Process for separating and extracting 98% quercetin from aboveground part of pubescent holly root

A technology of aerial parts and hairy holly, which is applied in the field of separation and extraction of plant active ingredients, can solve the problems of reducing the extraction rate of rutin, making no profit for production enterprises, and different production costs, so as to improve market competitiveness and reduce production costs. cost, and the effect of increasing corporate profits

Active Publication Date: 2011-03-16
GUILIN SANLENG BIOTECH
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  • Abstract
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  • Application Information

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Problems solved by technology

However, in actual production, it is difficult to ensure that the content of rutin in each batch of Sophora japonica reaches 23%, and the production cost will be different. Calculated according to the annual average production sum, the production cost may even be as high as 550 yuan / kg
The market price of quercetin is 500~800 yuan / kg, the specific price is restricted by the market situation, and the production enterprises basically have no profit
[0005] In addition, the production technology is also defective. The PH value of the water extract is adjusted with saturated lime water, which reduces the extraction rate of rutin; there are also problems with the product quality. The content of quercetin extracted from Sophora japonica is 96%-98%, which is rare. More than 98% quercetin

Method used

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  • Process for separating and extracting 98% quercetin from aboveground part of pubescent holly root
  • Process for separating and extracting 98% quercetin from aboveground part of pubescent holly root
  • Process for separating and extracting 98% quercetin from aboveground part of pubescent holly root

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Embodiment 1

[0029] With reference to Fig. 1, the present invention separates and extracts the technique of 98% quercetin from the aerial part of Ilex pubescens, comprises the steps:

[0030] (1) Cutting into sections: Take 1000kg of the above-ground part of fresh holly, and cut into sections of 0.5-2cm;

[0031] (2) Weak alkaline water extraction: Put a small piece of medicinal material into 6cm 3 In the extraction tank, use Na with a pH of 8.5 2 CO 3 The aqueous solution was extracted 3 times, the amount of the added extract: the first time was 5000L, the second time was 4000L, the third time was 4500L, the extraction time was 1.0, 0.5, 0.5h, and the extraction temperature was 50℃~60℃. Filtrate, combine the first 2 filtrates, and extract the third filtrate as the first extract of the next batch of materials. residue discarded;

[0032] (3) Adjusting and concentrating: Use dilute sulfuric acid with a concentration of 2% to adjust the pH of the first two combined filtrates to 6.0~7.0, ...

Embodiment 2

[0046] Carry out embodiment 1 repeatedly by the same step as described, but: step (2) is 10 Na with pH 2 CO 3 The aqueous solution was extracted 3 times; step (3) adjusted the pH of the first two combined filtrates to neutral with 4% dilute sulfuric acid; step (5) adjusted the pH value of the filtrate with 4% dilute sulfuric acid.

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Abstract

The invention discloses a process for separating and extracting 98% quercetin from the aboveground part of the pubescent holly root, which is characterized by comprising the following steps: slicing the aboveground part of the pubescent holly root which is taken as a raw material; extracting by weak alkaline water; neutralizing and concentrating; filtering by an alkalified plate frame; acidifying, insulating and depositing; filtering and washing; crystallizing and filtering; carrying out acid hydrolysis; carrying out suction filtration, and washing; discoloring and crystallizing; carrying out suction filtration, and washing; and carrying out vacuum drying to obtain a finished product. The invention has the advantages that (1) the new raw material (the aboveground part of pubescent holly root) for extracting the quercetin are found; (2) the production cost of the quercetin is reduced, the profit of enterprises is increased, energy saving and emission reduction are realized, and the market competitiveness of products is improved; (3) standard production lines and associated equipment for industrially producing the quercetin are established, thereby establishing a basis for industrial production; and (4) the problem of the quercetin purity in the prior art is solved, the content of the quercetin can reach more than 98% at an HPLC (high performance liquid chromatography) grade.

Description

technical field [0001] The invention relates to a process for separating and extracting plant active components, in particular to a process for separating and extracting 98% quercetin from the aerial parts of holly holly. Background technique [0002] Quercetin, also known as quercetin, quercetin, has a typical chemical structure of flavonols, is a kind of flavonoids with various biological activities, is the main component of flavonoids, and has high medicinal value. It is an important pharmaceutical raw material and intermediate, which can be used as medicine and health care product. It has good functions of eliminating phlegm, relieving cough and relieving asthma; Dilate coronary arteries and increase coronary blood flow. Clinically used for the treatment of chronic bronchitis, auxiliary treatment of coronary heart disease and hypertension. [0003] Studies in recent years have shown that quercetin can significantly inhibit the effect of cancer-promoting agents, inhibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40
Inventor 周迪平刘庚贵蒋新芳
Owner GUILIN SANLENG BIOTECH
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