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Traditional Chinese medicine component micro emulsion nano delivery system as well as preparation method and application thereof in preparing pharmaceutical preparation

A technology of traditional Chinese medicine components and delivery systems, which is applied in the direction of nano-medicine, nanotechnology, nanotechnology, etc., and can solve the problems of low drug loading, excessive consumption of conventional microemulsion excipients, and low oral bioavailability of insoluble Chinese medicine components. problems, to achieve high drug loading, enhance oral absorption and availability, and increase drug loading

Active Publication Date: 2014-07-23
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, Chinese medicine saponins are used as emulsifiers of microemulsions, oils of Chinese medicines are used as oil phases of microemulsions, active components of Chinese medicines are used as functional auxiliary materials to construct a microemulsion oral delivery system, and drugs are used to replace conventional auxiliary materials to construct a nano drug delivery system , to improve conventional microemulsion excipients such as excessive dosage, low drug loading, potential systemic toxicity and low oral bioavailability of insoluble traditional Chinese medicine components

Method used

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  • Traditional Chinese medicine component micro emulsion nano delivery system as well as preparation method and application thereof in preparing pharmaceutical preparation
  • Traditional Chinese medicine component micro emulsion nano delivery system as well as preparation method and application thereof in preparing pharmaceutical preparation
  • Traditional Chinese medicine component micro emulsion nano delivery system as well as preparation method and application thereof in preparing pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1, the preparation scheme of coix seed oil-ginsenoside microemulsion (CG-ME):

[0054] Take 1.0 g coix seed oil and 1.0 g ginsenosides, stir at room temperature for 4-6 h, mix thoroughly, add 0.5 g co-emulsifier PEG-400 to the above mixed system, continue stirring at room temperature for 3-6 h, set aside. 3 – 6 mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.

Embodiment 2

[0055] Example 2, the preparation scheme of traditional Chinese medicine oil-ginsenoside microemulsion (OG-ME):

[0056] Taking Brucea javanica oil as an example, take 0.8 g Brucea javanica oil and 0.75 g ginsenosides, stir at room temperature for 2 h, mix thoroughly, add 0.4 g co-emulsifier PEG-400 to the above mixing system, and continue stirring at room temperature for 4- 6 h, spare. 3 – 6 mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.

[0057] Similarly, the corresponding microemulsions of zedoary oil, linseed oil, catmint oil, Atractylodes macrocephala oil, and clove oil can all be prepared by the same method as above.

Embodiment 3

[0058] Example 3, the preparation scheme of coix seed oil-noginsenoside microemulsion (CN-ME):

[0059] Take 1.1 g coix seed oil and 0.8 g notoginseng saponins, stir at room temperature for 4-6 h, mix thoroughly, add 0.4 g co-emulsifier PEG-400 to the above mixed system, continue stirring at room temperature for 3-6 h, set aside . 3 – 6 mL of deionized water was slowly dropped into the above-prepared mixing system at a constant speed, and the system was continuously stirred at a constant speed until a transparent and clear system appeared.

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Abstract

The invention relates to a traditional Chinese medicine component micro emulsion nano delivery system as well as a preparation method and an application thereof in preparing a pharmaceutical preparation. The system consists of oil components, saponin components and insoluble components of traditional Chinese medicines, and is characterized by further comprising a co-emulsifier and water, wherein the weight ratio of the oil components to the saponin components to the insoluble components to the co-emulsifier to water is 40:(20-40):(1-4):(10-20):(80-200). The micro emulsion constructed by active components of traditional Chinese medicines can be used for solubilizing the insoluble components on one hand to control drug release and further form a nanoscale emulsion in water; on the other hand, by virtue of in vivo absorptive characteristics of the nano emulsion, the oral absorptive availability of the traditional Chinese medicine components is remarkably enhanced. The drug loading capacity can be greatly improved, and the potential toxicity in vivo can be reduced. Saponins and oils are combined to further have the synergic antitumor effect.

Description

technical field [0001] The invention relates to a preparation method of a microemulsion delivery system that replaces conventional oil phases and emulsifier auxiliary materials with pharmacologically active traditional Chinese medicine oils and saponins, and its application as a drug carrier in the preparation of medicines. Background technique [0002] Traditional Chinese medicine nano drug delivery system is a hot research field in the modernization of traditional Chinese medicine preparations. As a kind of nano drug delivery system, microemulsion is formed by self-assembly of emulsifier, co-emulsifier and oil phase, which can significantly solubilize insoluble traditional Chinese medicine components and promote their oral absorption. However, in the microemulsion preparation process, too many pharmaceutical excipients need to be introduced, which may bring potential systemic toxicity. Looking for active components with similar effects to pharmaceutical excipients fro...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/28A61K47/44A61K47/46A61K36/8994A61K31/704B82Y5/00A61P35/00A61K31/56
Inventor 陈彦瞿鼎刘聪燕
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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