5results about How to "Good development value" patented technology

The application discloses a method for efficiently separating high-purity conjugated linoleic acid from Tetrastigma hemsleyanum, which takes stems and leaves of Tetrastigma hemsleyanum as raw materials, and sequentially carries out ethanol extraction, ethyl acetate extraction, normal-phase silica gel column chromatography, gel column chromatography and semi-preparative reverse-phase liquid chromatography coupling purification process, so that 10E, 12Z-CLA monomers with chemical purity of greater than or equal to 99% are efficiently prepared. Experiments prove that the compound can significantly inhibit the inflammatory reaction of macrophages induced by lipopolysaccharide, and the mechanism is that the compound down-regulates TLR4 protein expression and inhibits NF-kappa B p65 phosphorylation, so as to block the activation of the TLR4 / NF-kappa B signal pathway. The application realizes high-value utilization of the abandoned resources of Tetrastigma hemsleyanum, and the obtained product can be used as a definite active ingredient for developing anti-inflammatory drugs, functional foods or cosmetics.

OCR04PP The present invention involves an indolone derivative which is replaced by pyrrole, a method. The preparation thereto, the components comprising derivatives, and the applications of those. The indolone derivative which is replaced by -pyrrol has a structure which is shown in formula(I) below. The current invention also involves the use of indolone derivatives which are replaced by... Pyrrol is used for therapeutic purposes through tyrosine kinase receptor-mediated therapy, and its components are linked to other treatments. Pharmaceuticals containing compounds with that structure for the treatment of related diseases, such as: tumor (Chemical formula)(I)

The application discloses application of a BMP9 inhibitor in preparation of a medicine for treating hypertension. It is found for the first time that knocking out BMP9 can reduce the blood pressure rise, vascular dysfunction and vascular remodeling phenomenon induced by AngII, that is, the BMP9 inhibitor can be used in effective treatment of hypertension, has a good application prospect and medicine development value in the technical field of hypertension treatment, and provides a brand-new thought and strategy for research and development of a hypertension treatment medicine.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

The application provides application of basic lanthanum oxide in preparation of a medicine for treating hyperphosphatemia or a disease related to hyperphosphatemia, and belongs to the technical field of medicines.The application provides application of basic lanthanum oxide in preparation of a medicine for treating hyperphosphatemia or a disease related to hyperphosphatemia, and the application adopts basic lanthanum oxide to prepare the medicine for treating hyperphosphatemia or the disease related to hyperphosphatemia; the basic lanthanum oxide has a higher lanthanum content, which can reach 80.8%, and is developed into the medicine for treating hyperphosphatemia or the disease related to hyperphosphatemia; the medicine has a smaller use amount or preparation specification in combination with the use amount of the medicine for the same amount of phosphate in blood of a hyperphosphatemia patient, is beneficial to improving the compliance of the patient, and has a better phosphorus-lowering effect.