322results about How to "Inhibition of translation" patented technology

An end effector usable with a surgical instrument includes a first jaw pivotably coupled to a second jaw. The first jaw includes staple forming depressions. A staple cartridge is releasably attachable to a channel of the second jaw. A plurality of staples is disposed in the staple cartridge. A shipping wedge is releasably attached to the staple cartridge. The shipping wedge maintains the staples in their respective retention slots and is usable to separate the staple cartridge from the channel of the second jaw.

Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

A total disc replacement (TDR) system for use in the spine and related methods, involving a first anchor plate having a first surface for engaging a first vertebra and a second surface including a semi-cylindrical articular surface, a second anchor plate having a first surface for engaging a second vertebra and a second surface including a semi-cylindrical articular surface, and an intradiscal element including a first articular surface having a generally arcuate cross-section for articulating with said semi-cylindrical articular surface of said first anchor plate, and a second articular surface having a generally arcuate cross-section for articulating with said semi-cylindrical articular surface of said second anchor plate.

A device for balance training and assessing dynamic balance by measuring a subject's ability to react to perturbations. A universal joint assembly is translated at the base of a support plate while a top plate on which the subject stands is fixed against translation. The universal joint permits the attached top plate to rotate about at least one and preferably multiple axes, and the subject must control balance following the translation of the universal joint. All components are housed in a one-piece platform assembly, made up of two plates in which the components are mounted. An existing force plate measurement system is placed on the top plate, and the subject stands thereon during use. A virtual environment, by image-creating devices, may be used to create a realistic sensation of tripping and general postural instability, or shifting of the support surface.

An end effector usable with a surgical instrument includes a first jaw pivotably coupled to a second jaw. The first jaw includes staple forming depressions. A staple cartridge is releasably attachable to a channel of the second jaw. A plurality of staples is disposed in the staple cartridge. A shipping wedge is releasably attached to the staple cartridge. The shipping wedge maintains the staples in their respective retention slots and is usable to separate the staple cartridge from the channel of the second jaw.

An artificial disc having a pair of opposing baseplates, for seating against opposing vertebral bone surfaces, separated by a ball and socket joint that includes a ball compression locked to a post extending from one of the baseplates. The ball is captured within a curvate socket formed in a peak of a convex structure attached to the other of the baseplates. The socket is formed by opposing curvate surfaces, one on the convex structure and one on the other of the baseplates. While the ball angulates freely in the socket, the rotation of the ball in the socket has a limited range due to interference between a protrusion on the convex structure that extends into the socket and a curvate recess on the ball. The ball and socket joint therefore permits the baseplates to rotate relative to one another through a limited range and also angulate relative to one another.

The present invention relates to apparatus and methods for thermally ablating uterine fibroids. More particularly, the present invention relates to a conduit having a plurality of channels for delivering a plurality of thermal ablation probes to an organic target such as a uterine fibroid, the probes being delivered in such configuration and orientation as to enable efficient and thorough ablation of the fibroid. In a preferred embodiment, the conduit is formed as a sleeve having a large central lumen sized to accommodate a hysteroscope, channels sized to accommodate cryoprobes are used as thermal ablation probes, and comprises thermal insulation materials serving to protect the cervix from damage by cold. The present invention further relates to bent cryoprobes usable in conjunction with such a conduit and designed to exit therefrom in a desired configuration useful for ablating a large fibroid.

The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titre recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titre rAAV vectors. The invention provides methods for regulating the expression of the AAV REP gene at the transcriptional and post-translational level. The methods and compositions of the invention can be used to produce high titre stocks of rAAV which can be used in gene therapy for the purpose of transferring genetic information into appropriate host cells for the management and correction of human diseases including inherited and acquired disorders.

A glenoid component for treatment of rotator cuff arthropathy includes attachment to the coracoid process by a pin or post imbedded into a hole formed in the coracoid process. The glenoid component preferably also has a keel for extending into the glenoid fossa and protrusions such as ridges cemented to the acromion process. This way, an attachment point is preferably provided in / on the coracoid process, the acromion process, and the glenoid fossa, and at least two of the attachment points include a protrusion extending into a hole / slot drilled or otherwise formed in the bone. A jig is used for guiding / drilling into the bone, wherein the jig has both a glenoid fossa drill guide and a coracoid drill guide. The coracoid drill guide includes structure that abuts against opposing sides of the base of the coracoid process to prevent rotation of the jig relative to the scapula.

An electrosurgical forceps is provided with a shaft that extends from a housing of the electrosurgical forceps. An end effector assembly operably coupled to the shaft includes a pair of first and second jaw members. One or both of the first and second jaw members is movable from an open configuration, to a clamping configuration. A knife blade assembly includes a knife blade translatable within the first and second jaw members. A knife blade lockout mechanism is in operative communication with the knife blade assembly and includes an elongated cam slot with a cam pin translatable therein from a distal end of the elongated cam slot corresponding to the knife blade lockout mechanism engaged with the knife blade assembly, to a proximal position corresponding to the knife blade lockout mechanism disengaged from the knife blade assembly.

Vascular embolic filtering devices and systems, as well as methods for using the same, are provided. The embolic filtering device includes a guide wire and an associated embolic filter for capturing emboli created during interventional procedures within a target vessel. Features of the subject devices and system provide for delivering of the guide wire independently of the filter, rotating of the guide wire with respect to the filter and limiting or preventing the proximal translation of the filter with respect to the guide wire. The embolic filter is attached to a sheath having either a shorter-length configuration or an extended-length configuration. The guide wire comprises a proximal stop mechanism engageable with the sheath to limit at least the proximal translation of the embolic filter. The subject embolic filter systems provide such guide wires and embolic filters, as well as and an embolic filter delivery, deployment and removal assembly. The methods of the present invention provide for the use of the subject devices and systems.

A windshield wiper blade assembly is disclosed which comprises a resilient wiper blade having an axial passage through which a flexible support beam is positioned to provide structure. A universal connector element for connecting the blade assembly to a plurality of different wiper arms crimps onto the blade and support beam assembly approximately midway along the wiper blade in a manner which does not puncture nor interfere with the resilient windshield wiper material, while at the same time preventing the relative axial translation of the support beam within the windshield wiper blade as well as translation between the blade and the connector itself.

A total disc replacement (TDR) system for use in the spine and related methods, involving a first anchor plate having a first surface for engaging a first vertebra and a second surface including a semi-cylindrical surface, a second anchor plate having a first surface for engaging a second vertebra and a second surface including a semi-cylindrical surface, a pair of intradiscal liners, each having a first semi-cylindrical surface for engaging with said anchor plates and a second semi-cylindrical surface for engaging with an intradiscal element, and an intradiscal element including a first articular surface having a generally arcuate cross-section for articulating with said first intradiscal liner, and a second articular surface having a generally arcuate cross-section for articulating with said second intradiscal liner.

A low profile acoustic array (10) is configured to selectively respond to shear waves while rejecting compression wave energy in the frequency range of interest. One sensor array is configured as a linear strip with a frame segment having at least one longitudinally extending rail and a plurality of sensor elements (20) extending therefrom. These sensor elements have a resilient core and opposing PDVF outer layers configured with opposing polarities onto the core. The linear strip array also includes a pair of separate electrical signal transmission paths. The transmission lines can include a series of undulations formed thereon to help minimize undesired mechanical crossover between sensors. A carrier member can be configured to be detachably releasable carries the discrete sensors to maintain the positional alignment until they are secured to a patient.

An electrosurgical forceps is provided with a shaft that extends from a housing of the electrosurgical forceps. An end effector assembly operably coupled to the shaft includes a pair of first and second jaw members. One or both of the first and second jaw members is movable from an open configuration, to a clamping configuration. A knife blade assembly includes a knife blade translatable within the first and second jaw members. A knife blade lockout mechanism is in operative communication with the knife blade assembly and includes an elongated cam slot with a cam pin translatable therein from a distal end of the elongated cam slot corresponding to the knife blade lockout mechanism engaged with the knife blade assembly, to a proximal position corresponding to the knife blade lockout mechanism disengaged from the knife blade assembly.

A system for manipulating energy transferred by members defining a joint. The system includes a first attachment structure configured to be attached to a first member of the joint and a second attachment structure configured to be attached to a second member of the joint. There is also an adjustable energy absorbing device attached to the first attachment structure and second attachment structure, wherein adjusting the energy absorbing device changes the load manipulating characteristics of the energy absorbing device.

A method, system, and apparatus for mediating address translation in a logically partitioned data processing system is provided. In one embodiment, a firmware component receives from an operating system within a logical partition a request to access a physical resource. The firmware component, responsive to a determination that the physical resource has been allocated to the logical partition, modifies an address translation table, if necessary, to allow access to the physical resource by the operating system. The operating system is prevented from directly modifying the address translation table, thus preventing potential interference between operating systems within the logically partitioned data processing system.

Embodiments of the invention include expandable, implantable devices and methods with a locking feature. Devices expand linearly to provide secure fixation between or among anatomical structures. In some embodiments, an implant replaces one or more vertebral bodies of the spine.

Information-bearing articles (10,50,100,100′,150, . . . 850) for securing to flexible tubing (38) such as catheters and their extension tubes, to provide important information about the tubing (38) such as flow rating or contraindications on types of cleaning fluid not to be used therewith. The devices are provided with large outwardly facing indicia-bearing surfaces (30,32;70,72;120,122; . . . 834) and may be clipped directly to the tubing (38) at a selected location therealong, or be clipped directly to a clamp member (40,330) that is disposed along and around the tubing for clamping the tubing (38) when desired to occlude fluid flow therethrough. Those devices (10,100,100′,550, . . . 750) clippable to the tubing may have a C-shaped channel (18,20,58,108,554,604) therealong that may be flexed open to be placed about the tubing, which may be temporarily compressed as well to enter the channel, or the devices may be rings (800,850) that clip closed about the tubing (38). Other devices (200,250, . . . 500) are adapted to be clipped to the clamp (40,330) by latch projections (208,210;258,260; . . . 508,510). Still others (50,150) may be clipped to the tubing (38) but be adapted to be placed partially around an end or a side of the clamp (40,330).

An artificial disc having a pair of opposing baseplates, for seating against opposing vertebral bone surfaces, separated by a ball and socket joint that includes a ball compression locked to a post extending from one of the baseplates. The ball is captured within a curvate socket formed in a peak of a convex structure attached to the other of the baseplates. The socket is formed by opposing curvate surfaces, one on the convex structure and one on the other of the baseplates. While the ball angulates freely in the socket, the rotation of the ball in the socket has a limited range due to interference between a protrusion on the convex structure that extends into the socket and a curvate recess on the ball. The ball and socket joint therefore permits the baseplates to rotate relative to one another through a limited range and also angulate relative to one another.

A process is described for producing hybrid seed using male-sterile plants created by employing molecular techniques to manipulate antisense DNA and other genes that are capable of controlling the production of fertile pollen in plants. Transformation techniques are used to introduce constructs containing antisense DNA and other genes into plants. Said plants are functionally male-sterile and are useful for the production of hybrid seed by the crossing of said male-sterile plants with pollen from male-fertile plants. Hybrid seed production is simplified and improved by this invention and can be extended to plant crop species for which commercially acceptable hybrid seed production methods are not currently available.

A system for manipulating energy transferred by members defining a joint. The system includes a first attachment structure configured to be attached to a first member of the joint and a second attachment structure configured to be attached to a second member of the joint. There is also an adjustable energy absorbing device attached to the first attachment structure and second attachment structure, wherein adjusting the energy absorbing device changes the load manipulating characteristics of the energy absorbing device.

A reverse obliquity fracture of the proximal femur is poorly secured with current generation hip screws, frequently necessitating the use of intramedullary fracture fixation devices or external fixation hardware. This compression hip screw comprises a femoral head lag screw, side plate, locking plug, and compressing screw, which can be assembled in a locked mode, preventing lateral translation of the lag screw within the side plate. In the locked mode, the proximal fracture fragment(s) are prevented from displacing laterally relative to the distal fragment, as occurs commonly when such a fracture is fixed with a conventional hip screw. No change in routine fracture reduction or insertion technique is required to use this compression hip screw. Additionally, this compression hip screw can be used in a dynamic or sliding mode, if so desired, when used to fix the more common femoral neck or intertrochanteric fracture patterns.

The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene transcript, for the manufacture of a medicament for the diagnosis, treatment or prevention of a cis-element repeat instability associated genetic disorders in humans. The invention hence provides a method of treatment for cis-element repeat instability associated genetic disorders. The invention also pertains to modified oligonucleotides which can be applied in method of the invention to prevent the accumulation and / or translation of repeat expanded transcripts in cells.

A safety lock mechanism for a folding knife includes a lock plate movably coupled to a handle of the knife for movement along a first direction from an engaged position to a disengaged position, the lock plate biased towards the engaged position. A rocker element is coupled to the lock plate for movement from a locked position to an unlocked position and is configured to prevent translational movement of the lock plate to the disengaged position when the rocker element is in the locked position. A control button coupled to the rocker element allows a user to move the rocker element from the locked position to the unlocked position and to move the lock plate towards the disengaged position to thereby release a blade of the knife.