Rhizoma corydalis extract preparation method and application thereof to analgesic

Abstract

The invention relates to the field of pharmaceuticals, and discloses a rhizoma corydalis extract preparation method and application of the rhizoma corydalis extract preparation method to the analgesic. The method comprises the following steps: (1) taking a rhizoma corydalis decoction piece, and conducting reflux extraction; (2) conducting vacuum concentration on an extracted solution until no alcohol taste is left, centrifuging, taking a liquid supernatant and preparing a loading solution; (3) processing a pretreated macroporous resin through a wet packing method, loading, removing an impurity, and abandoning an impurity removal solution; (4) eluting by using an elution solvent, abandoning the previous 0.5-1.5 BV elution solution, and then collecting; (5) conducting vacuum concentration onthe elution solution, and drying. The purity of the total alkaloids of the prepared rhizoma corydalis is high, the transfer rate is high, the pharmacodynamic effect is strong, the operation is simpleand convenient, and the preparation method is favorable for industrial production and promotion and application in the later period.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of Corydalis Corydalis extract and its application in analgesic drugs. Background technique [0002] In the application of analgesic drugs, traditional Chinese medicine has the advantages of a long history, unique methods, and certain curative effects. Corydalis yanhusuo (Corydalis yanhusuo W.T.Wang), a traditional Chinese medicine, is the dry tuber of Corydalis yanhusuo W.T.Wang, also known as Corydalis yanhusuo and Yanhu. , the effect of pain relief, used for chest pain, epigastric pain, tumbling swelling pain, etc., the main place of production is Zhejiang, one of the famous eight flavors of Zhejiang, and a famous analgesic recommended by Chinese medicine scientists in the past dynasties. Li Shizhen described Corydalis Corydalis in "Compendium of Materia Medica": "It is specially used to treat all kinds of pains in the whole body, and it is wonderful when used. It...

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Problems solved by technology

[0003] At present, the research generally uses the total alkaloids of Corydalis or one or several monomeric alkaloids as the index to conduct process investigation and optimization, and obtain a plan with a higher component. However, the curative effect of traditional Chinese medicine is expressed in the form of the whole, not a certain component. It is the result of the interaction between several components, so it is relatively one-sided to use a single component as an index to optimize and select the preparation scheme of traditional Chinese medicine.

[0004] After reviewing relevant literature and patents, it was found that many literatures did not report the transfer rate. The reason may be that the transfer rate of some schemes with relatively high purity of alkaloids is too low. If the cost of mass production is too high, it is not conducive to the promotion of drugs. and sales

And there is a patent report after purifying the total alkaloids of Corydalis Corydalis with the macroporous adsorption resin method, and then extracting with an organic solvent, and its purity can reach more than 90%, but this type of method has complex operations, loaded down with trivial details, inflammable and explosive materials, and high cost. High, adverse effects on the human body, difficult to be used in a series of problems such as industrial production

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