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Separation method for rabbit optic nerve and method for manufacturing rabbit optic nerve crushing injury model

A separation method and optic nerve technology, applied in the clinical field, can solve the problems of high probability of wound infection, long operation time, prolonging modeling time, etc., and achieve the effect of reducing separation tissue damage, small wound infection probability, and reducing operation time

Inactive Publication Date: 2018-07-10
四川格林泰科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. Large surgical trauma: Most of the existing technologies use the upper or lower eyelid opening method for surgery, which requires sutures after surgery, takes a long time to heal the wound, and the postoperative nursing procedures are cumbersome;
[0004] 2. The chance of wound infection is high: the length of the wound in the opening of the upper and lower eyelids is 2-3CM
[0005] 3. Long operation time: the existing technical operation process from disinfection, opening, separation, clamping, suturing to anti-inflammatory treatment takes about 10-15 minutes per animal if the operation is skilled;
[0006] 4. Long anesthesia time: Due to the animal operation time, the anesthesia time needs at least half an hour, so the general traditional method is to inject nerve inhibitory anesthetics or gas to maintain anesthesia. The former is more harmful to the animal, and the latter requires the use of a gas anesthesia machine. Debugging and installation are inconvenient to use and prolong the modeling time and increase energy consumption;
[0007] 5. The consistency of the existing technology model is poor, and the degree of damage is different: the traditional method has a lot of separated tissues, and the muscle and fascia are seriously damaged.

Method used

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  • Separation method for rabbit optic nerve and method for manufacturing rabbit optic nerve crushing injury model
  • Separation method for rabbit optic nerve and method for manufacturing rabbit optic nerve crushing injury model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: a kind of method of the separation of rabbit optic nerve, comprises the following steps:

[0034] ①Press the zygomatic fossa at the corner of the rabbit's eye to slightly protrude the eyeball and expose the rectus oculi muscle;

[0035] ② Pull the opening of the fascia at the fornix between the lateral rectus muscle and the superior rectus muscle on the upper edge of the eyeball;

[0036] ③ After the opening, the free part of the lateral rectus muscle is bluntly separated the fascia retrobulbarally, and the vortex vein can be seen after the separation;

[0037] ④Continue to separate vertically downward with the vortex vein as the center to see the optic nerve;

[0038] ⑤ Separate the fascia around the optic nerve of the fundus.

[0039] The method of preparing the rabbit optic nerve clamp injury model based on the above-mentioned rabbit optic nerve separation method is to modify the step ⑤ to separate the fascia around the optic nerve of the fundus, and ...

Embodiment 2

[0041] Embodiment 2: a kind of method of the separation of rabbit optic nerve, comprises the following steps:

[0042] ①Press the zygomatic fossa of New Zealand rabbits with fingers to slightly protrude the eyeball and expose the rectus oculi muscle;

[0043] ② Stretch the transverse opening of the fascia at the fornix between the lateral rectus muscle and the superior rectus muscle on the upper edge of the eyeball;

[0044] ③ After the transverse opening, the free part of the lateral rectus muscle is bluntly separated the fascia retrobulbarally, and the vortex vein can be seen after the separation;

[0045] ④Continue to separate vertically downward with the vortex vein as the center to see the optic nerve;

[0046] ⑤ Separate the fascia around the optic nerve of the fundus.

[0047] The method of preparing the rabbit optic nerve clamp injury model based on the above-mentioned rabbit optic nerve separation method is to modify the step ⑤ to separate the fascia around the opti...

Embodiment 3

[0049] Embodiment 3: a kind of method of the separation of rabbit optic nerve, comprises the following steps:

[0050] ①Use your thumb to press the corner of the eye and the zygomatic fossa of the New Zealand rabbit to slightly protrude the eyeball and expose the rectus oculi muscle;

[0051] ②Use small ophthalmic scissors to stretch the transverse opening of the fascia at the fornix between the lateral rectus muscle and the superior rectus muscle on the upper edge of the eyeball;

[0052] ③ After the transverse opening, the free part of the lateral rectus muscle is bluntly separated the fascia retrobulbarally, and the vortex vein can be seen after the separation;

[0053] ④Continue to separate vertically downward with the vortex vein as the center to see the optic nerve;

[0054] ⑤ Separate the fascia around the optic nerve of the fundus.

[0055] The method of preparing the rabbit optic nerve clamp injury model based on the above-mentioned rabbit optic nerve separation met...

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Abstract

The invention relates to the technical field of clinic, and specifically relates to a separation method for rabbit optic nerves and a method for manufacturing a rabbit optic nerve crushing injury model. The method is simple in steps, easy in operation, small in operation wound, low in infection probability, short in operation time and anesthesia time, high in consistency, and consistent in injurydegree, and can provide basis for a rabbit optic nerve crushing injury model, a rabbit optic nerve quantitative impact damage model, and a rabbit optic nerve chemical agent firing damage model.

Description

technical field [0001] The invention relates to the field of clinical technology, in particular to a method for separating a rabbit optic nerve and a method for preparing a rabbit optic nerve clamp injury model based on the method. Background technique [0002] In order to observe the law of the pathological process of indirect optic nerve injury and guide clinical treatment, a large number of rabbit optic nerve injury models are currently used. But the establishment method of existing rabbit optic nerve injury model has the following problems: [0003] 1. Large surgical trauma: Most of the existing technologies use the upper or lower eyelid opening method for surgery, which requires sutures after surgery, takes a long time to heal the wound, and the postoperative nursing procedures are cumbersome; [0004] 2. The chance of wound infection is high: the length of the wound in the opening of the upper and lower eyelids is 2-3 cm. Injured muscles have more fascia tissue, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61D1/00A61B90/00
CPCA61B17/00A61D1/00
Inventor 江万祥陈玥蒲琦石刚
Owner 四川格林泰科生物科技有限公司
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