40results about How to "Structural alteration" patented technology

A system for controlling operation of a radiofrequency treatment device to apply radiofrequency energy to tissue to heat tissue to create lesions without ablating the tissue. The system includes a first treatment device having at least one electrode for applying radiofrequency energy to tissue, a controller including a connector to which a first treatment device is coupled for use, and a generator for applying radiofrequency energy to the electrodes. The controller controls application of energy so that the tissue is thermally treated to create lesions but preventing thermal treatment beyond a threshold which would ablate the tissue.

A system for controlling operation of a radiofrequency treatment device to apply radiofrequency energy to tissue to treat tissue to create lesions without ablating the tissue. The system includes a first treatment device having a plurality of electrodes. The electrodes are maintained in axial alignment and fixed radial spacing in retracted and extended positions. The device includes a basket having a plurality of arms. The arms are maintained in a fixed radial spacing in the collapsed position of the basket.

A system for controlling operation of a radiofrequency treatment device to apply radiofrequency energy to tissue to heat tissue to create lesions without ablating the tissue. The system includes a first treatment device having at least one electrode for applying radiofrequency energy to tissue, a controller including a connector to which a first treatment device is coupled for use, and a generator for applying radiofrequency energy to the electrodes. The controller controls application of energy so that the tissue is thermally treated to create lesions but preventing thermal treatment beyond a threshold which would ablate the tissue.

A radio frequency identification device (RFID) antenna structure includes electrically-conductive material. The antenna structure includes low effective resistance-material areas and high effective resistance areas in regions where there would be little current flow if there were more low effective resistance material. The high effective resistance areas may be spaces within the antenna structure in which there is substantially no electrically conductive material. Alternatively, high effective resistance material in the high effective resistance areas may have a non-zero lower electrical conductivity than the low effective resistance material in the low effective resistance-material areas. Conductive material for the antenna structure may include conductive ink. By reducing or eliminating the amount of conductive material in the high effective resistance areas, it will be appreciated that reduced-cost devices may be obtained.

The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5′ untranslated region (5′ UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem / loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5′ UTR of an mRNA. A small RNA (trans-activating RNA, or taRNA), expressed in trans, interacts with the crRNA and alters the hairpin structure. This alteration allows the ribosome to gain access to the region of the transcript upstream of the start codon, thereby activating transcription from its previously repressed state.

Methods for enzymatically isolating lignin and other bioproducts, such as fermentable sugars, from herbaceous plant materials, are described. The methods can provide improvements, such as increased product purity and reduced process energy requirements and product modifications and contamination. Systems for practicing the methods also are provided.

A system for controlling operation of a radiofrequency treatment device to apply radiofrequency energy to tissue to heat tissue to create lesions without ablating the tissue. The system includes a first treatment device having at least one electrode for applying radiofrequency energy to tissue, a controller including a connector to which a first treatment device is coupled for use, and a generator for applying radiofrequency energy to the electrodes. The controller controls application of energy so that the tissue is thermally treated to create lesions but preventing thermal treatment beyond a threshold which would ablate the tissue.

An improved vibration suppressed bicycle structure includes a frame and a handle set that have ceramic piezoelectric elements located thereon to couple with passive and active control energy consuming mechanisms to convert the vibration energy of the bicycle body into electric energy, which is consumed in heat or gathered for active control use. The invention can absorb vibration energy of the bicycle to enhance structural performance, reduce vibration, and give bicycle riders more comfort over long distance rides and improved maneuverability.

A device for applying radiofrequency energy for sphincter treatment comprising a flexible outer tube, an expandable basket having a plurality of arms movable from a collapsed position to an expanded position, and a plurality of electrodes movable with respect to the arms from a retracted position to an extended position. An advancer is slidably disposed within the outer tube to move the plurality of electrodes to the extended position. An actuator moves the advancer from a first position to a second position to advance the plurality of electrodes. An aspiration tube extends within the outer tube. An assembly includes an aspiration disabler having a first position to enable aspiration from a distal portion of the aspiration tube to a proximal portion and a second position to disable aspiration.

A novel multilayer flexible metamaterial that can work at near infrared (NIR) regime that can be fabricated on transparent PET substrate using flip chip transfer (FCT) technique. An embodiment of the present invention also provides novel NIR metamaterial device that can be transformed into various shapes by bending the PET substrate, wherein said metamaterial device is tunable via physical manipulation of its flexible substrate with no requirement to change the material composition of the substrate. The flexibility allows the novel NIR metamaterial device to bend and stretch, which can alter the device structure. Since the resonant frequency of each device is a function of the device structure, the resonant frequency can be tuned by the bend and stretch of the substrate. Another embodiment of the present invention further provides novel tunable sensors and emitters using such flexible metamaterials and devices.

Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.

An automatic machine for arrissing the edges of glass sheets, comprising devices that allow to work glass sheets by way of rigid tools, such as diamond grinding wheels, by acting simultaneously on the two face edges along the perimeter of the sheet. The machine comprises at least one working head, provided with a tool with a probe and feedback circuits for grinding symmetrically the glass sheet and following the perimetric profile of the sheet by a combined action of moving the glass sheet and at least one working head.

A mixed solvent is prepared by dissolving acetic acid and lithium acetate in a mixture of isopropanol and water. This mixed solvent together with titanium alkoxide and carbon nanofiber (CNF) were introduced into a rotary reactor, the inner tube was rotated at a centrifugal force of 66,000 N (kgms−2) for 5 minutes to form a thin film of the reactant on the inner wall of the outer tube, and sheer stress and centrifugal force were applied to the reactant to allow promotion of chemical reaction, yielding CNF on which highly dispersed lithium titanate nanoparticle precursors are supported. The obtained composite powder was heated under nitrogen atmosphere at 900° C. for 3 minutes, yielding a composite powder in which highly dispersed lithium titanate nanoparticles are supported on CNF, wherein crystallization of lithium titanate was allowed to progress.

A method for modification and / or evaluation of ligand-protein and protein-protein systems is provided. Specifically, the method involves generating a final set of ligand or protein poses based on an initial set of ligand or protein poses. The method considers a variety of tools that can be applied to each pose. Energy scoring of each pose is performed based on results obtained from application of one or more of these tools. The design of the method allows for flexibility in which tools are used, the order in which they are used, and input parameters used for the different tools. This flexibility allows a user of the method to select a level of precision desired for a particular ligand-protein and protein-protein system that is being modified and / or evaluated.

The present invention relates to a host cell, preferably Myceliophthora thermophila cell, which expresses recombinant enzymes with beta-xylosidase activity, an enzymatic composition comprising said cell and / or the recombinant enzyme with beta-xylosidase activity expressed by said cell, the use of this host cell, the recombinant enzyme with beta-xylosidase activity expressed by said cell or the composition for the degradation of biomass and a method of producing bioproducts, preferably bioethanol, which comprises the use of said host cell, the recombinant enzyme with beta-xylosidase activity expressed by said cell or said composition.

The present invention relates to a software-based system, which may include a social networking website, implemented on a stand-alone computing device or over a network using computing devices. More specifically, the present invention relates to modifying the neurological structure or neurochemistry of a user of the system by improving mood, positivity level, or resilience level either over the Internet or on a stand-alone computing device so as to provide cognitive benefits to the user.

The field of manufacturing liquid crystal display panels, and in particular a modified glass panel is related. The glass panel comprises: a first metal layer used for forming scan lines and charge sharing lines, and a wiring metal layer used for forming connecting wires, wherein the connecting wires each have a via hole portion, and connect to the scan line and / or the charge sharing line via a via hole in the via hole portion. A corresponding manufacturing method is further provided. In this manner, a subsequently activated scan line can be used for activating a charge sharing line in a previous group. Hence, a reduced amount of chips on film will be used in the manufacturing and packaging procedures.

The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and / or fibrillation of amyloidogenic peptides such as amyloid beta peptide (Abeta or Aβ).

A chemiluminescent drug storing device with protection casing (1) comprising a crushable container (3) and a protective casing (1) provided on the external surface of the crushable container (3). The chemiluminescent drugs are sealed in the crushable container (3) and the protection casing (1) has at least one layer and has holes or gaps (2) to allow the flowing out of the chemiluminescent drugs. The chemiluminescent device comprises a transparent or translucent housing (4) and a chemiluminescent drug storing device with protection casing (1), the housing (4) is a deformable and sealed housing and has a cavity (5) inside, and the chemiluminescent drugs storing device is provided in the cavity (5).

The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present invention is a crystal of a dipeptidyl peptidase I (DPPI) and corresponding structural information obtained by X-ray crystallography from rat and human DPPI. In addition, this invention relates to methods for using structure co-ordinates of DDPI, mutants hereof and co-complexes, to design compounds that bind to the active site or accessory binding sites of DPPI and to design improved inhibitors of DPPI or homologues of the enzyme.

A curable coating composition comprising: (a) a silicate, such as sodium silicate, potassium silicate or lithium silicate; (b) a phosphate, such calcium phosphate, magnesium phosphate or sodium phosphate; and (c) a metal oxide, such as magnesium oxide, aluminum (III) oxide, scandium (III) oxide, yttrium (III) oxide, or zirconium oxide. Such curable coating compositions may be used as non-thermochromic (tailored based on expected operating environment) thermal control coating compositions for application to spacecraft and components thereof. As an alternative metal oxide component, for use in lower temperature applications, or in applications for which thermochromism at elevated temperatures is not a concern, the metal oxide may comprise zinc oxide. Also provided is a curable coating composition comprising: (a) a silicate (e.g. as above); (b) a phosphate (e.g. as above); and (c) a metal sulphate, such as a barium sulphate. Cured coatings are also provided, as are thermal control coatings, thermal control paints, and processes for making coated substrates.

A mixed solvent is prepared by dissolving acetic acid and lithium acetate in a mixture of isopropanol and water. This mixed solvent together with titanium alkoxide and carbon nanofiber (CNF) were introduced into a rotary reactor, the inner tube was rotated at a centrifugal force of 66,000 N (kgms−2) for 5 minutes to form a thin film of the reactant on the inner wall of the outer tube, and sheer stress and centrifugal force were applied to the reactant to allow promotion of chemical reaction, yielding CNF on which highly dispersed lithium titanate nanoparticle precursors are supported. The obtained composite powder was heated under nitrogen atmosphere at 900° C. for 3 minutes, yielding a composite powder in which highly dispersed lithium titanate nanoparticles are supported on CNF, wherein crystallization of lithium titanate was allowed to progress.

The present invention relates to a Myceliophthora thermophila cell, which expresses a nucleotide sequence that codifies a recombinant beta-xylosidase enzyme comprising an amino-acid sequence having at least 70% identity with SEQ ID NO: 1, an enzymatic composition comprising said cell and / or the recombinant enzyme with beta-xylosidase activity expressed by said cell, the use of this host cell, the recombinant enzyme with beta-xylosidase activity expressed by said cell or the composition for the degradation of biomass, and a method of producing biological products, preferably bioethanol, comprising the use of said host cell, the recombinant enzyme with the beta-xylosidase activity expressed by said cell or said composition.

A device for applying radiofrequency energy for sphincter treatment comprising a flexible outer tube, an expandable basket having a plurality of arms movable from a collapsed position to an expanded position, and a plurality of electrodes movable with respect to the arms from a retracted position to an extended position. An advancer is slidably disposed within the outer tube to move the plurality of electrodes to the extended position. An actuator moves the advancer from a first position to a second position to advance the plurality of electrodes. An aspiration tube extends within the outer tube. An assembly includes an aspiration disabler having a first position to enable aspiration from a distal portion of the aspiration tube to a proximal portion and a second position to disable aspiration.

The invention relates to a process for producing a plurality of capsules, each comprising an external shell of crosslinked hydrogel surrounding a central core, according to which a hydrogel solution and a composition of interest, intended to form the central core, are concentrically co-extruded so as to form mixed drops, each comprising a layer of hydrogel solution surrounding a drop of liquid composition of interest, characterized in that the co-extrusion step is carried out above a crosslinking aerosol so that the mixed drops pass through said crosslinking aerosol, such that the layer of hydrogel solution at least partially crosslinks around the drop of liquid composition of interest on contact with said aerosol.

The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and / or fibrillation of amyloidogenic peptides such as amyloid beta peptide (Abeta or Aβ).