268 results about "Bone tubercle" patented technology

A total ankle replacement system, novel surgical method for total ankle replacement, and novel surgical tools for performing the surgical method are described. The total ankle replacement system includes the calcaneus in fixation of a lower prosthesis body, thereby significantly increasing the amount of bone available for fixation of the lower prosthesis body and allowing the lower prosthesis body to be anchored with screws. The total ankle replacement system further includes a long tibial stem which can also be anchored into the tibia with, for example, screws, nails, anchors, or some other means of attachment. The novel surgical arthroscopic method allows introduction of ankle prostheses into the ankle joint through an exposure in the tibial tubercle. Various novel surgical instruments, such as a telescoping articulating reamer and a talo-calcaneal jig, which facilitate the novel surgical method, are also described.

A prosthesis for placement into a joint space between two or more bones is disclosed. The prosthesis includes a body formed from a pre-formed solid one piece elastomer, wherein the elastomer is formed from a synthetic organic polymer that is biocompatible and has a modulus of elasticity and a mechanical strength between 0.5 MPa and 75 MPa. The body having a shape contoured to fit within a joint space between the femoral condyle, tubercle, and tibial plateau without any means of attachment.

The invention discloses a lung tubercle automatic detection method based on a 3D convolutional neural network(CNN). According to the invention, detection is creatively divided into two phases: (1) a candidate lung tubercle detection phase and (2) a false positive lung tubercle screening-out phase. In every phase, a unique 3D CNN is constructed and trained to be suitable for detection and screening-out of lung tubercles. The 3D CNN of the first phase is used to detect candidate lung tubercle positions of suspected lung tubercles preliminarily, and the 3D CNN of the second phase is used to screen out the false positive lung tubercles of the candidate tubercles, and finally, the positions of the tubercles in a whole lung CT image are found. The existence condition of the tubercles in the whole lung CT image is automatically detected, and by comparing with a conventional artificial tubercle detection way, the lung tubercle automatic detection method provided by the invention has advantages of high detection accuracy, strong robustness, high efficiency, short consumed time, and realizing convenient and effective detection of lung tubercles.

A humerus head prosthesis including a head and a shaft. A hollow quiver which has one or more openings in the jacket is arranged at the shaft proximally and below the head. The quiver is located at the level of the anatomical position of the tubercles and laterally at the shaft. The jacket openings are formed as threaded bores for screws.

A proximal humerus fracture plate for promoting healing of a fracture of a human humerus, comprising: an upper section having at least one screw hole for receiving an upper screw, the trajectory of the screw hole is a lateral to medial orientation; a transitional section having at least one screw hole for receiving a middle screw, the transitional section integral with the upper section and curved sufficiently to avoid a deltoid tuberosity, the middle screw fixing the transitional section along a lateral cortex of the humerus; and, a lower section having at least one screw hole for receiving a lower screw, the trajectory of the screw hole is an anterior to posterior orientation, the lower section integral with the transitional section.

The invention discloses an automatic segmentation method for a lung-area CT sequence. The method is characterized by comprising the steps of 1) an image I of the lung-area CT sequence is input; 2) the image I is segmented via interactive region growth; 3) according to a segmentation result, an initial contour is obtained, and seed-point coordinates of adjacent images are calculated; 4) based on the seed-point coordinates of the image I, a present image II in the sequence is segmented via the interactive region growth in step 2; and 5) step 2, 3, 4 are repeated to determine whether all images in the CT sequence are segmented, and if no, the step 3 is turned to. The automatic segmentation method automatically calculates mapping of the seed-point areas by combining the image context object characteristic continuity of the sequence to realize sequence segmentation, thereby obtaining complete three-dimensional area data of the lung, and providing basis for VOI extraction and classification of a suspected lung tubercle for a CAD system.

The invention relates to the field of medical image processing and mode recognition, in particular to a tubercle bacillus target recognizing and counting algorithm based on diverse characteristics. The algorithm comprises the following steps of: image preprocessing: carrying out image reinforcement and constructing median filter and Gaussian filter on a tubercle bacillus microimage; color image partition: carrying out fixed threshold partition based on HSV (Hue-Saturation-Value) color space on a preprocessed image and then carrying out adaptive threshold partition which is based on CIE L*a*b* color space and keeps a geometric shape of a target; communication block morphological analysis and target recognition: carrying out communication block analysis on the partitioned image; and tubercle bacillus target counting: estimating the quantity of tubercle bacillus targets in the image by utilizing a histogram statistics and multistrategy calculation method. The invention can effectively extract the bacillus targets in the tubercle bacillus microimage subjected to acid-fast stain from background and impurities and carry out accurate counting, thereby realizing the automation and the intellectualization of the detection of tubercle bacilli.

The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and / or the growth of tubercle bacillus, and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and / or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and / or PDH activity key to a pathogen's survival.

The invention relates to a system and method for intelligently identify and count sputum smear microscopic image tubercle bacillus. The system includes a microscopic imaging device which is additionally provided with a CCD image sensor and the microscopic image of the tubercle bacillus is input into a computer by the CCD image sensor and an image collecting card; the lower side of the microscopic imaging device is provided with a 3D accurate control platform used for finishing the automatic switches of automatic focusing and continuous eyeshot so as to realize dynamic and automatic checking on the continuous eyeshot. A dry lens is adopted as an object lens and a multiple extender lens is added in a light path. Computer control realizes the dynamically intelligent identifying and counting on the tubercle bacillus with continuous eyeshot of the same sputum smear. The invention can replace manual spelling and counting, overcome the defects of manual spelling, improve the efficiency and accuracy of a sputum smear lens detecting method and is simultaneously helpful for improving the scientific level of a normal detecting method of the tubercle bacillus. The invention provides a scientific evidence for the clinical diagnosis and control of tuberculosis.

A method and apparatus of reattaching a bone fragment to a proximal humerus of a humerus in a shoulder joint. The method includes introducing a distal end of the humeral nail into a medullary canal of the humerus. A first proximal screw is engaged with the bone fragment and a first proximal bore in the proximal end of the humeral nail to move the bone fragment toward the proximal humerus. The humeral nail and the attached bone fragment are rotated relative to the medullary canal of the humerus to position the bone fragment to an anatomically optimal location. The bone fragment is preferably one of a greater or lesser tuberosity of the proximal humerus. The method and apparatus can be used to reattach bone fragments in a variety of other joints.

The invention relates to a device and a method for detecting sputum smear tubercle bacillus quickly. The device comprises a support, a charge coupled device (CCD) image sensor, a microscopic imaging system, a computer system, a three-dimensional accurate control console, an X-axis motor, a Y-axis motor, a Z-axis motor, wherein a high-accuracy grating ruler with a grating sensor is arranged in the Z-axis direction of the support additionally; a light-emitting diode (LED) light source plate of which the light intensity is controllable is positioned on the lower side of the microscopic imaging system and is used as an object stage; and the computer system comprises three software functional modules, namely a control module, an image target fusion module and a neural network classification and counting module. The method comprises a visual sense area interpretation algorithm and an optimum detection path scanning algorithm which are used for image detection and a method for fusing targets twice in image segmentation. By the device and the method, the detection accuracy and efficiency of machine vision can be improved, and the scientific reference is provided for the clinical diagnosis and prevention and treatment of tuberculosis.

Intramedullary guidance systems and methods introduce some and / or all surgical tools and ankle prostheses components through the tibia, using minimal invasive exposure in the tibia tubercle, or retrograde through the talus, using minimal invasive exposure in planar surface of the calcaneus. The systems and methods align the talus and tibia for the installation of one or more ankle prostheses components, and also maintain that alignment during the installation using intramedullary guidance, e.g., by use of a guide pin to form an intramedullar passage along which surgical tools and prosthetic components are guided.

The invention relates to application of kelimycin in mycobacterium tuberculosis infection resistance. The application comprises the following main steps: clinical first-line antitubercular drugs isoniazide and rifamycin are used as contrast, and the antimycobacterial activity of kelimycin is detected by adopting an absolute concentration method. The result indicates that the activity of kelimycin on clinically separated mycobacterium tuberculosis including drug-resistance bacteria is remarkably superior to those of the clinical first-line contrast drugs isoniazide and rifamycin, and novel application of kelimycin is expected to be developed in treatment of tubercle bacillus infected diseases.

The present invention relates to molecular immunology technology, and aims at screening out antigen epitope molecular simulation peptide capable of exciting human body's protective immunoreaction against tubercle bacillus, researching protective immunoreaction mechanism against tuberculosis, and further developing new type of concatenate polyepitope tuberculosis vaccine. The present invention provides one kind of antigen epitope molecular simulation peptide capable of exciting human body's protective immunoreaction against tubercle bacillus, and the peptide contains the amino acid sequence selected from SEQ ID Nos. 2, 5, 10, 12, 14 and 15. The present invention also provides the screening process and use of the peptide. The present invention may be used in preventing and controlling tuberculosis.

The invention relates to a recombinant virus carrier which can co-express tubercle bacillus Ag85a, ESAT6 and / or Ag85a / ESAT6 fusion protein as well as any immune auxiliary factor; an expression cassette containing at least one type of tubercle bacillus Ag85a coding sequence, ESAT6 coding sequence and Ag85a / ESAT6 fusion protein coding sequence and the any immune auxiliary factor coding sequence is inserted into a gene group DNA of the recombinant virus carrier. The invention also relates to a host cell containing the virus carrier, a pharmaceutical composition and a preparation method thereof. The recombinant virus carrier can co-express a plurality of antigens of m.tuberculosis and / or cell factors, and has improved prevention and / or curing effect to tuberculosis.

The invention discloses a reagent for detecting tubercle bacillus infection in vitro and a method thereof. The reagent comprises M233 polypeptide represented by SEQ ID No.1; and cytokine released from T cells is detected by contacting the M233 polypeptide or an analog thereof with the T cells of a tubercle bacillus host to determine whether the T cells identify the M233 polypeptide or the analog thereof. The reagent has the advantages of high sensitivity, good specificity, being free from interference of BCG vaccine and non-tuberculosis mycobacteria vaccine, being capable of detecting active pulmonary tuberculosis patients, the patients with dormant infection and healthy persons who contact with mycobacterium nontuberculosis. The reagent and the method are especially applicable to detecting tuberculosis and / or dormant infection thereof for Chinese people.

The quick method of identifying bovine mycobacterium and tubercle mycobacterium includes: adding bovine mycobacterium Vallee strain genome DNA to proliferate one 294 bp segment, detecting target gene from bovine mycobacterium DNA with bovine mycobacterium primer, adding tubercle mycobacterium H37vR strain genome DNA to proliferate one 294 bp segment, proliferating target genome from tubercle mycobacterium DNA with tubercle mycobacterium primer, adopting the same upstream primer and different downstream primers and adopting two gene segments of 294 bp and annealing temperature of 67 deg c. The method of present invention is used in the direct detection of bacterial cultured matter and clinical sample.

The invention relates to anti-tubercule bacillus recombination protein. It belongs to gene recombination technique field. Its manufacturing includes the following steps: combining antigen the 190-198 polypeptides of the Ag85B-Mpt64 with Mtb8.4; cloning into escherichia coli vector to express; further purifying to gain. It is recorded as Ag85B-Mpt64190-198-Mtb8.4(SEQ.ID.NO.1). The protein can be used as anti tubercule bacillus subunit vaccine.

Surgical devices, kits and methods of using thereof are described. Generally, the surgical kit includes an osteotomy guide device and / or a bone spacer guide device. The surgical kit can be used in a surgical method for correcting a malalignment of the knee joint that involves performing a fibular osteotomy and / or a tibial osteotomy, and / or administering stem cells. Generally, the osteotomy guide device is configured to allow drilling to occur around the tibia and across a horizontal cross-sectional plane of the tibia so that a direction of each of the drill holes that are formed in the tibia is substantially parallel to or on the same horizontal cross-sectional plane of the tibia. The osteotomy guide device allows drilling to be conducted efficiently and accurately.

The invention relates to Ag85B-ESAT-6 embedded protein vaccine, which is matched with agent MPL-TDM to immunize mouse, to make the IgG2a / IgG1 and IFN- gamma discharge higher then Ag85B-ESAT-6 fusion protein, while later one can generate same protective effect as BCG after infected by bacillus tubercle.

The present invention discloses a pulmonary nodule detection method for a multi-scale enhancement filter and 3D features. The method comprises: constructing a tubercle and blood vessel ideal model, and constructing an enhancement filter to perform enhancement of tubercle images and blood vessel images in a lung 3D image; extracting a suspected lung tubercle image, and extracting the SNOAH features thereof; and finally, employing the SVM classifiers with different kernel functions to perform classification of features. An experiment result shows that a pulmonary nodule feature descriptor-surface normal direction angle histogram is effective so as to distinguish other images such as tubercle images and blood vessel and effectively reduce the fake positive of a detection result.

The invention relates to a posterior fixing steel plate for fracture of acetabular anterior and posterior columns. The posterior fixing steel plate comprises a plate body covering the back wall of the acetabular posterior column; the plate body extends downwards to the root of an ischial spine from the upper part close to the top end of a greater sciatic notch along the inner side edge of the acetabular posterior column and then is bent and extends to the lower part of the top end of an ischial tuberosity; an anterior column threaded hole for being connected with a guide sleeve is formed in the end, at the top end of the greater sciatic notch, of the plate body, and the axis of the anterior column threaded hole points to the acetabular anterior column through sclerotin between an acetabular fossa and a square area; a posterior column threaded hole used for being connected with the guide sleeve is formed in the other end of the ischial tuberosity and the axis of the posterior column threaded hole points to the tail end of the ischial tuberosity through sclerotin in the ischial tuberosity; a plurality of fixing screw holes arranged along the plate body are formed between the anterior column threaded hole and the posterior column threaded hole; a limiting hook hooked to the upper part of the greater sciatic notch is arranged on the side edge, which is close to the greater sciatic notch, of the end and corresponding to the anterior column threaded hole, of the plate body.

The invention relates to a reagent kit for diagnosing enzyme linked immune spots infected by tubercle bacillus and a method for preparing a specific antigen. The reagent kit comprises a reagent kit body and a detection reagent arranged in the kit body; the detection reagent comprises a positive standard solution, a chromogenic agent, a concentrated detergent and a diluent; the detection reagent also comprises a specific antigen of mycobacterium tuberculosis, a coated INF-gamma resistant antibody and an enzyme label secondary antibody of a vector protein conjugate; the specific antigen of mycobacterium tuberculosis is fusion protein expressed by an ESAT-6 gene and an EIS gene of the mycobacterium tuberculosis; and the INF-gamma resistant antibody is a murine IgG antibody. The method for preparing the specific antigen comprises the following steps: proper tubercle bacillus special antigen ESAT-6 and EIS are combined; and the prepared recombining fusion protein contains main antigenic determinants of two antigens. The recombining fusion protein definitely contains a T cell epitope suitable for the limitation of different HLA, and does not influence results by different groups and different HLA distribution. Clinical tests on tuberculosis patients and healthy people of different groups show that the reagent kit has more excellent specificity and sensitivity than a current similar product.

The invention relates to a composition used for serological diagnosis of tuberculosis, which comprises a combination of a special antigen epitope peptide of tubercle bacillus Mtb16.3 with at least one tubercle bacillus special antigen epitope peptide selected from 38kD, ESAT-6, CFP10andMPT64.

A prosthetic hard socket has a modified curvature and / or shape, which eliminates or de-emphasizes the patellar bar to eliminate or reduce pressure on the wearer's patellar tendon, and, instead, enhances support of the anterior tibial condyle and / or tibial tubercle. Thus, the preferred socket is designed with the patellar tendon preferably not being weight-bearing. The preferred curvature and / or shape comprises a lowered socket edge and / or a gap in the socket wall in the region of the patellar tendon, so that the hard structure of the socket does not directly support or press upon the patellar tendon. The invented socket may include inwardly-protruding regions on each side of the lowered edge / gap, for helping to “capture” or otherwise press on a portion of the tibia for improved rotational control. This combination of shapes and curvatures provides for improved rotational control, comfort, and range of motion including even full extension or hyperextension. A flexible and / or cushioning member may be placed in the gap / trough (that is caused by the lowered edge or removed wall portion), for example, a fabric, leather, rubber, or other member may be attached to the socket to across a V-shaped trough of the lowered edge of the hard socket.