducing the amount of ATXN1 in a cell or subject. Such compounds, methods, and pharmaceutical compositions can be used to improve at least one symptom or marker of a neurodegenerative disease. Such symptoms and markers include gait and limb ataxia, cognitive impairment, difficulty speaking and swallowing, atrophy of the cerebellum and brainstem in magnetic resonance imaging (MRI), neurochemical abnormalities in the cerebellum and brainstem detected via magnetic resonance spectroscopy (MRS), and death within 10-15 years after symptom onset. Such neurodegenerative diseases include spinocerebellar ataxia type 1.

AI-BASED NEUROCHEMICAL SENSING MICROARRAY UNIT

The invention relates to an intracerebral dopamine selective microelectrode and a preparation method thereof, the intracerebral dopamine selective microelectrode comprises a working electrode, the working electrode comprises a carbon fiber electrode, and the carbon fiber electrode is filamentous; the modification layer comprises a carbon nanomaterial and a stable compound, the carbon nanomaterial is used for improving stability and promoting dopamine oxidation reduction, and the modification layer wraps at least part of the outer surface of the carbon fiber electrode wire. According to the invention, the appearance and physical and chemical properties of the dopamine electrode are improved, so that the purpose of detecting the dopamine with long-time sober activity can be achieved, and the research of neurochemistry closer to the real situation can be met.

The present application relates to a kind of mouse sleep fragmentation research system based on electrophysiological electrochemical synchronous recording, belong to animal experiment equipment technical field, solve the lack of electrophysiological, electrochemical signal synchronous recording function in the prior art in the process of modeling;Cannot assess the influence of modeling degree and neurochemistry level one of the problems etc..The present application includes sleep fragmentation modeling module, signal measurement and acquisition control module and analysis module;Sleep fragmentation modeling module provides sleep space for mouse, and interval predetermined time is carried out to mouse sleep interference;Signal measurement and acquisition control module is used to measure and collect the electrophysiological signal and electrochemical signal of disturbed mouse;Analysis module is used to assess sleep quality and modeling effect.The present application realizes the integrated design of mouse sleep fragmentation modeling, electrophysiological signal recording, electrochemical signal detection, provides complete experimental system for the neurochemical mechanism research of sleep fragmentation.

A dental composition for expediting recovery from dental anesthesia comprises Vitamin C (75-2,000 mg), caffeine (30-400 mg), and beet root extract (250-7,000 mg) in synergistic combination. The composition addresses prolonged numbness following dental procedures by employing multiple complementary mechanisms: Vitamin C counteracts anesthetic effects through neurochemical pathways, beet root extract enhances vascular delivery via increased blood flow, and caffeine accelerates metabolic clearance. Administered as capsules immediately after or during dental procedures, the composition reduces post-procedural numbness duration, prevents soft tissue injuries from inadvertent biting, restores normal speech and eating function sooner, and promotes wound healing. The invention provides a safe, effective solution to a long-standing problem in dental anesthesia management.