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Application of cobimetinib in preparation of medicaments for treating tuberculosis

A technology for cobitinib and tuberculosis, applied in the field of bioengineering, can solve the problems of slow research and development of anti-tuberculosis drugs, cross-drug resistance, etc.

Inactive Publication Date: 2019-08-23
THE THIRD PEOPLES HOSPITAL OF SHENZHEN
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the first-line anti-tuberculosis drugs currently used were all developed more than 40 years ago, and the development of new and effective anti-tuberculosis drugs is slow, and these drugs directly act on the tuberculosis itself, and there is always a risk of cross-drug resistance

Method used

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  • Application of cobimetinib in preparation of medicaments for treating tuberculosis
  • Application of cobimetinib in preparation of medicaments for treating tuberculosis
  • Application of cobimetinib in preparation of medicaments for treating tuberculosis

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Embodiment Construction

[0016] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments. In the present invention, two groups of experiments are used to determine the effect of cobitinib on enhancing the activity of macrophages to resist Mycobacterium tuberculosis in macrophages. The technical means used in the following experiments are conventional means well known to those skilled in the art, and all raw materials are general materials.

[0017] Experiment 1

[0018] 1. Differentiation of U937 macrophages (No. BNCC100967):

[0019] 1. Culture the suspended U937 macrophages in RPMI-1640 medium containing 10% FBS (fetal bovine serum), and place them at a temperature of 37°C with 5% CO 2 cultured in a cell culture incubator.

[0020] 2. Add PMA (phorbol myristate) at a final concentration of 20 ng / ml and culture overnight to differentiate them into macrophages.

[0021] 3. Wash twice with PBS (phosphate buffer saline), d...

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Abstract

The invention discloses application of cobimetinib in preparation of medicaments for treating tuberculosis. The application is high in safety, and the efficiency of killing mycobacterium tuberculosisis high. According to the application of cobimetinib in preparation of the medicaments for treating tuberculosis, the medicaments for treating tuberculosis are resistant to mycobacterium tuberculosis.The invention also provides a pharmaceutical composition for treating tuberculosis. The pharmaceutical composition comprises cobimetinib. Cobimetinib serving as a potential medicament for targeting HDT has been approved by FDA, is high in safety and has a great development value, so that by applying cobimetinib as a main component in anti-tuberculosis medicaments, the safety is high. Experimentsshow that cobimetinib in macrophages can obviously enhance the activity of the macrophages to kill tubercle bacillus.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to the application of cobitinib as a medicine for treating tuberculosis. Background technique [0002] Research and development of new drugs / programs for the effective treatment of tuberculosis in order to improve the treatment effect, shorten the course of treatment, reduce toxic side effects, and overcome clinical drug resistance is a major topic and research hotspot in the prevention and control of tuberculosis. The development of new anti-tuberculosis drugs is an important idea to solve tuberculosis drug resistance. However, the first-line anti-tuberculosis drugs used today were all developed more than 40 years ago. The development of new and effective anti-tuberculosis drugs is slow, and these drugs directly act on the tuberculosis itself, and there is always a risk of cross-drug resistance. HDT drugs achieve the purpose of treating tuberculosis by improving the host's ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4523A61P31/06
CPCA61K31/4523A61P31/06
Inventor 杨倩婷张明霞
Owner THE THIRD PEOPLES HOSPITAL OF SHENZHEN
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